ChloroquineV1, Hal, Corpus, bibRecord, 000025

Antiplasmodial benzophenone derivatives from the root barks of Symphonia globulifera (Clusiaceae).

Identifieur interne : 000025 ( Hal/Corpus ); précédent : 000024; suivant : 000026

Antiplasmodial benzophenone derivatives from the root barks of Symphonia globulifera (Clusiaceae).

Auteurs : Guillaume Marti ; Véronique Eparvier ; Christian Moretti ; Soizic Prado ; Philippe Grellier ; Nathalie Hue ; Odile Thoison ; Bernard Delpech ; Françoise Guéritte ; Marc Litaudon

Source :

Phytochemistry [ 0031-9422 ] ; 2010-06.

RBID : Hal:hal-00491751

Abstract

In an effort to find antimalarial drugs, a systematic in vitro evaluation on a chloroquine-resistant strain of Plasmodium falciparum (FcB1) was undertaken on sixty plant extracts collected in French Guiana. The ethyl acetate extract obtained from the root barks of Symphonia globulifera exhibited a strong antiplasmodial activity (97% at 10 microg/ml). The phytochemical investigation of this extract led to the isolation of nine polycyclic polyprenylated acylphloroglucinol (PPAPs) compounds and two oxidized derivatives. All compounds showed antiplasmodial activity with IC(50)s ranged from 2.1 to 10.1 microM. A LC/ESI-MS(n) study performed on polyprenylated benzophenones previously isolated from Moronobea coccinea provided a reliable method for their detection in the extract and structural elucidation.

Url:

https://hal.archives-ouvertes.fr/hal-00491751

DOI: 10.1016/j.phytochem.2010.03.008

Links to Exploration step

Hal:hal-00491751

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Antiplasmodial benzophenone derivatives from the root barks of Symphonia globulifera (Clusiaceae).</title>
<author><name sortKey="Marti, Guillaume" sort="Marti, Guillaume" uniqKey="Marti G" first="Guillaume" last="Marti">Guillaume Marti</name>
<affiliation><hal:affiliation type="laboratory" xml:id="struct-440" status="VALID">          <orgName>Institut de Chimie des Substances Naturelles</orgName>
          <orgName type="acronym">ICSN</orgName>
          <desc>            <address>              <addrLine>Avenue de la terrasse 91198 Gif sur yvette cedex</addrLine>
              <country key="FR"></country>
            </address>
          </desc>
          <listRelation>            <relation name="UPR2301" active="#struct-441569" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle name="UPR2301" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
</affiliation>
</author>
<author><name sortKey="Eparvier, Veronique" sort="Eparvier, Veronique" uniqKey="Eparvier V" first="Véronique" last="Eparvier">Véronique Eparvier</name>
<affiliation><hal:affiliation type="laboratory" xml:id="struct-440" status="VALID">          <orgName>Institut de Chimie des Substances Naturelles</orgName>
          <orgName type="acronym">ICSN</orgName>
          <desc>            <address>              <addrLine>Avenue de la terrasse 91198 Gif sur yvette cedex</addrLine>
              <country key="FR"></country>
            </address>
          </desc>
          <listRelation>            <relation name="UPR2301" active="#struct-441569" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle name="UPR2301" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
</affiliation>
</author>
<author><name sortKey="Moretti, Christian" sort="Moretti, Christian" uniqKey="Moretti C" first="Christian" last="Moretti">Christian Moretti</name>
</author>
<author><name sortKey="Prado, Soizic" sort="Prado, Soizic" uniqKey="Prado S" first="Soizic" last="Prado">Soizic Prado</name>
</author>
<author><name sortKey="Grellier, Philippe" sort="Grellier, Philippe" uniqKey="Grellier P" first="Philippe" last="Grellier">Philippe Grellier</name>
</author>
<author><name sortKey="Hue, Nathalie" sort="Hue, Nathalie" uniqKey="Hue N" first="Nathalie" last="Hue">Nathalie Hue</name>
</author>
<author><name sortKey="Thoison, Odile" sort="Thoison, Odile" uniqKey="Thoison O" first="Odile" last="Thoison">Odile Thoison</name>
<affiliation><hal:affiliation type="laboratory" xml:id="struct-440" status="VALID">          <orgName>Institut de Chimie des Substances Naturelles</orgName>
          <orgName type="acronym">ICSN</orgName>
          <desc>            <address>              <addrLine>Avenue de la terrasse 91198 Gif sur yvette cedex</addrLine>
              <country key="FR"></country>
            </address>
          </desc>
          <listRelation>            <relation name="UPR2301" active="#struct-441569" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle name="UPR2301" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
</affiliation>
</author>
<author><name sortKey="Delpech, Bernard" sort="Delpech, Bernard" uniqKey="Delpech B" first="Bernard" last="Delpech">Bernard Delpech</name>
<affiliation><hal:affiliation type="laboratory" xml:id="struct-440" status="VALID">          <orgName>Institut de Chimie des Substances Naturelles</orgName>
          <orgName type="acronym">ICSN</orgName>
          <desc>            <address>              <addrLine>Avenue de la terrasse 91198 Gif sur yvette cedex</addrLine>
              <country key="FR"></country>
            </address>
          </desc>
          <listRelation>            <relation name="UPR2301" active="#struct-441569" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle name="UPR2301" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
</affiliation>
</author>
<author><name sortKey="Gueritte, Francoise" sort="Gueritte, Francoise" uniqKey="Gueritte F" first="Françoise" last="Guéritte">Françoise Guéritte</name>
<affiliation><hal:affiliation type="laboratory" xml:id="struct-440" status="VALID">          <orgName>Institut de Chimie des Substances Naturelles</orgName>
          <orgName type="acronym">ICSN</orgName>
          <desc>            <address>              <addrLine>Avenue de la terrasse 91198 Gif sur yvette cedex</addrLine>
              <country key="FR"></country>
            </address>
          </desc>
          <listRelation>            <relation name="UPR2301" active="#struct-441569" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle name="UPR2301" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
</affiliation>
</author>
<author><name sortKey="Litaudon, Marc" sort="Litaudon, Marc" uniqKey="Litaudon M" first="Marc" last="Litaudon">Marc Litaudon</name>
<affiliation><hal:affiliation type="laboratory" xml:id="struct-440" status="VALID">          <orgName>Institut de Chimie des Substances Naturelles</orgName>
          <orgName type="acronym">ICSN</orgName>
          <desc>            <address>              <addrLine>Avenue de la terrasse 91198 Gif sur yvette cedex</addrLine>
              <country key="FR"></country>
            </address>
          </desc>
          <listRelation>            <relation name="UPR2301" active="#struct-441569" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle name="UPR2301" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">HAL</idno>
<idno type="RBID">Hal:hal-00491751</idno>
<idno type="halId">hal-00491751</idno>
<idno type="halUri">https://hal.archives-ouvertes.fr/hal-00491751</idno>
<idno type="url">https://hal.archives-ouvertes.fr/hal-00491751</idno>
<idno type="doi">10.1016/j.phytochem.2010.03.008</idno>
<date when="2010-06">2010-06</date>
<idno type="wicri:Area/Hal/Corpus">000025</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Antiplasmodial benzophenone derivatives from the root barks of Symphonia globulifera (Clusiaceae).</title>
