HIBISCUS: Hydroxychloroquine for the secondary prevention of thrombotic and obstetrical events in primary antiphospholipid syndrome
Identifieur interne : 000022 ( Hal/Checkpoint ); précédent : 000021; suivant : 000023HIBISCUS: Hydroxychloroquine for the secondary prevention of thrombotic and obstetrical events in primary antiphospholipid syndrome
Auteurs : Cristina Belizna [France] ; Francesca Pregnolato [Italie] ; Sébastien Abad [France] ; Jaume Alijotas-Reig [Espagne] ; Howard Amital [Israël] ; Zahir Amoura [France] ; Laura Andreoli [Italie] ; Emmanuel Andres [France] ; Achile Aouba [France] ; Sule Apras Bilgen [Turquie] ; Laurent Arnaud [France] ; Boris Bienvenu [France] ; Viktoria Bitsadze [Russie] ; Patrick Blanco [France] ; Miri Blank [Israël] ; Maria Borghi [Italie] ; Antonia Caligaro [Italie] ; Elisabeta Candrea [Roumanie] ; Valentina Canti [Italie] ; Laurent Chiche [France] ; Jean Chrétien [France] ; Jan Willem Cohen Tervaert [Pays-Bas] ; Laura Damian [Roumanie] ; Teresa Delross [Italie] ; Emmanuelle Dernis [France] ; Katrien Devreese [Belgique] ; Aleksandra Djokovic [Serbie] ; Enrique Esteve-Valverde [Espagne] ; Maria Favaro [Italie] ; Céline Fassot [France] ; Raquel Ferrer-Oliveras [Espagne] ; Alban Godon [France] ; Mohamed Hamidou [France] ; Milena Hasan [France] ; Daniel Henrion [France] ; Bernard Imbert [France] ; Pierre Yves Jeandel [France] ; Pascale Jeannin [France] ; Patrick Jego [France] ; Noemie Jourde-Chiche [France] ; Jamilya Khizroeva [Russie] ; Olivier Lambotte [France] ; Cédric Landron [France] ; Jose Omar Latino [Argentine] ; Estibaliz Lazaro [France] ; Karina De Leeuw [Pays-Bas] ; Thomas Le Gallou [France] ; Levent Kiliç [Turquie] ; Maarten Limper [Pays-Bas] ; Laurent Loufrani [France] ; Romain Lubin [France] ; Nadine Magy-Bertrand [France] ; Guillaume Mahé [France] ; Alexander Makatsariya [Russie] ; Thierry Martin [France] ; Christian Muchardt [France] ; Gyorgy Nagy ; Loukman Omarjee [France] ; Pieter Van Paasen [Hongrie] ; Gilles Pernod [France] ; Florence Perrinet ; Gilberto Pïres Rosa [Portugal] ; Marc Antoine Pistorius [France] ; Amelia Ruffatti [Italie] ; Fatma Said [Tunisie] ; Patrick Saulnier [France] ; Damien Sene [France] ; Loïc Sentilhes [France] ; Ova Shovman [Israël] ; Jean Sibilia [France] ; Crina Sinescu [Roumanie] ; Natasa Stanisavljevic [Serbie] ; Ljudmila Stojanovich [Serbie] ; Lai Shan Tam [République populaire de Chine] ; Angela Tincani [Italie] ; Fréderic Tollis [France] ; Sebastian Udry [Argentine] ; Marie Noelle Ungeheuer [France] ; Mathilde Versini [France] ; Ricard Cervera [Espagne] ; Pier Luigi Meroni [Italie]Source :
- Autoimmunity Reviews [ 1568-9972 ] ; 2018-12.
