Marrow transplantation for severe aplastic anemia associated with exposure to quinacrine
Identifieur interne : 001E43 ( Istex/Checkpoint ); précédent : 001E42; suivant : 001E44Marrow transplantation for severe aplastic anemia associated with exposure to quinacrine
Auteurs : Irene Schmid [États-Unis] ; Claudio Anasetti [États-Unis] ; Finn Bo Petersen [États-Unis] ; Rainer Storb [États-Unis]Source :
- Blut [ 0006-5242 ] ; 1990-08-01.
English descriptors
- KwdEn :
- Teeft :
- Anemia, Aplastic, Aplastic anemia, Case report, Direct cytotoxic effect, Discoid lupus, Erythematous lesions, Idiosyncratic reaction, Lupus, Lupus erythematosus, Marrow, Marrow failure, Marrow transplantation, Normal range, Platelet count, Previous observation, Quinacrine, Rheumatoid arthritis, Semin hematol, Severe aplastic anemia, Skin rash, Transplantation.
Abstract
Summary: Severe aplastic anemia developed in a patient after administration of quinacrine for treatment of discoid lupus erythematosus. Marrow transplantation was performed from an HLA genotypically identical sister after conditioning with cyclophosphamide. Quinacrine which was accumulated in the patient tissues did not interfere with engraftment, suggesting that the drug has no direct cytotoxic effect on hematopoietic stem cells. This study extends our previous observation that severe aplastic anemia acquired after exposure to drugs or toxins can be cured by marrow transplantation.
Url:
DOI: 10.1007/BF02076699
Affiliations:
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lesions</term><term>Idiosyncratic reaction</term><term>Lupus</term><term>Lupus erythematosus</term><term>Marrow</term><term>Marrow failure</term><term>Marrow transplantation</term><term>Normal range</term><term>Platelet count</term><term>Previous observation</term><term>Quinacrine</term><term>Rheumatoid arthritis</term><term>Semin hematol</term><term>Severe aplastic anemia</term><term>Skin rash</term><term>Transplantation</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Summary: Severe aplastic anemia developed in a patient after administration of quinacrine for treatment of discoid lupus erythematosus. Marrow transplantation was performed from an HLA genotypically identical sister after conditioning with cyclophosphamide. Quinacrine which was accumulated in the patient tissues did not interfere with engraftment, suggesting that the drug has no direct cytotoxic effect on hematopoietic stem cells. This study extends our previous observation that severe aplastic anemia acquired after exposure to drugs or toxins can be cured by marrow transplantation.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Washington (État)</li></region><settlement><li>Seattle</li></settlement><orgName><li>Université de Washington</li></orgName></list><tree><country name="États-Unis"><region name="Washington (État)"><name sortKey="Schmid, Irene" sort="Schmid, Irene" uniqKey="Schmid I" first="Irene" last="Schmid">Irene Schmid</name></region><name sortKey="Anasetti, Claudio" sort="Anasetti, Claudio" uniqKey="Anasetti C" first="Claudio" last="Anasetti">Claudio Anasetti</name><name sortKey="Petersen, Finn Bo" sort="Petersen, Finn Bo" uniqKey="Petersen F" first="Finn Bo" last="Petersen">Finn Bo Petersen</name><name sortKey="Storb, Rainer" sort="Storb, Rainer" uniqKey="Storb R" first="Rainer" last="Storb">Rainer Storb</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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