Measuring malaria morbidity in an area of seasonal transmission: Pyrogenic parasitemia thresholds based on a 20-year follow-up study
Identifieur interne : 000154 ( Hal/Curation ); précédent : 000153; suivant : 000155Measuring malaria morbidity in an area of seasonal transmission: Pyrogenic parasitemia thresholds based on a 20-year follow-up study
Auteurs : Marion Dollat [Sénégal] ; Cheikh Talla [Sénégal] ; Cheikh Sokhna [France] ; Fatoumata Diene Sarr [Sénégal] ; Jean-Francois Trape [France] ; Vincent Richard [Sénégal]Source :
- PLoS ONE [ 1932-6203 ] ; 2019-06-27.
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Abstract
Asymptomatic carriage of P. falciparum is frequent in areas endemic for malaria and individual diagnosis of clinical malaria attacks is still difficult. We investigated the impact of changes in malaria endemicity on the diagnostic criteria for malaria attacks in an area of seasonal malaria transmission.METHODS: We analyzed the longitudinal data collected over 20 years from a daily survey of all inhabitants of Ndiop, a rural community in central Senegal, in a logistic regression model to investigate the relationship between the level of Plasmodium falciparum parasitemia and the risk of fever, with the aim of determining the best parasitemia thresholds for attributing to malaria a fever episode.RESULTS: A total of 34,136 observations recorded from July 1993 to December 2013 from 850 individuals aged from 1 day to 87 years were included. P. falciparum asymptomatic carriage declined from 36% to 1% between 1993 and 2013. A total of 9,819 fever episodes were associated with a positive blood film for P. falciparum. Using age-dependent parasitemia thresholds for attributing to malaria a fever episode, we recorded 6,006 malaria attacks during the study period. Parasitemia thresholds seemed to be lower during the low-to-zero transmission season and tended to decrease with changes in control policies. The number of clinical malaria attacks was overestimated for all age groups throughout the study when all fever episodes associated with P. falciparum parasitemia were defined as malaria attacks.CONCLUSION: Pyrogenic thresholds are particularly sensitive to changes in malaria epidemiology and are therefore an interesting tool to accurately assess the burden of malaria in the context of declining transmission.
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DOI: 10.1371/journal.pone.0217903
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Infections tropicales et méditerranéennes</orgName> <orgName type="acronym">VITROME</orgName> <date type="start">2018-01-01</date> <desc> <address> <addrLine>IHU Méditerranée Infection19-21 Bd Jean Moulin13005 Marseille</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation name="UMR_D 257" active="#struct-67872" type="direct"></relation> <relation name="UMR MD4" active="#struct-198056" type="direct"></relation> <relation active="#struct-507058" type="direct"></relation> </listRelation> <tutelles><tutelle name="UMR_D 257" active="#struct-67872" type="direct"><org type="institution" xml:id="struct-67872" status="VALID"> <orgName>Institut de Recherche pour le Développement</orgName> <orgName type="acronym">IRD</orgName> <desc> <address> <addrLine>SiègeLe Sextant 44, bd de DunkerqueCS 9000913572 Marseille cedex 02</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.ird.fr/</ref> </desc> </org></tutelle><tutelle name="UMR MD4" active="#struct-198056" type="direct"><org type="institution" xml:id="struct-198056" status="VALID"> <idno type="IdRef">15863621X</idno> <idno type="ISNI">0000 0001 2176 4817</idno> <orgName>Aix Marseille Université</orgName> <orgName type="acronym">AMU</orgName> <date type="start">2012-01-01</date> <desc> <address> <addrLine>Aix-Marseille UniversitéJardins du Pharo58 Boulevard Charles Livon13284 Marseille cedex 7</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-amu.fr/</ref> </desc> </org></tutelle><tutelle active="#struct-507058" type="direct"><org type="institution" xml:id="struct-507058" status="VALID"> <orgName>Institut de Recherche Biomédicale des Armées</orgName> <orgName type="acronym">IRBA</orgName> <desc> <address> <addrLine>Brétigny-sur-Orge</addrLine> <country