Hydroxychloroquine in systemic lupus erythematosus: results of a French multicentre controlled trial (PLUS Study).
Identifieur interne : 000114 ( Hal/Corpus ); précédent : 000113; suivant : 000115Hydroxychloroquine in systemic lupus erythematosus: results of a French multicentre controlled trial (PLUS Study).
Auteurs : Nathalie Costedoat-Chalumeau ; Lionel Galicier ; Olivier Aumaître ; Camille Francès ; Véronique Le Guern ; Frédéric Lioté ; Amar Smail ; Nicolas Limal ; Laurent Perard ; Hélène Desmurs-Clavel ; Du Le Thi Huong Boutin ; Bouchra Asli ; Jean-Emmanuel Kahn ; Jacques Pourrat ; Laurent Sailler ; Félix Ackermann ; Thomas Papo ; Karim Sacré ; Olivier Fain ; Jerome Stirnemann ; Patrice Cacoub ; Moez Jallouli ; Gaelle Leroux ; Judith Cohen-Bittan ; Marie-Laure Tanguy ; Jean-Sébastien Hulot ; Philippe Lechat ; Lucile Musset ; Zahir Amoura ; Jean-Charles Piette ; Aurelien DellucSource :
- Annals of the Rheumatic Diseases [ 0003-4967 ] ; 2013-11-01.
Abstract
INTRODUCTION: Hydroxychloroquine (HCQ) is an important medication for treating systemic lupus erythematosus (SLE). Its blood concentration ([HCQ]) varies widely between patients and is a marker and predictor of SLE flares. This prospective randomised, double-blind, placebo-controlled, multicentre study sought to compare standard and adjusted HCQ dosing schedules that target [HCQ] ≥1000 ng/ml to reduce SLE flares. PATIENTS AND METHODS: [HCQ] was measured in 573 patients with SLE (stable disease and SELENA-SLEDAI≤12) treated with HCQ for at least 6 months. Patients with [HCQ] from 100 to 750 ng/ml were randomised to one of two treatment groups: no daily dose change (group 1) or increased HCQ dose to achieve the target [HCQ] (group 2). The primary end point was the number of patients with flares during 7 months of follow-up. RESULTS: Overall, mean [HCQ] was 918±451 ng/ml. Active SLE was less prevalent in patients with higher [HCQ]. A total of 171 patients were randomised and followed for 7 months. SLE flare rates were similar in the two groups (25% in group 1 vs 27.6% in group 2; p=0.7), but a significant spontaneous increase in [HCQ] in both groups between inclusion and randomisation strongly suggested improved treatment adherence. Patients at the therapeutic target throughout follow-up tended to have fewer flares than those with low [HCQ] (20.5% vs 35.1%, p=0.12). CONCLUSIONS: Although low [HCQ] is associated with higher SLE activity, adapting the HCQ dose did not reduce SLE flares over a 7-month follow-up.
Url:
DOI: 10.1136/annrheumdis-2012-202322
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Paris 6</orgName> <orgName type="acronym">UPMC</orgName> <date type="end">2017-12-31</date> <desc> <address> <addrLine>4 place Jussieu - 75005 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.upmc.fr/</ref> </desc> </org></tutelle><tutelle active="#struct-300631" type="direct"><org type="institution" xml:id="struct-300631" status="VALID"> <orgName>IFR14</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle name="U621" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Lechat, Philippe" sort="Lechat, Philippe" uniqKey="Lechat P" first="Philippe" last="Lechat">Philippe Lechat</name></author><author><name sortKey="Musset, Lucile" sort="Musset, Lucile" uniqKey="Musset L" first="Lucile" last="Musset">Lucile Musset</name><affiliation><hal:affiliation type="department" xml:id="struct-45150" status="VALID"> <orgName>Service d'immunologie [CHU Pitié-Salpétrière]</orgName> <desc> <address> <addrLine>47-83, boulevard de l'Hôpital 75651 PARIS Cedex 13</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300068" type="direct"></relation> <relation active="#struct-353778" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - 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Hôpitaux de Paris (AP-HP)</orgName> <orgName type="acronym">APHP</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-353778" type="direct"><org type="institution" xml:id="struct-353778" status="VALID"> <orgName>CHU Pitié-Salpêtrière [APHP]</orgName> <desc> <address> <addrLine>47-83 Boulevard de l'Hôpital, 75013 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.aphp.fr/contenu/hopital-universitaire-pitie-salpetriere-0</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Piette, Jean Charles" sort="Piette, Jean Charles" uniqKey="Piette J" first="Jean-Charles" last="Piette">Jean-Charles Piette</name><affiliation><hal:affiliation type="department" xml:id="struct-18474" status="VALID"> <orgName>Service de médecine interne [CHU Pitié-Salpétrière]</orgName> <desc> <address> <addrLine>47-83, boulevard de l'Hôpital 75651 PARIS Cedex 13</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300068" type="direct"></relation> <relation active="#struct-353778" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName> <orgName type="acronym">APHP</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-353778" type="direct"><org type="institution" xml:id="struct-353778" status="VALID"> <orgName>CHU Pitié-Salpêtrière [APHP]</orgName> <desc> <address> <addrLine>47-83 Boulevard de l'Hôpital, 75013 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.aphp.fr/contenu/hopital-universitaire-pitie-salpetriere-0</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Delluc, Aurelien" sort="Delluc, Aurelien" uniqKey="Delluc A" first="Aurelien" last="Delluc">Aurelien Delluc</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-102913" status="VALID"> <orgName>Département de Médecine Interne et Pneumologie [Brest]</orgName> <orgName type="acronym">DMIP - Brest</orgName> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.chu-brest.fr/web/guest/pneumologie</ref> </desc> <listRelation> <relation active="#struct-356603" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-356603" type="direct"><org type="institution" xml:id="struct-356603" status="VALID"> <orgName>Centre Hospitalier Régional Universitaire de Brest</orgName> <orgName type="acronym">CHRU Brest</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">HAL</idno><idno type="RBID">Hal:hal-00933279</idno><idno type="halId">hal-00933279</idno><idno type="halUri">https://hal.univ-brest.fr/hal-00933279</idno><idno type="url">https://hal.univ-brest.fr/hal-00933279</idno><idno type="doi">10.1136/annrheumdis-2012-202322</idno><date when="2013-11-01">2013-11-01</date><idno type="wicri:Area/Hal/Corpus">000114</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Hydroxychloroquine in systemic lupus erythematosus: results of a French multicentre controlled trial (PLUS Study).