Assessment of Plasmodium falciparum resistance to ferroquine (SSR97193) in field isolates and in W2 strain under pressure.
Identifieur interne : 000235 ( Hal/Checkpoint ); précédent : 000234; suivant : 000236Assessment of Plasmodium falciparum resistance to ferroquine (SSR97193) in field isolates and in W2 strain under pressure.
Auteurs : Wassim Daher [France] ; Christophe Biot [France] ; Thierry Fandeur [France] ; Helene Jouin [France] ; Lydie Pelinski [France] ; Eric Viscogliosi [France] ; Laurent Fraisse [France] ; Bruno Pradines [France] ; Jacques Brocard [France] ; Jamal Khalife [France] ; Daniel Dive [France]Source :
- Malaria Journal [ 1475-2875 ] ; 2006.
Abstract
BACKGROUND: Ferroquine (FQ), or SSR97193, is a novel antimalarial drug currently in phase I clinical trials. FQ is a unique organometallic compound designed to overcome the chloroquine (CQ) resistance problem. FQ revealed to be equally active on CQ-sensitive and CQ-resistant Plasmodium falciparum laboratory strains and field isolates. FQ is also curative on rodent malaria parasites. As FQ will be tested in patients, the potential for resistance to this drug was evaluated. METHODS: The relationship between CQ-resistant transporter gene genotype and susceptibility to FQ were studied in 33 Cambodian P. falciparum field isolates previously studied for their in vitro response to CQ. In parallel, the ability of the CQ-resistant strain W2, to become resistant to FQ under drug pressure was assessed. RESULTS: The IC50 values for FQ in field isolates were found to be unrelated to mutations occurring in the P. falciparum chloroquine resistance transporter (PfCRT) or to the level of expression of the corresponding mRNA. In vitro, under a drug pressure of 100 nM of FQ, transient survival was observed in only one of two experiments. CONCLUSION: Field isolates studies and experimental drug pressure experiments showed that FQ overcomes CQ resistance, which reinforces the potential of this compound as a new antimalarial drug.
Url:
DOI: 10.1186/1475-2875-5-11
Links toward previous steps (curation, corpus...)
Links to Exploration step
Hal:inserm-00091291Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Assessment of Plasmodium falciparum resistance to ferroquine (SSR97193) in field isolates and in W2 strain under pressure.</title><author><name sortKey="Daher, Wassim" sort="Daher, Wassim" uniqKey="Daher W" first="Wassim" last="Daher">Wassim Daher</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-2906" status="VALID"> <orgName>Schistosomiase, paludisme et inflammation</orgName> <desc> <address> <addrLine>Institut Pasteur 1, Rue du Professeur Calmette 59019 LILLE CEDEX</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300166" type="direct"></relation> <relation active="#struct-301247" type="indirect"></relation> <relation name="U547" active="#struct-303623" type="direct"></relation> <relation active="#struct-361611" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300166" type="direct"><org type="institution" xml:id="struct-300166" status="VALID"> <orgName>Institut Pasteur de Lille</orgName> <date type="start">1894</date> <desc> <address> <addrLine>1 Rue du Professeur Calmette - Lille Cedex - 59019</addrLine> <country key="FR"></country> </address> <ref type="url">https://www.pasteur-lille.fr/accueil/</ref> </desc> <listRelation> <relation active="#struct-301247" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-301247" type="indirect"><org type="regroupinstitution" xml:id="struct-301247" status="VALID"> <orgName>Réseau International des Instituts Pasteur</orgName> <orgName type="acronym">RIIP</orgName> <desc> <address> <addrLine>25, rue du Dr Roux 75724 Paris Cedex 15</addrLine> <country key="FR"></country> </address> <ref type="url">https://research.pasteur.fr/ip-network</ref> </desc> </org></tutelle><tutelle name="U547" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc> </org></tutelle><tutelle active="#struct-361611" type="direct"><org type="institution" xml:id="struct-361611" status="OLD"> <idno type="ISNI">0000000120977060</idno> <idno type="IdRef">026404389</idno> <orgName>Université de Lille, Droit et Santé</orgName> <date type="end">2017-12-31</date> <desc> <address> <addrLine>42 rue Paul Duez 59000 Lille</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-lille2.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Biot, Christophe" sort="Biot, Christophe" uniqKey="Biot C" first="Christophe" last="Biot">Christophe Biot</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-3209" status="VALID"> <idno type="IdRef">161608809</idno> <idno type="ISNI">0000 0004 0368 3038</idno> <idno type="RNSR">200612828X</idno> <orgName>Unité de Catalyse et de Chimie du Solide - UMR 8181</orgName> <orgName type="acronym">UCCS</orgName> <desc> <address> <addrLine>Cité Scientifique - Bâtiment C3 59655 Villeneuve d'Ascq Cedex</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-56711" type="direct"></relation> <relation active="#struct-120930" type="direct"></relation> <relation active="#struct-300369" type="direct"></relation> <relation active="#struct-374570" type="direct"></relation> <relation name="UMR8181" active="#struct-441569" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-56711" type="direct"><org type="institution" xml:id="struct-56711" status="VALID"> <orgName>Université d'Artois</orgName> <orgName type="acronym">UA</orgName> <desc> <address> <addrLine>9 rue du Temple - BP 10665 - 62030 Arras cedex</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-artois.fr/</ref> </desc> </org></tutelle><tutelle active="#struct-120930" type="direct"><org type="institution" xml:id="struct-120930" status="VALID"> <orgName>Ecole Centrale de Lille</orgName> <desc> <address> <addrLine>Cité Scientifique - CS 20048 59651 Villeneuve d'Ascq Cedex</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.ec-lille.fr/</ref> </desc> </org></tutelle><tutelle active="#struct-300369" type="direct"><org type="institution" xml:id="struct-300369" status="VALID"> <orgName>Ecole Nationale Supérieure de Chimie de Lille</orgName> <orgName type="acronym">ENSCL</orgName> <desc> <address> <addrLine>Cité ScientifiqueBât. C7Avenue MendeleïevCS 9010859652 VILLENEUVE D’ASCQ CEDEX</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.ensc-lille.fr</ref> </desc> </org></tutelle><tutelle active="#struct-374570" type="direct"><org type="institution" xml:id="struct-374570" status="VALID"> <idno type="IdRef">223446556</idno> <orgName>Université de Lille</orgName> <date type="start">2018-01-01</date> <desc> <address> <addrLine>Lille</addrLine> <country key="FR"></country> </address> <ref type="url">https://www.univ-lille.fr/</ref> </desc> </org></tutelle><tutelle name="UMR8181" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno> <idno type="ISNI">0000000122597504</idno> <orgName>Centre National de la Recherche Scientifique</orgName> <orgName type="acronym">CNRS</orgName> <date type="start">1939-10-19</date> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.cnrs.