Lysosomal stabilizing effect of chlorphentermine in the rabbit alveolar macrophage
Identifieur interne : 002615 ( Istex/Checkpoint ); précédent : 002614; suivant : 002616Lysosomal stabilizing effect of chlorphentermine in the rabbit alveolar macrophage
Auteurs : Mark J. Reasor [États-Unis] ; Elizabeth R. Walker [États-Unis]Source :
- General Pharmacology [ 0306-3623 ] ; 1979.
English descriptors
- Teeft :
- Acid hydrolases, Acid phosphatase, Alveolar foam cells, Alveolar macrophage, Alveolar macrophages, Amphiphilic, Amphiphilic drug, Amphiphilic drugs, Anorectic drug, Aryl sulfatase, Blood cells, Cell size, Chlorphentermine, Chlorphentermine administration, Chlorphentermine treatment, Chronic administration, Control rabbits, Difrancesco bickel, Drug administration, Enzyme activity, Foam cells, High levels, Hydrolases, Hypotonic solution, Lamellated inclusions, Latency, Lysis, Lysosomal, Lysosomal acid hydrolases, Lysosomal enzymes, Lysosomal membrane, Lysosomal membranes, Lysosomal properties, Lysosome, Macrophage, Media composition, Myeloid bodies, Normal rabbits, Other species, Percent lysis, Phosphatase, Phospholipidosis, Present study, Pulmonary aspergillosis, Rabbit alveolar macrophages, Specific effects, Tile sample, Toxic appl, Ultrastructural, Ultrastructural alterations, Ultrastructural changes, Warner chilcott.
Abstract
Abstract: 1. Rabbits were injected (i.p.) daily with chlorphentermine (30 mg/kg), 5 days a week for 7 weeks.2. Alveolar macrophages were collected from the lungs of control and treated rabbits by pulmonary lavage.3. When compared to controls, the latencies of the lysosomal acid hydrolases, acid phosphatase and β-N-acetyl glucosaminidase were increased in lysosome-containing fractions from alveolar macrophages of treated rabbits. The same results were obtained when chlorphentermine was incubated in vitro with a lysosomal fraction from macrophages of normal rabbits.4. The increased latency of lysosomal enzymes following chlorphentermine treatment can be explained by the drug's ability to stabilize lysosomal membranes.
Url:
DOI: 10.1016/0306-3623(79)90040-5
Affiliations:
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ISTEX:9DB47341B5E55CD22FE125118B963BA226E9C66FLe document en format XML
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<term>Alveolar foam cells</term>
<term>Alveolar macrophage</term>
<term>Alveolar macrophages</term>
<term>Amphiphilic</term>
<term>Amphiphilic drug</term>
<term>Amphiphilic drugs</term>
<term>Anorectic drug</term>
<term>Aryl sulfatase</term>
<term>Blood cells</term>
<term>Cell size</term>
<term>Chlorphentermine</term>
<term>Chlorphentermine administration</term>
<term>Chlorphentermine treatment</term>
<term>Chronic administration</term>
<term>Control rabbits</term>
<term>Difrancesco bickel</term>
<term>Drug administration</term>
<term>Enzyme activity</term>
<term>Foam cells</term>
<term>High levels</term>
<term>Hydrolases</term>
<term>Hypotonic solution</term>
<term>Lamellated inclusions</term>
<term>Latency</term>
<term>Lysis</term>
<term>Lysosomal</term>
<term>Lysosomal acid hydrolases</term>
<term>Lysosomal enzymes</term>
<term>Lysosomal membrane</term>
<term>Lysosomal membranes</term>
<term>Lysosomal properties</term>
<term>Lysosome</term>
<term>Macrophage</term>
<term>Media composition</term>
<term>Myeloid bodies</term>
<term>Normal rabbits</term>
<term>Other species</term>
<term>Percent lysis</term>
<term>Phosphatase</term>
<term>Phospholipidosis</term>
<term>Present study</term>
<term>Pulmonary aspergillosis</term>
<term>Rabbit alveolar macrophages</term>
<term>Specific effects</term>
<term>Tile sample</term>
<term>Toxic appl</term>
<term>Ultrastructural</term>
<term>Ultrastructural alterations</term>
<term>Ultrastructural changes</term>
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<front><div type="abstract" xml:lang="en">Abstract: 1. Rabbits were injected (i.p.) daily with chlorphentermine (30 mg/kg), 5 days a week for 7 weeks.2. Alveolar macrophages were collected from the lungs of control and treated rabbits by pulmonary lavage.3. When compared to controls, the latencies of the lysosomal acid hydrolases, acid phosphatase and β-N-acetyl glucosaminidase were increased in lysosome-containing fractions from alveolar macrophages of treated rabbits. The same results were obtained when chlorphentermine was incubated in vitro with a lysosomal fraction from macrophages of normal rabbits.4. The increased latency of lysosomal enzymes following chlorphentermine treatment can be explained by the drug's ability to stabilize lysosomal membranes.</div>
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