Recommendations for the assessment and optimization of adherence to disease-modifying drugs in chronic inflammatory rheumatic diseases: A process based on literature reviews and expert consensus
Identifieur interne : 000203 ( Hal/Corpus ); précédent : 000202; suivant : 000204Recommendations for the assessment and optimization of adherence to disease-modifying drugs in chronic inflammatory rheumatic diseases: A process based on literature reviews and expert consensus
Auteurs : Laure Gossec ; Anna Molt ; Xavier Romand ; Déborah Puyraimond-Zemmour ; Matthieu Lavielle ; Catherine Beauvais ; Eric Senbel ; René-Marc Flipo ; Sophie Pouplin ; Christophe Richez ; Alain Saraux ; Maryse Mezieres ; Loriane Gutermann ; Philippe Gaudin ; Daniel Wendling ; Maxime DougadosSource :
- Joint Bone Spine [ 1297-319X ] ; 2019-01.
English descriptors
Abstract
BACKGROUND:Adherence to treatment is a key issue in chronic inflammatory rheumatic diseases (CIRDs).OBJECTIVE:To develop recommendations to facilitate in daily practice, the management of non-adherence to disease-modifying drugs in patients with rheumatoid arthritis, spondyloarthritis, psoriatic arthritis, connective tissue diseases or other CIRDs.METHODS:The process comprised (a) systematic literature reviews of methods (including questionnaires) to measure non-adherence, risk factors for non-adherence and efficacy of targeted interventions; (b) development of recommendations through consensus of 104 rheumatologist and nurse experts; (c) assessment of agreement and ease of applicability (1-5 where 5 is highest) by the 104 experts.RESULTS:(a) Overall, 274 publications were analysed. (b) The consensus process led to 5 overarching principles and 10 recommendations regarding adherence. Key points include that adherence should be assessed at each outpatient visit, at least using an open question; questionnaires and hydroxychloroquine blood level assessments may also be useful. Risk factors associated to non-adherence were listed. Patient information and education, and patient/physician shared decision, are key to optimize adherence. Other techniques such as formalized education sessions, motivational interviewing and cognitive behavioral therapy may be useful. All health professionals can get involved and e-health may be a support. (c) The agreement with the recommendations was high (range of means, 3.9-4.5) but ease of applicability was lower (2.7-4.4).CONCLUSIONS:Using an evidence-based approach followed by expert consensus, this initiative should improve the assessment and optimization of adherence in chronic inflammatory rheumatic disorders.
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DOI: 10.1016/j.jbspin.2018.08.006
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Hal:hal-02171141Le document en format XML
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75006 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.sorbonne-universite.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Lavielle, Matthieu" sort="Lavielle, Matthieu" uniqKey="Lavielle M" first="Matthieu" last="Lavielle">Matthieu Lavielle</name><affiliation><hal:affiliation type="institution" xml:id="struct-300123" status="VALID"> <orgName>CHU Cochin [AP-HP]</orgName> <desc> <address> <addrLine>27 Rue du Faubourg Saint-Jacques 75014 Paris</addrLine> <country key="FR"></country> </address> </desc> </hal:affiliation></affiliation></author><author><name sortKey="Beauvais, Catherine" sort="Beauvais, Catherine" uniqKey="Beauvais C" first="Catherine" last="Beauvais">Catherine Beauvais</name><affiliation><hal:affiliation type="department" xml:id="struct-487941" status="VALID"> <orgName>Service de rhumatologie [CHU Saint-Antoine] </orgName> <desc> <address> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300068" type="direct"></relation> <relation active="#struct-454982" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName> <orgName type="acronym">APHP</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-454982" type="direct"><org