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Abstract
The relapse rate in antiphospholipid syndrome (APS) remains high, i.e. around 20%–21% at 5 years in thrombotic APS and 20–28% in obstetrical APS [2, 3].Hydroxychloroquine (HCQ) appears as an additional therapy, as it possesses immunomodulatory and anti-thrombotic various effects [4–16].Our group recently obtained the orphan designation of HCQ in antiphospholipid syndrome by the European Medicine Agency.Furthermore, the leaders of the project made the proposal of an international project, HIBISCUS, about the use of Hydroxychloroquine in secondary prevention of obstetrical and thrombotic events in primary APS. This study has been launched in several countries and at now, 53 centers from 16 countries participate to this international trial.This trial consists in two parts: a retrospective and a prospective study.The French part of the trial in thrombosis has been granted by the French Minister of Health in December 2015 (the academic trial independent of the pharmaceutical industry PHRC N PAPIRUS) and is coordinated by one of the members of the leading consortium of HIBISCUS.
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DOI: 10.1016/j.autrev.2018.05.012
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type="wicri:source">HAL</idno><idno type="RBID">Hal:hal-01936357</idno><idno type="halId">hal-01936357</idno><idno type="halUri">https://hal-univ-rennes1.archives-ouvertes.fr/hal-01936357</idno><idno type="url">https://hal-univ-rennes1.archives-ouvertes.fr/hal-01936357</idno><idno type="doi">10.1016/j.autrev.2018.05.012</idno><date when="2018-12">2018-12</date><idno type="wicri:Area/Hal/Corpus">000107</idno><idno type="wicri:Area/Hal/Curation">000107</idno><idno type="wicri:Area/Hal/Checkpoint">000022</idno><idno type="wicri:explorRef" wicri:stream="Hal" wicri:step="Checkpoint">000022</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">HIBISCUS: Hydroxychloroquine for the secondary prevention of thrombotic and obstetrical events in primary antiphospholipid syndrome</title><author><name sortKey="Belizna, Cristina" sort="Belizna, Cristina" uniqKey="Belizna C" first="Cristina" last="Belizna">Cristina Belizna</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-151939" status="VALID"> <orgName>Centre Hospitalier Universitaire d'Angers</orgName> <orgName type="acronym">CHU Angers</orgName> <desc> <address> <addrLine>4 rue Larrey - 49933 Angers cedex 9</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.chu-angers.fr/</ref> </desc> <listRelation> <relation active="#struct-301358" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-301358" type="direct"><org type="regroupinstitution" xml:id="struct-301358" status="OLD"> <idno type="IdRef">187401039</idno> <orgName>PRES Université Nantes Angers Le Mans</orgName> <orgName type="acronym">UNAM</orgName> <date type="start">2008-12-31</date> <date type="end">2016-01-01</date> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Pregnolato, Francesca" sort="Pregnolato, Francesca" uniqKey="Pregnolato F" first="Francesca" last="Pregnolato">Francesca Pregnolato</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-380289" status="VALID"> <orgName>Istituto di Ricovero e Cura a Carattere Scientifico</orgName> <orgName type="acronym">IRCCS</orgName> <desc> <address> <addrLine>Via Conte Ruggiero, 73, 94018 Troina EN</addrLine> <country key="IT"></country> </address> </desc> </hal:affiliation><country>Italie</country></affiliation></author><author><name sortKey="Abad, Sebastien" sort="Abad, Sebastien" uniqKey="Abad S" first="Sébastien" last="Abad">Sébastien Abad</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-15786" status="VALID"> <orgName>Université Paris 13</orgName> <orgName type="acronym">UP13</orgName> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.univ-paris13.fr/</ref> </desc> </hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Alijotas Reig, Jaume" sort="Alijotas Reig, Jaume" uniqKey="Alijotas Reig J" first="Jaume" last="Alijotas-Reig">Jaume Alijotas-Reig</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-410219" status="VALID"> <orgName>Vall d'Hebron University Hospital [Barcelona]</orgName> <desc> <address> <addrLine>C/ Natzaret, 115-11708035 Barcelona</addrLine> <country key="ES"></country> </address> <ref type="url">http://www.vhio.net/about-vhio/en_hospital-vall-hebron.php</ref> </desc> </hal:affiliation><country>Espagne</country></affiliation></author><author><name sortKey="Amital, Howard" sort="Amital, Howard" uniqKey="Amital H" first="Howard" last="Amital">Howard Amital</name><affiliation wicri:level="1"><hal:affiliation type="regrouplaboratory" xml:id="struct-425188" status="VALID"> <orgName>Sackler Faculty of Medicine</orgName> <desc> <address> <addrLine>Tel Aviv 69978</addrLine> <country key="IL"></country> </address> </desc> <listRelation> <relation 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Box 39040, Tel Aviv 6997801</addrLine> <country key="IL"></country> </address> <ref type="url">http://english.tau.ac.il/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>Israël</country></affiliation></author><author><name sortKey="Amoura, Zahir" sort="Amoura, Zahir" uniqKey="Amoura Z" first="Zahir" last="Amoura">Zahir Amoura</name><affiliation wicri:level="1"><hal:affiliation type="department" xml:id="struct-18474" status="VALID"> <orgName>Service de médecine interne [CHU Pitié-Salpétrière]</orgName> <desc> <address> <addrLine>47-83, boulevard de l'Hôpital 75651 PARIS Cedex 13</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300068" type="direct"></relation> <relation active="#struct-353778" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName> <orgName type="acronym">APHP</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-353778" type="direct"><org type="institution" xml:id="struct-353778" status="VALID"> <orgName>CHU Pitié-Salpêtrière [APHP]</orgName> <desc> <address> <addrLine>47-83 Boulevard de l'Hôpital, 75013 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.aphp.fr/contenu/hopital-universitaire-pitie-salpetriere-0</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Andreoli, Laura" sort="Andreoli, Laura" uniqKey="Andreoli L" first="Laura" last="Andreoli">Laura Andreoli</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-446585" status="VALID"> <orgName>University of Brescia</orgName> <desc> <address> <addrLine>Piazza del Mercato, 15, Brescia BS, Italia</addrLine> <country key="IT"></country> </address> <ref type="url">http://www.unibs.it/</ref> </desc> </hal:affiliation><country>Italie</country></affiliation></author><author><name sortKey="Andres, Emmanuel" sort="Andres, Emmanuel" uniqKey="Andres E" first="Emmanuel" last="Andres">Emmanuel Andres</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-300149" status="VALID"> <orgName>CHU Strasbourg</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Aouba, Achile" sort="Aouba, Achile" uniqKey="Aouba A" first="Achile" last="Aouba">Achile Aouba</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-7127" status="VALID"> <idno type="IdRef">026403064</idno> <idno type="ISNI">0000000121864076</idno> <orgName>Université de Caen Normandie</orgName> <orgName type="acronym">UNICAEN</orgName> <date type="start">1432-01-01</date> <desc> <address> <addrLine>Esplanade de la Paix - CS 14032 - 14032 CAEN Cedex 5</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.unicaen.fr/</ref> </desc> <listRelation> <relation active="#struct-455934" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-455934" type="direct"><org type="regroupinstitution" xml:id="struct-455934" status="VALID"> <idno type="IdRef">190906332</idno> <idno type="ISNI">0000000417859671 </idno> <orgName>Normandie Université</orgName> <orgName type="acronym">NU</orgName> <date type="start">2015-01-01</date> <desc> <address> <addrLine>Esplanade de la Paix - CS 14032 - 14032 Caen Cedex 5</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.normandie-univ.