</title><author><name sortKey="Costedoat Chalumeau, Nathalie" sort="Costedoat Chalumeau, Nathalie" uniqKey="Costedoat Chalumeau N" first="Nathalie" last="Costedoat-Chalumeau">Nathalie Costedoat-Chalumeau</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-93435" status="OLD"> <orgName>Immunologie - Immunopathologie - Immunothérapeutique</orgName> <orgName type="acronym">I3</orgName> <desc> <address> <addrLine>F-75013, Paris</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-93591" type="direct"></relation> <relation name="U959" active="#struct-303623" type="direct"></relation> <relation name="UMR7211" active="#struct-441569" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-93591" type="direct"><org type="institution" xml:id="struct-93591" status="OLD"> <orgName>Université Pierre et Marie Curie - Paris 6</orgName> <orgName type="acronym">UPMC</orgName> <date type="end">2017-12-31</date> <desc> <address> <addrLine>4 place Jussieu - 75005 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.upmc.fr/</ref> </desc> </org></tutelle><tutelle name="U959" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc> </org></tutelle><tutelle name="UMR7211" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno> <idno type="ISNI">0000000122597504</idno> <orgName>Centre National de la Recherche Scientifique</orgName> <orgName type="acronym">CNRS</orgName> <date type="start">1939-10-19</date> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.cnrs.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Galicier, Lionel" sort="Galicier, Lionel" uniqKey="Galicier L" first="Lionel" last="Galicier">Lionel Galicier</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-41226" status="OLD"> <orgName>Service d'immunologie clinique</orgName> <date type="end">2019-12-31</date> <desc> <address> <addrLine>1, avenue Claude-Vellefaux 75010 Paris</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300068" type="direct"></relation> <relation active="#struct-300301" type="direct"></relation> <relation active="#struct-421654" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName> <orgName type="acronym">APHP</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-300301" type="direct"><org type="institution" xml:id="struct-300301" status="VALID"> <idno type="ISNI">0000000121514068</idno> <idno type="IdRef">027542084</idno> <orgName>Université Paris Diderot - Paris 7</orgName> <orgName type="acronym">UPD7</orgName> <desc> <address> <addrLine>5 rue Thomas-Mann - 75205 Paris cedex 13</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-paris-diderot.fr</ref> </desc> </org></tutelle><tutelle active="#struct-421654" type="direct"><org type="institution" xml:id="struct-421654" status="VALID"> <orgName>Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris]</orgName> <desc> <address> <addrLine>200 rue du Faubourg Saint-Denis 75475 Paris (Nord) Cedex 10</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300068" type="direct"></relation> </listRelation> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Aumaitre, Olivier" sort="Aumaitre, Olivier" uniqKey="Aumaitre O" first="Olivier" last="Aumaître">Olivier Aumaître</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-232091" status="INCOMING"> <orgName>Service de médecine interne, hôpital Gabriel-Montpied</orgName> <desc> <address> <addrLine>Service de médecine interne, hôpital Gabriel-Montpied, 58, rue Montalembert, 63003 Clermont-Ferrand cedex 1, France</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300144" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300144" type="direct"><org type="institution" xml:id="struct-300144" status="VALID"> <orgName>CHU Clermont-Ferrand</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Frances, Camille" sort="Frances, Camille" uniqKey="Frances C" first="Camille" last="Francès">Camille Francès</name><affiliation><hal:affiliation type="department" xml:id="struct-223222" status="VALID"> <orgName>Service de Dermatologie [CHU Tenon]</orgName> <desc> <address> <addrLine>4 Rue de la Chine 75020 Paris</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300068" type="direct"></relation> <relation active="#struct-328304" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - 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Hôpitaux de Paris (AP-HP)</orgName> <orgName type="acronym">APHP</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-300128" type="direct"><org type="institution" xml:id="struct-300128" status="VALID"> <orgName>Hôpital Lariboisière</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-300301" type="direct"><org type="institution" xml:id="struct-300301" status="VALID"> <idno type="ISNI">0000000121514068</idno> <idno type="IdRef">027542084</idno> <orgName>Université Paris Diderot - Paris 7</orgName> <orgName type="acronym">UPD7</orgName> <desc> <address> <addrLine>5 rue Thomas-Mann - 75205 Paris cedex 