key="FR"></country> </address> <ref type="url">https://www.defense.gouv.fr/sante/notre-expertise/recherche-biomedicale/recherche-biomedicale</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country><placeName><settlement type="city">Marseille</settlement><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region></placeName><orgName type="university">Université d'Aix-Marseille</orgName></affiliation></author><author><name sortKey="Diene Sarr, Fatoumata" sort="Diene Sarr, Fatoumata" uniqKey="Diene Sarr F" first="Fatoumata" last="Diene Sarr">Fatoumata Diene Sarr</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-217849" status="VALID"> <orgName>Unité d'Epidémiologie des Maladies Infectieuses</orgName> <desc> <address> <addrLine>36, Avenue Pasteur B.P. 220 - Dakar</addrLine> <country key="SN"></country> </address> </desc> <listRelation> <relation active="#struct-42095" type="direct"></relation> <relation active="#struct-301247" type="indirect"></relation> </listRelation> <tutelles><tutelle active="#struct-42095" type="direct"><org type="institution" xml:id="struct-42095" status="VALID"> <orgName>Institut Pasteur de Dakar</orgName> <desc> <address> <addrLine>B.P. 220 Dakar</addrLine> <country key="SN"></country> </address> <ref type="url">http://www.pasteur.sn/</ref> </desc> <listRelation> <relation active="#struct-301247" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-301247" type="indirect"><org type="regroupinstitution" xml:id="struct-301247" status="VALID"> <orgName>Réseau International des Instituts Pasteur</orgName> <orgName type="acronym">RIIP</orgName> <desc> <address> <addrLine>25, rue du Dr Roux 75724 Paris Cedex 15</addrLine> <country key="FR"></country> </address> <ref type="url">https://research.pasteur.fr/ip-network</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>Sénégal</country></affiliation></author><author><name sortKey="Trape, Jean Francois" sort="Trape, Jean Francois" uniqKey="Trape J" first="Jean-Francois" last="Trape">Jean-Francois Trape</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-67872" status="VALID"> <orgName>Institut de Recherche pour le Développement</orgName> <orgName type="acronym">IRD</orgName> <desc> <address> <addrLine>SiègeLe Sextant 44, bd de DunkerqueCS 9000913572 Marseille cedex 02</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.ird.fr/</ref> </desc> </hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Richard, Vincent" sort="Richard, Vincent" uniqKey="Richard V" first="Vincent" last="Richard">Vincent Richard</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-217849" status="VALID"> <orgName>Unité d'Epidémiologie des Maladies Infectieuses</orgName> <desc> <address> <addrLine>36, Avenue Pasteur B.P. 220 - Dakar</addrLine> <country key="SN"></country> </address> </desc> <listRelation> <relation active="#struct-42095" type="direct"></relation> <relation active="#struct-301247" type="indirect"></relation> </listRelation> <tutelles><tutelle active="#struct-42095" type="direct"><org type="institution" xml:id="struct-42095" status="VALID"> <orgName>Institut Pasteur de Dakar</orgName> <desc> <address> <addrLine>B.P. 220 Dakar</addrLine> <country key="SN"></country> </address> <ref type="url">http://www.pasteur.sn/</ref> </desc> <listRelation> <relation active="#struct-301247" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-301247" type="indirect"><org type="regroupinstitution" xml:id="struct-301247" status="VALID"> <orgName>Réseau International des Instituts Pasteur</orgName> <orgName type="acronym">RIIP</orgName> <desc> <address> <addrLine>25, rue du Dr Roux 75724 Paris Cedex 15</addrLine> <country key="FR"></country> </address> <ref type="url">https://research.pasteur.fr/ip-network</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>Sénégal</country></affiliation></author></analytic><idno type="DOI">10.1371/journal.pone.0217903</idno><series><title level="j">PLoS ONE</title><idno type="ISSN">1932-6203</idno><imprint><date type="datePub">2019-06-27</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="mix" xml:lang="en"><term>Chloroquine</term><term>Fevers</term><term>Malaria</term><term>Malarial parasites</term><term>Parasitemia</term><term>Parasitic