Adherence to treatment in systemic lupus erythematosus patients
Identifieur interne : 000133 ( Hal/Checkpoint ); précédent : 000132; suivant : 000134Adherence to treatment in systemic lupus erythematosus patients
Auteurs : Nathalie Costedoat-Chalumeau [France] ; Jacques Pouchot [France] ; Gaëlle Guettrot-Imbert [France] ; Veronique Le Guern [France] ; Gaëlle Leroux [France] ; Donata Marra [France] ; Nathalie Morel [France] ; Jean-Charles Piette [France]Source :
- Best Practice and Research: Clinical Rheumatology [ 1521-6942 ] ; 2013-06.
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- mix :
Abstract
Adherence is defined as "the extent to which a person's behaviour coincides with medical or health advice." Poor adherence to therapeutic regimens is a common and expensive problem in patients with chronic diseases including systemic lupus erythematosus (SLE) and is associated with a higher risk of flares, morbidity, hospitalisations and poor renal outcome. Non-adherence to the treatment is multifactorial for most patients and varies according to unintentional or intentional patterns. The rates of non-adherence in SLE patients range from 3% to 76% depending on the assessment methods, which are all subject to limitations. Indeed, poor adherence to therapeutic regimens is difficult to evaluate. Two studies have shown that undetectable blood hydroxychloroquine (HCQ) concentration may be a simple, objective and reliable marker of non-adherence in SLE patients. The accurate diagnosis of non-adherence may prevent one from incorrectly interpreting disease manifestations as a lack of response. It may then avoid an unnecessary or even dangerous treatment escalation.
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DOI: 10.1016/j.berh.2013.07.001
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Paris 5</orgName> <orgName type="acronym">UPD5</orgName> <date type="start">1971-01-01</date> <date type="end">2019-12-31</date> <desc> <address> <addrLine>12, rue de l'École de Médecine - 75270 Paris cedex 06</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.parisdescartes.fr/</ref> </desc> </hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Pouchot, Jacques" sort="Pouchot, Jacques" uniqKey="Pouchot J" first="Jacques" last="Pouchot">Jacques Pouchot</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-204525" status="VALID"> <orgName>Service de Médecine Interne [CHU HEGP]</orgName> <desc> <address> <addrLine>20, rue Leblanc 75015 Paris</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300068" type="direct"></relation> <relation active="#struct-300119" type="direct"></relation> <relation active="#struct-353414" type="indirect"></relation> <relation active="#struct-341272" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - 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Hôpitaux de Paris (AP-HP)</orgName> <orgName type="acronym">APHP</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Leroux, Gaelle" sort="Leroux, Gaelle" uniqKey="Leroux G" first="Gaëlle" last="Leroux">Gaëlle Leroux</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-353778" status="VALID"> <orgName>CHU Pitié-Salpêtrière [APHP]</orgName> <desc> <address> <addrLine>47-83 Boulevard de l'Hôpital, 75013 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.aphp.fr/contenu/hopital-universitaire-pitie-salpetriere-0</ref> </desc> </hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Marra, Donata" sort="Marra, Donata" uniqKey="Marra D" first="Donata" last="Marra">Donata Marra</name><affiliation wicri:level="1"><hal:affiliation type="department" xml:id="struct-457318" status="VALID"> <orgName>Service de Chirurgie Générale [CHU Pitié-Salpêtrière]</orgName> <desc> <address> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300068" type="direct"></relation> <relation active="#struct-353778" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName> <orgName type="acronym">APHP</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-353778" type="direct"><org type="institution" xml:id="struct-353778" status="VALID"> <orgName>CHU Pitié-Salpêtrière [APHP]</orgName> <desc> <address> <addrLine>47-83 Boulevard de l'Hôpital, 75013 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.aphp.fr/contenu/hopital-universitaire-pitie-salpetriere-0</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Morel, Nathalie" sort="Morel, Nathalie" uniqKey="Morel N" first="Nathalie" last="Morel">Nathalie Morel</name><affiliation wicri:level="1"><hal:affiliation type="department" xml:id="struct-189806" status="VALID"> <orgName>Service de médecine interne et centre de référence des maladies rares [CHU Cochin]</orgName> <desc> <address> <addrLine>27, rue du Faubourg Saint-Jacques 75014 Paris</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300123" type="direct"></relation> <relation active="#struct-300068" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300123" type="direct"><org type="institution" xml:id="struct-300123" status="VALID"> <orgName>CHU Cochin [AP-HP]</orgName> <desc> <address> <addrLine>27 Rue du Faubourg Saint-Jacques 75014 Paris</addrLine> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName> <orgName type="acronym">APHP</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Piette, Jean Charles" sort="Piette, Jean Charles" uniqKey="Piette