13</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-paris-diderot.fr</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Smail, Amar" sort="Smail, Amar" uniqKey="Smail A" first="Amar" last="Smail">Amar Smail</name></author><author><name sortKey="Limal, Nicolas" sort="Limal, Nicolas" uniqKey="Limal N" first="Nicolas" last="Limal">Nicolas Limal</name></author><author><name sortKey="Perard, Laurent" sort="Perard, Laurent" uniqKey="Perard L" first="Laurent" last="Perard">Laurent Perard</name></author><author><name sortKey="Desmurs Clavel, Helene" sort="Desmurs Clavel, Helene" uniqKey="Desmurs Clavel H" first="Hélène" last="Desmurs-Clavel">Hélène Desmurs-Clavel</name></author><author><name sortKey="Boutin, Du Le Thi Huong" sort="Boutin, Du Le Thi Huong" uniqKey="Boutin D" first="Du Le Thi Huong" last="Boutin">Du Le Thi Huong Boutin</name></author><author><name sortKey="Asli, Bouchra" sort="Asli, Bouchra" uniqKey="Asli B" first="Bouchra" last="Asli">Bouchra Asli</name></author><author><name sortKey="Kahn, Jean Emmanuel" sort="Kahn, Jean Emmanuel" uniqKey="Kahn J" first="Jean-Emmanuel" last="Kahn">Jean-Emmanuel Kahn</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-160913" status="VALID"> <orgName>Laboratoire d'Immunologie</orgName> <orgName type="acronym">EA 2686</orgName> <desc> <address> <addrLine>1, place de Verdun 59045 Lille Cédex</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation name="EA2686" active="#struct-361611" type="direct"></relation> </listRelation> <tutelles><tutelle name="EA2686" active="#struct-361611" type="direct"><org type="institution" xml:id="struct-361611" status="OLD"> <idno type="ISNI">0000000120977060</idno> <idno type="IdRef">026404389</idno> <orgName>Université de Lille, Droit et Santé</orgName> <date type="end">2017-12-31</date> <desc> <address> <addrLine>42 rue Paul Duez 59000 Lille</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-lille2.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Pourrat, Jacques" sort="Pourrat, Jacques" uniqKey="Pourrat J" first="Jacques" last="Pourrat">Jacques Pourrat</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-192646" status="VALID"> <orgName>Service de Néphrologie - Immunologie Clinique [Toulouse]</orgName> <desc> <address> <addrLine>1, avenue du Professeur Jean Poulhès - TSA 50032 - 31059 Toulouse cedex 9</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300075" type="direct"></relation> <relation active="#struct-300791" type="direct"></relation> <relation active="#struct-301089" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300075" type="direct"><org type="regroupinstitution" xml:id="struct-300075" status="VALID"> <orgName>CHU Toulouse [Toulouse]</orgName> <desc> <address> <addrLine>Hôtel-Dieu Saint Jacques2, rue ViguerieTSA 8003531059 Toulouse cedex 9</addrLine> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-300791" type="direct"><org type="institution" xml:id="struct-300791" status="VALID"> <orgName>Hôpital de Rangueil</orgName> <desc> <address> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300075" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-301089" type="direct"><org type="institution" xml:id="struct-301089" status="OLD"> <orgName>PRES Université de Toulouse</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Sailler, Laurent" sort="Sailler, Laurent" uniqKey="Sailler L" first="Laurent" last="Sailler">Laurent Sailler</name></author><author><name sortKey="Ackermann, Felix" sort="Ackermann, Felix" uniqKey="Ackermann F" first="Félix" last="Ackermann">Félix Ackermann</name></author><author><name sortKey="Papo, Thomas" sort="Papo, Thomas" uniqKey="Papo T" first="Thomas" last="Papo">Thomas Papo</name><affiliation><hal:affiliation type="institution" xml:id="struct-26728" status="INCOMING"> <orgName>Hôpital Bichat - Claude Bernard</orgName> <desc> <address> <addrLine>46, rue Henri-Huchard 75018 Paris</addrLine> <country key="FR"></country> </address> </desc> </hal:affiliation></affiliation></author><author><name sortKey="Sacre, Karim" sort="Sacre, Karim" uniqKey="Sacre K" first="Karim" last="Sacré">Karim Sacré</name></author><author><name sortKey="Fain, Olivier" sort="Fain, Olivier" uniqKey="Fain O" first="Olivier" last="Fain">Olivier Fain</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-135015" status="INCOMING"> <orgName>Service de médecine interne</orgName> <desc> <address> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300068" type="direct"></relation> <relation active="#struct-303442" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName> <orgName type="acronym">APHP</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-303442" type="direct"><org type="regrouplaboratory" xml:id="struct-303442" status="VALID"> <orgName>Hôpital Jean Verdier [Bondy]</orgName> <desc> <address> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300068" type="direct"></relation> </listRelation> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Stirnemann, Jerome" sort="Stirnemann, Jerome" uniqKey="Stirnemann J" first="Jerome" last="Stirnemann">Jerome Stirnemann</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-3096" status="OLD"> <orgName>Modèles et méthodes de l'évaluation thérapeutique des maladies chroniques</orgName> <desc> <address> <addrLine>Faculté de médecine Paris 7 16, Rue Henri Huchard 75018 Paris</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300301" type="direct"></relation> <relation name="U738" active="#struct-303623" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300301" type="direct"><org type="institution" xml:id="struct-300301" status="VALID"> <idno type="ISNI">0000000121514068</idno> <idno type="IdRef">027542084</idno> <orgName>Université Paris Diderot - Paris 7</orgName> <orgName type="acronym">UPD7</orgName> <desc> <address> <addrLine>5 rue Thomas-Mann - 75205 Paris