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Fandeur, Thierry" sort="Fandeur, Thierry" uniqKey="Fandeur T" first="Thierry" last="Fandeur">Thierry Fandeur</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-140964" status="VALID"> <orgName>Infectiologie et Santé Publique</orgName> <orgName type="acronym">ISP</orgName> <desc> <address> <addrLine>UFR Médecine, Université François Rabelais de Tours, 37032 Tours Cedex, France</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation name="EA3854" active="#struct-300298" type="direct"></relation> <relation active="#struct-300638" type="direct"></relation> </listRelation> <tutelles><tutelle name="EA3854" active="#struct-300298" type="direct"><org type="institution" xml:id="struct-300298" status="VALID"> <idno type="IdRef">026404478</idno> <orgName>Université de Tours</orgName> <date type="start">1970-12-17</date> <desc> <address> <addrLine>60 rue du Plat d'Étain, 37020 Tours cedex 1 </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-tours.fr</ref> </desc> </org></tutelle><tutelle active="#struct-300638" type="direct"><org type="institution" xml:id="struct-300638" status="VALID"> <orgName>IFR136</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country><placeName><settlement type="city">Tours</settlement><region type="old region" nuts="2">Région Centre</region><region type="region" nuts="2">Centre-Val de Loire</region></placeName><orgName type="university">Université de Tours</orgName><orgName type="institution" wicri:auto="newGroup">Centre Val de Loire Université</orgName></affiliation></author><author><name sortKey="Jouin, Helene" sort="Jouin, Helene" uniqKey="Jouin H" first="Helene" last="Jouin">Helene Jouin</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-2906" status="VALID"> <orgName>Schistosomiase, paludisme et inflammation</orgName> <desc> <address> <addrLine>Institut Pasteur 1, Rue du Professeur Calmette 59019 LILLE CEDEX</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300166" type="direct"></relation> <relation active="#struct-301247" type="indirect"></relation> <relation name="U547" active="#struct-303623" type="direct"></relation> <relation active="#struct-361611" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300166" type="direct"><org type="institution" xml:id="struct-300166" status="VALID"> <orgName>Institut Pasteur de Lille</orgName> <date type="start">1894</date> <desc> <address> <addrLine>1 Rue du Professeur Calmette - Lille Cedex - 59019</addrLine> <country key="FR"></country> </address> <ref type="url">https://www.pasteur-lille.fr/accueil/</ref> </desc> <listRelation> <relation active="#struct-301247" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-301247" type="indirect"><org type="regroupinstitution" xml:id="struct-301247" status="VALID"> <orgName>Réseau International des Instituts Pasteur</orgName> <orgName type="acronym">RIIP</orgName> <desc> <address> <addrLine>25, rue du Dr Roux 75724 Paris Cedex 15</addrLine> <country key="FR"></country> </address> <ref type="url">https://research.pasteur.fr/ip-network</ref> </desc> </org></tutelle><tutelle name="U547" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc> </org></tutelle><tutelle active="#struct-361611" type="direct"><org type="institution" xml:id="struct-361611" status="OLD"> <idno type="ISNI">0000000120977060</idno> <idno type="IdRef">026404389</idno> <orgName>Université de Lille, Droit et Santé</orgName> <date type="end">2017-12-31</date> <desc> <address> <addrLine>42 rue Paul Duez 59000 Lille</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-lille2.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Pelinski, Lydie" sort="Pelinski, Lydie" uniqKey="Pelinski L" first="Lydie" last="Pelinski">Lydie Pelinski</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-3209" status="VALID"> <idno type="IdRef">161608809</idno> <idno type="ISNI">0000 0004 0368 3038</idno> <idno type="RNSR">200612828X</idno> <orgName>Unité de Catalyse et de Chimie du Solide - UMR 8181</orgName> <orgName type="acronym">UCCS</orgName> <desc> <address> <addrLine>Cité Scientifique - Bâtiment C3 59655 Villeneuve d'Ascq Cedex</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-56711" type="direct"></relation> <relation active="#struct-120930" type="direct"></relation> <relation active="#struct-300369" type="direct"></relation> <relation active="#struct-374570" type="direct"></relation> <relation name="UMR8181" active="#struct-441569" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-56711" type="direct"><org type="institution" xml:id="struct-56711" status="VALID"> <orgName>Université d'Artois</orgName> <orgName type="acronym">UA</orgName> <desc> <address> <addrLine>9 rue du Temple - BP 10665 - 62030 Arras cedex</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-artois.fr/</ref> </desc> </org></tutelle><tutelle active="#struct-120930" type="direct"><org type="institution" xml:id="struct-120930" status="VALID"> <orgName>Ecole Centrale de Lille</orgName> <desc> <address> <addrLine>Cité Scientifique - CS 20048 59651 Villeneuve d'Ascq Cedex</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.ec-lille.fr/</ref> </desc> </org></tutelle><tutelle active="#struct-300369" type="direct"><org type="institution" xml:id="struct-300369" status="VALID"> <orgName>Ecole Nationale Supérieure de Chimie de Lille</orgName> <orgName type="acronym">ENSCL</orgName> <desc> <address> <addrLine>Cité ScientifiqueBât. C7Avenue MendeleïevCS 9010859652 VILLENEUVE D’ASCQ CEDEX</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.ensc-lille.fr</ref> </desc> </org></tutelle><tutelle active="#struct-374570" type="direct"><org type="institution" xml:id="struct-374570" status="VALID"> <idno type="IdRef">223446556</idno> <orgName>Université de Lille</orgName> <date type="start">2018-01-01</date> <desc> <address> <addrLine>Lille</addrLine> <country key="FR"></country> </address> <ref type="url">https://www.univ-lille.fr/</ref> </desc> </org></tutelle><tutelle name="UMR8181" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno> <idno type="ISNI">0000000122597504</idno> <orgName>Centre National de la Recherche Scientifique</orgName> <orgName type="acronym">CNRS</orgName> <date type="start">1939-10-19</date> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.cnrs.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Viscogliosi, Eric" sort="Viscogliosi, Eric" uniqKey="Viscogliosi E" first="Eric" last="Viscogliosi">Eric Viscogliosi</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-2906" status="VALID"> <orgName>Schistosomiase, paludisme et inflammation</orgName> <desc> <address> <addrLine>Institut Pasteur 1, Rue du Professeur Calmette 59019 LILLE CEDEX</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300166" type="direct"></relation> <relation active="#struct-301247" type="indirect"></relation> <relation name="U547" active="#struct-303623" type="direct"></relation> <relation active="#struct-361611" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300166" type="direct"><org type="institution" xml:id="struct-300166" status="VALID"> <orgName>Institut Pasteur de Lille</orgName> <date type="start">1894</date> <desc> <address> <addrLine>1 Rue du Professeur Calmette - Lille Cedex - 59019</addrLine> <country key="FR"></country> </address> <ref type="url">https://www.pasteur-lille.fr/accueil/</ref> </desc> <listRelation> <relation active="#struct-301247" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-301247" type="indirect"><org type="regroupinstitution" xml:id="struct-301247" status="VALID"> <orgName>Réseau International des Instituts Pasteur</orgName> <orgName type="acronym">RIIP</orgName> <desc> <address> <addrLine>25, rue du Dr Roux 75724 Paris Cedex 15</addrLine> <country key="FR"></country> </address> <ref type="url">https://research.pasteur.fr/ip-network</ref> </desc> </org></tutelle><tutelle name="U547" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc> </org></tutelle><tutelle active="#struct-361611" type="direct"><org type="institution" xml:id="struct-361611" status="OLD"> <idno type="ISNI">0000000120977060</idno> <idno type="IdRef">026404389</idno> <orgName>Université de Lille, Droit et Santé</orgName> <date type="end">2017-12-31</date> <desc> <address> <addrLine>42 rue Paul Duez 59000 Lille</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-lille2.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Fraisse, Laurent" sort="Fraisse, Laurent" uniqKey="Fraisse L" first="Laurent" last="Fraisse">Laurent Fraisse</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-19072" status="INCOMING"> <orgName>Département découverte</orgName> <desc> <address> <addrLine>31000 Toulouse Cedex</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-307022" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-307022" type="direct"><org type="institution" xml:id="struct-307022" status="INCOMING"> <orgName>Sanofi Aventis Recherche</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Pradines, Bruno" sort="Pradines, Bruno" uniqKey="Pradines B" first="Bruno" last="Pradines">Bruno Pradines</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-19073" status="INCOMING"> <orgName>Unité de Parasitologie</orgName> <desc> <address> <addrLine>Bd Charles Livon, Parc le Pharo, BP 46 13998 Marseille Armées</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-307023" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-307023" type="direct"><org type="institution" xml:id="struct-307023" status="INCOMING"> <orgName>Institut de Médecine Tropicale du Service de Santé des Armées</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Brocard, Jacques" sort="Brocard, Jacques" uniqKey="Brocard J" first="Jacques" last="Brocard">Jacques Brocard</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-3209" status="VALID"> <idno type="IdRef">161608809</idno> <idno type="ISNI">0000 0004 0368 3038</idno> <idno type="RNSR">200612828X</idno> <orgName>Unité de Catalyse et de Chimie du Solide - UMR 8181</orgName> <orgName type="acronym">UCCS</orgName> <desc> <address> <addrLine>Cité Scientifique - Bâtiment C3 59655 Villeneuve d'Ascq Cedex</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-56711" type="direct"></relation> <relation active="#struct-120930" type="direct"></relation> <relation active="#struct-300369" type="direct"></relation> <relation active="#struct-374570" type="direct"></relation> <relation name="UMR8181" active="#struct-441569" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-56711" type="direct"><org type="institution" xml:id="struct-56711" status="VALID"> <orgName>Université d'Artois</orgName> <orgName type="acronym">UA</orgName> <desc> <address> <addrLine>9 rue du Temple - BP 10665 - 62030 Arras cedex</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-artois.fr/</ref> </desc> </org></tutelle><tutelle active="#struct-120930" type="direct"><org type="institution" xml:id="struct-120930" status="VALID"> <orgName>Ecole Centrale de Lille</orgName> <desc> <address> <addrLine>Cité Scientifique - CS 20048 59651 Villeneuve d'Ascq Cedex</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.ec-lille.fr/</ref> </desc> </org></tutelle><tutelle active="#struct-300369" type="direct"><org type="institution" xml:id="struct-300369" status="VALID"> <orgName>Ecole Nationale Supérieure de Chimie de Lille</orgName> <orgName type="acronym">ENSCL</orgName> <desc> <address> <addrLine>Cité ScientifiqueBât. C7Avenue MendeleïevCS 9010859652 VILLENEUVE D’ASCQ CEDEX</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.ensc-lille.fr</ref> </desc> </org></tutelle><tutelle active="#struct-374570" type="direct"><org type="institution" xml:id="struct-374570" status="VALID"> <idno type="IdRef">223446556</idno> <orgName>Université de Lille</orgName> <date type="start">2018-01-01</date> <desc> <address> <addrLine>Lille</addrLine> <country key="FR"></country> </address> <ref type="url">https://www.univ-lille.fr/</ref> </desc> </org></tutelle><tutelle name="UMR8181" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno> <idno type="ISNI">0000000122597504</idno> <orgName>Centre National de la Recherche Scientifique</orgName> <orgName type="acronym">CNRS</orgName> <date type="start">1939-10-19</date> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.cnrs.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Khalife, Jamal" sort="Khalife, Jamal" uniqKey="Khalife J" first="Jamal" last="Khalife">Jamal Khalife</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-2906" status="VALID"> <orgName>Schistosomiase, paludisme et inflammation</orgName> <desc> <address> <addrLine>Institut Pasteur 1, Rue du Professeur Calmette 59019 LILLE CEDEX</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300166" type="direct"></relation> <relation active="#struct-301247" type="indirect"></relation> <relation name="U547" active="#struct-303623" type="direct"></relation> <relation active="#struct-361611" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300166" type="direct"><org type="institution" xml:id="struct-300166" status="VALID"> <orgName>Institut Pasteur de Lille</orgName> <date type="start">1894</date> <desc> <address> <addrLine>1 Rue du Professeur Calmette - Lille Cedex - 59019</addrLine> <country key="FR"></country> </address> <ref type="url">https://www.pasteur-lille.fr/accueil/</ref> </desc> <listRelation> <relation active="#struct-301247" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-301247" type="indirect"><org type="regroupinstitution" xml:id="struct-301247" status="VALID"> <orgName>Réseau International des Instituts Pasteur</orgName> <orgName type="acronym">RIIP</orgName> <desc> <address> <addrLine>25, rue du Dr Roux 75724 Paris Cedex 15</addrLine> <country key="FR"></country> </address> <ref type="url">https://research.pasteur.fr/ip-network</ref> </desc> </org></tutelle><tutelle name="U547" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc> </org></tutelle><tutelle active="#struct-361611" type="direct"><org type="institution" xml:id="struct-361611" status="OLD"> <idno type="ISNI">0000000120977060</idno> <idno type="IdRef">026404389</idno> <orgName>Université de Lille, Droit et Santé</orgName> <date type="end">2017-12-31</date> <desc> <address> <addrLine>42 rue Paul Duez 59000 Lille</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-lille2.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Dive, Daniel" sort="Dive, Daniel" uniqKey="Dive D" first="Daniel" last="Dive">Daniel Dive</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-2906" status="VALID"> <orgName>Schistosomiase, paludisme et inflammation</orgName> <desc> <address> <addrLine>Institut Pasteur 1, Rue du Professeur Calmette 59019 LILLE CEDEX</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300166" type="direct"></relation> <relation active="#struct-301247" type="indirect"></relation> <relation name="U547" active="#struct-303623" type="direct"></relation> <relation active="#struct-361611" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300166" type="direct"><org type="institution" xml:id="struct-300166" status="VALID"> <orgName>Institut Pasteur de Lille</orgName> <date type="start">1894</date> <desc> <address> <addrLine>1 Rue du Professeur Calmette - Lille Cedex - 59019</addrLine> <country key="FR"></country> </address> <ref type="url">https://www.pasteur-lille.fr/accueil/</ref> </desc> <listRelation> <relation active="#struct-301247" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-301247" type="indirect"><org type="regroupinstitution" xml:id="struct-301247" status="VALID"> <orgName>Réseau International des Instituts Pasteur</orgName> <orgName type="acronym">RIIP</orgName> <desc> <address> <addrLine>25, rue du Dr Roux 75724 Paris Cedex 15</addrLine> <country key="FR"></country> </address> <ref type="url">https://research.pasteur.fr/ip-network</ref> </desc> </org></tutelle><tutelle name="U547" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc> </org></tutelle><tutelle active="#struct-361611" type="direct"><org type="institution" xml:id="struct-361611" status="OLD"> <idno type="ISNI">0000000120977060</idno> <idno type="IdRef">026404389</idno> <orgName>Université de Lille, Droit et Santé</orgName> <date type="end">2017-12-31</date> <desc> <address> <addrLine>42 rue Paul Duez 59000 Lille</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-lille2.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">HAL</idno><idno type="RBID">Hal:inserm-00091291</idno><idno type="halId">inserm-00091291</idno><idno type="halUri">https://www.hal.inserm.fr/inserm-00091291</idno><idno type="url">https://www.hal.inserm.fr/inserm-00091291</idno><idno type="doi">10.1186/1475-2875-5-11</idno><date when="2006">2006</date><idno type="wicri:Area/Hal/Corpus">000031</idno><idno type="wicri:Area/Hal/Curation">000031</idno><idno type="wicri:Area/Hal/Checkpoint">000235</idno><idno type="wicri:explorRef" wicri:stream="Hal" wicri:step="Checkpoint">000235</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Assessment of Plasmodium falciparum resistance to ferroquine (SSR97193) in field isolates and in W2 strain under pressure.</title><author><name sortKey="Daher, Wassim" sort="Daher, Wassim" uniqKey="Daher W" first="Wassim" last="Daher">Wassim Daher</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-2906" status="VALID"> <orgName>Schistosomiase, paludisme et inflammation</orgName> <desc> <address> <addrLine>Institut Pasteur 1, Rue du Professeur Calmette 59019 LILLE CEDEX</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300166" type="direct"></relation> <relation active="#struct-301247" type="indirect"></relation> <relation name="U547" active="#struct-303623" type="direct"></relation> <relation active="#struct-361611" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300166" type="direct"><org type="institution" xml:id="struct-300166" status="VALID"> <orgName>Institut Pasteur de Lille</orgName> <date type="start">1894</date> <desc> <address> <addrLine>1 Rue du Professeur Calmette - Lille Cedex - 59019</addrLine> <country key="FR"></country> </address> <ref type="url">https://www.pasteur-lille.fr/accueil/</ref> </desc> <listRelation> <relation active="#struct-301247" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-301247" type="indirect"><org type="regroupinstitution" xml:id="struct-301247" status="VALID"> <orgName>Réseau International des Instituts Pasteur</orgName> <orgName type="acronym">RIIP</orgName> <desc> <address> <addrLine>25, rue du Dr Roux 75724 Paris Cedex 15</addrLine> <country key="FR"></country> </address> <ref type="url">https://research.pasteur.fr/ip-network</ref> </desc> </org></tutelle><tutelle name="U547" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc> </org></tutelle><tutelle active="#struct-361611" type="direct"><org type="institution" xml:id="struct-361611" status="OLD"> <idno type="ISNI">0000000120977060</idno> <idno type="IdRef">026404389</idno> <orgName>Université de Lille, Droit et Santé</orgName> <date type="end">2017-12-31</date> <desc> <address> <addrLine>42 rue Paul Duez 59000 Lille</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-lille2.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Biot, Christophe" sort="Biot, Christophe" uniqKey="Biot C" first="Christophe" last="Biot">Christophe Biot</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-3209" status="VALID"> <idno type="IdRef">161608809</idno> <idno type="ISNI">0000 0004 0368 3038</idno> <idno type="RNSR">200612828X</idno> <orgName>Unité de Catalyse et de Chimie du Solide - UMR 8181</orgName> <orgName type="acronym">UCCS</orgName> <desc> <address> <addrLine>Cité Scientifique - Bâtiment C3 59655 Villeneuve d'Ascq Cedex</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-56711" type="direct"></relation> <relation active="#struct-120930" type="direct"></relation> <relation active="#struct-300369" type="direct"></relation> <relation active="#struct-374570" type="direct"></relation> <relation name="UMR8181" active="#struct-441569" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-56711" type="direct"><org type="institution" xml:id="struct-56711" status="VALID"> <orgName>Université d'Artois</orgName> <orgName type="acronym">UA</orgName> <desc> <address> <addrLine>9 rue du Temple - BP 10665 - 62030 Arras cedex</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-artois.fr/</ref> </desc> </org></tutelle><tutelle active="#struct-120930" type="direct"><org type="institution" xml:id="struct-120930" status="VALID"> <orgName>Ecole Centrale de Lille</orgName> <desc> <address> <addrLine>Cité Scientifique - CS 20048 59651 Villeneuve d'Ascq Cedex</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.ec-lille.fr/</ref> </desc> </org></tutelle><tutelle active="#struct-300369" type="direct"><org type="institution" xml:id="struct-300369" status="VALID"> <orgName>Ecole Nationale Supérieure de Chimie de Lille</orgName> <orgName type="acronym">ENSCL</orgName> <desc> <address> <addrLine>Cité ScientifiqueBât. C7Avenue MendeleïevCS 9010859652 VILLENEUVE D’ASCQ CEDEX</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.ensc-lille.fr</ref> </desc> </org></tutelle><tutelle active="#struct-374570" type="direct"><org type="institution" xml:id="struct-374570" status="VALID"> <idno type="IdRef">223446556</idno> <orgName>Université de Lille</orgName> <date type="start">2018-01-01</date> <desc> <address> <addrLine>Lille</addrLine> <country key="FR"></country> </address> <ref type="url">https://www.univ-lille.fr/</ref> </desc> </org></tutelle><tutelle name="UMR8181" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno> <idno type="ISNI">0000000122597504</idno> <orgName>Centre National de la Recherche Scientifique</orgName> <orgName type="acronym">CNRS</orgName> <date type="start">1939-10-19</date> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.cnrs.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Fandeur, Thierry" sort="Fandeur, Thierry" uniqKey="Fandeur T" first="Thierry" last="Fandeur">Thierry Fandeur</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-140964" status="VALID"> <orgName>Infectiologie et Santé Publique</orgName> <orgName type="acronym">ISP</orgName> <desc> <address> <addrLine>UFR Médecine, Université François Rabelais de Tours, 37032 Tours Cedex, France</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation name="EA3854" active="#struct-300298" type="direct"></relation> <relation active="#struct-300638" type="direct"></relation> </listRelation> <tutelles><tutelle name="EA3854" active="#struct-300298" type="direct"><org type="institution" xml:id="struct-300298" status="VALID"> <idno type="IdRef">026404478</idno> <orgName>Université de Tours</orgName> <date type="start">1970-12-17</date> <desc> <address> <addrLine>60 rue du Plat d'Étain, 37020 Tours cedex 1 </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-tours.fr</ref> </desc> </org></tutelle><tutelle active="#struct-300638" type="direct"><org type="institution" xml:id="struct-300638" status="VALID"> <orgName>IFR136</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country><placeName><settlement type="city">Tours</settlement><region type="old region" nuts="2">Région Centre</region><region type="region" nuts="2">Centre-Val de Loire</region></placeName><orgName type="university">Université de Tours</orgName><orgName type="institution" wicri:auto="newGroup">Centre Val de Loire Université</orgName></affiliation></author><author><name sortKey="Jouin, Helene" sort="Jouin, Helene" uniqKey="Jouin H" first="Helene" last="Jouin">Helene Jouin</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-2906" status="VALID"> <orgName>Schistosomiase, paludisme et inflammation</orgName> <desc> <address> <addrLine>Institut Pasteur 1, Rue du Professeur Calmette 59019 LILLE CEDEX</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300166" type="direct"></relation> <relation active="#struct-301247" type="indirect"></relation> <relation name="U547" active="#struct-303623" type="direct"></relation> <relation active="#struct-361611" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300166" type="direct"><org type="institution" xml:id="struct-300166" status="VALID"> <orgName>Institut Pasteur de Lille</orgName> <date type="start">1894</date> <desc> <address> <addrLine>1 Rue du Professeur Calmette - Lille Cedex - 59019</addrLine> <country key="FR"></country> </address> <ref type="url">https://www.pasteur-lille.fr/accueil/</ref> </desc> <listRelation> <relation active="#struct-301247" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-301247" type="indirect"><org type="regroupinstitution" xml:id="struct-301247" status="VALID"> <orgName>Réseau International des Instituts Pasteur</orgName> <orgName type="acronym">RIIP</orgName> <desc> <address> <addrLine>25, rue du Dr Roux 75724 Paris Cedex 15</addrLine> <country key="FR"></country> </address> <ref type="url">https://research.pasteur.fr/ip-network</ref> </desc> </org></tutelle><tutelle name="U547" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc> </org></tutelle><tutelle active="#struct-361611" type="direct"><org type="institution" xml:id="struct-361611" status="OLD"> <idno type="ISNI">0000000120977060</idno> <idno type="IdRef">026404389</idno> <orgName>Université de Lille, Droit et Santé</orgName> <date type="end">2017-12-31</date> <desc> <address> <addrLine>42 rue Paul Duez 59000 Lille</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-lille2.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Pelinski, Lydie" sort="Pelinski, Lydie" uniqKey="Pelinski L" first="Lydie" last="Pelinski">Lydie Pelinski</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-3209" status="VALID"> <idno type="IdRef">161608809</idno> <idno type="ISNI">0000 0004 0368 3038</idno> <idno type="RNSR">200612828X</idno> <orgName>Unité de Catalyse et de Chimie du Solide - UMR 8181</orgName> <orgName type="acronym">UCCS</orgName> <desc> <address> <addrLine>Cité Scientifique - Bâtiment C3 59655 Villeneuve d'Ascq Cedex</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-56711" type="direct"></relation> <relation active="#struct-120930" type="direct"></relation> <relation active="#struct-300369" type="direct"></relation> <relation active="#struct-374570" type="direct"></relation> <relation name="UMR8181" active="#struct-441569" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-56711" type="direct"><org type="institution" xml:id="struct-56711" status="VALID"> <orgName>Université d'Artois</orgName> <orgName type="acronym">UA</orgName> <desc> <address> <addrLine>9 rue du Temple - BP 10665 - 62030 Arras cedex</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-artois.fr/</ref> </desc> </org></tutelle><tutelle active="#struct-120930" type="direct"><org type="institution" xml:id="struct-120930" status="VALID"> <orgName>Ecole Centrale de Lille</orgName> <desc> <address> <addrLine>Cité Scientifique - CS 20048 59651 Villeneuve d'Ascq Cedex</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.ec-lille.fr/</ref> </desc> </org></tutelle><tutelle active="#struct-300369" type="direct"><org type="institution" xml:id="struct-300369" status="VALID"> <orgName>Ecole Nationale Supérieure de Chimie de Lille</orgName> <orgName type="acronym">ENSCL</orgName> <desc> <address> <addrLine>Cité ScientifiqueBât. C7Avenue MendeleïevCS 9010859652 VILLENEUVE D’ASCQ CEDEX</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.ensc-lille.fr</ref> </desc> </org></tutelle><tutelle active="#struct-374570" type="direct"><org type="institution" xml:id="struct-374570" status="VALID"> <idno type="IdRef">223446556</idno> <orgName>Université de Lille</orgName> <date type="start">2018-01-01</date> <desc> <address> <addrLine>Lille</addrLine> <country key="FR"></country> </address> <ref type="url">https://www.univ-lille.fr/</ref> </desc> </org></tutelle><tutelle name="UMR8181" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno> <idno type="ISNI">0000000122597504</idno> <orgName>Centre National de la Recherche Scientifique</orgName> <orgName type="acronym">CNRS</orgName> <date type="start">1939-10-19</date> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.cnrs.