diseases</term><term>Plasmodium</term><term>Quinine</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"> <p>Asymptomatic carriage of P. falciparum is frequent in areas endemic for malaria and individual diagnosis of clinical malaria attacks is still difficult. We investigated the impact of changes in malaria endemicity on the diagnostic criteria for malaria attacks in an area of seasonal malaria transmission.METHODS: We analyzed the longitudinal data collected over 20 years from a daily survey of all inhabitants of Ndiop, a rural community in central Senegal, in a logistic regression model to investigate the relationship between the level of Plasmodium falciparum parasitemia and the risk of fever, with the aim of determining the best parasitemia thresholds for attributing to malaria a fever episode.RESULTS: A total of 34,136 observations recorded from July 1993 to December 2013 from 850 individuals aged from 1 day to 87 years were included. P. falciparum asymptomatic carriage declined from 36% to 1% between 1993 and 2013. A total of 9,819 fever episodes were associated with a positive blood film for P. falciparum. Using age-dependent parasitemia thresholds for attributing to malaria a fever episode, we recorded 6,006 malaria attacks during the study period. Parasitemia thresholds seemed to be lower during the low-to-zero transmission season and tended to decrease with changes in control policies. The number of clinical malaria attacks was overestimated for all age groups throughout the study when all fever episodes associated with P. falciparum parasitemia were defined as malaria attacks.CONCLUSION: Pyrogenic thresholds are particularly sensitive to changes in malaria epidemiology and are therefore an interesting tool to accurately assess the burden of malaria in the context of declining transmission.</p> </div></front></TEI><hal api="V3"> <titleStmt> <title xml:lang="en">Measuring malaria morbidity in an area of seasonal transmission: Pyrogenic parasitemia thresholds based on a 20-year follow-up study</title> <author role="crp"> <persName> <forename type="first">Marion</forename> <surname>Dollat</surname> </persName> <email type="md5">4f6e1bed49aad43bfd0e406d7a1b5a26</email> <email type="domain">gmail.com</email> <idno type="halauthorid">11777130</idno> <affiliation ref="#struct-217849"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Cheikh</forename> <surname>Talla</surname> </persName> <idno type="halauthorid">11192043</idno> <affiliation ref="#struct-217849"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Cheikh</forename> <surname>Sokhna</surname> </persName> <email type="md5">7fd9b956f5a06dd0d5b45baf36c99892</email> <email type="domain">ird.fr</email> <idno type="halauthorid">689404</idno> <affiliation ref="#struct-527045"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Fatoumata</forename> <surname>Diene Sarr</surname> </persName> <idno type="halauthorid">643425</idno> <affiliation ref="#struct-217849"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Jean-Francois</forename> <surname>Trape</surname> </persName> <email type="md5">fe0e5e32f2db922a18e078d2a50224bf</email> <email type="domain">ird.fr</email> <idno type="halauthorid">689402</idno> <affiliation ref="#struct-67872"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Vincent</forename> <surname>Richard</surname> </persName> <idno type="halauthorid">517925</idno> <affiliation ref="#struct-217849"></affiliation> </author> <editor role="depositor"> <persName> <forename>Isabelle</forename> <surname>COMBE</surname> </persName> <email type="md5">bab35ba509b8723b03542abc690b8507</email> <email type="domain">univ-amu.fr</email> </editor> <funder>The Dielmo and Ndiop Cohort was implemented by "Institut Pasteur de Dakar" and "Institut de recherche pour le développement" through their own budget funded by different sources (Institut Pasteur, Ministry of research…) since 1990. the combination of different funding was able to maintain the follow-up activities included in the annual budget of each institution. The staff of the IRD and Pasteur Institutes of Dakar and Paris contributed to the design, healthcare, data collection, and data treatment during the 20 years of the project.