J" first="Jean-Charles" last="Piette">Jean-Charles Piette</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-353778" status="VALID"> <orgName>CHU Pitié-Salpêtrière [APHP]</orgName> <desc> <address> <addrLine>47-83 Boulevard de l'Hôpital, 75013 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.aphp.fr/contenu/hopital-universitaire-pitie-salpetriere-0</ref> </desc> </hal:affiliation><country>France</country></affiliation></author></analytic><idno type="DOI">10.1016/j.berh.2013.07.001</idno><series><title level="j">Best Practice and Research: Clinical Rheumatology</title><idno type="ISSN">1521-6942</idno><imprint><date type="datePub">2013-06</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="mix" xml:lang="en"><term>Adherence</term><term>Compliance</term><term>Flare</term><term>Hydroxychloroquine</term><term>Systemic lupus erythematosus</term><term>Therapeutic drug monitoring</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"> <p>Adherence is defined as "the extent to which a person's behaviour coincides with medical or health advice." Poor adherence to therapeutic regimens is a common and expensive problem in patients with chronic diseases including systemic lupus erythematosus (SLE) and is associated with a higher risk of flares, morbidity, hospitalisations and poor renal outcome. Non-adherence to the treatment is multifactorial for most patients and varies according to unintentional or intentional patterns. The rates of non-adherence in SLE patients range from 3% to 76% depending on the assessment methods, which are all subject to limitations. Indeed, poor adherence to therapeutic regimens is difficult to evaluate. Two studies have shown that undetectable blood hydroxychloroquine (HCQ) concentration may be a simple, objective and reliable marker of non-adherence in SLE patients. The accurate diagnosis of non-adherence may prevent one from incorrectly interpreting disease manifestations as a lack of response. It may then avoid an unnecessary or even dangerous treatment escalation.</p> </div></front></TEI><hal api="V3"> <titleStmt> <title xml:lang="en">Adherence to treatment in systemic lupus erythematosus patients</title> <author role="aut"> <persName> <forename type="first">Nathalie</forename> <surname>Costedoat-Chalumeau</surname> </persName> <idno type="halauthorid">822653</idno> <affiliation ref="#struct-301664"></affiliation> <affiliation ref="#struct-189806"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Jacques</forename> <surname>Pouchot</surname> </persName> <idno type="halauthorid">700931</idno> <affiliation ref="#struct-204525"></affiliation> <affiliation ref="#struct-301664"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Gaëlle</forename> <surname>Guettrot-Imbert</surname> </persName> <idno type="halauthorid">974650</idno> <affiliation ref="#struct-301246"></affiliation> <affiliation ref="#struct-3215"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Veronique</forename> <surname>Le Guern</surname> </persName> <idno type="halauthorid">726666</idno> <affiliation ref="#struct-189806"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Gaëlle</forename> <surname>Leroux</surname> </persName> <idno type="halauthorid">11483300</idno> <affiliation ref="#struct-353778"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Donata</forename> <surname>Marra</surname> </persName> <idno type="halauthorid">11200634</idno> <affiliation ref="#struct-457318"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Nathalie</forename> <surname>Morel</surname> </persName> <email type="md5">b3683e981d766817b6bb39203517b25e</email> <email type="domain">sciences-po.fr</email> <idno type="halauthorid">1074196</idno> <orgName ref="#struct-378194"></orgName> <affiliation ref="#struct-189806"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Jean-Charles</forename> <surname>Piette</surname> </persName> <idno type="halauthorid">209164</idno> <affiliation ref="#struct-353778"></affiliation> </author> <editor role="depositor"> <persName> <forename>APEMAC</forename> <surname>UL</surname> </persName> <email type="md5">218c3331912c44530dad0f7d8b23c977</email> <email type="domain">univ-lorraine.fr</email> </editor> </titleStmt> <editionStmt> <edition n="v1" type="current"> <date type="whenSubmitted">2018-05-14 14:44:27</date> <date type="whenModified">2020-03-24 16:10:23</date> <date type="whenReleased">2018-05-14 14:44:27</date> <date type="whenProduced">2013-06</date> </edition> <respStmt> <resp>contributor</resp> <name key="572730"> <persName> <forename>APEMAC</forename> <surname>UL</surname> </persName> <email type="md5">218c3331912c44530dad0f7d8b23c977</email> <email type="domain">univ-lorraine.fr</email> </name> </respStmt> </editionStmt> <publicationStmt> <distributor>CCSD</distributor> <idno type="halId">hal-01791229</idno> <idno type="halUri">https://hal.univ-lorraine.fr/hal-01791229</idno> <idno type="halBibtex">costedoatchalumeau:hal-01791229</idno> <idno type="halRefHtml">Best Practice and Research: Clinical Rheumatology, Elsevier, 2013, 27 (3), pp.329 - 340. ⟨10.1016/j.berh.2013.07.001⟩</idno> <idno type="halRef">Best Practice and Research: Clinical Rheumatology, Elsevier, 2013, 27 (3), pp.329 - 340. ⟨10.1016/j.berh.2013.07.001⟩</idno> </publicationStmt> <seriesStmt> <idno