Osseous sarcoidosis: a multicenter case-control study
Identifieur interne : 000178 ( Hal/Corpus ); précédent : 000177; suivant : 000179Osseous sarcoidosis: a multicenter case-control study
Auteurs : Imen Ben Hassine ; Christopher Rein ; Cloé Comarmond ; Camille Glanowski ; Nathalie Saidenberg-Kermanac ; Benoit Meunier ; Nicolas Schleinitz ; Noémie Chanson ; Karim Sacre ; Marc Scherlinger ; Christophe Richez ; Sandrine Hirschi ; Matthieu Groh ; Hervé Devilliers ; Philip Bielefeld ; David Saadoun ; Catherine Chapelon-Abric ; Laurent Arnaud ; Patrice CacoubSource :
- Joint Bone Spine [ 1297-319X ] ; 2019.
English descriptors
Abstract
Objective: To describe the clinical presentation, distribution of lesions, treatment, and outcomes of osseous sarcoidosis.Methods: A French retrospective multicenter study of patients with biopsy-proven sarcoidosis analyzed patients with 1) a biopsy-proven granuloma without caseous necrosis, and either 2) osseous clinical manifestations, or 3) abnormal osseous imaging. Sarcoidosis patients with osseous involvement (cases) were compared with 264 age- and sex-matched sarcoidosis patients with no osseous manifestations (controls).Results: In the osseous sarcoidosis group (n = 88), forty-two (48%) patients had osseous-related symptoms involving the axial (69%) and/or appendicular (58%) skeleton. On imaging, the most commonly affected bones were in the spine (52%), pelvis (42%), hands (22%) and femur (19%). Compared with controls, cases had higher rates of mediastinal (93% vs. 47%) and extra-thoracic lymph node involvement (66% vs. 21%), pulmonary (90% vs. 65%) and cutaneous involvement (44% vs. 23%) (all P < 0.0001), and hypercalcemia (8.5% vs. 2%, P = 0.014). Spleen/liver and gastrointestinal involvement were less frequent in the osseous sarcoidosis group (29% vs. 45%, and 1% vs. 17%, respectively, P < 0.0001). Response rates to with glucocorticoids alone, glucocorticoids plus methotrexate or glucocorticoids plus hydroxychloroquine were 23/44 (52%), 9/13 (69%) and 4/6 (67%), respectively.Conclusion: In patients with osseous sarcoidosis the spine and pelvis were the most commonly affected bones. Compared with controls, cases with osseous sarcoidosis have higher rates of thoracic and extra-thoracic lymph node involvement, pulmonary and cutaneous involvement, and hypercalcemia. Most patients with osseous sarcoidosis had a good response to glucocorticoids in combination with methotrexate or hydroxychloroquine.
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DOI: 10.1016/j.jbspin.2019.07.009
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Hal:hal-02291291Le document en format XML
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Immunopathologie - Immunothérapie</orgName> <orgName type="acronym">I3</orgName> <desc> <address> <addrLine>Bâtiment CERVI, CHU Pitié-Salpêtrière 83 boulevard de l'Hôpital 75651 Paris Cedex 13 (France)</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation name="U959" active="#struct-303623" type="direct"></relation> <relation active="#struct-413221" type="direct"></relation> <relation name="UMR7211" active="#struct-441569" type="direct"></relation> </listRelation> <tutelles><tutelle name="U959" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc> </org></tutelle><tutelle active="#struct-413221" type="direct"><org type="institution" xml:id="struct-413221" status="VALID"> <orgName>Sorbonne Université</orgName> <orgName type="acronym">SU</orgName> <date type="start">2018-01-01</date> <desc> <address> <addrLine>21 rue de l’École de médecine - 75006 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.sorbonne-universite.fr/</ref> </desc> </org></tutelle><tutelle name="UMR7211" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno> <idno type="ISNI">0000000122597504</idno> <orgName>Centre National de la Recherche Scientifique</orgName> <orgName type="acronym">CNRS</orgName> <date type="start">1939-10-19</date> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.cnrs.