<author><name sortKey="Marti, Guillaume" sort="Marti, Guillaume" uniqKey="Marti G" first="Guillaume" last="Marti">Guillaume Marti</name>
<affiliation><hal:affiliation type="laboratory" xml:id="struct-440" status="VALID">          <orgName>Institut de Chimie des Substances Naturelles</orgName>
          <orgName type="acronym">ICSN</orgName>
          <desc>            <address>              <addrLine>Avenue de la terrasse 91198 Gif sur yvette cedex</addrLine>
              <country key="FR"></country>
            </address>
          </desc>
          <listRelation>            <relation name="UPR2301" active="#struct-441569" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle name="UPR2301" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
</affiliation>
</author>
<author><name sortKey="Eparvier, Veronique" sort="Eparvier, Veronique" uniqKey="Eparvier V" first="Véronique" last="Eparvier">Véronique Eparvier</name>
<affiliation><hal:affiliation type="laboratory" xml:id="struct-440" status="VALID">          <orgName>Institut de Chimie des Substances Naturelles</orgName>
          <orgName type="acronym">ICSN</orgName>
          <desc>            <address>              <addrLine>Avenue de la terrasse 91198 Gif sur yvette cedex</addrLine>
              <country key="FR"></country>
            </address>
          </desc>
          <listRelation>            <relation name="UPR2301" active="#struct-441569" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle name="UPR2301" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
</affiliation>
</author>
<author><name sortKey="Moretti, Christian" sort="Moretti, Christian" uniqKey="Moretti C" first="Christian" last="Moretti">Christian Moretti</name>
</author>
<author><name sortKey="Prado, Soizic" sort="Prado, Soizic" uniqKey="Prado S" first="Soizic" last="Prado">Soizic Prado</name>
</author>
<author><name sortKey="Grellier, Philippe" sort="Grellier, Philippe" uniqKey="Grellier P" first="Philippe" last="Grellier">Philippe Grellier</name>
</author>
<author><name sortKey="Hue, Nathalie" sort="Hue, Nathalie" uniqKey="Hue N" first="Nathalie" last="Hue">Nathalie Hue</name>
</author>
<author><name sortKey="Thoison, Odile" sort="Thoison, Odile" uniqKey="Thoison O" first="Odile" last="Thoison">Odile Thoison</name>
<affiliation><hal:affiliation type="laboratory" xml:id="struct-440" status="VALID">          <orgName>Institut de Chimie des Substances Naturelles</orgName>
          <orgName type="acronym">ICSN</orgName>
          <desc>            <address>              <addrLine>Avenue de la terrasse 91198 Gif sur yvette cedex</addrLine>
              <country key="FR"></country>
            </address>
          </desc>
          <listRelation>            <relation name="UPR2301" active="#struct-441569" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle name="UPR2301" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
</affiliation>
</author>
<author><name sortKey="Delpech, Bernard" sort="Delpech, Bernard" uniqKey="Delpech B" first="Bernard" last="Delpech">Bernard Delpech</name>
<affiliation><hal:affiliation type="laboratory" xml:id="struct-440" status="VALID">          <orgName>Institut de Chimie des Substances Naturelles</orgName>
          <orgName type="acronym">ICSN</orgName>
          <desc>            <address>              <addrLine>Avenue de la terrasse 91198 Gif sur yvette cedex</addrLine>
              <country key="FR"></country>
            </address>
          </desc>
          <listRelation>            <relation name="UPR2301" active="#struct-441569" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle name="UPR2301" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
</affiliation>
</author>
<author><name sortKey="Gueritte, Francoise" sort="Gueritte, Francoise" uniqKey="Gueritte F" first="Françoise" last="Guéritte">Françoise Guéritte</name>
<affiliation><hal:affiliation type="laboratory" xml:id="struct-440" status="VALID">          <orgName>Institut de Chimie des Substances Naturelles</orgName>
          <orgName type="acronym">ICSN</orgName>
          <desc>            <address>              <addrLine>Avenue de la terrasse 91198 Gif sur yvette cedex</addrLine>
              <country key="FR"></country>
            </address>
          </desc>
          <listRelation>            <relation name="UPR2301" active="#struct-441569" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle name="UPR2301" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
</affiliation>
</author>
<author><name sortKey="Litaudon, Marc" sort="Litaudon, Marc" uniqKey="Litaudon M" first="Marc" last="Litaudon">Marc Litaudon</name>
<affiliation><hal:affiliation type="laboratory" xml:id="struct-440" status="VALID">          <orgName>Institut de Chimie des Substances Naturelles</orgName>
          <orgName type="acronym">ICSN</orgName>
          <desc>            <address>              <addrLine>Avenue de la terrasse 91198 Gif sur yvette cedex</addrLine>
              <country key="FR"></country>
            </address>
          </desc>
          <listRelation>            <relation name="UPR2301" active="#struct-441569" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle name="UPR2301" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
</affiliation>
</author>
</analytic>
<idno type="DOI">10.1016/j.phytochem.2010.03.008</idno>
<series><title level="j">Phytochemistry</title>
<idno type="ISSN">0031-9422</idno>