</funder> </titleStmt> <editionStmt> <edition n="v1" type="current"> <date type="whenSubmitted">2020-03-17 16:58:07</date> <date type="whenModified">2020-03-24 01:40:59</date> <date type="whenReleased">2020-03-18 13:07:24</date> <date type="whenProduced">2019-06-27</date> <date type="whenEndEmbargoed">2020-03-17</date> <ref type="file" target="https://hal-amu.archives-ouvertes.fr/hal-02508073/document"> <date notBefore="2020-03-17"></date> </ref> <ref type="file" subtype="publisherPaid" n="1" target="https://hal-amu.archives-ouvertes.fr/hal-02508073/file/Measuring_malaria_morbidity_in_an_area_of_seasonal_transmission.pdf"> <date notBefore="2020-03-17"></date> </ref> <ref type="externalLink" target="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6597048/pdf"></ref> </edition> <respStmt> <resp>contributor</resp> <name key="487267"> <persName> <forename>Isabelle</forename> <surname>COMBE</surname> </persName> <email type="md5">bab35ba509b8723b03542abc690b8507</email> <email type="domain">univ-amu.fr</email> </name> </respStmt> </editionStmt> <publicationStmt> <distributor>CCSD</distributor> <idno type="halId">hal-02508073</idno> <idno type="halUri">https://hal-amu.archives-ouvertes.fr/hal-02508073</idno> <idno type="halBibtex">dollat:hal-02508073</idno> <idno type="halRefHtml">PLoS ONE, Public Library of Science, 2019, 14 (6), pp.e0217903. ⟨10.1371/journal.pone.0217903⟩</idno> <idno type="halRef">PLoS ONE, Public Library of Science, 2019, 14 (6), pp.e0217903. ⟨10.1371/journal.pone.0217903⟩</idno> <availability status="restricted"> <licence target="http://creativecommons.org/licenses/by/">Attribution</licence> </availability> </publicationStmt> <seriesStmt> <idno type="stamp" n="UNIV-AMU">Aix Marseille Université</idno> <idno type="stamp" n="RIIP">Institut Pasteur RIIP (Réseau International)</idno> <idno type="stamp" n="CARDIO" corresp="INSERM">Cardiovasculaire</idno> <idno type="stamp" n="RIIP_DAKAR" corresp="RIIP">Institut Pasteur de Dakar</idno> <idno type="stamp" n="IRD">IRD - Institut de recherche pour le développement</idno> <idno type="stamp" n="TEST-AMU">Espace de test AMU</idno> </seriesStmt> <notesStmt> <note type="audience" n="2">International</note> <note type="popular" n="0">No</note> <note type="peer" n="1">Yes</note> </notesStmt> <sourceDesc> <biblStruct> <analytic> <title xml:lang="en">Measuring malaria morbidity in an area of seasonal transmission: Pyrogenic parasitemia thresholds based on a 20-year follow-up study</title> <author role="crp"> <persName> <forename type="first">Marion</forename> <surname>Dollat</surname> </persName> <email type="md5">4f6e1bed49aad43bfd0e406d7a1b5a26</email> <email type="domain">gmail.com</email> <idno type="halauthorid">11777130</idno> <affiliation ref="#struct-217849"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Cheikh</forename> <surname>Talla</surname> </persName> <idno type="halauthorid">11192043</idno> <affiliation ref="#struct-217849"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Cheikh</forename> <surname>Sokhna</surname> </persName> <email type="md5">7fd9b956f5a06dd0d5b45baf36c99892</email> <email type="domain">ird.fr</email> <idno type="halauthorid">689404</idno> <affiliation ref="#struct-527045"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Fatoumata</forename> <surname>Diene Sarr</surname> </persName> <idno type="halauthorid">643425</idno> <affiliation ref="#struct-217849"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Jean-Francois</forename> <surname>Trape</surname> </persName> <email type="md5">fe0e5e32f2db922a18e078d2a50224bf</email> <email type="domain">ird.fr</email> <idno type="halauthorid">689402</idno> <affiliation ref="#struct-67872"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Vincent</forename> <surname>Richard</surname> </persName> <idno type="halauthorid">517925</idno> <affiliation ref="#struct-217849"></affiliation> </author> </analytic> <monogr> <idno type="halJournalId" status="VALID">28700</idno> <idno type="issn">1932-6203</idno> <idno type="eissn">1932-6203</idno> <title level="j">PLoS ONE</title> <imprint> <publisher>Public Library of Science</publisher> <biblScope unit="volume">14</biblScope> <biblScope unit="issue">6</biblScope> <biblScope unit="pp">e0217903</biblScope> <date type="datePub">2019-06-27</date> </imprint> </monogr> <idno