Serveur d'exploration Chloroquine

Attention, ce site est en cours de développement !
Attention, site généré par des moyens informatiques à partir de corpus bruts.
Les informations ne sont donc pas validées.

Synthesis of modulators of chloroquine resistance in Plasmodium falciparum, analogues of malagashanine from strychnobrasiline

Identifieur interne : 000229 ( Hal/Corpus ); précédent : 000228; suivant : 000230

Synthesis of modulators of chloroquine resistance in Plasmodium falciparum, analogues of malagashanine from strychnobrasiline

Auteurs : F. Trigalo ; R. Joyeau ; V. C. Pham ; J. J. Youté ; P. Rasoanaivo ; F. Frappier

Source :

RBID : Hal:hal-00016012

Abstract

The syntheses of three malagashanine analogues are reported. They involve conversion of strychnobrasiline in multiple steps and obtaining (i) unsaturation of the bond 3-14, (ii) inversion of configuration on carbon C3, (iii) inversion of configuration on carbon C3 and reduction of the benzene ring.


Url:
DOI: 10.1016/j.tet.2004.04.068

Links to Exploration step

Hal:hal-00016012

Le document en format XML

<record>
<TEI>
<teiHeader>
<fileDesc>
<titleStmt>
<title xml:lang="en">Synthesis of modulators of chloroquine resistance in Plasmodium falciparum, analogues of malagashanine from strychnobrasiline</title>
<author>
<name sortKey="Trigalo, F" sort="Trigalo, F" uniqKey="Trigalo F" first="F." last="Trigalo">F. Trigalo</name>
<affiliation>
<hal:affiliation type="laboratory" xml:id="struct-19260" status="VALID">
<orgName>Laboratoire de Chimie et Biochimie des Substances Naturelles</orgName>
<desc>
<address>
<addrLine>Département RDDM Case Postale 54 57 rue Cuvier F 75005 PARIS</addrLine>
<country key="FR"></country>
</address>
</desc>
<listRelation>
<relation name="UMR5154" active="#struct-441569" type="direct"></relation>
</listRelation>
<tutelles>
<tutelle name="UMR5154" active="#struct-441569" type="direct">
<org type="institution" xml:id="struct-441569" status="VALID">
<idno type="IdRef">02636817X</idno>
<idno type="ISNI">0000000122597504</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc>
<address>
<country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Joyeau, R" sort="Joyeau, R" uniqKey="Joyeau R" first="R." last="Joyeau">R. Joyeau</name>
<affiliation>
<hal:affiliation type="laboratory" xml:id="struct-19260" status="VALID">
<orgName>Laboratoire de Chimie et Biochimie des Substances Naturelles</orgName>
<desc>
<address>
<addrLine>Département RDDM Case Postale 54 57 rue Cuvier F 75005 PARIS</addrLine>
<country key="FR"></country>
</address>
</desc>
<listRelation>
<relation name="UMR5154" active="#struct-441569" type="direct"></relation>
</listRelation>
<tutelles>
<tutelle name="UMR5154" active="#struct-441569" type="direct">
<org type="institution" xml:id="struct-441569" status="VALID">
<idno type="IdRef">02636817X</idno>
<idno type="ISNI">0000000122597504</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc>
<address>
<country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Pham, V C" sort="Pham, V C" uniqKey="Pham V" first="V. C." last="Pham">V. C. Pham</name>
<affiliation>
<hal:affiliation type="laboratory" xml:id="struct-19260" status="VALID">
<orgName>Laboratoire de Chimie et Biochimie des Substances Naturelles</orgName>
<desc>
<address>
<addrLine>Département RDDM Case Postale 54 57 rue Cuvier F 75005 PARIS</addrLine>
<country key="FR"></country>
</address>
</desc>
<listRelation>
<relation name="UMR5154" active="#struct-441569" type="direct"></relation>
</listRelation>
<tutelles>
<tutelle name="UMR5154" active="#struct-441569" type="direct">
<org type="institution" xml:id="struct-441569" status="VALID">
<idno type="IdRef">02636817X</idno>
<idno type="ISNI">0000000122597504</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc>
<address>
<country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Youte, J J" sort="Youte, J J" uniqKey="Youte J" first="J. J." last="Youté">J. J. Youté</name>
<affiliation>
<hal:affiliation type="laboratory" xml:id="struct-19260" status="VALID">
<orgName>Laboratoire de Chimie et Biochimie des Substances Naturelles</orgName>
<desc>
<address>
<addrLine>Département RDDM Case Postale 54 57 rue Cuvier F 75005 PARIS</addrLine>
<country key="FR"></country>
</address>
</desc>
<listRelation>
<relation name="UMR5154" active="#struct-441569" type="direct"></relation>
</listRelation>
<tutelles>
<tutelle name="UMR5154" active="#struct-441569" type="direct">
<org type="institution" xml:id="struct-441569" status="VALID">
<idno type="IdRef">02636817X</idno>
<idno type="ISNI">0000000122597504</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc>
<address>
<country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Rasoanaivo, P" sort="Rasoanaivo, P" uniqKey="Rasoanaivo P" first="P." last="Rasoanaivo">P. Rasoanaivo</name>
</author>
<author>
<name sortKey="Frappier, F" sort="Frappier, F" uniqKey="Frappier F" first="F." last="Frappier">F. Frappier</name>
<affiliation>
<hal:affiliation type="laboratory" xml:id="struct-19260" status="VALID">
<orgName>Laboratoire de Chimie et Biochimie des Substances Naturelles</orgName>
<desc>
<address>
<addrLine>Département RDDM Case Postale 54 57 rue Cuvier F 75005 PARIS</addrLine>
<country key="FR"></country>
</address>
</desc>
<listRelation>
<relation name="UMR5154" active="#struct-441569" type="direct"></relation>
</listRelation>
<tutelles>
<tutelle name="UMR5154" active="#struct-441569" type="direct">
<org type="institution" xml:id="struct-441569" status="VALID">
<idno type="IdRef">02636817X</idno>
<idno type="ISNI">0000000122597504</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc>
<address>
<country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
</affiliation>
</author>
</titleStmt>
<publicationStmt>
<idno type="wicri:source">HAL</idno>
<idno type="RBID">Hal:hal-00016012</idno>
<idno type="halId">hal-00016012</idno>
<idno type="halUri">https://hal.archives-ouvertes.fr/hal-00016012</idno>
<idno type="url">https://hal.archives-ouvertes.fr/hal-00016012</idno>
<idno type="doi">10.1016/j.tet.2004.04.068</idno>
<date when="2004-06-14">2004-06-14</date>
<idno type="wicri:Area/Hal/Corpus">000229</idno>
</publicationStmt>
<sourceDesc>
<biblStruct>
<analytic>
<title xml:lang="en">Synthesis of modulators of chloroquine resistance in Plasmodium falciparum, analogues of malagashanine from strychnobrasiline</title>
<author>
<name sortKey="Trigalo, F" sort="Trigalo, F" uniqKey="Trigalo F" first="F." last="Trigalo">F. Trigalo</name>
<affiliation>
<hal:affiliation type="laboratory" xml:id="struct-19260" status="VALID">
<orgName>Laboratoire de Chimie et Biochimie des Substances Naturelles</orgName>
<desc>
<address>
<addrLine>Département RDDM Case Postale 54 57 rue Cuvier F 75005 PARIS</addrLine>
<country key="FR"></country>
</address>
</desc>
<listRelation>
<relation name="UMR5154" active="#struct-441569" type="direct"></relation>
</listRelation>
<tutelles>
<tutelle name="UMR5154" active="#struct-441569" type="direct">
<org type="institution" xml:id="struct-441569" status="VALID">
<idno type="IdRef">02636817X</idno>
<idno type="ISNI">0000000122597504</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc>
<address>
<country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Joyeau, R" sort="Joyeau, R" uniqKey="Joyeau R" first="R." last="Joyeau">R. Joyeau</name>
<affiliation>
<hal:affiliation type="laboratory" xml:id="struct-19260" status="VALID">
<orgName>Laboratoire de Chimie et Biochimie des Substances Naturelles</orgName>
<desc>
<address>
<addrLine>Département RDDM Case Postale 54 57 rue Cuvier F 75005 PARIS</addrLine>
<country key="FR"></country>
</address>
</desc>
<listRelation>
<relation name="UMR5154" active="#struct-441569" type="direct"></relation>
</listRelation>
<tutelles>
<tutelle name="UMR5154" active="#struct-441569" type="direct">
<org type="institution" xml:id="struct-441569" status="VALID">
<idno type="IdRef">02636817X</idno>
<idno type="ISNI">0000000122597504</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc>
<address>
<country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Pham, V C" sort="Pham, V C" uniqKey="Pham V" first="V. C." last="Pham">V. C. Pham</name>
<affiliation>
<hal:affiliation type="laboratory" xml:id="struct-19260" status="VALID">
<orgName>Laboratoire de Chimie et Biochimie des Substances Naturelles</orgName>
<desc>
<address>
<addrLine>Département RDDM Case Postale 54 57 rue Cuvier F 75005 PARIS</addrLine>
<country key="FR"></country>
</address>
</desc>
<listRelation>
<relation name="UMR5154" active="#struct-441569" type="direct"></relation>
</listRelation>
<tutelles>
<tutelle name="UMR5154" active="#struct-441569" type="direct">
<org type="institution" xml:id="struct-441569" status="VALID">
<idno type="IdRef">02636817X</idno>
<idno type="ISNI">0000000122597504</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc>
<address>
<country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Youte, J J" sort="Youte, J J" uniqKey="Youte J" first="J. J." last="Youté">J. J. Youté</name>
<affiliation>
<hal:affiliation type="laboratory" xml:id="struct-19260" status="VALID">
<orgName>Laboratoire de Chimie et Biochimie des Substances Naturelles</orgName>
<desc>
<address>
<addrLine>Département RDDM Case Postale 54 57 rue Cuvier F 75005 PARIS</addrLine>
<country key="FR"></country>
</address>
</desc>
<listRelation>
<relation name="UMR5154" active="#struct-441569" type="direct"></relation>
</listRelation>
<tutelles>
<tutelle name="UMR5154" active="#struct-441569" type="direct">
<org type="institution" xml:id="struct-441569" status="VALID">
<idno type="IdRef">02636817X</idno>
<idno type="ISNI">0000000122597504</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc>
<address>
<country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Rasoanaivo, P" sort="Rasoanaivo, P" uniqKey="Rasoanaivo P" first="P." last="Rasoanaivo">P. Rasoanaivo</name>
</author>
<author>
<name sortKey="Frappier, F" sort="Frappier, F" uniqKey="Frappier F" first="F." last="Frappier">F. Frappier</name>
<affiliation>
<hal:affiliation type="laboratory" xml:id="struct-19260" status="VALID">
<orgName>Laboratoire de Chimie et Biochimie des Substances Naturelles</orgName>
<desc>
<address>
<addrLine>Département RDDM Case Postale 54 57 rue Cuvier F 75005 PARIS</addrLine>
<country key="FR"></country>
</address>
</desc>
<listRelation>
<relation name="UMR5154" active="#struct-441569" type="direct"></relation>
</listRelation>
<tutelles>
<tutelle name="UMR5154" active="#struct-441569" type="direct">
<org type="institution" xml:id="struct-441569" status="VALID">
<idno type="IdRef">02636817X</idno>
<idno type="ISNI">0000000122597504</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc>
<address>
<country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
</affiliation>
</author>
</analytic>
<idno type="DOI">10.1016/j.tet.2004.04.068</idno>
<series>
<title level="j">Tetrahedron</title>
<idno type="ISSN">0040-4020</idno>
<imprint>
<date type="datePub">2004-06-14</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc>
<textClass></textClass>
</profileDesc>
</teiHeader>
<front>
<div type="abstract" xml:lang="en">
<p>The syntheses of three malagashanine analogues are reported. They involve conversion of strychnobrasiline in multiple steps and obtaining (i) unsaturation of the bond 3-14, (ii) inversion of configuration on carbon C3, (iii) inversion of configuration on carbon C3 and reduction of the benzene ring.</p>
</div>
</front>
</TEI>
<hal api="V3">
<titleStmt>
<title xml:lang="en">Synthesis of modulators of chloroquine resistance in Plasmodium falciparum, analogues of malagashanine from strychnobrasiline</title>
<author role="aut">
<persName>
<forename type="first">F.</forename>
<surname>Trigalo</surname>
</persName>
<idno type="halauthorid">65131</idno>
<affiliation ref="#struct-19260"></affiliation>
</author>
<author role="aut">
<persName>
<forename type="first">R.</forename>
<surname>Joyeau</surname>
</persName>
<idno type="halauthorid">75012</idno>
<affiliation ref="#struct-19260"></affiliation>
</author>
<author role="aut">
<persName>
<forename type="first">V.C.</forename>
<surname>Pham</surname>
</persName>
<idno type="halauthorid">64713</idno>
<affiliation ref="#struct-19260"></affiliation>
</author>
<author role="aut">
<persName>
<forename type="first">J.J.</forename>
<surname>Youté</surname>
</persName>
<idno type="halauthorid">65133</idno>
<affiliation ref="#struct-19260"></affiliation>
</author>
<author role="aut">
<persName>
<forename type="first">P.</forename>
<surname>Rasoanaivo</surname>
</persName>
<idno type="halauthorid">65018</idno>
</author>
<author role="aut">
<persName>
<forename type="first">F.</forename>
<surname>Frappier</surname>
</persName>
<idno type="halauthorid">65020</idno>
<affiliation ref="#struct-19260"></affiliation>
</author>
<editor role="depositor">
<persName>
<forename>Annick</forename>
<surname>Larmor</surname>
</persName>
<email type="md5">4c7e5f4d8febc6f1a993d58743bcdbbc</email>
<email type="domain">mnhn.fr</email>
</editor>
</titleStmt>
<editionStmt>
<edition n="v1" type="current">
<date type="whenSubmitted">2005-12-16 10:45:50</date>
<date type="whenModified">2018-01-11 06:20:36</date>
<date type="whenReleased">2005-12-16 10:45:50</date>
<date type="whenProduced">2004-06-14</date>
</edition>
<respStmt>
<resp>contributor</resp>
<name key="103754">
<persName>
<forename>Annick</forename>
<surname>Larmor</surname>
</persName>
<email type="md5">4c7e5f4d8febc6f1a993d58743bcdbbc</email>
<email type="domain">mnhn.fr</email>
</name>
</respStmt>
</editionStmt>
<publicationStmt>
<distributor>CCSD</distributor>
<idno type="halId">hal-00016012</idno>
<idno type="halUri">https://hal.archives-ouvertes.fr/hal-00016012</idno>
<idno type="halBibtex">trigalo:hal-00016012</idno>
<idno type="halRefHtml">Tetrahedron, Elsevier, 2004, 60 (25), pp.5471-5474. ⟨10.1016/j.tet.2004.04.068⟩</idno>
<idno type="halRef">Tetrahedron, Elsevier, 2004, 60 (25), pp.5471-5474. ⟨10.1016/j.tet.2004.04.068⟩</idno>
</publicationStmt>
<seriesStmt>
<idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
</seriesStmt>
<notesStmt>
<note type="audience" n="1">Not set</note>
<note type="popular" n="0">No</note>
<note type="peer" n="1">Yes</note>
</notesStmt>
<sourceDesc>
<biblStruct>
<analytic>
<title xml:lang="en">Synthesis of modulators of chloroquine resistance in Plasmodium falciparum, analogues of malagashanine from strychnobrasiline</title>
<author role="aut">
<persName>
<forename type="first">F.</forename>
<surname>Trigalo</surname>
</persName>
<idno type="halauthorid">65131</idno>
<affiliation ref="#struct-19260"></affiliation>
</author>
<author role="aut">
<persName>
<forename type="first">R.</forename>
<surname>Joyeau</surname>
</persName>
<idno type="halauthorid">75012</idno>
<affiliation ref="#struct-19260"></affiliation>
</author>
<author role="aut">
<persName>
<forename type="first">V.C.</forename>
<surname>Pham</surname>
</persName>
<idno type="halauthorid">64713</idno>
<affiliation ref="#struct-19260"></affiliation>
</author>
<author role="aut">
<persName>
<forename type="first">J.J.</forename>
<surname>Youté</surname>
</persName>
<idno type="halauthorid">65133</idno>
<affiliation ref="#struct-19260"></affiliation>
</author>
<author role="aut">
<persName>
<forename type="first">P.</forename>
<surname>Rasoanaivo</surname>
</persName>
<idno type="halauthorid">65018</idno>
</author>
<author role="aut">
<persName>
<forename type="first">F.</forename>
<surname>Frappier</surname>
</persName>
<idno type="halauthorid">65020</idno>
<affiliation ref="#struct-19260"></affiliation>
</author>
</analytic>
<monogr>
<idno type="halJournalId" status="VALID">19385</idno>
<idno type="issn">0040-4020</idno>
<title level="j">Tetrahedron</title>
<imprint>
<publisher>Elsevier</publisher>
<biblScope unit="volume">60</biblScope>
<biblScope unit="issue">25</biblScope>
<biblScope unit="pp">5471-5474</biblScope>
<date type="datePub">2004-06-14</date>
</imprint>
</monogr>
<idno type="doi">10.1016/j.tet.2004.04.068</idno>
</biblStruct>
</sourceDesc>
<profileDesc>
<langUsage>
<language ident="en">English</language>
</langUsage>
<textClass>
<classCode scheme="halDomain" n="sdv.bbm.bc">Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biomolecules [q-bio.BM]</classCode>
<classCode scheme="halTypology" n="ART">Journal articles</classCode>
</textClass>
<abstract xml:lang="en">
<p>The syntheses of three malagashanine analogues are reported. They involve conversion of strychnobrasiline in multiple steps and obtaining (i) unsaturation of the bond 3-14, (ii) inversion of configuration on carbon C3, (iii) inversion of configuration on carbon C3 and reduction of the benzene ring.</p>
</abstract>
</profileDesc>
</hal>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Hal/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000229 | SxmlIndent | more

Ou

HfdSelect -h $EXPLOR_AREA/Data/Hal/Corpus/biblio.hfd -nk 000229 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    ChloroquineV1
   |flux=    Hal
   |étape=   Corpus
   |type=    RBID
   |clé=     Hal:hal-00016012
   |texte=   Synthesis of modulators of chloroquine resistance in Plasmodium falciparum, analogues of malagashanine from strychnobrasiline
}}

Wicri

This area was generated with Dilib version V0.6.33.
Data generation: Wed Mar 25 22:43:59 2020. Site generation: Sun Jan 31 12:44:45 2021