Positron emission tomography of experimental melanoma with [76Br]5-bromo-2-thiouracil
Identifieur interne : 001327 ( Istex/Checkpoint ); précédent : 001326; suivant : 001328Positron emission tomography of experimental melanoma with [76Br]5-bromo-2-thiouracil
Auteurs : Ulla M Rs [Suède] ; Vladimir Tolmachev [Suède] ; Anders Sundin [Suède]Source :
- Nuclear Medicine and Biology [ 0969-8051 ] ; 2000.
English descriptors
- KwdEn :
- Teeft :
- Acetic acid, Autoradiography, Bladder liver kidney muscle, Cancer patients, Clear delineation, Clinical immunology, Diagnostic modality, Diagnostic radiology, Elsevier science, High uptake, Human melanoma, Imaging, Larsson, Malignant melanoma, Melanin, Melanoma, Melanoma cells, Melanoma seeker, Melanoma tumors, Melanotic melanoma, Murine, Murine melanoma, Nascent melanin, Normal tissues, Nucl, Ocular melanoma, Other tissues, Overall concentration, Phosphate buffer, Pigment cell, Positron emission tomography, Preformed melanin, Present study, Previous autoradiographic studies, Radioactivity, Radioactivity concentrations, Relative concentration, Selective accumulation, Selective incorporation, Selective uptake, Sodium metabisulphite, Subcutaneous melanoma, Thiouracil, Tracer, Uppsala, Uppsala university.
Abstract
Abstract: Positron emission tomography (PET) has evolved as a new diagnostic modality in cancer patients. Thioureylenes, such as thiouracil and methimazole, are known to be incorporated into growing melanin and selectively retained in melanotic melanoma. In the present study we used [76Br]5-bromo-2-thiouracil as tracer for PET imaging of human and murine melanotic melanoma transplanted subcutaneously into rats. The melanomas were clearly depicted 1 day after the injection, when [76Br]5-bromo-2-thiouracil was retained in the tumors though the overall radioactivity concentration in the body had declined. Accumulation of 76Br was also seen in bladder, liver, and kidney. In addition, the rats were simultaneously injected with [125I]5-iodo-2-thiouracil and the tissue distribution of radioactivity was mapped by whole-body autoradiography. The results confirmed the selective uptake of thiouracil in the melanoma where the concentration of 125I-radioactivity was about three-fold higher than that in the liver and lungs. These results show the possibility of using [76Br]5-bromo-2-thiouracil for PET diagnostics of melanoma, including dosimetry, prior to targeted therapy using [131I]5-iodo-2-thiouracil or [211At]5-astato-2-thiouracil.
Url:
DOI: 10.1016/S0969-8051(00)00147-5
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
ISTEX:71278FD93BB5B13566B59F3807739BFA73A2B762Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Positron emission tomography of experimental melanoma with [76Br]5-bromo-2-thiouracil</title><author><name sortKey="M Rs, Ulla" sort="M Rs, Ulla" uniqKey="M Rs U" first="Ulla" last="M Rs">Ulla M Rs</name></author><author><name sortKey="Tolmachev, Vladimir" sort="Tolmachev, Vladimir" uniqKey="Tolmachev V" first="Vladimir" last="Tolmachev">Vladimir Tolmachev</name></author><author><name sortKey="Sundin, Anders" sort="Sundin, Anders" uniqKey="Sundin A" first="Anders" last="Sundin">Anders Sundin</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:71278FD93BB5B13566B59F3807739BFA73A2B762</idno><date when="2000" year="2000">2000</date><idno type="doi">10.1016/S0969-8051(00)00147-5</idno><idno type="url">https://api.istex.fr/ark:/67375/6H6-WP2NN2FT-9/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">001D18</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001D18</idno><idno type="wicri:Area/Istex/Curation">001D18</idno><idno type="wicri:Area/Istex/Checkpoint">001327</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">001327</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Positron emission tomography of experimental melanoma with [76Br]5-bromo-2-thiouracil</title><author><name sortKey="M Rs, Ulla" sort="M Rs, Ulla" uniqKey="M Rs U" first="Ulla" last="M Rs">Ulla M Rs</name><affiliation wicri:level="1"><country wicri:rule="url">Suède</country></affiliation><affiliation wicri:level="4"><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Pharmaceutical Biosciences, Division of Toxicology, Uppsala University, Uppsala</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author><author><name sortKey="Tolmachev, Vladimir" sort="Tolmachev, Vladimir" uniqKey="Tolmachev V" first="Vladimir" last="Tolmachev">Vladimir Tolmachev</name><affiliation wicri:level="4"><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Diagnostic Radiology, Oncology and Clinical Immunology, Division of Biomedical Radiation Sciences, Uppsala University, Uppsala</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author><author><name sortKey="Sundin, Anders" sort="Sundin, Anders" uniqKey="Sundin A" first="Anders" last="Sundin">Anders