type="doi">10.1371/journal.pone.0217903</idno> <idno type="ird">fdi:010077004</idno> <idno type="pubmed">31246965</idno> <idno type="pubmedcentral">PMC6597048</idno> </biblStruct> </sourceDesc> <profileDesc> <langUsage> <language ident="en">English</language> </langUsage> <textClass> <keywords scheme="author"> <term xml:lang="en">Malarial parasites</term> <term xml:lang="en">Parasitemia</term> <term xml:lang="en">Malaria</term> <term xml:lang="en">Fevers</term> <term xml:lang="en">Plasmodium</term> <term xml:lang="en">Quinine</term> <term xml:lang="en">Chloroquine</term> <term xml:lang="en">Parasitic diseases</term> </keywords> <classCode scheme="mesh">Age Distribution</classCode> <classCode scheme="mesh">Child</classCode> <classCode scheme="mesh">Humans</classCode> <classCode scheme="mesh">Malaria, Falciparum/epidemiology*</classCode> <classCode scheme="mesh">Malaria, Falciparum/parasitology</classCode> <classCode scheme="mesh">Malaria, Falciparum/transmission*</classCode> <classCode scheme="mesh">Morbidity</classCode> <classCode scheme="mesh">Parasitemia/epidemiology*</classCode> <classCode scheme="mesh">Plasmodium falciparum/physiology</classCode> <classCode scheme="mesh">Prevalence</classCode> <classCode scheme="mesh">Seasons*</classCode> <classCode scheme="mesh">Senegal/epidemiology</classCode> <classCode scheme="mesh">Child, Preschool</classCode> <classCode scheme="mesh">Fever/complications</classCode> <classCode scheme="mesh">Follow-Up Studies</classCode> <classCode scheme="mesh">Humans</classCode> <classCode scheme="halDomain" n="sdv.mp.bac">Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology</classCode> <classCode scheme="halDomain" n="sdv.mp.vir">Life Sciences [q-bio]/Microbiology and Parasitology/Virology</classCode> <classCode scheme="halDomain" n="sdv.mp.par">Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology</classCode> <classCode scheme="halDomain" n="sdv.mhep.csc">Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system</classCode> <classCode scheme="halDomain" n="sdv.mhep.me">Life Sciences [q-bio]/Human health and pathology/Emerging diseases</classCode> <classCode scheme="halDomain" n="sdv.mhep.mi">Life Sciences [q-bio]/Human health and pathology/Infectious diseases</classCode> <classCode scheme="halTypology" n="ART">Journal articles</classCode> </textClass> <abstract xml:lang="en"> <p>Asymptomatic carriage of P. falciparum is frequent in areas endemic for malaria and individual diagnosis of clinical malaria attacks is still difficult. We investigated the impact of changes in malaria endemicity on the diagnostic criteria for malaria attacks in an area of seasonal malaria transmission.METHODS: We analyzed the longitudinal data collected over 20 years from a daily survey of all inhabitants of Ndiop, a rural community in central Senegal, in a logistic regression model to investigate the relationship between the level of Plasmodium falciparum parasitemia and the risk of fever, with the aim of determining the best parasitemia thresholds for attributing to malaria a fever episode.RESULTS: A total of 34,136 observations recorded from July 1993 to December 2013 from 850 individuals aged from 1 day to 87 years were included. P. falciparum asymptomatic carriage declined from 36% to 1% between 1993 and 2013. A total of 9,819 fever episodes were associated with a positive blood film for P. falciparum. Using age-dependent parasitemia thresholds for attributing to malaria a fever episode, we recorded 6,006 malaria attacks during the study period. Parasitemia thresholds seemed to be lower during the low-to-zero transmission season and tended to decrease with changes in control policies. The number of clinical malaria attacks was overestimated for all age groups throughout the study when all fever episodes associated with P. falciparum parasitemia were defined as malaria attacks.CONCLUSION: Pyrogenic thresholds are particularly sensitive to changes in malaria epidemiology and are therefore an interesting tool to accurately assess the burden of malaria in the context of declining transmission.</p> </abstract> </profileDesc> </hal></record>Pour manipuler ce document sous Unix (Dilib)
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