ChloroquineV1, Hal, Curation, bibRecord, 000144

Invasion of Africa by a single pfcrt allele of South East Asian type.

Identifieur interne : 000144 ( Hal/Curation ); précédent : 000143; suivant : 000145

Invasion of Africa by a single pfcrt allele of South East Asian type.

Auteurs : Frédéric Ariey [Cambodge] ; Thierry Fandeur [France] ; Remy Durand [France] ; Milijaona Randrianarivelojosia [Madagascar] ; Ronan Jambou [Sénégal] ; Eric Legrand ; Marie Thérèse Ekala [France] ; Christiane Bouchier [France] ; Sandrine Cojean [France] ; Jean Bernard Duchemin [Niger] ; Vincent Robert [France] ; Jacques Le Bras [France] ; Odile Mercereau-Puijalon [France]

Source :

Malaria Journal [ 1475-2875 ] ; 2006.

RBID : Hal:pasteur-00590988

Abstract

BACKGROUND: Because of its dramatic public health impact, Plasmodium falciparum resistance to chloroquine (CQ) has been documented early on. Chloroquine-resistance (CQR) emerged in the late 1950's independently in South East Asia and South America and progressively spread over all malaria areas. CQR was reported in East Africa in the 1970's, and has since invaded the African continent. Many questions remain about the actual selection and spreading process of CQR parasites, and about the evolution of the ancestral mutant gene(s) during spreading. METHODS: Eleven clinical isolates of P. falciparum from Cambodia and 238 from Africa (Senegal, Ivory Coast, Bukina Faso, Mali, Guinea, Togo, Benin, Niger, Congo, Madagascar, Comoros Islands, Tanzania, Kenya, Mozambique, Cameroun, Gabon) were collected during active case detection surveys carried out between 1996 and 2001. Parasite DNA was extracted from frozen blood aliquots and amplification of the gene pfcrt exon 2 (codon 72-76), exon 4 and intron 4 (codon 220 and microsatellite marker) were performed. All fragments were sequenced. RESULTS: 124 isolates with a sensitive (c76/c220:CVMNK/A) haplotype and 125 isolates with a resistant c76/c220:CVIET/S haplotype were found. The microsatellite showed 17 different types in the isolates carrying the c76/c220:CVMNK/A haplotype while all 125 isolates with a CVIET/S haplotype but two had a single microsatellite type, namely (TAAA)3(TA)15, whatever the location or time of collection. CONCLUSION: Those results are consistent with the migration of a single ancestral pfcrt CQR allele from Asia to Africa. This is related to the importance of PFCRT in the fitness of P. falciparum point out this protein as a potential target for developments of new antimalarial drugs.

Url:

https://hal-riip.archives-ouvertes.fr/pasteur-00590988

DOI: 10.1186/1475-2875-5-34

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Eric Legrand

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Le document en format XML

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<author><name sortKey="Mercereau Puijalon, Odile" sort="Mercereau Puijalon, Odile" uniqKey="Mercereau Puijalon O" first="Odile" last="Mercereau-Puijalon">Odile Mercereau-Puijalon</name>
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<idno type="DOI">10.1186/1475-2875-5-34</idno>
<series><title level="j">Malaria Journal</title>
<idno type="ISSN">1475-2875</idno>
<imprint><date type="datePub">2006</date>
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<front><div type="abstract" xml:lang="en">              <p>BACKGROUND: Because of its dramatic public health impact, Plasmodium falciparum resistance to chloroquine (CQ) has been documented early on. Chloroquine-resistance (CQR) emerged in the late 1950's independently in South East Asia and South America and progressively spread over all malaria areas. CQR was reported in East Africa in the 1970's, and has since invaded the African continent. Many questions remain about the actual selection and spreading process of CQR parasites, and about the evolution of the ancestral mutant gene(s) during spreading. METHODS: Eleven clinical isolates of P. falciparum from Cambodia and 238 from Africa (Senegal, Ivory Coast, Bukina Faso, Mali, Guinea, Togo, Benin, Niger, Congo, Madagascar, Comoros Islands, Tanzania, Kenya, Mozambique, Cameroun, Gabon) were collected during active case detection surveys carried out between 1996 and 2001. Parasite DNA was extracted from frozen blood aliquots and amplification of the gene pfcrt exon 2 (codon 72-76), exon 4 and intron 4 (codon 220 and microsatellite marker) were performed. All fragments were sequenced. RESULTS: 124 isolates with a sensitive (c76/c220:CVMNK/A) haplotype and 125 isolates with a resistant c76/c220:CVIET/S haplotype were found. The microsatellite showed 17 different types in the isolates carrying the c76/c220:CVMNK/A haplotype while all 125 isolates with a CVIET/S haplotype but two had a single microsatellite type, namely (TAAA)3(TA)15, whatever the location or time of collection. CONCLUSION: Those results are consistent with the migration of a single ancestral pfcrt CQR allele from Asia to Africa. This is related to the importance of PFCRT in the fitness of P. falciparum point out this protein as a potential target for developments of new antimalarial drugs.</p>
            </div>
</front>
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            <author role="crp">              <persName>                <forename type="first">Frédéric</forename>
                <surname>Ariey</surname>
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            <author role="aut">              <persName>                <forename type="first">Thierry</forename>
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            <author role="aut">              <persName>                <forename type="first">Milijaona</forename>
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              <date type="whenModified">2020-03-17 03:22:32</date>
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            <idno type="stamp" n="UNIV-PARIS13">Université Paris-Nord - Paris XIII </idno>
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                <author role="aut">                  <persName>                    <forename type="first">Ronan</forename>
                    <surname>Jambou</surname>
                  </persName>
                  <idno type="halauthorid">502678</idno>
                  <affiliation ref="#struct-42095"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Eric</forename>
                    <surname>Legrand</surname>
                  </persName>
                  <email type="md5">1e23d2e80dc9ad6759c43603e1f72ee7</email>
                  <email type="domain">pasteur.fr</email>
                  <idno type="idhal" notation="string">eric-legrand</idno>
                  <idno type="idhal" notation="numeric">2337</idno>
                  <idno type="halauthorid">592014</idno>
                  <affiliation ref="#struct-300193"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Marie Thérèse</forename>
                    <surname>Ekala</surname>
                  </persName>
                  <idno type="halauthorid">605434</idno>
                  <affiliation ref="#struct-300027"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Christiane</forename>
                    <surname>Bouchier</surname>
                  </persName>
                  <idno type="halauthorid">105709</idno>
                  <affiliation ref="#struct-300027"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Sandrine</forename>
                    <surname>Cojean</surname>
                  </persName>
                  <idno type="halauthorid">605435</idno>
                  <affiliation ref="#struct-59749"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Jean Bernard</forename>
                    <surname>Duchemin</surname>
                  </persName>
                  <idno type="halauthorid">605436</idno>
                  <affiliation ref="#struct-55918"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Vincent</forename>
                    <surname>Robert</surname>
                  </persName>
                  <idno type="halauthorid">45921</idno>
                  <affiliation ref="#struct-67872"></affiliation>
                  <affiliation ref="#struct-7512"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Jacques</forename>
                    <surname>Le Bras</surname>
                  </persName>
                  <idno type="halauthorid">529998</idno>
                  <affiliation ref="#struct-129119"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Odile</forename>
                    <surname>Mercereau-Puijalon</surname>
                  </persName>
                  <idno type="halauthorid">159952</idno>
                  <affiliation ref="#struct-300027"></affiliation>
                </author>
              </analytic>
              <monogr>                <idno type="halJournalId" status="VALID">1704</idno>
                <idno type="issn">1475-2875</idno>
                <title level="j">Malaria Journal</title>
                <imprint>                  <publisher>BioMed Central</publisher>
                  <biblScope unit="volume">5</biblScope>
                  <biblScope unit="pp">34</biblScope>
                  <date type="datePub">2006</date>
                  <date type="dateEpub">2006-04-26</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1186/1475-2875-5-34</idno>
              <idno type="pubmed">16638153</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>            <langUsage>              <language ident="en">English</language>
            </langUsage>
            <textClass>              <classCode scheme="mesh">Africa</classCode>
              <classCode scheme="mesh">Alleles</classCode>
              <classCode scheme="mesh">Humans</classCode>
              <classCode scheme="mesh">Malaria, Falciparum</classCode>
              <classCode scheme="mesh">Membrane Proteins</classCode>
              <classCode scheme="mesh">Membrane Transport Proteins</classCode>
              <classCode scheme="mesh">Microsatellite Repeats</classCode>
              <classCode scheme="mesh">Molecular Sequence Data</classCode>
              <classCode scheme="mesh">Plasmodium falciparum</classCode>
              <classCode scheme="mesh">Protozoan Proteins</classCode>
              <classCode scheme="mesh">Animals</classCode>
              <classCode scheme="mesh">Antimalarials</classCode>
              <classCode scheme="mesh">Base Sequence</classCode>
              <classCode scheme="mesh">Cambodia</classCode>
              <classCode scheme="mesh">Chloroquine</classCode>
              <classCode scheme="mesh">DNA, Protozoan</classCode>
              <classCode scheme="mesh">Drug Resistance</classCode>
              <classCode scheme="mesh">Haplotypes</classCode>
              <classCode scheme="halDomain" n="sdv.mp.par">Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">              <p>BACKGROUND: Because of its dramatic public health impact, Plasmodium falciparum resistance to chloroquine (CQ) has been documented early on. Chloroquine-resistance (CQR) emerged in the late 1950's independently in South East Asia and South America and progressively spread over all malaria areas. CQR was reported in East Africa in the 1970's, and has since invaded the African continent. Many questions remain about the actual selection and spreading process of CQR parasites, and about the evolution of the ancestral mutant gene(s) during spreading. METHODS: Eleven clinical isolates of P. falciparum from Cambodia and 238 from Africa (Senegal, Ivory Coast, Bukina Faso, Mali, Guinea, Togo, Benin, Niger, Congo, Madagascar, Comoros Islands, Tanzania, Kenya, Mozambique, Cameroun, Gabon) were collected during active case detection surveys carried out between 1996 and 2001. Parasite DNA was extracted from frozen blood aliquots and amplification of the gene pfcrt exon 2 (codon 72-76), exon 4 and intron 4 (codon 220 and microsatellite marker) were performed. All fragments were sequenced. RESULTS: 124 isolates with a sensitive (c76/c220:CVMNK/A) haplotype and 125 isolates with a resistant c76/c220:CVIET/S haplotype were found. The microsatellite showed 17 different types in the isolates carrying the c76/c220:CVMNK/A haplotype while all 125 isolates with a CVIET/S haplotype but two had a single microsatellite type, namely (TAAA)3(TA)15, whatever the location or time of collection. CONCLUSION: Those results are consistent with the migration of a single ancestral pfcrt CQR allele from Asia to Africa. This is related to the importance of PFCRT in the fitness of P. falciparum point out this protein as a potential target for developments of new antimalarial drugs.</p>
            </abstract>
          </profileDesc>
        </hal>
</record>

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Invasion of Africa by a single pfcrt allele of South East Asian type.

Invasion of Africa by a single pfcrt allele of South East Asian type.

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