cedex 13</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-paris-diderot.fr</ref> </desc> </org></tutelle><tutelle name="U738" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Cacoub, Patrice" sort="Cacoub, Patrice" uniqKey="Cacoub P" first="Patrice" last="Cacoub">Patrice Cacoub</name><affiliation><hal:affiliation type="department" xml:id="struct-18474" status="VALID"> <orgName>Service de médecine interne [CHU Pitié-Salpétrière]</orgName> <desc> <address> <addrLine>47-83, boulevard de l'Hôpital 75651 PARIS Cedex 13</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300068" type="direct"></relation> <relation active="#struct-353778" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName> <orgName type="acronym">APHP</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-353778" type="direct"><org type="institution" xml:id="struct-353778" status="VALID"> <orgName>CHU Pitié-Salpêtrière [APHP]</orgName> <desc> <address> <addrLine>47-83 Boulevard de l'Hôpital, 75013 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.aphp.fr/contenu/hopital-universitaire-pitie-salpetriere-0</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Jallouli, Moez" sort="Jallouli, Moez" uniqKey="Jallouli M" first="Moez" last="Jallouli">Moez Jallouli</name></author><author><name sortKey="Leroux, Gaelle" sort="Leroux, Gaelle" uniqKey="Leroux G" first="Gaelle" last="Leroux">Gaelle Leroux</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-244085" status="VALID"> <orgName>Institut des Maladies Neurodégénératives [Bordeaux]</orgName> <orgName type="acronym">IMN</orgName> <desc> <address> <addrLine>Bât. 3b 1er étage 146 Rue Léo Saignat 33076 Bordeaux </addrLine> <country key="FR"></country> </address> <ref type="url">http://imn-bordeaux.org/</ref> </desc> <listRelation> <relation active="#struct-259761" type="direct"></relation> <relation name="UMR5293" active="#struct-441569" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-259761" type="direct"><org type="institution" xml:id="struct-259761" status="VALID"> <orgName>Université de Bordeaux</orgName> <orgName type="acronym">UB</orgName> <desc> <address> <addrLine>35, place Pey Berland - 33076 Bordeaux</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.u-bordeaux.fr/</ref> </desc> </org></tutelle><tutelle name="UMR5293" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno> <idno type="ISNI">0000000122597504</idno> <orgName>Centre National de la Recherche Scientifique</orgName> <orgName type="acronym">CNRS</orgName> <date type="start">1939-10-19</date> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.cnrs.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Cohen Bittan, Judith" sort="Cohen Bittan, Judith" uniqKey="Cohen Bittan J" first="Judith" last="Cohen-Bittan">Judith Cohen-Bittan</name></author><author><name sortKey="Tanguy, Marie Laure" sort="Tanguy, Marie Laure" uniqKey="Tanguy M" first="Marie-Laure" last="Tanguy">Marie-Laure Tanguy</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-15366" status="VALID"> <orgName>Service de biostatistiques et information médicale [CHU Pitié-Salpêtrière]</orgName> <desc> <address> <addrLine>47-83, boulevard de l'Hôpital 75651 PARIS Cedex 13</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300068" type="direct"></relation> <relation active="#struct-353778" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName> <orgName type="acronym">APHP</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-353778" type="direct"><org type="institution" xml:id="struct-353778" status="VALID"> <orgName>CHU Pitié-Salpêtrière [APHP]</orgName> <desc> <address> <addrLine>47-83 Boulevard de l'Hôpital, 75013 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.aphp.fr/contenu/hopital-universitaire-pitie-salpetriere-0</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Hulot, Jean Sebastien" sort="Hulot, Jean Sebastien" uniqKey="Hulot J" first="Jean-Sébastien" last="Hulot">Jean-Sébastien Hulot</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-2979" status="OLD"> <orgName>Physiopathologie, génétique et pharmacologie du remodelage cardiovasculaire</orgName> <desc> <address> <addrLine>GH Pitie-Salpetriere 91, Boulevard de L'Hopital 75634 PARIS CEDEX 13</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-93591" type="direct"></relation> <relation active="#struct-300631" type="direct"></relation> <relation name="U621" active="#struct-303623" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-93591" type="direct"><org type="institution" xml:id="struct-93591" status="OLD"> <orgName>Université Pierre et Marie Curie - Paris 6</orgName> <orgName type="acronym">UPMC</orgName> <date type="end">2017-12-31</date> <desc> <address> <addrLine>4 place Jussieu - 75005 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.upmc.fr/</ref> </desc> </org></tutelle><tutelle active="#struct-300631" type="direct"><org type="institution" xml:id="struct-300631" status="VALID"> <orgName>IFR14</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle name="U621" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Lechat, Philippe" sort="Lechat, Philippe" uniqKey="Lechat P" first="Philippe" last="Lechat">Philippe Lechat</name></author><author><name sortKey="Musset, Lucile" sort="Musset, Lucile" uniqKey="Musset L" first="Lucile" last="Musset">Lucile Musset</name><affiliation><hal:affiliation type="department" xml:id="struct-45150" status="VALID"> <orgName>Service d'immunologie [CHU Pitié-Salpétrière]</orgName> <desc> <address> <addrLine>47-83, boulevard de l'Hôpital 75651 PARIS Cedex 13</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300068" type="direct"></relation> <relation active="#struct-353778" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName> <orgName