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Apras Bilgen, Sule" sort="Apras Bilgen, Sule" uniqKey="Apras Bilgen S" first="Sule" last="Apras Bilgen">Sule Apras Bilgen</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-65505" status="VALID"> <orgName>Hacettepe University = Hacettepe Üniversitesi</orgName> <desc> <address> <addrLine>Hacettepe Üniversitesi Rektörlüğü Sıhhiye / ANKARA</addrLine> <country key="TR"></country> </address> <ref type="url">https://www.hacettepe.edu.tr/english/</ref> </desc> </hal:affiliation><country>Turquie</country></affiliation></author><author><name sortKey="Arnaud, Laurent" sort="Arnaud, Laurent" uniqKey="Arnaud L" first="Laurent" last="Arnaud">Laurent Arnaud</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-300149" status="VALID"> <orgName>CHU Strasbourg</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Bienvenu, Boris" sort="Bienvenu, Boris" uniqKey="Bienvenu B" first="Boris" last="Bienvenu">Boris Bienvenu</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-311338" status="VALID"> <orgName>Hôpital Saint-Joseph [Marseille]</orgName> <date type="start">1919</date> <desc> <address> <addrLine>Hôpital Saint-Joseph26 Boulevard de Louvain, 13000 Marseille</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.hopital-saint-joseph.fr/index.php</ref> </desc> </hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Bitsadze, Viktoria" sort="Bitsadze, Viktoria" uniqKey="Bitsadze V" first="Viktoria" last="Bitsadze">Viktoria Bitsadze</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-548801" status="INCOMING"> <orgName>Department of Obstetrics and Gynecology, I.M. 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<tutelles><tutelle active="#struct-300027" type="direct"><org type="institution" xml:id="struct-300027" status="VALID"> <idno type="IdRef">027936643</idno> <idno type="ISNI">0000 0001 2353 6535</idno> <orgName>Institut Pasteur [Paris]</orgName> <date type="start">1887-06-04</date> <desc> <address> <addrLine>25-28, rue du docteur Roux, 75724 Paris cedex 15</addrLine> <country key="FR"></country> </address> <ref type="url">https://www.pasteur.fr</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Versini, Mathilde" sort="Versini, Mathilde" uniqKey="Versini M" first="Mathilde" last="Versini">Mathilde Versini</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-469997" status="VALID"> <orgName>Institut Arnault Tzanck</orgName> <desc> <address> <addrLine>Institut Arnaud Tzanck, Liver Unit, St. Laurent du Var, France</addrLine> <country key="FR"></country> </address> <ref type="url">http://saintlaurentduvar.tzanck.org/</ref> </desc> </hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Cervera, Ricard" sort="Cervera, Ricard" uniqKey="Cervera R" first="Ricard" last="Cervera">Ricard Cervera</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-125182" status="VALID"> <orgName>Barcelona Centre for International Health Research, Hospital Clinic</orgName> <orgName type="acronym">CRESIB</orgName> <desc> <address> <addrLine>Barcelona</addrLine> <country key="ES"></country> </address> </desc> <listRelation> <relation active="#struct-3447" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-3447" type="direct"><org type="institution" xml:id="struct-3447" status="VALID"> <orgName>Universitat de Barcelona</orgName> <orgName type="acronym">UB</orgName> <desc> <address> <addrLine>Gran Via de les Corts Catalanes, 585, 08007 Barcelona</addrLine> <country key="ES"></country> </address> <ref type="url">http://www.ub.edu/web/ub/en</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>Espagne</country><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName><orgName type="university">Université de Barcelone</orgName></affiliation></author><author><name sortKey="Meroni, Pier Luigi" sort="Meroni, Pier Luigi" uniqKey="Meroni P" first="Pier Luigi" last="Meroni">Pier Luigi Meroni</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-363961" status="VALID"> <orgName>Istituti di Ricovero e Cura a Carattere Scientifico </orgName> <orgName type="acronym">IRCCS</orgName> <desc> <address> <country key="IT"></country> </address> <ref type="url">http://www.salute.gov.it/portale/temi/p2_6.jsp?lingua=italiano&id=794&area=Ricerca%20sanitaria&menu=ssn</ref> </desc> </hal:affiliation><country>Italie</country></affiliation></author></analytic><idno type="DOI">10.1016/j.autrev.2018.05.012</idno><series><title level="j">Autoimmunity Reviews</title><idno type="ISSN">1568-9972</idno><imprint><date type="datePub">2018-12</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="mix" xml:lang="en"><term>Antiphospholipid syndrome</term><term>Hydroxychloroquine</term><term>Primary antiphospholipid syndrome</term><term>Secondary prevention</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"> <p>The relapse rate in antiphospholipid syndrome (APS) remains high, i.e. around 20%–21% at 5 years in thrombotic APS and 20–28% in obstetrical APS [2, 3].Hydroxychloroquine (HCQ) appears as an additional therapy, as it possesses immunomodulatory and anti-thrombotic various effects [4–16].Our group recently obtained the orphan designation of HCQ in antiphospholipid syndrome by the European Medicine Agency.Furthermore, the leaders of the project made the proposal of an international project, HIBISCUS, about the use of Hydroxychloroquine in secondary prevention of obstetrical and thrombotic events in primary APS. This study has been launched in several countries and at now, 53 centers from 16 countries participate to this international trial.This trial consists in two parts: a retrospective and a prospective study.The French part of the trial in thrombosis has been granted by the French Minister of Health in December 2015 (the academic trial independent of the pharmaceutical industry PHRC N PAPIRUS) and is coordinated by one of the members of the leading consortium of HIBISCUS.</p> </div></front></TEI><hal api="V3"> <titleStmt> <title xml:lang="en">HIBISCUS: Hydroxychloroquine for the secondary prevention of thrombotic and obstetrical events in primary antiphospholipid syndrome</title> <author role="aut"> <persName> <forename type="first">Cristina</forename> <surname>Belizna</surname> </persName> <idno type="halauthorid">1299311</idno> <affiliation ref="#struct-151939"></affiliation> <affiliation ref="#struct-179941"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Francesca</forename> <surname>Pregnolato</surname> </persName> <idno type="halauthorid">11335000</idno> <affiliation ref="#struct-380289"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Sébastien</forename> <surname>Abad</surname> </persName> <idno type="halauthorid">1195400</idno> <affiliation ref="#struct-15786"></affiliation> <affiliation ref="#struct-116551"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Jaume</forename> <surname>Alijotas-Reig</surname> </persName> <idno type="halauthorid">11335001</idno> <affiliation ref="#struct-410219"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Howard</forename> <surname>Amital</surname> </persName> <idno type="halauthorid">802053</idno> <affiliation ref="#struct-425188"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Zahir</forename> <surname>Amoura</surname> </persName> <idno 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type="domain">hotmail.com</email> <idno type="halauthorid">724682</idno> <affiliation ref="#struct-300122"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Ova</forename> <surname>Shovman</surname> </persName> <idno type="halauthorid">11335028</idno> <affiliation ref="#struct-425188"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Jean</forename> <surname>Sibilia</surname> </persName> <email type="md5">f17089adc2c98d77dca69e76c67f304e</email> <email type="domain">chru-strasbourg.fr</email> <idno type="halauthorid">945230</idno> <affiliation ref="#struct-102530"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Crina</forename> <surname>Sinescu</surname> </persName> <idno type="halauthorid">11335029</idno> <affiliation ref="#struct-301424"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Natasa</forename> <surname>Stanisavljevic</surname> </persName> <idno 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type="first">Sebastian</forename> <surname>Udry</surname> </persName> <idno type="halauthorid">11335034</idno> <affiliation ref="#struct-535787"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Marie Noelle</forename> <surname>Ungeheuer</surname> </persName> <idno type="halauthorid">11238318</idno> <affiliation ref="#struct-411827"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Mathilde</forename> <surname>Versini</surname> </persName> <idno type="halauthorid">1586196</idno> <affiliation ref="#struct-469997"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Ricard</forename> <surname>Cervera</surname> </persName> <idno type="halauthorid">1510915</idno> <affiliation ref="#struct-125182"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Pier Luigi</forename> <surname>Meroni</surname> </persName> <idno type="halauthorid">11238324</idno> <affiliation ref="#struct-363961"></affiliation> </author> <editor role="depositor"> <persName> <forename>Laurent</forename> <surname>Jonchère</surname> </persName> <email type="md5">8503b29898396526c56d96d8ae07e3e5</email> <email type="domain">univ-rennes1.fr</email> </editor> <funder>The HIBISCUS study is funded for its French part of the trial by the Ministery of Health, France in 2015 (PHRC N PAPIRUS).