Synthesis of modulators of chloroquine resistance in Plasmodium falciparum, analogues of malagashanine from strychnobrasiline
Identifieur interne : 000229 ( Hal/Corpus ); précédent : 000228; suivant : 000230Synthesis of modulators of chloroquine resistance in Plasmodium falciparum, analogues of malagashanine from strychnobrasiline
Auteurs : F. Trigalo ; R. Joyeau ; V. C. Pham ; J. J. Youté ; P. Rasoanaivo ; F. FrappierSource :
- Tetrahedron [ 0040-4020 ] ; 2004-06-14.
Abstract
The syntheses of three malagashanine analogues are reported. They involve conversion of strychnobrasiline in multiple steps and obtaining (i) unsaturation of the bond 3-14, (ii) inversion of configuration on carbon C3, (iii) inversion of configuration on carbon C3 and reduction of the benzene ring.
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DOI: 10.1016/j.tet.2004.04.068
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<front><div type="abstract" xml:lang="en"> <p>The syntheses of three malagashanine analogues are reported. They involve conversion of strychnobrasiline in multiple steps and obtaining (i) unsaturation of the bond 3-14, (ii) inversion of configuration on carbon C3, (iii) inversion of configuration on carbon C3 and reduction of the benzene ring.</p>
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