type="acronym">APHP</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-353778" type="direct"><org type="institution" xml:id="struct-353778" status="VALID"> <orgName>CHU Pitié-Salpêtrière [APHP]</orgName> <desc> <address> <addrLine>47-83 Boulevard de l'Hôpital, 75013 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.aphp.fr/contenu/hopital-universitaire-pitie-salpetriere-0</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Amoura, Zahir" sort="Amoura, Zahir" uniqKey="Amoura Z" first="Zahir" last="Amoura">Zahir Amoura</name><affiliation><hal:affiliation type="department" xml:id="struct-18474" status="VALID"> <orgName>Service de médecine interne [CHU Pitié-Salpétrière]</orgName> <desc> <address> <addrLine>47-83, boulevard de l'Hôpital 75651 PARIS Cedex 13</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300068" type="direct"></relation> <relation active="#struct-353778" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName> <orgName type="acronym">APHP</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-353778" type="direct"><org type="institution" xml:id="struct-353778" status="VALID"> <orgName>CHU Pitié-Salpêtrière [APHP]</orgName> <desc> <address> <addrLine>47-83 Boulevard de l'Hôpital, 75013 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.aphp.fr/contenu/hopital-universitaire-pitie-salpetriere-0</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Piette, Jean Charles" sort="Piette, Jean Charles" uniqKey="Piette J" first="Jean-Charles" last="Piette">Jean-Charles Piette</name><affiliation><hal:affiliation type="department" xml:id="struct-18474" status="VALID"> <orgName>Service de médecine interne [CHU Pitié-Salpétrière]</orgName> <desc> <address> <addrLine>47-83, boulevard de l'Hôpital 75651 PARIS Cedex 13</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300068" type="direct"></relation> <relation active="#struct-353778" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName> <orgName type="acronym">APHP</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-353778" type="direct"><org type="institution" xml:id="struct-353778" status="VALID"> <orgName>CHU Pitié-Salpêtrière [APHP]</orgName> <desc> <address> <addrLine>47-83 Boulevard de l'Hôpital, 75013 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.aphp.fr/contenu/hopital-universitaire-pitie-salpetriere-0</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Delluc, Aurelien" sort="Delluc, Aurelien" uniqKey="Delluc A" first="Aurelien" last="Delluc">Aurelien Delluc</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-102913" status="VALID"> <orgName>Département de Médecine Interne et Pneumologie [Brest]</orgName> <orgName type="acronym">DMIP - Brest</orgName> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.chu-brest.fr/web/guest/pneumologie</ref> </desc> <listRelation> <relation active="#struct-356603" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-356603" type="direct"><org type="institution" xml:id="struct-356603" status="VALID"> <orgName>Centre Hospitalier Régional Universitaire de Brest</orgName> <orgName type="acronym">CHRU Brest</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author></analytic><idno type="DOI">10.1136/annrheumdis-2012-202322</idno><series><title level="j">Annals of the Rheumatic Diseases</title><idno type="ISSN">0003-4967</idno><imprint><date type="datePub">2013-11-01</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"> <p>INTRODUCTION: Hydroxychloroquine (HCQ) is an important medication for treating systemic lupus erythematosus (SLE). Its blood concentration ([HCQ]) varies widely between patients and is a marker and predictor of SLE flares. This prospective randomised, double-blind, placebo-controlled, multicentre study sought to compare standard and adjusted HCQ dosing schedules that target [HCQ] ≥1000 ng/ml to reduce SLE flares. PATIENTS AND METHODS: [HCQ] was measured in 573 patients with SLE (stable disease and SELENA-SLEDAI≤12) treated with HCQ for at least 6 months. Patients with [HCQ] from 100 to 750 ng/ml were randomised to one of two treatment groups: no daily dose change (group 1) or increased HCQ dose to achieve the target [HCQ] (group 2). The primary end point was the number of patients with flares during 7 months of follow-up. RESULTS: Overall, mean [HCQ] was 918±451 ng/ml. Active SLE was less prevalent in patients with higher [HCQ]. A total of 171 patients were randomised and followed for 7 months. SLE flare rates were similar in the two groups (25% in group 1 vs 27.6% in group 2; p=0.7), but a significant spontaneous increase in [HCQ] in both groups between inclusion and randomisation strongly suggested improved treatment adherence. Patients at the therapeutic target throughout follow-up tended to have fewer flares than those with low [HCQ] (20.5% vs 35.1%, p=0.12). CONCLUSIONS: Although low [HCQ] is associated with higher SLE activity, adapting the HCQ dose did not reduce SLE flares over a 7-month follow-up.</p> </div></front></TEI><hal api="V3"> <titleStmt> <title xml:lang="en">Hydroxychloroquine in systemic lupus erythematosus: results of a French multicentre controlled trial (PLUS Study).