type="institution" xml:id="struct-454982" status="VALID"> <orgName>CHU Saint-Antoine [APHP]</orgName> <desc> <address> <addrLine>184, rue du Faubourg Saint-Antoine 75571 Paris cedex 12</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.aphp.fr/contenu/hopital-saint-antoine-1</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Senbel, Eric" sort="Senbel, Eric" uniqKey="Senbel E" first="Eric" last="Senbel">Eric Senbel</name></author><author><name sortKey="Flipo, Rene Marc" sort="Flipo, Rene Marc" uniqKey="Flipo R" first="René-Marc" last="Flipo">René-Marc Flipo</name><affiliation><hal:affiliation type="institution" xml:id="struct-425779" status="VALID"> <orgName>Centre Hospitalier Régional Universitaire [Lille]</orgName> <orgName type="acronym">CHRU Lille</orgName> <desc> <address> <addrLine>2, avenue Oscar Lambret - 59037 Lille Cedex</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.chru-lille.fr/</ref> </desc> </hal:affiliation></affiliation></author><author><name sortKey="Pouplin, Sophie" sort="Pouplin, Sophie" uniqKey="Pouplin S" first="Sophie" last="Pouplin">Sophie Pouplin</name><affiliation><hal:affiliation type="institution" xml:id="struct-300147" status="VALID"> <idno type="IdRef">169975681</idno> <orgName>CHU Rouen</orgName> <desc> <address> <addrLine>1, rue de Germont 76031 Rouen cedex</addrLine> <country key="FR"></country> </address> <ref type="url">https://www.chu-rouen.fr/</ref> </desc> <listRelation> <relation active="#struct-455934" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-455934" type="direct"><org type="regroupinstitution" xml:id="struct-455934" status="VALID"> <idno type="IdRef">190906332</idno> <idno type="ISNI">0000000417859671 </idno> <orgName>Normandie Université</orgName> <orgName type="acronym">NU</orgName> <date type="start">2015-01-01</date> <desc> <address> <addrLine>Esplanade de la Paix - CS 14032 - 14032 Caen Cedex 5</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.normandie-univ.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Richez, Christophe" sort="Richez, Christophe" uniqKey="Richez C" first="Christophe" last="Richez">Christophe Richez</name><affiliation><hal:affiliation type="institution" xml:id="struct-300122" status="VALID"> <orgName>CHU Bordeaux [Bordeaux]</orgName> <desc> <address> <addrLine>place Amélie Raba Léon33076 BORDEAUX CEDEX</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.chu-bordeaux.fr/</ref> </desc> </hal:affiliation></affiliation></author><author><name sortKey="Saraux, Alain" sort="Saraux, Alain" uniqKey="Saraux A" first="Alain" last="Saraux">Alain Saraux</name><affiliation><hal:affiliation type="institution" xml:id="struct-439755" status="VALID"> <orgName>Hôpital de la Cavale Blanche - CHRU Brest</orgName> <orgName type="acronym">CHU - BREST </orgName> <desc> <address> <addrLine>Boulevard Tanguy Prigent 29609 Brest Cedex</addrLine> <country key="FR"></country> </address> </desc> </hal:affiliation></affiliation></author><author><name sortKey="Mezieres, Maryse" sort="Mezieres, Maryse" uniqKey="Mezieres M" first="Maryse" last="Mezieres">Maryse Mezieres</name><affiliation><hal:affiliation type="department" xml:id="struct-18258" status="VALID"> <orgName>Service de rhumatologie [CHU Cochin]</orgName> <desc> <address> <addrLine>27 rue du Faubourg Saint-Jacques 75014 Paris</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300123" type="direct"></relation> <relation active="#struct-300068" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300123" type="direct"><org type="institution" xml:id="struct-300123" status="VALID"> <orgName>CHU Cochin [AP-HP]</orgName> <desc> <address> <addrLine>27 Rue du Faubourg Saint-Jacques 75014 Paris</addrLine> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName> <orgName type="acronym">APHP</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Gutermann, Loriane" sort="Gutermann, Loriane" uniqKey="Gutermann L" first="Loriane" last="Gutermann">Loriane Gutermann</name><affiliation><hal:affiliation type="institution" xml:id="struct-300123" status="VALID"> <orgName>CHU