1-(7-Chloroquinolin-4-yl)-2-[(1H-pyrrol-2-yl)methylene]hydrazine: a potent compound against cancer
Identifieur interne : 000571 ( Istex/Checkpoint ); précédent : 000570; suivant : 0005721-(7-Chloroquinolin-4-yl)-2-[(1H-pyrrol-2-yl)methylene]hydrazine: a potent compound against cancer
Auteurs : Raquel Carvalho Montenegro [Brésil] ; Letícia Veras Lotufo [Brésil] ; Manoel Odorico De Moraes [Brésil] ; Cláudia Do Pessoa [Brésil] ; Felipe Augusto Rocha Rodrigues [Brésil] ; Marcelle De Lima Ferreira Bispo [Brésil] ; Camila Cataldi De Alcantara [Brésil] ; Carlos Roland Kaiser [Brésil] ; Marcus Vinícius Nora De Souza [Brésil]Source :
- Medicinal Chemistry Research [ 1054-2523 ] ; 2012-11-01.
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- Wicri :
- topic : Cancer.
English descriptors
- KwdEn :
Abstract
Abstract: Heteroaromatic derivatives (3a–f) have been synthesized and evaluated for their activity against four cancer cell lines. Among the studied compounds, 1-(7-Chloroquinolin-4-yl)-2-[(1H-pyrrol-2-yl)methylene]hydrazine (3e) exhibited an excellent cytotoxic activity against the referred lines, and especially on melanoma cells (MDAMB-435). In this case, compound 3e is four times more active than the standard substance Doxorubicin. Together with other results from our group, 7-chloro-4-quinolinylhydrazones derived from chloroquine could be considered a relevant finding toward the rational design of new leads for antitumor compounds.
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DOI: 10.1007/s00044-011-9894-8
Affiliations:
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<front><div type="abstract" xml:lang="en">Abstract: Heteroaromatic derivatives (3a–f) have been synthesized and evaluated for their activity against four cancer cell lines. Among the studied compounds, 1-(7-Chloroquinolin-4-yl)-2-[(1H-pyrrol-2-yl)methylene]hydrazine (3e) exhibited an excellent cytotoxic activity against the referred lines, and especially on melanoma cells (MDAMB-435). In this case, compound 3e is four times more active than the standard substance Doxorubicin. Together with other results from our group, 7-chloro-4-quinolinylhydrazones derived from chloroquine could be considered a relevant finding toward the rational design of new leads for antitumor compounds.</div>
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