</title> <author role="aut"> <persName> <forename type="first">Nathalie</forename> <surname>Costedoat-Chalumeau</surname> </persName> <idno type="halauthorid">822653</idno> <affiliation ref="#struct-93435"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Lionel</forename> <surname>Galicier</surname> </persName> <idno type="halauthorid">464500</idno> <affiliation ref="#struct-41226"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Olivier</forename> <surname>Aumaître</surname> </persName> <idno type="halauthorid">899035</idno> <affiliation ref="#struct-232091"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Camille</forename> <surname>Francès</surname> </persName> <idno type="halauthorid">822651</idno> <affiliation ref="#struct-223222"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Véronique</forename> <surname>Le Guern</surname> </persName> <idno type="halauthorid">972732</idno> <affiliation ref="#struct-454982"></affiliation> <affiliation ref="#struct-192648"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Frédéric</forename> <surname>Lioté</surname> </persName> <idno type="halauthorid">119412</idno> <affiliation ref="#struct-241172"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Amar</forename> <surname>Smail</surname> </persName> <idno type="halauthorid">846758</idno> </author> <author role="aut"> <persName> <forename type="first">Nicolas</forename> <surname>Limal</surname> </persName> <idno type="halauthorid">301310</idno> </author> <author role="aut"> <persName> <forename type="first">Laurent</forename> <surname>Perard</surname> </persName> <idno type="halauthorid">972733</idno> </author> <author role="aut"> <persName> <forename type="first">Hélène</forename> <surname>Desmurs-Clavel</surname> </persName> <idno type="halauthorid">453251</idno> </author> <author role="aut"> <persName> <forename type="first">Du Le Thi Huong</forename> <surname>Boutin</surname> </persName> <idno type="halauthorid">972734</idno> </author> <author role="aut"> <persName> <forename type="first">Bouchra</forename> <surname>Asli</surname> </persName> <idno type="halauthorid">209159</idno> </author> <author role="aut"> <persName> <forename type="first">Jean-Emmanuel</forename> <surname>Kahn</surname> </persName> <idno type="halauthorid">856227</idno> <affiliation ref="#struct-160913"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Jacques</forename> <surname>Pourrat</surname> </persName> <idno type="halauthorid">620977</idno> <affiliation ref="#struct-192646"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Laurent</forename> <surname>Sailler</surname> </persName> <idno type="halauthorid">972735</idno> </author> <author role="aut"> <persName> <forename type="first">Félix</forename> <surname>Ackermann</surname> </persName> <idno type="halauthorid">972736</idno> </author> <author role="aut"> <persName> <forename type="first">Thomas</forename> <surname>Papo</surname> </persName> <idno type="halauthorid">568710</idno> <affiliation ref="#struct-26728"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Karim</forename> <surname>Sacré</surname> </persName> <idno type="halauthorid">972737</idno> </author> <author role="aut"> <persName> <forename type="first">Olivier</forename> <surname>Fain</surname> </persName> <idno type="halauthorid">555165</idno> <affiliation ref="#struct-135015"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Jerome</forename> <surname>Stirnemann</surname> </persName> <idno type="halauthorid">972738</idno> <affiliation ref="#struct-3096"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Patrice</forename> <surname>Cacoub</surname> </persName> <idno type="halauthorid">301315</idno> <affiliation ref="#struct-18474"></affiliation> <affiliation ref="#struct-1031"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Moez</forename> <surname>Jallouli</surname> </persName> <idno type="halauthorid">972739</idno> </author> <author role="aut"> <persName> <forename type="first">Gaelle</forename> <surname>Leroux</surname> </persName> <idno type="halauthorid">11483302</idno> <affiliation ref="#struct-244085"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Judith</forename> <surname>Cohen-Bittan</surname> </persName> <idno type="halauthorid">972741</idno> </author> <author role="aut"> <persName> <forename type="first">Marie-Laure</forename> <surname>Tanguy</surname> </persName> <idno type="halauthorid">147259</idno> <affiliation ref="#struct-15366"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Jean-Sébastien</forename> <surname>Hulot</surname> </persName> <idno type="halauthorid">291925</idno> <affiliation ref="#struct-2979"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Philippe</forename> <surname>Lechat</surname> </persName> <idno type="halauthorid">972742</idno> </author> <author role="aut"> <persName> <forename type="first">Lucile</forename> <surname>Musset</surname> </persName> <idno type="halauthorid">435903</idno> <affiliation ref="#struct-45150"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Zahir</forename> <surname>Amoura</surname> </persName> <idno type="halauthorid">401623</idno> <affiliation ref="#struct-18474"></affiliation> <affiliation ref="#struct-81476"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Jean-Charles</forename> <surname>Piette</surname> </persName> <idno type="halauthorid">209164</idno> <affiliation ref="#struct-18474"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Aurelien</forename> <surname>Delluc</surname> </persName> <email type="md5">a26cbf706568537be7b0ffc101e19bb4</email> <email type="domain">chu-brest.fr</email> <idno type="halauthorid">714819</idno> <affiliation ref="#struct-102913"></affiliation> <affiliation ref="#struct-144516"></affiliation> <affiliation ref="#struct-144531"></affiliation> </author> <editor role="depositor"> <persName> <forename>Ghislaine</forename> <surname>Calvez</surname> </persName> <email type="md5">04fbec01080569099cb24c9a3a3b6279</email> <email type="domain">chu-brest.fr</email> </editor> </titleStmt> <editionStmt> <edition n="v1" type="current"> <date type="whenSubmitted">2014-01-20 11:59:12</date> <date type="whenModified">2020-03-24 16:09:33</date> <date type="whenReleased">2014-01-20 11:59:12</date> <date type="whenProduced">2013-11-01</date> <ref type="externalLink" target="https://api.istex.fr/document/DE8AB20572B30840080F479A0ED87D2CB86E9CFF/fulltext/pdf?sid=hal"></ref> </edition> <respStmt> <resp>contributor</resp> <name