<imprint><date type="datePub">2010-06</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">              <p>In an effort to find antimalarial drugs, a systematic in vitro evaluation on a chloroquine-resistant strain of Plasmodium falciparum (FcB1) was undertaken on sixty plant extracts collected in French Guiana. The ethyl acetate extract obtained from the root barks of Symphonia globulifera exhibited a strong antiplasmodial activity (97% at 10 microg/ml). The phytochemical investigation of this extract led to the isolation of nine polycyclic polyprenylated acylphloroglucinol (PPAPs) compounds and two oxidized derivatives. All compounds showed antiplasmodial activity with IC(50)s ranged from 2.1 to 10.1 microM. A LC/ESI-MS(n) study performed on polyprenylated benzophenones previously isolated from Moronobea coccinea provided a reliable method for their detection in the extract and structural elucidation.</p>
            </div>
</front>
</TEI>
<hal api="V3">          <titleStmt>            <title xml:lang="en">Antiplasmodial benzophenone derivatives from the root barks of Symphonia globulifera (Clusiaceae).</title>
            <author role="aut">              <persName>                <forename type="first">Guillaume</forename>
                <surname>Marti</surname>
              </persName>
              <idno type="halauthorid">395276</idno>
              <affiliation ref="#struct-440"></affiliation>
            </author>
            <author role="aut">              <persName>                <forename type="first">Véronique</forename>
                <surname>Eparvier</surname>
              </persName>
              <email type="md5">cb2ae7248a0c27dcb300bca908fa5bdc</email>
              <email type="domain">cnrs.fr</email>
              <idno type="idhal" notation="string">veronique-eparvier</idno>
              <idno type="idhal" notation="numeric">180588</idno>
              <idno type="halauthorid">301015</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-2954-0866</idno>
              <affiliation ref="#struct-440"></affiliation>
            </author>
            <author role="aut">              <persName>                <forename type="first">Christian</forename>
                <surname>Moretti</surname>
              </persName>
              <idno type="halauthorid">109683</idno>
            </author>
            <author role="aut">              <persName>                <forename type="first">Soizic</forename>
                <surname>Prado</surname>
              </persName>
              <idno type="halauthorid">200994</idno>
            </author>
            <author role="aut">              <persName>                <forename type="first">Philippe</forename>
                <surname>Grellier</surname>
              </persName>
              <idno type="halauthorid">128593</idno>
            </author>
            <author role="aut">              <persName>                <forename type="first">Nathalie</forename>
                <surname>Hue</surname>
              </persName>
              <idno type="halauthorid">500293</idno>
            </author>
            <author role="aut">              <persName>                <forename type="first">Odile</forename>
                <surname>Thoison</surname>
              </persName>
              <idno type="halauthorid">83103</idno>
              <affiliation ref="#struct-440"></affiliation>
            </author>
            <author role="aut">              <persName>                <forename type="first">Bernard</forename>
                <surname>Delpech</surname>
              </persName>
              <idno type="halauthorid">469192</idno>
              <affiliation ref="#struct-440"></affiliation>
            </author>
            <author role="aut">              <persName>                <forename type="first">Françoise</forename>
                <surname>Guéritte</surname>
              </persName>
              <idno type="halauthorid">301016</idno>
              <affiliation ref="#struct-440"></affiliation>
            </author>
            <author role="aut">              <persName>                <forename type="first">Marc</forename>
                <surname>Litaudon</surname>
              </persName>
              <idno type="halauthorid">83050</idno>
              <affiliation ref="#struct-440"></affiliation>
            </author>
            <editor role="depositor">              <persName>                <forename>Jocelyne</forename>
                <surname>Brunet</surname>
              </persName>
              <email type="md5">5dd83d345d42190f284baae0dc2702e8</email>
              <email type="domain">icsn.cnrs-gif.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>            <edition n="v1" type="current">              <date type="whenSubmitted">2010-06-14 11:37:50</date>
              <date type="whenWritten">2010</date>
              <date type="whenModified">2019-12-11 16:24:06</date>
              <date type="whenReleased">2010-06-14 11:37:50</date>
              <date type="whenProduced">2010-06</date>
            </edition>
            <respStmt>              <resp>contributor</resp>
              <name key="103776">                <persName>                  <forename>Jocelyne</forename>
                  <surname>Brunet</surname>
                </persName>
                <email type="md5">5dd83d345d42190f284baae0dc2702e8</email>
                <email type="domain">icsn.cnrs-gif.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>            <distributor>CCSD</distributor>
            <idno type="halId">hal-00491751</idno>
            <idno type="halUri">https://hal.archives-ouvertes.fr/hal-00491751</idno>
            <idno type="halBibtex">marti:hal-00491751</idno>
            <idno type="halRefHtml">Phytochemistry, Elsevier, 2010, 71 (8-9), pp.964-974. ⟨10.1016/j.phytochem.2010.03.008⟩</idno>
            <idno type="halRef">Phytochemistry, Elsevier, 2010, 71 (8-9), pp.964-974. ⟨10.1016/j.phytochem.2010.03.008⟩</idno>
          </publicationStmt>
          <seriesStmt>            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="ICSN">Collection des Publications de l'Institut de Chimie des Substances Naturelles, UPR2301, Gif sur Yvette</idno>
            <idno type="stamp" n="INC-CNRS">Institut de Chimie du CNRS</idno>
          </seriesStmt>