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Viscogliosi, Eric" sort="Viscogliosi, Eric" uniqKey="Viscogliosi E" first="Eric" last="Viscogliosi">Eric Viscogliosi</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-2906" status="VALID"> <orgName>Schistosomiase, paludisme et inflammation</orgName> <desc> <address> <addrLine>Institut Pasteur 1, Rue du Professeur Calmette 59019 LILLE CEDEX</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300166" type="direct"></relation> <relation active="#struct-301247" type="indirect"></relation> <relation name="U547" active="#struct-303623" type="direct"></relation> <relation active="#struct-361611" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300166" type="direct"><org type="institution" xml:id="struct-300166" status="VALID"> <orgName>Institut Pasteur de Lille</orgName> <date type="start">1894</date> <desc> <address> <addrLine>1 Rue du Professeur Calmette - Lille Cedex - 59019</addrLine> <country key="FR"></country> </address> <ref type="url">https://www.pasteur-lille.fr/accueil/</ref> </desc> <listRelation> <relation active="#struct-301247" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-301247" type="indirect"><org type="regroupinstitution" xml:id="struct-301247" status="VALID"> <orgName>Réseau International des Instituts Pasteur</orgName> <orgName type="acronym">RIIP</orgName> <desc> <address> <addrLine>25, rue du Dr Roux 75724 Paris Cedex 15</addrLine> <country key="FR"></country> </address> <ref type="url">https://research.pasteur.fr/ip-network</ref> </desc> </org></tutelle><tutelle name="U547" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc> </org></tutelle><tutelle active="#struct-361611" type="direct"><org type="institution" xml:id="struct-361611" status="OLD"> <idno type="ISNI">0000000120977060</idno> <idno type="IdRef">026404389</idno> <orgName>Université de Lille, Droit et Santé</orgName> <date type="end">2017-12-31</date> <desc> <address> <addrLine>42 rue Paul Duez 59000 Lille</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-lille2.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Fraisse, Laurent" sort="Fraisse, Laurent" uniqKey="Fraisse L" first="Laurent" last="Fraisse">Laurent Fraisse</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-19072" status="INCOMING"> <orgName>Département découverte</orgName> <desc> <address> <addrLine>31000 Toulouse Cedex</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-307022" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-307022" type="direct"><org type="institution" xml:id="struct-307022" status="INCOMING"> <orgName>Sanofi Aventis Recherche</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Pradines, Bruno" sort="Pradines, Bruno" uniqKey="Pradines B" first="Bruno" last="Pradines">Bruno Pradines</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-19073" status="INCOMING"> <orgName>Unité de Parasitologie</orgName> <desc> <address> <addrLine>Bd Charles Livon, Parc le Pharo, BP 46 13998 Marseille Armées</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-307023" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-307023" type="direct"><org type="institution" xml:id="struct-307023" status="INCOMING"> <orgName>Institut de Médecine Tropicale du Service de Santé des Armées</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Brocard, Jacques" sort="Brocard, Jacques" uniqKey="Brocard J" first="Jacques" last="Brocard">Jacques Brocard</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-3209" status="VALID"> <idno type="IdRef">161608809</idno> <idno type="ISNI">0000 0004 0368 3038</idno> <idno type="RNSR">200612828X</idno> <orgName>Unité de Catalyse et de Chimie du Solide - UMR 8181</orgName> <orgName type="acronym">UCCS</orgName> <desc> <address> <addrLine>Cité Scientifique - Bâtiment C3 59655 Villeneuve d'Ascq Cedex</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-56711" type="direct"></relation> <relation active="#struct-120930" type="direct"></relation> <relation active="#struct-300369" type="direct"></relation> <relation active="#struct-374570" type="direct"></relation> <relation name="UMR8181" active="#struct-441569" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-56711" type="direct"><org type="institution" xml:id="struct-56711" status="VALID"> <orgName>Université d'Artois</orgName> <orgName type="acronym">UA</orgName> <desc> <address> <addrLine>9 rue du Temple - BP 10665 - 62030 Arras cedex</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-artois.fr/</ref> </desc> </org></tutelle><tutelle active="#struct-120930" type="direct"><org type="institution" xml:id="struct-120930" status="VALID"> <orgName>Ecole Centrale de Lille</orgName> <desc> <address> <addrLine>Cité Scientifique - CS 20048 59651 Villeneuve d'Ascq Cedex</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.ec-lille.fr/</ref> </desc> </org></tutelle><tutelle active="#struct-300369" type="direct"><org type="institution" xml:id="struct-300369" status="VALID"> <orgName>Ecole Nationale Supérieure de Chimie de Lille</orgName> <orgName type="acronym">ENSCL</orgName> <desc> <address> <addrLine>Cité ScientifiqueBât. C7Avenue MendeleïevCS 9010859652 VILLENEUVE D’ASCQ CEDEX</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.ensc-lille.fr</ref> </desc> </org></tutelle><tutelle active="#struct-374570" type="direct"><org type="institution" xml:id="struct-374570" status="VALID"> <idno type="IdRef">223446556</idno> <orgName>Université de Lille</orgName> <date type="start">2018-01-01</date> <desc> <address> <addrLine>Lille</addrLine> <country key="FR"></country> </address> <ref type="url">https://www.univ-lille.fr/</ref> </desc> </org></tutelle><tutelle name="UMR8181" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno> <idno type="ISNI">0000000122597504</idno> <orgName>Centre National de la Recherche Scientifique</orgName> <orgName type="acronym">CNRS</orgName> <date type="start">1939-10-19</date> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.cnrs.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Khalife, Jamal" sort="Khalife, Jamal" uniqKey="Khalife J" first="Jamal" last="Khalife">Jamal Khalife</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-2906" status="VALID"> <orgName>Schistosomiase, paludisme et inflammation</orgName> <desc> <address> <addrLine>Institut Pasteur 1, Rue du Professeur Calmette 59019 LILLE CEDEX</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300166" type="direct"></relation> <relation active="#struct-301247" type="indirect"></relation> <relation name="U547" active="#struct-303623" type="direct"></relation> <relation active="#struct-361611" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300166" type="direct"><org type="institution" xml:id="struct-300166" status="VALID"> <orgName>Institut Pasteur de Lille</orgName> <date type="start">1894</date> <desc> <address> <addrLine>1 Rue du Professeur Calmette - Lille Cedex - 59019</addrLine> <country key="FR"></country> </address> <ref type="url">https://www.pasteur-lille.fr/accueil/</ref> </desc> <listRelation> <relation active="#struct-301247" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-301247" type="indirect"><org type="regroupinstitution" xml:id="struct-301247" status="VALID"> <orgName>Réseau International des Instituts Pasteur</orgName> <orgName type="acronym">RIIP</orgName> <desc> <address> <addrLine>25, rue du Dr Roux 75724 Paris Cedex 15</addrLine> <country key="FR"></country> </address> <ref type="url">https://research.pasteur.fr/ip-network</ref> </desc> </org></tutelle><tutelle name="U547" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc> </org></tutelle><tutelle active="#struct-361611" type="direct"><org type="institution" xml:id="struct-361611" status="OLD"> <idno type="ISNI">0000000120977060</idno> <idno type="IdRef">026404389</idno> <orgName>Université de Lille, Droit et Santé</orgName> <date type="end">2017-12-31</date> <desc> <address> <addrLine>42 rue Paul Duez 59000 Lille</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-lille2.