Sundin</name><affiliation wicri:level="1"><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Diagnostic Radiology, Oncology and Clinical Immunology, Division of Diagnostic Radiology and Uppsala University PETcentre, Uppsala University, Uppsala</wicri:regionArea><wicri:noRegion>Uppsala</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Nuclear Medicine and Biology</title><title level="j" type="abbrev">NMB</title><idno type="ISSN">0969-8051</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="2000">2000</date><biblScope unit="volume">27</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="845">845</biblScope><biblScope unit="page" to="849">849</biblScope></imprint><idno type="ISSN">0969-8051</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0969-8051</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>76Br</term><term>Autoradiography</term><term>Melanin</term><term>Melanoma</term><term>PET</term><term>Thiouracil</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Acetic acid</term><term>Autoradiography</term><term>Bladder liver kidney muscle</term><term>Cancer patients</term><term>Clear delineation</term><term>Clinical immunology</term><term>Diagnostic modality</term><term>Diagnostic radiology</term><term>Elsevier science</term><term>High uptake</term><term>Human melanoma</term><term>Imaging</term><term>Larsson</term><term>Malignant melanoma</term><term>Melanin</term><term>Melanoma</term><term>Melanoma cells</term><term>Melanoma seeker</term><term>Melanoma tumors</term><term>Melanotic melanoma</term><term>Murine</term><term>Murine melanoma</term><term>Nascent melanin</term><term>Normal tissues</term><term>Nucl</term><term>Ocular melanoma</term><term>Other tissues</term><term>Overall concentration</term><term>Phosphate buffer</term><term>Pigment cell</term><term>Positron emission tomography</term><term>Preformed melanin</term><term>Present study</term><term>Previous autoradiographic studies</term><term>Radioactivity</term><term>Radioactivity concentrations</term><term>Relative concentration</term><term>Selective accumulation</term><term>Selective incorporation</term><term>Selective uptake</term><term>Sodium metabisulphite</term><term>Subcutaneous melanoma</term><term>Thiouracil</term><term>Tracer</term><term>Uppsala</term><term>Uppsala university</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Positron emission tomography (PET) has evolved as a new diagnostic modality in cancer patients. Thioureylenes, such as thiouracil and methimazole, are known to be incorporated into growing melanin and selectively retained in melanotic melanoma. In the present study we used [76Br]5-bromo-2-thiouracil as tracer for PET imaging of human and murine melanotic melanoma transplanted subcutaneously into rats. The melanomas were clearly depicted 1 day after the injection, when [76Br]5-bromo-2-thiouracil was retained in the tumors though the overall radioactivity concentration in the body had declined. Accumulation of 76Br was also seen in bladder, liver, and kidney. In addition, the rats were simultaneously injected with [125I]5-iodo-2-thiouracil and the tissue distribution of radioactivity was mapped by whole-body autoradiography. The results confirmed the selective uptake of thiouracil in the melanoma where the concentration of 125I-radioactivity was about three-fold higher than that in the liver and lungs. These results show the possibility of using [76Br]5-bromo-2-thiouracil for PET diagnostics of melanoma, including dosimetry, prior to targeted therapy using [131I]5-iodo-2-thiouracil or [211At]5-astato-2-thiouracil.</div></front></TEI><affiliations><list><country><li>Suède</li></country><region><li>East Middle Sweden</li><li>Svealand</li></region><settlement><li>Uppsala</li></settlement><orgName><li>Université d'Uppsala</li></orgName></list><tree><country name="Suède"><noRegion><name sortKey="M Rs, Ulla" sort="M Rs, Ulla" uniqKey="M Rs U" first="Ulla" last="M Rs">Ulla M Rs</name></noRegion><name sortKey="M Rs, Ulla" sort="M Rs, Ulla" uniqKey="M Rs U" first="Ulla" last="M Rs">Ulla M Rs</name><name sortKey="Sundin, Anders" sort="Sundin, Anders" uniqKey="Sundin A" first="Anders" last="Sundin">Anders Sundin</name><name sortKey="Tolmachev, Vladimir" sort="Tolmachev, Vladimir" uniqKey="Tolmachev V" first="Vladimir" last="Tolmachev">Vladimir Tolmachev</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Istex/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001327 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Checkpoint/biblio.hfd -nk 001327 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= ChloroquineV1
|flux= Istex
|étape= Checkpoint
|type= RBID
|clé= ISTEX:71278FD93BB5B13566B59F3807739BFA73A2B762
|texte= Positron emission tomography of experimental melanoma with [76Br]5-bromo-2-thiouracil
}}
| This area was generated with Dilib version V0.6.33. |  |