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Rein, Christopher" sort="Rein, Christopher" uniqKey="Rein C" first="Christopher" last="Rein">Christopher Rein</name><affiliation><hal:affiliation type="regrouplaboratory" xml:id="struct-37974" status="VALID"> <orgName>Hôpital d'Instruction des Armées Legouest</orgName> <desc> <address> <addrLine>27 Avenue de Plantières BP 10 57998 Metz Armées</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300092" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300092" type="direct"><org type="institution" xml:id="struct-300092" status="VALID"> <orgName>Service de Santé des Armées</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Comarmond, Cloe" sort="Comarmond, Cloe" uniqKey="Comarmond C" first="Cloé" last="Comarmond">Cloé Comarmond</name><affiliation><hal:affiliation type="department" xml:id="struct-454547" status="VALID"> <orgName>Service de médecine interne et d'immunologie clinique [CHU Pitié-Salpêtrière]</orgName> <desc> <address> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300068" type="direct"></relation> <relation active="#struct-353778" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName> <orgName type="acronym">APHP</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-353778" type="direct"><org type="institution" xml:id="struct-353778" status="VALID"> <orgName>CHU Pitié-Salpêtrière [APHP]</orgName> <desc> <address> <addrLine>47-83 Boulevard de l'Hôpital, 75013 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.aphp.fr/contenu/hopital-universitaire-pitie-salpetriere-0</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Glanowski, Camille" sort="Glanowski, Camille" uniqKey="Glanowski C" first="Camille" last="Glanowski">Camille Glanowski</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-37970" status="VALID"> <orgName>Hôpital d'Instruction des Armées Begin</orgName> <desc> <address> <addrLine>69 avenue de Paris, 94160 Saint-Mandé</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300092" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300092" type="direct"><org type="institution" xml:id="struct-300092" status="VALID"> <orgName>Service de Santé des Armées</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Saidenberg Kermanac, Nathalie" sort="Saidenberg Kermanac, Nathalie" uniqKey="Saidenberg Kermanac N" first="Nathalie" last="Saidenberg-Kermanac">Nathalie Saidenberg-Kermanac</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-246021" status="OLD"> <orgName>Physiopathologie, Cibles et Thérapies de la Polyarthrite Rhumatoïde</orgName> <date type="end">2019-12-31</date> <desc> <address> <addrLine>74 rue Marcel Cachin 93017 Bobigny</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-15786" type="direct"></relation> <relation name="U1125" active="#struct-303623" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-15786" type="direct"><org type="institution" xml:id="struct-15786" status="VALID"> <orgName>Université Paris 13</orgName> <orgName type="acronym">UP13</orgName> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.univ-paris13.fr/</ref> </desc> </org></tutelle><tutelle name="U1125" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Meunier, Benoit" sort="Meunier, Benoit" uniqKey="Meunier B" first="Benoit" last="Meunier">Benoit Meunier</name><affiliation><hal:affiliation type="regrouplaboratory" xml:id="struct-412213" status="VALID"> <orgName>Aix-Marseille Université - Faculté de médecine</orgName> <orgName type="acronym">AMU MED</orgName> <desc> <address> <addrLine>27 bd Jean Moulin - 13385 Marseille cedex 5</addrLine> <country key="FR"></country> </address> <ref type="url">http://medecine.univ-amu.fr/</ref> </desc> <listRelation> <relation active="#struct-198056" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-198056" type="direct"><org type="institution" xml:id="struct-198056" status="VALID"> <idno type="IdRef">15863621X</idno> <idno type="ISNI">0000 0001 2176 4817</idno> <orgName>Aix Marseille Université</orgName> <orgName type="acronym">AMU</orgName> <date type="start">2012-01-01</date> <desc> <address> <addrLine>Aix-Marseille UniversitéJardins du Pharo58 Boulevard Charles Livon13284 Marseille cedex 7</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-amu.