Cochin [AP-HP]</orgName> <desc> <address> <addrLine>27 Rue du Faubourg Saint-Jacques 75014 Paris</addrLine> <country key="FR"></country> </address> </desc> </hal:affiliation></affiliation></author><author><name sortKey="Gaudin, Philippe" sort="Gaudin, Philippe" uniqKey="Gaudin P" first="Philippe" last="Gaudin">Philippe Gaudin</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-58056" status="VALID"> <orgName>Groupe de Recherche et d'Etudes du Processus Inflammatoire</orgName> <orgName type="acronym">GREPI</orgName> <desc> <address> <country key="FR"></country> </address> </desc> <listRelation> <relation name="EA2938" active="#struct-51016" type="direct"></relation> </listRelation> <tutelles><tutelle name="EA2938" active="#struct-51016" type="direct"><org type="institution" xml:id="struct-51016" status="OLD"> <idno type="IdRef">026404796</idno> <orgName>Université Joseph Fourier - Grenoble 1</orgName> <orgName type="acronym">UJF</orgName> <date type="end">2015-12-31</date> <desc> <address> <addrLine>BP 53 - 38041 Grenoble Cedex 9</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.ujf-grenoble.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Wendling, Daniel" sort="Wendling, Daniel" uniqKey="Wendling D" first="Daniel" last="Wendling">Daniel Wendling</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-53272" status="VALID"> <orgName>Service de Rhumatologie</orgName> <desc> <address> <addrLine>Besançon</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300165" type="direct"></relation> <relation active="#struct-301131" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300165" type="direct"><org type="institution" xml:id="struct-300165" status="VALID"> <orgName>Centre Hospitalier Régional Universitaire [Besançon]</orgName> <orgName type="acronym">CHRU Besançon</orgName> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.chu-besancon.fr/</ref> </desc> </org></tutelle><tutelle active="#struct-301131" type="direct"><org type="institution" xml:id="struct-301131" status="VALID"> <orgName>Hôpital Jean Minjoz</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Dougados, Maxime" sort="Dougados, Maxime" uniqKey="Dougados M" first="Maxime" last="Dougados">Maxime Dougados</name><affiliation><hal:affiliation type="department" xml:id="struct-18258" status="VALID"> <orgName>Service de rhumatologie [CHU Cochin]</orgName> <desc> <address> <addrLine>27 rue du Faubourg Saint-Jacques 75014 Paris</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300123" type="direct"></relation> <relation active="#struct-300068" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300123" type="direct"><org type="institution" xml:id="struct-300123" status="VALID"> <orgName>CHU Cochin [AP-HP]</orgName> <desc> <address> <addrLine>27 Rue du Faubourg Saint-Jacques 75014 Paris</addrLine> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName> <orgName type="acronym">APHP</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author></analytic><idno type="DOI">10.1016/j.jbspin.2018.08.006</idno><series><title level="j">Joint Bone Spine</title><idno type="ISSN">1297-319X</idno><imprint><date type="datePub">2019-01</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="mix" xml:lang="en"><term>Adherence</term><term>Compliance</term><term>Recommendations</term><term>Rheumatoid arthritis</term><term>Spondyloarthritis</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"> <p>BACKGROUND:Adherence to treatment is a key issue in chronic inflammatory rheumatic diseases (CIRDs).OBJECTIVE:To develop recommendations to facilitate in daily practice, the management of non-adherence to disease-modifying drugs in patients with rheumatoid arthritis, spondyloarthritis, psoriatic arthritis, connective tissue diseases or other CIRDs.METHODS:The process comprised (a) systematic literature reviews of methods (including questionnaires) to measure non-adherence, risk factors for non-adherence and efficacy of targeted interventions; (b) development of recommendations through consensus of 104 rheumatologist and nurse experts; (c) assessment of agreement and ease of applicability (1-5 where 5 is highest) by the 104 experts.RESULTS:(a) Overall, 274 publications were analysed. (b) The consensus process led to 5 overarching principles and 10 recommendations regarding adherence. Key points include that adherence should be assessed at each outpatient visit, at least using an open question; questionnaires and hydroxychloroquine blood level assessments may also be useful. Risk factors associated to non-adherence were listed. Patient information and education, and patient/physician shared decision, are key to optimize adherence. Other techniques such as formalized education sessions, motivational interviewing and cognitive behavioral therapy may be useful. All health professionals can get involved and e-health may be a support. (c) The agreement with the recommendations was high (range of means, 3.9-4.5) but ease of applicability was lower (2.7-4.4).CONCLUSIONS:Using an evidence-based approach followed by expert consensus, this initiative should improve the assessment and optimization of adherence in chronic inflammatory rheumatic disorders.</p> </div></front></TEI><hal api="V3"> <titleStmt> <title xml:lang="en">Recommendations for the assessment and optimization of adherence to disease-modifying drugs in chronic inflammatory rheumatic diseases: A process based on literature reviews and expert consensus</title> <author role="aut"> <persName> <forename type="first">Laure</forename> <surname>Gossec</surname> </persName> <email type="md5">c8c06cfad576146e8beadf6a5b073459</email> <email type="domain">cch.aphp.fr</email> <idno type="halauthorid">239364</idno> <affiliation ref="#struct-541998"></affiliation> <affiliation ref="#struct-413221"></affiliation> <affiliation ref="#struct-542132"></affiliation> <affiliation ref="#struct-262233"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Anna</forename> <surname>Moltó</surname> </persName> <idno type="halauthorid">1273518</idno> <affiliation ref="#struct-300123"></affiliation> <affiliation ref="#struct-446175"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Xavier</forename> <surname>Romand</surname> </persName> <idno type="halauthorid">11288808</idno> <affiliation ref="#struct-97332"></affiliation> <affiliation ref="#struct-58056"></affiliation> <affiliation ref="#struct-460879"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Déborah</forename> <surname>Puyraimond-Zemmour</surname> </persName> <idno type="halauthorid">1449548</idno> <affiliation ref="#struct-542132"></affiliation> <affiliation ref="#struct-541998"></affiliation> <affiliation ref="#struct-262233"></affiliation> <affiliation ref="#struct-413221"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Matthieu</forename> <surname>Lavielle</surname> </persName> <idno type="halauthorid">1421856</idno> <affiliation ref="#struct-300123"></affiliation> <affiliation ref="#struct-446175"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Catherine</forename> <surname>Beauvais</surname> </persName> <idno type="halauthorid">1716110</idno> <affiliation ref="#struct-487941"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Eric</forename> <surname>Senbel</surname> </persName> <idno type="halauthorid">1358133</idno> </author> <author role="aut"> <persName> <forename type="first">René-Marc</forename> <surname>Flipo</surname> </persName> <email type="md5">a04805f896928e92e938cebbf3fb9203</email> <email type="domain">chru-lille.fr</email> <idno type="halauthorid">684022</idno> <affiliation ref="#struct-425779"></affiliation> <affiliation ref="#struct-181744"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Sophie</forename> <surname>Pouplin</surname> </persName> <idno type="halauthorid">119239</idno> <affiliation ref="#struct-300147"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Christophe</forename> <surname>Richez</surname> </persName> <idno type="halauthorid">84802</idno> <affiliation ref="#struct-300122"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Alain</forename> <surname>Saraux</surname> </persName> <email type="md5">ad2227f79b04d39122fe6e9cb08e538b</email> <email type="domain">chu-brest.fr</email> <idno type="halauthorid">757749</idno> <affiliation ref="#struct-439755"></affiliation> <affiliation ref="#struct-162449"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Maryse</forename> <surname>Mezieres</surname> </persName> <idno type="halauthorid">1358131</idno> <affiliation ref="#struct-18258"></affiliation> <affiliation ref="#struct-446175"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Loriane</forename> <surname>Gutermann</surname> </persName> <idno type="halauthorid">11510863</idno> <affiliation ref="#struct-300123"></affiliation> <affiliation ref="#struct-446175"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Philippe</forename> <surname>Gaudin</surname> </persName> <idno type="halauthorid">253664</idno> <affiliation ref="#struct-58056"></affiliation> <affiliation ref="#struct-460879"></affiliation> <affiliation ref="#struct-97332"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Daniel</forename> <surname>Wendling</surname> </persName> <email type="md5">d3ecbebbeca2cb113056f7c23dcb009c</email> <email type="domain">chu-besancon.fr</email> <idno type="halauthorid">575058</idno> <affiliation ref="#struct-53272"></affiliation> <affiliation ref="#struct-538610"></affiliation> <affiliation ref="#struct-493756"></affiliation> <affiliation ref="#struct-458810"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Maxime</forename> <surname>Dougados</surname> </persName> <email type="md5">21068e5fbe0089f66ef7c8640f94f50c</email> <email type="domain">cch.aphp.fr</email> <idno type="halauthorid">191437</idno> <affiliation ref="#struct-18258"></affiliation> <affiliation ref="#struct-446175"></affiliation> </author> <editor role="depositor"> <persName> <forename>Gestionnaire</forename> <surname>HAL-SU</surname> </persName> <email type="md5">20ce03d813b4e6b0eba84db23565c63b</email> <email type="domain">sorbonne-universite.fr</email> </editor> </titleStmt> <editionStmt> <edition n="v1" type="current"> <date type="whenSubmitted">2019-07-02 16:32:21</date> <date type="whenModified">2020-03-24 16:10:42</date> <date type="whenReleased">2019-07-08 13:15:57</date> <date type="whenProduced">2019-01</date> <date type="whenEndEmbargoed">2019-07-02</date> <ref 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type="halBibtex">gossec:hal-02171141</idno> <idno type="halRefHtml">Joint Bone Spine, Elsevier Masson, 2019, 86 (1), pp.13-19. ⟨10.1016/j.jbspin.2018.08.006⟩</idno> <idno type="halRef">Joint Bone Spine, Elsevier Masson, 2019, 86 (1), pp.13-19. ⟨10.1016/j.jbspin.2018.08.006⟩</idno> </publicationStmt> <seriesStmt> <idno type="stamp" n="UNIV-GRENOBLE1" corresp="UGA">Université Joseph Fourier - Grenoble I</idno> <idno type="stamp" n="UNIV-BREST">Université de Bretagne occidentale - Brest (UBO)</idno> <idno type="stamp" n="INRA">INRA - Institut national de la recherche agronomique</idno> <idno type="stamp" n="UNIV-FCOMTE">Université de Franche-Comté</idno> <idno type="stamp" n="APHP" corresp="INSERM">AP-HP</idno> <idno type="stamp" n="SORBONNE-UNIV" corresp="SORBONNE-UNIVERSITE">Sorbonne Université 01/01/2018</idno> <idno type="stamp" n="AGREENIUM">Archive ouverte en agrobiosciences</idno> <idno type="stamp" n="IPLESP" corresp="SORBONNE-UNIVERSITE">Institut Pierre Louis d'Epidémiologie et de Santé Publique</idno> <idno type="stamp" n="UNIV-PARIS5">Université Paris Descartes (Paris 5)</idno> <idno type="stamp" n="SORBONNE-UNIVERSITE">Sorbonne Université</idno> <idno type="stamp" n="UNIV-PARIS7">Université Denis Diderot - Paris VII</idno> <idno type="stamp" n="INSERM">INSERM - Institut national de la santé et de la recherche médicale</idno> <idno type="stamp" n="UGA">HAL Grenoble Alpes</idno> <idno type="stamp" n="USPC">Université Sorbonne Paris Cité</idno> <idno type="stamp" n="SU-MEDECINE" corresp="SORBONNE-UNIVERSITE">Faculté de Médecine de Sorbonne Université</idno> <idno