type="stamp" n="UNIV-LORRAINE">Université de Lorraine</idno> <idno type="stamp" n="SANTE_PUB_INSERM" corresp="INSERM">Santé Publique à l'Inserm</idno> <idno type="stamp" n="APHP" corresp="INSERM">AP-HP</idno> <idno type="stamp" n="CHU-UNIV-PARIS5">Les centres hospitaliers de Paris Descartes</idno> <idno type="stamp" n="UNIV-PARIS5">Université Paris Descartes (Paris 5)</idno> <idno type="stamp" n="USPC">Université Sorbonne Paris Cité</idno> </seriesStmt> <notesStmt> <note type="audience" n="2">International</note> <note type="popular" n="0">No</note> <note type="peer" n="1">Yes</note> </notesStmt> <sourceDesc> <biblStruct> <analytic> <title xml:lang="en">Adherence to treatment in systemic lupus erythematosus patients</title> <author role="aut"> <persName> <forename type="first">Nathalie</forename> <surname>Costedoat-Chalumeau</surname> </persName> <idno type="halauthorid">822653</idno> <affiliation ref="#struct-301664"></affiliation> <affiliation ref="#struct-189806"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Jacques</forename> <surname>Pouchot</surname> </persName> <idno type="halauthorid">700931</idno> <affiliation ref="#struct-204525"></affiliation> <affiliation ref="#struct-301664"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Gaëlle</forename> <surname>Guettrot-Imbert</surname> </persName> <idno type="halauthorid">974650</idno> <affiliation ref="#struct-301246"></affiliation> <affiliation ref="#struct-3215"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Veronique</forename> <surname>Le Guern</surname> </persName> <idno type="halauthorid">726666</idno> <affiliation ref="#struct-189806"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Gaëlle</forename> <surname>Leroux</surname> </persName> <idno type="halauthorid">11483300</idno> <affiliation ref="#struct-353778"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Donata</forename> <surname>Marra</surname> </persName> <idno type="halauthorid">11200634</idno> <affiliation ref="#struct-457318"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Nathalie</forename> <surname>Morel</surname> </persName> <email type="md5">b3683e981d766817b6bb39203517b25e</email> <email type="domain">sciences-po.fr</email> <idno type="halauthorid">1074196</idno> <orgName ref="#struct-378194"></orgName> <affiliation ref="#struct-189806"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Jean-Charles</forename> <surname>Piette</surname> </persName> <idno type="halauthorid">209164</idno> <affiliation ref="#struct-353778"></affiliation> </author> </analytic> <monogr> <idno type="halJournalId" status="VALID">11049</idno> <idno type="issn">1521-6942</idno> <title level="j">Best Practice and Research: Clinical Rheumatology</title> <imprint> <publisher>Elsevier</publisher> <biblScope unit="volume">27</biblScope> <biblScope unit="issue">3</biblScope> <biblScope unit="pp">329 - 340</biblScope> <date type="datePub">2013-06</date> </imprint> </monogr> <idno type="doi">10.1016/j.berh.2013.07.001</idno> <idno type="pubmed">24238690</idno> </biblStruct> </sourceDesc> <profileDesc> <langUsage> <language ident="en">English</language> </langUsage> <textClass> <keywords scheme="author"> <term xml:lang="en">Adherence</term> <term xml:lang="en">Compliance</term> <term xml:lang="en">Flare</term> <term xml:lang="en">Hydroxychloroquine</term> <term xml:lang="en">Systemic lupus erythematosus</term> <term xml:lang="en">Therapeutic drug monitoring</term> </keywords> <classCode scheme="mesh">Antirheumatic Agents</classCode> <classCode scheme="mesh">Attitude to Health</classCode> <classCode scheme="mesh">Biomarkers</classCode> <classCode scheme="mesh">Drug Monitoring</classCode> <classCode scheme="mesh">Humans</classCode> <classCode scheme="mesh">Hydroxychloroquine</classCode> <classCode scheme="mesh">Lupus Erythematosus, Systemic</classCode> <classCode scheme="mesh">Medication Adherence</classCode> <classCode scheme="halDomain" n="sdv.spee">Life Sciences [q-bio]/Santé publique et épidémiologie</classCode> <classCode scheme="halTypology" n="ART">Journal articles</classCode> </textClass> <abstract xml:lang="en"> <p>Adherence is defined as "the extent to which a person's behaviour coincides with medical or health advice." Poor adherence to therapeutic regimens is a common and expensive problem in patients with chronic diseases including systemic lupus erythematosus (SLE) and is associated with a higher risk of flares, morbidity, hospitalisations and poor renal outcome. Non-adherence to the treatment is multifactorial for most patients and varies according to unintentional or intentional patterns. The rates of non-adherence in SLE patients range from 3% to 76% depending on the assessment methods, which are all subject to limitations. Indeed, poor adherence to therapeutic regimens is difficult to evaluate. Two studies have shown that undetectable blood hydroxychloroquine (HCQ) concentration may be a simple, objective and reliable marker of non-adherence in SLE patients. The accurate diagnosis of non-adherence may prevent one from incorrectly interpreting disease manifestations as a lack of response. It may then avoid an unnecessary or even dangerous treatment escalation.</p> </abstract> </profileDesc> </hal></record>Pour manipuler ce document sous Unix (Dilib)
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