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Schleinitz, Nicolas" sort="Schleinitz, Nicolas" uniqKey="Schleinitz N" first="Nicolas" last="Schleinitz">Nicolas Schleinitz</name><affiliation><hal:affiliation type="institution" xml:id="struct-300093" status="VALID"> <idno type="ISNI">0000 0001 0404 1115 </idno> <orgName> Hôpital de la Timone [CHU - APHM]</orgName> <orgName type="acronym">TIMONE</orgName> <date type="start">1974</date> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://fr.ap-hm.fr/nos-hopitaux/hopital-de-la-timone</ref> </desc> </hal:affiliation></affiliation></author><author><name sortKey="Chanson, Noemie" sort="Chanson, Noemie" uniqKey="Chanson N" first="Noémie" last="Chanson">Noémie Chanson</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-2607" status="VALID"> <orgName>CIC - CHU Bichat</orgName> <desc> <address> <addrLine>Gh Xavier Bichat - Claude Bernard PARIS VII 46, Rue Henri Huchard 75018 PARIS</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation name="CIC7" active="#struct-303623" type="direct"></relation> </listRelation> <tutelles><tutelle name="CIC7" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Sacre, Karim" sort="Sacre, Karim" uniqKey="Sacre K" first="Karim" last="Sacre">Karim Sacre</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-2607" status="VALID"> <orgName>CIC - CHU Bichat</orgName> <desc> <address> <addrLine>Gh Xavier Bichat - Claude Bernard PARIS VII 46, Rue Henri Huchard 75018 PARIS</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation name="CIC7" active="#struct-303623" type="direct"></relation> </listRelation> <tutelles><tutelle name="CIC7" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Scherlinger, Marc" sort="Scherlinger, Marc" uniqKey="Scherlinger M" first="Marc" last="Scherlinger">Marc Scherlinger</name><affiliation><hal:affiliation type="institution" xml:id="struct-300122" status="VALID"> <orgName>CHU Bordeaux [Bordeaux]</orgName> <desc> <address> <addrLine>place Amélie Raba Léon33076 BORDEAUX CEDEX</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.chu-bordeaux.fr/</ref> </desc> </hal:affiliation></affiliation></author><author><name sortKey="Richez, Christophe" sort="Richez, Christophe" uniqKey="Richez C" first="Christophe" last="Richez">Christophe Richez</name><affiliation><hal:affiliation type="institution" xml:id="struct-300122" status="VALID"> <orgName>CHU Bordeaux [Bordeaux]</orgName> <desc> <address> <addrLine>place Amélie Raba Léon33076 BORDEAUX CEDEX</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.chu-bordeaux.fr/</ref> </desc> </hal:affiliation></affiliation></author><author><name sortKey="Hirschi, Sandrine" sort="Hirschi, Sandrine" uniqKey="Hirschi S" first="Sandrine" last="Hirschi">Sandrine Hirschi</name><affiliation><hal:affiliation type="institution" xml:id="struct-300149" status="VALID"> <orgName>CHU Strasbourg</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </hal:affiliation></affiliation></author><author><name sortKey="Groh, Matthieu" sort="Groh, Matthieu" uniqKey="Groh M" first="Matthieu" last="Groh">Matthieu Groh</name><affiliation><hal:affiliation type="institution" xml:id="struct-410109" status="VALID"> <orgName>Hôpital Foch [Suresnes]</orgName> <desc> <address> <addrLine>40 Rue Worth 92150 Suresnes</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.hopital-foch.com/</ref> </desc> </hal:affiliation></affiliation></author><author><name sortKey="Devilliers, Herve" sort="Devilliers, Herve" uniqKey="Devilliers H" first="Hervé" last="Devilliers">Hervé Devilliers</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-475861" status="VALID"> <orgName>Service de médecine interne et maladies systémiques (SOC 2) [CHU de Dijon]</orgName> <desc> <address> <addrLine>CHU de Dijon - 14 Rue Paul Gaffarel, 21000 Dijon</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.chu-dijon.fr/fr/service/medecine-interne-maladies-systemiques-medecine-2-soc-2</ref> </desc> <listRelation> <relation active="#struct-300924" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300924" type="direct"><org type="institution" xml:id="struct-300924" status="VALID"> <orgName>Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand</orgName> <orgName type="acronym">CHU Dijon</orgName> <desc> <address> <addrLine>CHU Dijon - 14 rue Paul Gaffarel - 21079 Dijon</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.chu-dijon.fr/fr</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Bielefeld, Philip" sort="Bielefeld, Philip" uniqKey="Bielefeld P" first="Philip" last="Bielefeld">Philip Bielefeld</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-475861" status="VALID"> <orgName>Service de médecine interne et maladies systémiques (SOC 2) [CHU de Dijon]</orgName> <desc> <address> <addrLine>CHU de Dijon - 14 Rue Paul Gaffarel, 21000 Dijon</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.chu-dijon.fr/fr/service/medecine-interne-maladies-systemiques-medecine-2-soc-2</ref> </desc> <listRelation> <relation