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Dive, Daniel" sort="Dive, Daniel" uniqKey="Dive D" first="Daniel" last="Dive">Daniel Dive</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-2906" status="VALID"> <orgName>Schistosomiase, paludisme et inflammation</orgName> <desc> <address> <addrLine>Institut Pasteur 1, Rue du Professeur Calmette 59019 LILLE CEDEX</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300166" type="direct"></relation> <relation active="#struct-301247" type="indirect"></relation> <relation name="U547" active="#struct-303623" type="direct"></relation> <relation active="#struct-361611" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300166" type="direct"><org type="institution" xml:id="struct-300166" status="VALID"> <orgName>Institut Pasteur de Lille</orgName> <date type="start">1894</date> <desc> <address> <addrLine>1 Rue du Professeur Calmette - Lille Cedex - 59019</addrLine> <country key="FR"></country> </address> <ref type="url">https://www.pasteur-lille.fr/accueil/</ref> </desc> <listRelation> <relation active="#struct-301247" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-301247" type="indirect"><org type="regroupinstitution" xml:id="struct-301247" status="VALID"> <orgName>Réseau International des Instituts Pasteur</orgName> <orgName type="acronym">RIIP</orgName> <desc> <address> <addrLine>25, rue du Dr Roux 75724 Paris Cedex 15</addrLine> <country key="FR"></country> </address> <ref type="url">https://research.pasteur.fr/ip-network</ref> </desc> </org></tutelle><tutelle name="U547" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc> </org></tutelle><tutelle active="#struct-361611" type="direct"><org type="institution" xml:id="struct-361611" status="OLD"> <idno type="ISNI">0000000120977060</idno> <idno type="IdRef">026404389</idno> <orgName>Université de Lille, Droit et Santé</orgName> <date type="end">2017-12-31</date> <desc> <address> <addrLine>42 rue Paul Duez 59000 Lille</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-lille2.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author></analytic><idno type="DOI">10.1186/1475-2875-5-11</idno><series><title level="j">Malaria Journal</title><idno type="ISSN">1475-2875</idno><imprint><date type="datePub">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"> <p>BACKGROUND: Ferroquine (FQ), or SSR97193, is a novel antimalarial drug currently in phase I clinical trials. FQ is a unique organometallic compound designed to overcome the chloroquine (CQ) resistance problem. FQ revealed to be equally active on CQ-sensitive and CQ-resistant Plasmodium falciparum laboratory strains and field isolates. FQ is also curative on rodent malaria parasites. As FQ will be tested in patients, the potential for resistance to this drug was evaluated. METHODS: The relationship between CQ-resistant transporter gene genotype and susceptibility to FQ were studied in 33 Cambodian P. falciparum field isolates previously studied for their in vitro response to CQ. In parallel, the ability of the CQ-resistant strain W2, to become resistant to FQ under drug pressure was assessed. RESULTS: The IC50 values for FQ in field isolates were found to be unrelated to mutations occurring in the P. falciparum chloroquine resistance transporter (PfCRT) or to the level of expression of the corresponding mRNA. In vitro, under a drug pressure of 100 nM of FQ, transient survival was observed in only one of two experiments. CONCLUSION: Field isolates studies and experimental drug pressure experiments showed that FQ overcomes CQ resistance, which reinforces the potential of this compound as a new antimalarial drug.</p> </div></front></TEI><hal api="V3"> <titleStmt> <title xml:lang="en">Assessment of Plasmodium falciparum resistance to ferroquine (SSR97193) in field isolates and in W2 strain under pressure.</title> <author role="aut"> <persName> <forename type="first">Wassim</forename> <surname>Daher</surname> </persName> <idno type="halauthorid">113556</idno> <affiliation ref="#struct-2906"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Christophe</forename> <surname>Biot</surname> </persName> <idno type="halauthorid">120622</idno> <affiliation ref="#struct-3209"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Thierry</forename> <surname>Fandeur</surname> </persName> <idno type="halauthorid">120623</idno> <affiliation ref="#struct-140964"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Helene</forename> <surname>Jouin</surname> </persName> <idno type="halauthorid">120624</idno> <affiliation ref="#struct-2906"></affiliation> <affiliation ref="#struct-17213"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Lydie</forename> <surname>Pelinski</surname> </persName> <email type="md5">7c8fbcc88169f9dbdbee58975bc91eb9</email> <email type="domain">ensc-lille.fr</email> <idno type="idhal" notation="string">lydie-pelinski</idno> <idno type="idhal" notation="numeric">17821</idno> <idno type="halauthorid">113489</idno> <idno type="ORCID">https://orcid.org/0000-0002-5691-7550</idno> <affiliation ref="#struct-3209"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Eric</forename> <surname>Viscogliosi</surname> </persName> <idno type="halauthorid">120625</idno> <affiliation ref="#struct-2906"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Laurent</forename> <surname>Fraisse</surname> </persName> <idno type="halauthorid">120626</idno> <affiliation ref="#struct-19072"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Bruno</forename> <surname>Pradines</surname> </persName> <idno type="halauthorid">120627</idno> <affiliation ref="#struct-19073"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Jacques</forename> <forename type="middle">S.</forename> <surname>Brocard</surname> </persName> <idno type="halauthorid">106753</idno> <affiliation ref="#struct-3209"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Jamal</forename> <surname>Khalife</surname> </persName> <idno type="halauthorid">113564</idno> <affiliation ref="#struct-2906"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Daniel</forename> <surname>Dive</surname> </persName> <idno type="halauthorid">113560</idno> <affiliation ref="#struct-2906"></affiliation> </author> <editor role="depositor"> <persName> <forename>Delphine</forename> <surname>Autard</surname> </persName> <email type="md5">f048e2cc60ba3ff0d2a63cd993824e0f</email> <email type="domain">inserm.fr</email> </editor> <funder>This work and Wassim Daher were supported by grants of Sanofi-Aventis and Fondation des Treilles.</funder> </titleStmt> <editionStmt> <edition n="v1" type="current"> <date type="whenSubmitted">2006-09-05 16:48:36</date> <date type="whenModified">2020-01-13 17:08:05</date> <date type="whenReleased">2006-09-05 16:48:00</date> <date type="whenProduced">2006</date> <date type="whenEndEmbargoed">2006-09-05</date> <ref type="file" target="https://www.hal.inserm.fr/inserm-00091291/document"> <date notBefore="2006-09-05"></date> </ref> <ref type="file" n="1" target="https://www.hal.inserm.fr/inserm-00091291/file/1475-2875-5-11.pdf"> <date notBefore="2006-09-05"></date> </ref> <ref type="externalLink" target="https://malariajournal.biomedcentral.com/track/pdf/10.1186/1475-2875-5-11"></ref> </edition> <respStmt> <resp>contributor</resp> <name key="110394"> <persName> <forename>Delphine</forename> <surname>Autard</surname> </persName> <email type="md5">f048e2cc60ba3ff0d2a63cd993824e0f</email> <email type="domain">inserm.fr</email> </name> </respStmt> </editionStmt> <publicationStmt> <distributor>CCSD</distributor> <idno type="halId">inserm-00091291</idno> <idno type="halUri">https://www.hal.inserm.fr/inserm-00091291</idno> <idno type="halBibtex">daher:inserm-00091291</idno> <idno type="halRefHtml">Malaria Journal, BioMed Central, 2006, 5, pp.11. ⟨10.1186/1475-2875-5-11⟩</idno> <idno type="halRef">Malaria Journal, BioMed Central, 2006, 5, pp.11. ⟨10.1186/1475-2875-5-11⟩</idno> </publicationStmt> <seriesStmt> <idno type="stamp" n="INSERM">INSERM - Institut national de la santé et de la recherche médicale</idno> <idno type="stamp" n="PASTEUR">Institut Pasteur</idno> <idno type="stamp" n="UCCS">Unité de Catalyse et de Chimie du Solide</idno> <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno> <idno type="stamp" n="EC-LILLE">Ecole Centrale de Lille</idno> <idno type="stamp" n="ENSC-LILLE">Ecole Nationale Supérieure de Chimie de Lille</idno> <idno type="stamp" n="RIIP_PARIS">Institut Pasteur de Paris</idno> <idno type="stamp" n="RIIP_LILLE">Institut Pasteur de Lille</idno> <idno type="stamp" n="INC-CNRS">Institut de Chimie du CNRS</idno> <idno type="stamp" n="UNIV-ARTOIS">Université d'Artois</idno> <idno type="stamp" n="SSA">Service de Santé des Armées</idno> <idno type="stamp" n="UNIV-TOURS">Université François Rabelais</idno> <idno type="stamp" n="RIIP">Institut Pasteur RIIP (Réseau International)</idno> <idno type="stamp" n="UNIV-LILLE">Université de Lille</idno> </seriesStmt> <notesStmt> <note type="audience" n="1">Not set</note> <note type="popular" n="0">No</note> <note type="peer" n="1">Yes</note> </notesStmt> <sourceDesc> <biblStruct> <analytic> <title xml:lang="en">Assessment of Plasmodium falciparum resistance to ferroquine (SSR97193) in field isolates and in W2 strain under pressure.</title> <author role="aut"> <persName> <forename type="first">Wassim</forename> <surname>Daher</surname> </persName> <idno type="halauthorid">113556</idno> <affiliation ref="#struct-2906"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Christophe</forename> <surname>Biot</surname> </persName> <idno type="halauthorid">120622</idno> <affiliation ref="#struct-3209"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Thierry</forename> <surname>Fandeur</surname> </persName> <idno type="halauthorid">120623</idno> <affiliation ref="#struct-140964"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Helene</forename> <surname>Jouin</surname> </persName> <idno type="halauthorid">120624</idno> <affiliation ref="#struct-2906"></affiliation> <affiliation ref="#struct-17213"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Lydie</forename> <surname>Pelinski</surname> </persName> <email type="md5">7c8fbcc88169f9dbdbee58975bc91eb9</email> <email type="domain">ensc-lille.fr</email> <idno type="idhal" notation="string">lydie-pelinski</idno> <idno type="idhal" notation="numeric">17821</idno> <idno type="halauthorid">113489</idno> <idno type="ORCID">https://orcid.org/0000-0002-5691-7550</idno> <affiliation ref="#struct-3209"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Eric</forename> <surname>Viscogliosi</surname> </persName> <idno type="halauthorid">120625</idno> <affiliation ref="#struct-2906"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Laurent</forename> <surname>Fraisse</surname> </persName> <idno type="halauthorid">120626</idno> <affiliation ref="#struct-19072"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Bruno</forename> <surname>Pradines</surname> </persName> <idno type="halauthorid">120627</idno> <affiliation ref="#struct-19073"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Jacques</forename> <forename type="middle">S.</forename> <surname>Brocard</surname> </persName> <idno type="halauthorid">106753</idno> <affiliation ref="#struct-3209"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Jamal</forename> <surname>Khalife</surname> </persName> <idno type="halauthorid">113564</idno> <affiliation ref="#struct-2906"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Daniel</forename> <surname>Dive</surname> </persName> <idno type="halauthorid">113560</idno> <affiliation ref="#struct-2906"></affiliation> </author> </analytic> <monogr> <idno type="halJournalId" status="VALID">1704</idno> <idno type="issn">1475-2875</idno> <title level="j">Malaria Journal</title> <imprint> <publisher>BioMed Central</publisher> <biblScope unit="volume">5</biblScope> <biblScope unit="pp">11</biblScope> <date type="datePub">2006</date> </imprint> </monogr> <idno type="doi">10.1186/1475-2875-5-11</idno> <idno type="pubmed">16464254</idno> </biblStruct> </sourceDesc> <profileDesc> <langUsage> <language ident="en">English</language> </langUsage> <textClass> <classCode scheme="halDomain" n="sdv.mhep.mi">Life Sciences [q-bio]/Human health and pathology/Infectious diseases</classCode> <classCode scheme="halTypology" n="ART">Journal articles</classCode> </textClass> <abstract xml:lang="en"> <p>BACKGROUND: Ferroquine (FQ), or SSR97193, is a novel antimalarial drug currently in phase I clinical trials. FQ is a unique organometallic compound designed to overcome the chloroquine (CQ) resistance problem. FQ revealed to be equally active on CQ-sensitive and CQ-resistant Plasmodium falciparum laboratory strains and field isolates. FQ is also curative on rodent malaria parasites. As FQ will be tested in patients, the potential for resistance to this drug was evaluated. METHODS: The relationship between CQ-resistant transporter gene genotype and susceptibility to FQ were studied in 33 Cambodian P. falciparum field isolates previously studied for their in vitro response to CQ. In parallel, the ability of the CQ-resistant strain W2, to become resistant to FQ under drug pressure was assessed. RESULTS: The IC50 values for FQ in field isolates were found to be unrelated to mutations occurring in the P. falciparum chloroquine resistance transporter (PfCRT) or to the level of expression of the corresponding mRNA. In vitro, under a drug pressure of 100 nM of FQ, transient survival was observed in only one of two experiments. CONCLUSION: Field isolates studies and experimental drug pressure experiments showed that FQ overcomes CQ resistance, which reinforces the potential of this compound as a new antimalarial drug.</p> </abstract> </profileDesc> </hal></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Hal/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000235 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Hal/Checkpoint/biblio.hfd -nk 000235 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= ChloroquineV1
|flux= Hal
|étape= Checkpoint
|type= RBID
|clé= Hal:inserm-00091291
|texte= Assessment of Plasmodium falciparum resistance to ferroquine (SSR97193) in field isolates and in W2 strain under pressure.
}}
| This area was generated with Dilib version V0.6.33. |  |