type="stamp" n="COMUE-NORMANDIE">Normandie Université</idno> <idno type="stamp" n="INRAE">Institut National de Recherche en Agriculture, Alimentation et Environnement</idno> </seriesStmt> <notesStmt> <note type="audience" n="2">International</note> <note type="popular" n="0">No</note> <note type="peer" n="1">Yes</note> </notesStmt> <sourceDesc> <biblStruct> <analytic> <title xml:lang="en">Recommendations for the assessment and optimization of adherence to disease-modifying drugs in chronic inflammatory rheumatic diseases: A process based on literature reviews and expert consensus</title> <author role="aut"> <persName> <forename type="first">Laure</forename> <surname>Gossec</surname> </persName> <email type="md5">c8c06cfad576146e8beadf6a5b073459</email> <email type="domain">cch.aphp.fr</email> <idno type="halauthorid">239364</idno> <affiliation ref="#struct-541998"></affiliation> <affiliation ref="#struct-413221"></affiliation> <affiliation ref="#struct-542132"></affiliation> <affiliation ref="#struct-262233"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Anna</forename> <surname>Moltó</surname> </persName> <idno type="halauthorid">1273518</idno> <affiliation ref="#struct-300123"></affiliation> <affiliation ref="#struct-446175"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Xavier</forename> <surname>Romand</surname> </persName> <idno type="halauthorid">11288808</idno> <affiliation ref="#struct-97332"></affiliation> <affiliation ref="#struct-58056"></affiliation> <affiliation ref="#struct-460879"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Déborah</forename> <surname>Puyraimond-Zemmour</surname> </persName> <idno type="halauthorid">1449548</idno> <affiliation ref="#struct-542132"></affiliation> <affiliation ref="#struct-541998"></affiliation> <affiliation ref="#struct-262233"></affiliation> <affiliation ref="#struct-413221"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Matthieu</forename> <surname>Lavielle</surname> </persName> <idno type="halauthorid">1421856</idno> <affiliation ref="#struct-300123"></affiliation> <affiliation ref="#struct-446175"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Catherine</forename> <surname>Beauvais</surname> </persName> <idno type="halauthorid">1716110</idno> <affiliation ref="#struct-487941"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Eric</forename> <surname>Senbel</surname> </persName> <idno type="halauthorid">1358133</idno> </author> <author role="aut"> <persName> <forename type="first">René-Marc</forename> <surname>Flipo</surname> </persName> <email type="md5">a04805f896928e92e938cebbf3fb9203</email> <email type="domain">chru-lille.fr</email> <idno type="halauthorid">684022</idno> <affiliation ref="#struct-425779"></affiliation> <affiliation ref="#struct-181744"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Sophie</forename> <surname>Pouplin</surname> </persName> <idno type="halauthorid">119239</idno> <affiliation ref="#struct-300147"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Christophe</forename> <surname>Richez</surname> </persName> <idno type="halauthorid">84802</idno> <affiliation ref="#struct-300122"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Alain</forename> <surname>Saraux</surname> </persName> <email type="md5">ad2227f79b04d39122fe6e9cb08e538b</email> <email type="domain">chu-brest.fr</email> <idno type="halauthorid">757749</idno> <affiliation ref="#struct-439755"></affiliation> <affiliation ref="#struct-162449"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Maryse</forename> <surname>Mezieres</surname> </persName> <idno type="halauthorid">1358131</idno> <affiliation ref="#struct-18258"></affiliation> <affiliation ref="#struct-446175"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Loriane</forename> <surname>Gutermann</surname> </persName> <idno type="halauthorid">11510863</idno> <affiliation ref="#struct-300123"></affiliation> <affiliation ref="#struct-446175"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Philippe</forename> <surname>Gaudin</surname> </persName> <idno