active="#struct-300924" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300924" type="direct"><org type="institution" xml:id="struct-300924" status="VALID"> <orgName>Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand</orgName> <orgName type="acronym">CHU Dijon</orgName> <desc> <address> <addrLine>CHU Dijon - 14 rue Paul Gaffarel - 21079 Dijon</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.chu-dijon.fr/fr</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Saadoun, David" sort="Saadoun, David" uniqKey="Saadoun D" first="David" last="Saadoun">David Saadoun</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-542085" status="VALID"> <idno type="RNSR">200918530G</idno> <orgName>Immunologie - Immunopathologie - Immunothérapie</orgName> <orgName type="acronym">I3</orgName> <desc> <address> <addrLine>Bâtiment CERVI, CHU Pitié-Salpêtrière 83 boulevard de l'Hôpital 75651 Paris Cedex 13 (France)</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation name="U959" active="#struct-303623" type="direct"></relation> <relation active="#struct-413221" type="direct"></relation> <relation name="UMR7211" active="#struct-441569" type="direct"></relation> </listRelation> <tutelles><tutelle name="U959" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc> </org></tutelle><tutelle active="#struct-413221" type="direct"><org type="institution" xml:id="struct-413221" status="VALID"> <orgName>Sorbonne Université</orgName> <orgName type="acronym">SU</orgName> <date type="start">2018-01-01</date> <desc> <address> <addrLine>21 rue de l’École de médecine - 75006 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.sorbonne-universite.fr/</ref> </desc> </org></tutelle><tutelle name="UMR7211" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno> <idno type="ISNI">0000000122597504</idno> <orgName>Centre National de la Recherche Scientifique</orgName> <orgName type="acronym">CNRS</orgName> <date type="start">1939-10-19</date> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.cnrs.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Chapelon Abric, Catherine" sort="Chapelon Abric, Catherine" uniqKey="Chapelon Abric C" first="Catherine" last="Chapelon-Abric">Catherine Chapelon-Abric</name><affiliation><hal:affiliation type="department" xml:id="struct-454547" status="VALID"> <orgName>Service de médecine interne et d'immunologie clinique [CHU Pitié-Salpêtrière]</orgName> <desc> <address> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300068" type="direct"></relation> <relation active="#struct-353778" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName> <orgName type="acronym">APHP</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-353778" type="direct"><org type="institution" xml:id="struct-353778" status="VALID"> <orgName>CHU Pitié-Salpêtrière [APHP]</orgName> <desc> <address> <addrLine>47-83 Boulevard de l'Hôpital, 75013 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.aphp.fr/contenu/hopital-universitaire-pitie-salpetriere-0</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Arnaud, Laurent" sort="Arnaud, Laurent" uniqKey="Arnaud L" first="Laurent" last="Arnaud">Laurent Arnaud</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-102530" status="VALID"> <orgName>Service de rhumatologie [Strasbourg]</orgName> <desc> <address> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300149" type="direct"></relation> <relation active="#struct-357391" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300149" type="direct"><org type="institution" xml:id="struct-300149" status="VALID"> <orgName>CHU Strasbourg</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-357391" type="direct"><org type="institution" xml:id="struct-357391" status="VALID"> <orgName>Hôpital de Hautepierre [Strasbourg]</orgName> <desc> <address> <addrLine>Avenue Molière67200 Strasbourg</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.chru-strasbourg.fr/Hopital-de-Hautepierre</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Cacoub, Patrice" sort="Cacoub, Patrice" uniqKey="Cacoub P" first="Patrice" last="Cacoub">Patrice Cacoub</name><affiliation><hal:affiliation type="department" xml:id="struct-454547" status="VALID"> <orgName>Service de médecine interne et d'immunologie clinique [CHU Pitié-Salpêtrière]</orgName> <desc> <address> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300068" type="direct"></relation> <relation active="#struct-353778" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName> <orgName type="acronym">APHP</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-353778" type="direct"><org type="institution" xml:id="struct-353778" status="VALID"> <orgName>CHU Pitié-Salpêtrière [APHP]</orgName> <desc> <address> <addrLine>47-83 Boulevard de l'Hôpital, 75013 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.aphp.fr/contenu/hopital-universitaire-pitie-salpetriere-0</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author></analytic><idno type="DOI">10.1016/j.jbspin.2019.07.009</idno><series><title level="j">Joint Bone Spine</title><idno type="ISSN">1297-319X</idno><imprint><date type="datePub" subtype="inPress">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="mix" xml:lang="en"><term>Bone involvement</term><term>Osseous manifestations</term><term>Sarcoidosis</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"> <p>Objective: To describe the clinical presentation, distribution of lesions, treatment, and outcomes of osseous sarcoidosis.Methods: A French retrospective multicenter study of patients with biopsy-proven sarcoidosis analyzed patients with 1) a biopsy-proven granuloma without caseous necrosis, and either 2) osseous clinical manifestations, or 3) abnormal osseous imaging. Sarcoidosis patients with osseous involvement (cases) were compared with 264 age- and sex-matched sarcoidosis patients with no osseous manifestations (controls).Results: In the osseous sarcoidosis group (n = 88), forty-two (48%) patients had osseous-related symptoms involving the axial (69%) and/or appendicular (58%) skeleton. On imaging, the most commonly affected bones were in the spine (52%), pelvis (42%), hands (22%) and femur (19%). Compared with controls, cases had higher rates of mediastinal (93% vs. 47%) and extra-thoracic lymph node involvement (66% vs. 21%), pulmonary (90% vs. 65%) and cutaneous involvement (44% vs. 23%) (all P < 0.0001), and hypercalcemia (8.5% vs. 2%, P = 0.014). Spleen/liver and gastrointestinal involvement were less frequent in the osseous sarcoidosis group (29% vs. 45%, and 1% vs. 17%, respectively, P < 0.0001). Response rates to with glucocorticoids alone, glucocorticoids plus methotrexate or glucocorticoids plus hydroxychloroquine were 23/44 (52%), 9/13 (69%) and 4/6 (67%), respectively.Conclusion: In patients with osseous sarcoidosis the spine and pelvis were the most commonly affected bones. Compared with controls, cases with osseous sarcoidosis have higher rates of thoracic and extra-thoracic lymph node involvement, pulmonary and cutaneous involvement, and hypercalcemia. Most patients with osseous sarcoidosis had a good response to glucocorticoids in combination with methotrexate or hydroxychloroquine.</p> </div></front></TEI><hal api="V3"> <titleStmt> <title xml:lang="en">Osseous sarcoidosis: a multicenter case-control study</title> <author role="aut"> <persName> <forename type="first">Imen</forename> <surname>Ben Hassine</surname> </persName> <idno type="halauthorid">11578657</idno> <affiliation ref="#struct-542085"></affiliation> <affiliation ref="#struct-454547"></affiliation> <affiliation ref="#struct-542111"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Christopher</forename> <surname>Rein</surname> </persName> <idno type="halauthorid">1620499</idno> <affiliation ref="#struct-37974"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Cloé</forename> <surname>Comarmond</surname> </persName> <email type="md5">d75d19c7f02c16abf2a10209fc2443df</email> <email type="domain">free.com</email> <idno type="halauthorid">1015046</idno> <affiliation ref="#struct-454547"></affiliation> <affiliation ref="#struct-542085"></affiliation> <affiliation ref="#struct-246522"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Camille</forename> <surname>Glanowski</surname> </persName> <idno type="halauthorid">11578658</idno> <affiliation ref="#struct-37970"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Nathalie</forename> <surname>Saidenberg-Kermanac’h</surname> </persName> <idno type="halauthorid">11578659</idno> <affiliation ref="#struct-246021"></affiliation> <affiliation ref="#struct-303171"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Benoit</forename> <surname>Meunier</surname> </persName> <idno type="halauthorid">11524189</idno> <affiliation ref="#struct-412213"></affiliation> <affiliation ref="#struct-300093"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Nicolas</forename> <surname>Schleinitz</surname> </persName> <idno type="halauthorid">464501</idno> <affiliation ref="#struct-300093"></affiliation> <affiliation ref="#struct-412213"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Noémie</forename> <surname>Chanson</surname> </persName> <idno type="halauthorid">11578660</idno> <affiliation ref="#struct-2607"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Karim</forename> <surname>Sacre</surname> </persName> <idno type="halauthorid">974649</idno> <affiliation ref="#struct-2607"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Marc</forename> <surname>Scherlinger</surname> </persName> <idno type="halauthorid">11384594</idno> <affiliation ref="#struct-300122"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Christophe</forename> <surname>Richez</surname> </persName> <idno type="halauthorid">84802</idno> <affiliation ref="#struct-300122"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Sandrine</forename> <surname>Hirschi</surname> </persName> <idno type="halauthorid">1161726</idno> <affiliation ref="#struct-300149"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Matthieu</forename> <surname>Groh</surname> </persName> <idno type="halauthorid">1195399</idno> <affiliation ref="#struct-410109"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Hervé</forename> <surname>Devilliers</surname> </persName> <idno type="halauthorid">899760</idno> <affiliation ref="#struct-475861"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Philip</forename> <surname>Bielefeld</surname> </persName> <idno type="halauthorid">1194892</idno> <affiliation ref="#struct-475861"></affiliation> </author> <author role="aut"> <persName> <forename type="first">David</forename> <surname>Saadoun</surname> </persName> <idno type="halauthorid">301308</idno> <affiliation ref="#struct-542085"></affiliation> <affiliation ref="#struct-542111"></affiliation> <affiliation ref="#struct-454547"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Catherine</forename> <surname>Chapelon-Abric</surname> </persName> <idno type="halauthorid">822669</idno> <affiliation ref="#struct-454547"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Laurent</forename> <surname>Arnaud</surname> </persName> <email type="md5">fb21e98832463a80f852116b5247d7da</email> <email type="domain">psl.aphp.fr</email> <idno type="halauthorid">848242</idno> <affiliation ref="#struct-102530"></affiliation> <affiliation ref="#struct-222993"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Patrice</forename> <surname>Cacoub</surname> </persName> <idno type="halauthorid">301315</idno> <affiliation ref="#struct-454547"></affiliation> <affiliation ref="#struct-542085"></affiliation> <affiliation ref="#struct-542111"></affiliation> </author> <editor role="depositor"> <persName> <forename>Gestionnaire</forename> <surname>HAL-SU</surname> </persName> <email type="md5">20ce03d813b4e6b0eba84db23565c63b</email> <email type="domain">sorbonne-universite.fr</email> </editor> </titleStmt> <editionStmt> <edition n="v1" type="current"> <date type="whenSubmitted">2019-09-18 15:38:50</date> <date type="whenModified">2020-03-16 14:50:04</date> <date type="whenReleased">2019-09-18 15:56:03</date> <date type="whenProduced">2019</date> <date type="whenEndEmbargoed">2020-01-30</date> <ref type="file" target="https://hal.sorbonne-universite.fr/hal-02291291/document"> <date notBefore="2020-01-30"></date> </ref> <ref type="file" subtype="author" n="1" target="https://hal.sorbonne-universite.fr/hal-02291291/file/Ben%20Hassine%20et%20al.%20-%202019%20-%20Osseous%20sarcoidosis%20A%20multicenter%20retrospective%20c.pdf"> <date notBefore="2020-01-30"></date> </ref> </edition> <respStmt> <resp>contributor</resp> <name key="662159"> <persName> <forename>Gestionnaire</forename> <surname>HAL-SU</surname> </persName> <email type="md5">20ce03d813b4e6b0eba84db23565c63b</email> <email type="domain">sorbonne-universite.fr</email> </name> </respStmt> </editionStmt> <publicationStmt> <distributor>CCSD</distributor> <idno type="halId">hal-02291291</idno> <idno type="halUri">https://hal.sorbonne-universite.fr/hal-02291291</idno> <idno type="halBibtex">benhassine:hal-02291291</idno> <idno type="halRefHtml">Joint Bone Spine, Elsevier Masson, In press, ⟨10.1016/j.jbspin.2019.07.009⟩</idno> <idno type="halRef">Joint Bone Spine, Elsevier Masson, In press, ⟨10.1016/j.jbspin.2019.07.009⟩</idno> </publicationStmt> <seriesStmt> <idno type="stamp" n="SORBONNE-UNIVERSITE">Sorbonne Université</idno> <idno type="stamp" n="SSA">Service de Santé des Armées</idno> <idno type="stamp" n="I3" corresp="SORBONNE-UNIVERSITE">Immunologie-Immunopathologie-Immunothérapie</idno> <idno type="stamp" n="UNIV-STRASBG">Université de Strasbourg</idno> <idno type="stamp" n="SANTE_PUB_INSERM" corresp="INSERM">Santé Publique à l'Inserm</idno> <idno type="stamp" n="APHP" corresp="INSERM">AP-HP</idno> <idno type="stamp" n="SORBONNE-UNIV" corresp="SORBONNE-UNIVERSITE">Sorbonne Université 01/01/2018</idno> <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno> <idno type="stamp" n="UNIV-PARIS13">Université Paris-Nord - Paris XIII </idno> <idno type="stamp" n="TEST-AMU">Espace de test AMU</idno> <idno type="stamp" n="SITE-ALSACE">Archive ouverte du site Alsace</idno> <idno type="stamp" n="UNIV-AMU">Aix Marseille Université</idno> <idno type="stamp" n="SU-MEDECINE" corresp="SORBONNE-UNIVERSITE">Faculté de Médecine de Sorbonne Université</idno> <idno type="stamp" n="USPC">Université Sorbonne Paris Cité</idno> <idno type="stamp" n="SORBONNE-PARIS-NORD">Université Sorbonne Paris Nord</idno> </seriesStmt> <notesStmt> <note type="audience" n="2">International</note> <note type="popular" n="0">No</note> <note type="peer" n="1">Yes</note> </notesStmt> <sourceDesc> <biblStruct> <analytic> <title xml:lang="en">Osseous sarcoidosis: a multicenter case-control study</title> <author role="aut"> <persName> <forename type="first">Imen</forename> <surname>Ben Hassine</surname> </persName> <idno type="halauthorid">11578657</idno> <affiliation ref="#struct-542085"></affiliation> <affiliation ref="#struct-454547"></affiliation> <affiliation ref="#struct-542111"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Christopher</forename> <surname>Rein</surname> </persName> <idno type="halauthorid">1620499</idno> <affiliation ref="#struct-37974"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Cloé</forename> <surname>Comarmond</surname> </persName> <email type="md5">d75d19c7f02c16abf2a10209fc2443df</email> <email type="domain">free.com</email> <idno type="halauthorid">1015046</idno> <affiliation ref="#struct-454547"></affiliation> <affiliation ref="#struct-542085"></affiliation> <affiliation ref="#struct-246522"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Camille</forename> <surname>Glanowski</surname> </persName> <idno type="halauthorid">11578658</idno> <affiliation ref="#struct-37970"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Nathalie</forename> <surname>Saidenberg-Kermanac’h</surname> </persName> <idno type="halauthorid">11578659</idno> <affiliation ref="#struct-246021"></affiliation> <affiliation ref="#struct-303171"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Benoit</forename> <surname>Meunier</surname> </persName> <idno type="halauthorid">11524189</idno> <affiliation ref="#struct-412213"></affiliation> <affiliation ref="#struct-300093"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Nicolas</forename> <surname>Schleinitz</surname> </persName> <idno type="halauthorid">464501</idno> <affiliation ref="#struct-300093"></affiliation> <affiliation ref="#struct-412213"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Noémie</forename> <surname>Chanson</surname> </persName> <idno type="halauthorid">11578660</idno> <affiliation ref="#struct-2607"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Karim</forename> <surname>Sacre</surname> </persName> <idno type="halauthorid">974649</idno> <affiliation ref="#struct-2607"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Marc</forename> <surname>Scherlinger</surname> </persName> <idno type="halauthorid">11384594</idno> <affiliation ref="#struct-300122"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Christophe</forename> <surname>Richez</surname> </persName> <idno type="halauthorid">84802</idno> <affiliation ref="#struct-300122"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Sandrine</forename> <surname>Hirschi</surname> </persName> <idno type="halauthorid">1161726</idno> <affiliation ref="#struct-300149"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Matthieu</forename> <surname>Groh</surname> </persName> <idno type="halauthorid">1195399</idno> <affiliation ref="#struct-410109"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Hervé</forename> <surname>Devilliers</surname> </persName> <idno type="halauthorid">899760</idno> <affiliation ref="#struct-475861"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Philip</forename> <surname>Bielefeld</surname> </persName> <idno type="halauthorid">1194892</idno> <affiliation ref="#struct-475861"></affiliation> </author> <author role="aut"> <persName> <forename type="first">David</forename> <surname>Saadoun</surname> </persName> <idno type="halauthorid">301308</idno> <affiliation ref="#struct-542085"></affiliation> <affiliation ref="#struct-542111"></affiliation> <affiliation ref="#struct-454547"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Catherine</forename> <surname>Chapelon-Abric</surname> </persName> <idno type="halauthorid">822669</idno> <affiliation ref="#struct-454547"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Laurent</forename> <surname>Arnaud</surname> </persName> <email type="md5">fb21e98832463a80f852116b5247d7da</email> <email type="domain">psl.aphp.fr</email> <idno type="halauthorid">848242</idno> <affiliation ref="#struct-102530"></affiliation> <affiliation ref="#struct-222993"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Patrice</forename> <surname>Cacoub</surname> </persName> <idno type="halauthorid">301315</idno> <affiliation ref="#struct-454547"></affiliation> <affiliation ref="#struct-542085"></affiliation> <affiliation ref="#struct-542111"></affiliation> </author> </analytic> <monogr> <idno type="halJournalId" status="VALID">14977</idno> <idno type="issn">1297-319X</idno> <title level="j">Joint Bone Spine</title> <imprint> <publisher>Elsevier Masson</publisher> <date type="datePub" subtype="inPress">2019</date> <date type="dateEpub">2019-07-30</date> </imprint> </monogr> <idno type="doi">10.1016/j.jbspin.2019.07.009</idno> </biblStruct> </sourceDesc> <profileDesc> <langUsage> <language ident="en">English</language> </langUsage> <textClass> <keywords scheme="author"> <term xml:lang="en">Bone involvement</term> <term xml:lang="en">Osseous manifestations</term> <term xml:lang="en">Sarcoidosis</term> </keywords> <classCode scheme="halDomain" n="sdv.mhep.rsoa">Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system</classCode> <classCode scheme="halDomain" n="sdv.spee">Life Sciences [q-bio]/Santé publique et épidémiologie</classCode> <classCode scheme="halTypology" n="ART">Journal articles</classCode> </textClass> <abstract xml:lang="en"> <p>Objective: To describe the clinical presentation, distribution of lesions, treatment, and outcomes of osseous sarcoidosis.Methods: A French retrospective multicenter study of patients with biopsy-proven sarcoidosis analyzed patients with 1) a biopsy-proven granuloma without caseous necrosis, and either 2) osseous clinical manifestations, or 3) abnormal osseous imaging. Sarcoidosis patients with osseous involvement (cases) were compared with 264 age- and sex-matched sarcoidosis patients with no osseous manifestations (controls).Results: In the osseous sarcoidosis group (n = 88), forty-two (48%) patients had osseous-related symptoms involving the axial (69%) and/or appendicular (58%) skeleton. On imaging, the most commonly affected bones were in the spine (52%), pelvis (42%), hands (22%) and femur (19%). Compared with controls, cases had higher rates of mediastinal (93% vs. 47%) and extra-thoracic lymph node involvement (66% vs. 21%), pulmonary (90% vs. 65%) and cutaneous involvement (44% vs. 23%) (all P < 0.0001), and hypercalcemia (8.5% vs. 2%, P = 0.014). Spleen/liver and gastrointestinal involvement were less frequent in the osseous sarcoidosis group (29% vs. 45%, and 1% vs. 17%, respectively, P < 0.0001). Response rates to with glucocorticoids alone, glucocorticoids plus methotrexate or glucocorticoids plus hydroxychloroquine were 23/44 (52%), 9/13 (69%) and 4/6 (67%), respectively.Conclusion: In patients with osseous sarcoidosis the spine and pelvis were the most commonly affected bones. Compared with controls, cases with osseous sarcoidosis have higher rates of thoracic and extra-thoracic lymph node involvement, pulmonary and cutaneous involvement, and hypercalcemia. Most patients with osseous sarcoidosis had a good response to glucocorticoids in combination with methotrexate or hydroxychloroquine.</p> </abstract> </profileDesc> </hal></record>Pour manipuler ce document sous Unix (Dilib)
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