ChloroquineV1, Hal, Curation, bibRecord, 000250

[A new hope against malaria: The contribution of organometallic chemistry]

Identifieur interne : 000250 ( Hal/Curation ); précédent : 000249; suivant : 000251

[A new hope against malaria: The contribution of organometallic chemistry]

Auteurs : Christophe Biot [France] ; Daniel Dive [France]

Source :

RBID : Hal:hal-00641812

Descripteurs français

mix :
- Paludisme, candidat médicament, ferroquine, mécanisme d’action, résistance.

English descriptors

mix :
- Malaria, drug candidate, ferroquine, mechanism of action, resistance.

Abstract

Emblem of bioorganometallics, ferroquine is the most advanced organometallic drug candidate and about to complete phase II clinical trials as a treatment for uncomplicated malaria. This ferrocene-containing compound is active against both susceptible and resistant Plasmodium falciparum and Plasmodium vivax strains and/or isolates to the most used drug, chloroquine. This article sums up the discovery of ferroquine, its antimalarial activity, the hypothesis of its mode of action and the current absence of resistance in vitro.

Url:

https://hal.archives-ouvertes.fr/hal-00641812

Links toward previous steps (curation, corpus...)

to stream Hal, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000250

Links to Exploration step

Hal:hal-00641812

Le document en format XML

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<front><div type="abstract" xml:lang="en">              <p>Emblem of bioorganometallics, ferroquine is the most advanced organometallic drug candidate and about to complete phase II clinical trials as a treatment for uncomplicated malaria. This ferrocene-containing compound is active against both susceptible and resistant Plasmodium falciparum and Plasmodium vivax strains and/or isolates to the most used drug, chloroquine. This article sums up the discovery of ferroquine, its antimalarial activity, the hypothesis of its mode of action and the current absence of resistance in vitro.</p>
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            <abstract xml:lang="en">              <p>Emblem of bioorganometallics, ferroquine is the most advanced organometallic drug candidate and about to complete phase II clinical trials as a treatment for uncomplicated malaria. This ferrocene-containing compound is active against both susceptible and resistant Plasmodium falciparum and Plasmodium vivax strains and/or isolates to the most used drug, chloroquine. This article sums up the discovery of ferroquine, its antimalarial activity, the hypothesis of its mode of action and the current absence of resistance in vitro.</p>
            </abstract>
            <abstract xml:lang="fr">              <p>Emblème de la bioorganométallique, la ferroquine est le candidat médicament organométallique le plus avancé dans son développement industriel et devrait achever des études cliniques de phase II comme traitement du paludisme non compliqué. Ce composé à base de ferrocène est extrêmement actif contre des isolats et/ou des clones de Plasmodium falciparum sensibles ou résistants à l’antipaludique le plus utilisé, la chloroquine, et contre Plasmodium vivax. Cet article résume la découverte de la ferroquine, son activité antipaludique, les hypothèses liées à son mode d’action et l’absence actuelle de résistance in vitro.</p>
            </abstract>
            <particDesc>              <org type="consortium">Les auteurs remercient sincèrement tous ceux qui ont cru en ce projet scientifique et l’ont soutenu depuis 1994, tous les co-auteurs des articles et les doctorants qui ont contribué au projet. Ils remercient également Christian Slomianny pour les photographies en microscopie électronique à transmission</org>
            </particDesc>
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[A new hope against malaria: The contribution of organometallic chemistry]

[A new hope against malaria: The contribution of organometallic chemistry]

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