type="halauthorid">253664</idno> <affiliation ref="#struct-58056"></affiliation> <affiliation ref="#struct-460879"></affiliation> <affiliation ref="#struct-97332"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Daniel</forename> <surname>Wendling</surname> </persName> <email type="md5">d3ecbebbeca2cb113056f7c23dcb009c</email> <email type="domain">chu-besancon.fr</email> <idno type="halauthorid">575058</idno> <affiliation ref="#struct-53272"></affiliation> <affiliation ref="#struct-538610"></affiliation> <affiliation ref="#struct-493756"></affiliation> <affiliation ref="#struct-458810"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Maxime</forename> <surname>Dougados</surname> </persName> <email type="md5">21068e5fbe0089f66ef7c8640f94f50c</email> <email type="domain">cch.aphp.fr</email> <idno type="halauthorid">191437</idno> <affiliation ref="#struct-18258"></affiliation> <affiliation ref="#struct-446175"></affiliation> </author> </analytic> <monogr> <idno type="halJournalId" status="VALID">14977</idno> <idno type="issn">1297-319X</idno> <title level="j">Joint Bone Spine</title> <imprint> <publisher>Elsevier Masson</publisher> <biblScope unit="volume">86</biblScope> <biblScope unit="issue">1</biblScope> <biblScope unit="pp">13-19</biblScope> <date type="datePub">2019-01</date> </imprint> </monogr> <idno type="doi">10.1016/j.jbspin.2018.08.006</idno> <idno type="pubmed">30243782</idno> </biblStruct> </sourceDesc> <profileDesc> <langUsage> <language ident="en">English</language> </langUsage> <textClass> <keywords scheme="author"> <term xml:lang="en">Adherence</term> <term xml:lang="en">Compliance</term> <term xml:lang="en">Recommendations</term> <term xml:lang="en">Rheumatoid arthritis</term> <term xml:lang="en">Spondyloarthritis</term> </keywords> <classCode scheme="halDomain" n="sdv">Life Sciences [q-bio]</classCode> <classCode scheme="halDomain" n="sdv.mhep.rsoa">Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system</classCode> <classCode scheme="halTypology" n="ART">Journal articles</classCode> </textClass> <abstract xml:lang="en"> <p>BACKGROUND:Adherence to treatment is a key issue in chronic inflammatory rheumatic diseases (CIRDs).OBJECTIVE:To develop recommendations to facilitate in daily practice, the management of non-adherence to disease-modifying drugs in patients with rheumatoid arthritis, spondyloarthritis, psoriatic arthritis, connective tissue diseases or other CIRDs.METHODS:The process comprised (a) systematic literature reviews of methods (including questionnaires) to measure non-adherence, risk factors for non-adherence and efficacy of targeted interventions; (b) development of recommendations through consensus of 104 rheumatologist and nurse experts; (c) assessment of agreement and ease of applicability (1-5 where 5 is highest) by the 104 experts.RESULTS:(a) Overall, 274 publications were analysed. (b) The consensus process led to 5 overarching principles and 10 recommendations regarding adherence. Key points include that adherence should be assessed at each outpatient visit, at least using an open question; questionnaires and hydroxychloroquine blood level assessments may also be useful. Risk factors associated to non-adherence were listed. Patient information and education, and patient/physician shared decision, are key to optimize adherence. Other techniques such as formalized education sessions, motivational interviewing and cognitive behavioral therapy may be useful. All health professionals can get involved and e-health may be a support. (c) The agreement with the recommendations was high (range of means, 3.9-4.5) but ease of applicability was lower (2.7-4.4).CONCLUSIONS:Using an evidence-based approach followed by expert consensus, this initiative should improve the assessment and optimization of adherence in chronic inflammatory rheumatic disorders.</p> </abstract> </profileDesc> </hal></record>Pour manipuler ce document sous Unix (Dilib)
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