key="159516"> <persName> <forename>Ghislaine</forename> <surname>Calvez</surname> </persName> <email type="md5">04fbec01080569099cb24c9a3a3b6279</email> <email type="domain">chu-brest.fr</email> </name> </respStmt> </editionStmt> <publicationStmt> <distributor>CCSD</distributor> <idno type="halId">hal-00933279</idno> <idno type="halUri">https://hal.univ-brest.fr/hal-00933279</idno> <idno type="halBibtex">costedoatchalumeau:hal-00933279</idno> <idno type="halRefHtml">Annals of the Rheumatic Diseases, BMJ Publishing Group, 2013, 72 (11), pp.1786-92. ⟨10.1136/annrheumdis-2012-202322⟩</idno> <idno type="halRef">Annals of the Rheumatic Diseases, BMJ Publishing Group, 2013, 72 (11), pp.1786-92. ⟨10.1136/annrheumdis-2012-202322⟩</idno> </publicationStmt> <seriesStmt> <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno> <idno type="stamp" n="UNIV-PARIS5">Université Paris Descartes (Paris 5)</idno> <idno type="stamp" n="UNIV-BREST">Université de Bretagne occidentale - Brest (UBO)</idno> <idno type="stamp" n="GETBO" corresp="UNIV-BREST">Groupe d'Etude de la Thrombose de Bretagne Occidentale</idno> <idno type="stamp" n="I3" corresp="SORBONNE-UNIVERSITE">Immunologie-Immunopathologie-Immunothérapie</idno> <idno type="stamp" n="UPMC" corresp="SORBONNE-UNIVERSITE">Université Pierre et Marie Curie</idno> <idno type="stamp" n="APHP" corresp="INSERM">AP-HP</idno> <idno type="stamp" n="USPC">Université Sorbonne Paris Cité</idno> <idno type="stamp" n="UPMC_POLE_4" corresp="UPMC">UPMC Pôle 4</idno> <idno type="stamp" n="IBSAM" corresp="UNIV-BREST">Institut Brestois Sané Agro Matière</idno> <idno type="stamp" n="SORBONNE-UNIVERSITE">Sorbonne Université</idno> <idno type="stamp" n="SU-MEDECINE" corresp="SORBONNE-UNIVERSITE">Faculté de Médecine de Sorbonne Université</idno> <idno type="stamp" n="UNIV-PARIS7">Université Denis Diderot - Paris VII</idno> <idno type="stamp" n="SU-MED" corresp="SORBONNE-UNIVERSITE">Médecine - Sorbonne Université</idno> <idno type="stamp" n="CHU-CLERMONTFERRAND">CHU DE CLERMONT FERRAND</idno> </seriesStmt> <notesStmt> <note type="audience" n="2">International</note> <note type="popular" n="0">No</note> <note type="peer" n="1">Yes</note> </notesStmt> <sourceDesc> <biblStruct> <analytic> <title xml:lang="en">Hydroxychloroquine in systemic lupus erythematosus: results of a French multicentre controlled trial (PLUS Study).</title> <author role="aut"> <persName> <forename type="first">Nathalie</forename> <surname>Costedoat-Chalumeau</surname> </persName> <idno type="halauthorid">822653</idno> <affiliation ref="#struct-93435"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Lionel</forename> <surname>Galicier</surname> </persName> <idno type="halauthorid">464500</idno> <affiliation ref="#struct-41226"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Olivier</forename> <surname>Aumaître</surname> </persName> <idno type="halauthorid">899035</idno> <affiliation ref="#struct-232091"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Camille</forename> <surname>Francès</surname> </persName> <idno type="halauthorid">822651</idno> <affiliation ref="#struct-223222"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Véronique</forename> <surname>Le Guern</surname> </persName> <idno type="halauthorid">972732</idno> <affiliation ref="#struct-454982"></affiliation> <affiliation ref="#struct-192648"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Frédéric</forename> <surname>Lioté</surname> </persName> <idno type="halauthorid">119412</idno> <affiliation ref="#struct-241172"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Amar</forename> <surname>Smail</surname> </persName> <idno type="halauthorid">846758</idno> </author> <author role="aut"> <persName> <forename type="first">Nicolas</forename> <surname>Limal</surname> </persName> <idno type="halauthorid">301310</idno> </author> <author role="aut"> <persName> <forename type="first">Laurent</forename> <surname>Perard</surname> </persName> <idno type="halauthorid">972733</idno> </author> <author role="aut"> <persName> <forename type="first">Hélène</forename> <surname>Desmurs-Clavel</surname> </persName> <idno type="halauthorid">453251</idno> </author> <author role="aut"> <persName> <forename type="first">Du Le Thi Huong</forename> <surname>Boutin</surname> </persName> <idno type="halauthorid">972734</idno> </author> <author role="aut"> <persName> <forename type="first">Bouchra</forename> <surname>Asli</surname> </persName> <idno type="halauthorid">209159</idno> </author> <author role="aut"> <persName> <forename type="first">Jean-Emmanuel</forename> <surname>Kahn</surname> </persName> <idno type="halauthorid">856227</idno> <affiliation ref="#struct-160913"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Jacques</forename> <surname>Pourrat</surname> </persName> <idno type="halauthorid">620977</idno> <affiliation ref="#struct-192646"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Laurent</forename> <surname>Sailler</surname> </persName> <idno type="halauthorid">972735</idno> </author> <author role="aut"> <persName> <forename type="first">Félix</forename> <surname>Ackermann</surname> </persName> <idno type="halauthorid">972736</idno> </author> <author role="aut"> <persName> <forename type="first">Thomas</forename> <surname>Papo</surname> </persName> <idno type="halauthorid">568710</idno> <affiliation ref="#struct-26728"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Karim</forename> <surname>Sacré</surname> </persName> <idno type="halauthorid">972737</idno> </author> <author role="aut"> <persName> <forename type="first">Olivier</forename> <surname>Fain</surname> </persName> <idno type="halauthorid">555165</idno> <affiliation