          <notesStmt>            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>            <biblStruct>              <analytic>                <title xml:lang="en">Antiplasmodial benzophenone derivatives from the root barks of Symphonia globulifera (Clusiaceae).</title>
                <author role="aut">                  <persName>                    <forename type="first">Guillaume</forename>
                    <surname>Marti</surname>
                  </persName>
                  <idno type="halauthorid">395276</idno>
                  <affiliation ref="#struct-440"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Véronique</forename>
                    <surname>Eparvier</surname>
                  </persName>
                  <email type="md5">cb2ae7248a0c27dcb300bca908fa5bdc</email>
                  <email type="domain">cnrs.fr</email>
                  <idno type="idhal" notation="string">veronique-eparvier</idno>
                  <idno type="idhal" notation="numeric">180588</idno>
                  <idno type="halauthorid">301015</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-2954-0866</idno>
                  <affiliation ref="#struct-440"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Christian</forename>
                    <surname>Moretti</surname>
                  </persName>
                  <idno type="halauthorid">109683</idno>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Soizic</forename>
                    <surname>Prado</surname>
                  </persName>
                  <idno type="halauthorid">200994</idno>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Philippe</forename>
                    <surname>Grellier</surname>
                  </persName>
                  <idno type="halauthorid">128593</idno>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Nathalie</forename>
                    <surname>Hue</surname>
                  </persName>
                  <idno type="halauthorid">500293</idno>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Odile</forename>
                    <surname>Thoison</surname>
                  </persName>
                  <idno type="halauthorid">83103</idno>
                  <affiliation ref="#struct-440"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Bernard</forename>
                    <surname>Delpech</surname>
                  </persName>
                  <idno type="halauthorid">469192</idno>
                  <affiliation ref="#struct-440"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Françoise</forename>
                    <surname>Guéritte</surname>
                  </persName>
                  <idno type="halauthorid">301016</idno>
                  <affiliation ref="#struct-440"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Marc</forename>
                    <surname>Litaudon</surname>
                  </persName>
                  <idno type="halauthorid">83050</idno>
                  <affiliation ref="#struct-440"></affiliation>
                </author>
              </analytic>
              <monogr>                <idno type="localRef">2010069</idno>
                <idno type="halJournalId" status="VALID">7802</idno>
                <idno type="issn">0031-9422</idno>
                <title level="j">Phytochemistry</title>
                <imprint>                  <publisher>Elsevier</publisher>
                  <biblScope unit="volume">71</biblScope>
                  <biblScope unit="issue">8-9</biblScope>
                  <biblScope unit="pp">964-974</biblScope>
                  <date type="datePub">2010-06</date>
                  <date type="dateEpub">2010-03-29</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1016/j.phytochem.2010.03.008</idno>
              <idno type="pubmed">20356612</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>            <langUsage>              <language ident="en">English</language>
            </langUsage>
            <textClass>              <classCode scheme="halDomain" n="sdv.bc">Life Sciences [q-bio]/Cellular Biology</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">              <p>In an effort to find antimalarial drugs, a systematic in vitro evaluation on a chloroquine-resistant strain of Plasmodium falciparum (FcB1) was undertaken on sixty plant extracts collected in French Guiana. The ethyl acetate extract obtained from the root barks of Symphonia globulifera exhibited a strong antiplasmodial activity (97% at 10 microg/ml). The phytochemical investigation of this extract led to the isolation of nine polycyclic polyprenylated acylphloroglucinol (PPAPs) compounds and two oxidized derivatives. All compounds showed antiplasmodial activity with IC(50)s ranged from 2.1 to 10.1 microM. A LC/ESI-MS(n) study performed on polyprenylated benzophenones previously isolated from Moronobea coccinea provided a reliable method for their detection in the extract and structural elucidation.</p>
            </abstract>
          </profileDesc>
        </hal>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Hal/Corpus

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000025 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Hal/Corpus/biblio.hfd -nk 000025 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    ChloroquineV1
   |flux=    Hal
   |étape=   Corpus
   |type=    RBID
   |clé=     Hal:hal-00491751
   |texte=   Antiplasmodial benzophenone derivatives from the root barks of Symphonia globulifera (Clusiaceae).
}}

This area was generated with Dilib version V0.6.33.
Data generation: Wed Mar 25 22:43:59 2020. Site generation: Sun Jan 31 12:44:45 2021

	Serveur d'exploration Chloroquine
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration Chloroquine

Antiplasmodial benzophenone derivatives from the root barks of Symphonia globulifera (Clusiaceae).

Antiplasmodial benzophenone derivatives from the root barks of Symphonia globulifera (Clusiaceae).

Source :

Abstract

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri