ChloroquineV1, Hal, Corpus, bibRecord, 000059

Cycloartane triterpenes from the leaves of Neoboutonia macrocalyx L.

Identifieur interne : 000059 ( Hal/Corpus ); précédent : 000058; suivant : 000060

Cycloartane triterpenes from the leaves of Neoboutonia macrocalyx L.

Auteurs : Jane Namukobe ; Bernard T. Kiremire ; Robert Byamukama ; John M. Kasenene ; Vincent Dumontet ; Françoise Guéritte ; Sabrina Krief ; Isabelle Florent ; John D. Kabasa

Source :

Phytochemistry [ 0031-9422 ] ; 2014-06.

RBID : Hal:hal-01005175

Abstract

Neoboutonia macrocalyx is used by people in south western Uganda around Kibale National Park in the treatment of malaria. Phytochemical investigation on the leaves of this plant led to the isolation of nine cycloartane triterpenes (1-9) and one phenanthrene; 7-methoxy-2,8 dimethyl-9,10-dihydrophenantherene-3,6 diol (10) along with three known compounds which included 22-de-O-acetyl-26-deoxyneoboutomellerone (11), mellerin B (12) and 6-hydroxystigmast-4-en-3-one (13). The chemical structures of the compounds were established mainly through a combination of spectroscopic techniques. The isolated compounds were evaluated for antiplasmodial activity against the chloroquine-resistant FcB1/Colombia strain of Plasmodium falciparum and for cytotoxicity against the KB (nasopharyngeal epidermoid carcinoma) and MRC-5 (human diploid embryonic lung) cells. Seven out of 13 compounds exhibited good antiplasmodial activity with IC50 of ⩽5μg/ml with two compounds exhibiting low cytotoxicity and five compounds having significant cytotoxicity.

Url:

https://hal.archives-ouvertes.fr/hal-01005175

DOI: 10.1016/j.phytochem.2014.02.005

Links to Exploration step

Hal:hal-01005175

Le document en format XML

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<front><div type="abstract" xml:lang="en">              <p>Neoboutonia macrocalyx is used by people in south western Uganda around Kibale National Park in the treatment of malaria. Phytochemical investigation on the leaves of this plant led to the isolation of nine cycloartane triterpenes (1-9) and one phenanthrene; 7-methoxy-2,8 dimethyl-9,10-dihydrophenantherene-3,6 diol (10) along with three known compounds which included 22-de-O-acetyl-26-deoxyneoboutomellerone (11), mellerin B (12) and 6-hydroxystigmast-4-en-3-one (13). The chemical structures of the compounds were established mainly through a combination of spectroscopic techniques. The isolated compounds were evaluated for antiplasmodial activity against the chloroquine-resistant FcB1/Colombia strain of Plasmodium falciparum and for cytotoxicity against the KB (nasopharyngeal epidermoid carcinoma) and MRC-5 (human diploid embryonic lung) cells. Seven out of 13 compounds exhibited good antiplasmodial activity with IC50 of ⩽5μg/ml with two compounds exhibiting low cytotoxicity and five compounds having significant cytotoxicity.</p>
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                <imprint>                  <publisher>Elsevier</publisher>
                  <biblScope unit="volume">102</biblScope>
                  <biblScope unit="pp">189-196</biblScope>
                  <date type="datePub">2014-06</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1016/j.phytochem.2014.02.005</idno>
              <idno type="pubmed">24680168</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>            <langUsage>              <language ident="en">English</language>
            </langUsage>
            <textClass>              <classCode scheme="halDomain" n="chim.orga">Chemical Sciences/Organic chemistry</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">              <p>Neoboutonia macrocalyx is used by people in south western Uganda around Kibale National Park in the treatment of malaria. Phytochemical investigation on the leaves of this plant led to the isolation of nine cycloartane triterpenes (1-9) and one phenanthrene; 7-methoxy-2,8 dimethyl-9,10-dihydrophenantherene-3,6 diol (10) along with three known compounds which included 22-de-O-acetyl-26-deoxyneoboutomellerone (11), mellerin B (12) and 6-hydroxystigmast-4-en-3-one (13). The chemical structures of the compounds were established mainly through a combination of spectroscopic techniques. The isolated compounds were evaluated for antiplasmodial activity against the chloroquine-resistant FcB1/Colombia strain of Plasmodium falciparum and for cytotoxicity against the KB (nasopharyngeal epidermoid carcinoma) and MRC-5 (human diploid embryonic lung) cells. Seven out of 13 compounds exhibited good antiplasmodial activity with IC50 of ⩽5μg/ml with two compounds exhibiting low cytotoxicity and five compounds having significant cytotoxicity.</p>
            </abstract>
          </profileDesc>
        </hal>
</record>

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Cycloartane triterpenes from the leaves of Neoboutonia macrocalyx L.

Cycloartane triterpenes from the leaves of Neoboutonia macrocalyx L.

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