ref="#struct-135015"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Jerome</forename> <surname>Stirnemann</surname> </persName> <idno type="halauthorid">972738</idno> <affiliation ref="#struct-3096"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Patrice</forename> <surname>Cacoub</surname> </persName> <idno type="halauthorid">301315</idno> <affiliation ref="#struct-18474"></affiliation> <affiliation ref="#struct-1031"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Moez</forename> <surname>Jallouli</surname> </persName> <idno type="halauthorid">972739</idno> </author> <author role="aut"> <persName> <forename type="first">Gaelle</forename> <surname>Leroux</surname> </persName> <idno type="halauthorid">11483302</idno> <affiliation ref="#struct-244085"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Judith</forename> <surname>Cohen-Bittan</surname> </persName> <idno type="halauthorid">972741</idno> </author> <author role="aut"> <persName> <forename type="first">Marie-Laure</forename> <surname>Tanguy</surname> </persName> <idno type="halauthorid">147259</idno> <affiliation ref="#struct-15366"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Jean-Sébastien</forename> <surname>Hulot</surname> </persName> <idno type="halauthorid">291925</idno> <affiliation ref="#struct-2979"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Philippe</forename> <surname>Lechat</surname> </persName> <idno type="halauthorid">972742</idno> </author> <author role="aut"> <persName> <forename type="first">Lucile</forename> <surname>Musset</surname> </persName> <idno type="halauthorid">435903</idno> <affiliation ref="#struct-45150"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Zahir</forename> <surname>Amoura</surname> </persName> <idno type="halauthorid">401623</idno> <affiliation ref="#struct-18474"></affiliation> <affiliation ref="#struct-81476"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Jean-Charles</forename> <surname>Piette</surname> </persName> <idno type="halauthorid">209164</idno> <affiliation ref="#struct-18474"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Aurelien</forename> <surname>Delluc</surname> </persName> <email type="md5">a26cbf706568537be7b0ffc101e19bb4</email> <email type="domain">chu-brest.fr</email> <idno type="halauthorid">714819</idno> <affiliation ref="#struct-102913"></affiliation> <affiliation ref="#struct-144516"></affiliation> <affiliation ref="#struct-144531"></affiliation> </author> </analytic> <monogr> <idno type="halJournalId" status="VALID">10511</idno> <idno type="issn">0003-4967</idno> <idno type="eissn">1468-2060</idno> <title level="j">Annals of the Rheumatic Diseases</title> <imprint> <publisher>BMJ Publishing Group</publisher> <biblScope unit="volume">72</biblScope> <biblScope unit="issue">11</biblScope> <biblScope unit="pp">1786-92</biblScope> <date type="datePub">2013-11-01</date> <date type="dateEpub">2012-11-10</date> </imprint> </monogr> <idno type="doi">10.1136/annrheumdis-2012-202322</idno> <idno type="pubmed">23144449</idno> </biblStruct> </sourceDesc> <profileDesc> <langUsage> <language ident="en">English</language> </langUsage> <textClass> <classCode scheme="mesh">Adult</classCode> <classCode scheme="mesh">Antirheumatic Agents</classCode> <classCode scheme="mesh">France</classCode> <classCode scheme="mesh">Humans</classCode> <classCode scheme="mesh">Hydroxychloroquine</classCode> <classCode scheme="mesh">Lupus Erythematosus, Systemic</classCode> <classCode scheme="mesh">Male</classCode> <classCode scheme="mesh">Middle Aged</classCode> <classCode scheme="mesh">Prospective Studies</classCode> <classCode scheme="mesh">Treatment Outcome</classCode> <classCode scheme="mesh">Dose-Response Relationship, Drug</classCode> <classCode scheme="mesh">Double-Blind Method</classCode> <classCode scheme="mesh">Drug Monitoring</classCode> <classCode scheme="mesh">Female</classCode> <classCode scheme="halDomain" n="sdv">Life Sciences [q-bio]</classCode> <classCode scheme="halTypology" n="ART">Journal articles</classCode> </textClass> <abstract xml:lang="en"> <p>INTRODUCTION: Hydroxychloroquine (HCQ) is an important medication for treating systemic lupus erythematosus (SLE). Its blood concentration ([HCQ]) varies widely between patients and is a marker and predictor of SLE flares. This prospective randomised, double-blind, placebo-controlled, multicentre study sought to compare standard and adjusted HCQ dosing schedules that target [HCQ] ≥1000 ng/ml to reduce SLE flares. PATIENTS AND METHODS: [HCQ] was measured in 573 patients with SLE (stable disease and SELENA-SLEDAI≤12) treated with HCQ for at least 6 months. Patients with [HCQ] from 100 to 750 ng/ml were randomised to one of two treatment groups: no daily dose change (group 1) or increased HCQ dose to achieve the target [HCQ] (group 2). The primary end point was the number of patients with flares during 7 months of follow-up. RESULTS: Overall, mean [HCQ] was 918±451 ng/ml. Active SLE was less prevalent in patients with higher [HCQ]. A total of 171 patients were randomised and followed for 7 months. SLE flare rates were similar in the two groups (25% in group 1 vs 27.6% in group 2; p=0.7), but a significant spontaneous increase in [HCQ] in both groups between inclusion and randomisation strongly suggested improved treatment adherence. Patients at the therapeutic target throughout follow-up tended to have fewer flares than those with low [HCQ] (20.5% vs 35.1%, p=0.12). CONCLUSIONS: Although low [HCQ] is associated with higher SLE activity, adapting the HCQ dose did not reduce SLE flares over a 7-month follow-up.</p> </abstract> </profileDesc> </hal></record>Pour manipuler ce document sous Unix (Dilib)
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