</funder> </titleStmt> <editionStmt> <edition n="v1" type="current"> <date type="whenSubmitted">2018-11-27 13:33:16</date> <date type="whenModified">2020-03-25 13:01:01</date> <date type="whenReleased">2018-11-27 13:33:16</date> <date type="whenProduced">2018-12</date> </edition> <respStmt> <resp>contributor</resp> <name key="113861"> <persName> <forename>Laurent</forename> <surname>Jonchère</surname> </persName> <email type="md5">8503b29898396526c56d96d8ae07e3e5</email> <email type="domain">univ-rennes1.fr</email> </name> </respStmt> </editionStmt> <publicationStmt> 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type="halauthorid">11335029</idno> <affiliation ref="#struct-301424"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Natasa</forename> <surname>Stanisavljevic</surname> </persName> <idno type="halauthorid">11335030</idno> <affiliation ref="#struct-167343"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Ljudmila</forename> <surname>Stojanovich</surname> </persName> <idno type="halauthorid">11238315</idno> <affiliation ref="#struct-167343"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Lai Shan</forename> <surname>Tam</surname> </persName> <idno type="halauthorid">11335031</idno> <affiliation ref="#struct-93116"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Angela</forename> <surname>Tincani</surname> </persName> <idno type="halauthorid">11335032</idno> <affiliation ref="#struct-446585"></affiliation> </author> <author role="aut"> <persName> <forename 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ref="#struct-125182"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Pier Luigi</forename> <surname>Meroni</surname> </persName> <idno type="halauthorid">11238324</idno> <affiliation ref="#struct-363961"></affiliation> </author> </analytic> <monogr> <idno type="halJournalId" status="VALID">10938</idno> <idno type="issn">1568-9972</idno> <title level="j">Autoimmunity Reviews</title> <imprint> <publisher>Elsevier</publisher> <biblScope unit="volume">17</biblScope> <biblScope unit="issue">12</biblScope> <biblScope unit="pp">1153 - 1168</biblScope> <date type="datePub">2018-12</date> </imprint> </monogr> <idno type="doi">10.1016/j.autrev.2018.05.012</idno> <idno type="pubmed">30316994</idno> </biblStruct> </sourceDesc> <profileDesc> <langUsage> <language ident="en">English</language> </langUsage> <textClass> <keywords scheme="author"> <term xml:lang="en">Primary antiphospholipid syndrome</term> <term xml:lang="en">Antiphospholipid syndrome</term> <term xml:lang="en">Hydroxychloroquine</term> <term xml:lang="en">Secondary prevention</term> </keywords> <classCode scheme="halDomain" n="sdv">Life Sciences [q-bio]</classCode> <classCode scheme="halDomain" n="sdv.imm">Life Sciences [q-bio]/Immunology</classCode> <classCode scheme="halTypology" n="ART">Journal articles</classCode> </textClass> <abstract xml:lang="en"> <p>The relapse rate in antiphospholipid syndrome (APS) remains high, i.e. around 20%–21% at 5 years in thrombotic APS and 20–28% in obstetrical APS [2, 3].Hydroxychloroquine (HCQ) appears as an additional therapy, as it possesses immunomodulatory and anti-thrombotic various effects [4–16].Our group recently obtained the orphan designation of HCQ in antiphospholipid syndrome by the European Medicine Agency.Furthermore, the leaders of the project made the proposal of an international project, HIBISCUS, about the use of Hydroxychloroquine in secondary prevention of obstetrical and thrombotic events in primary APS. This study has been launched in several countries and at now, 53 centers from 16 countries participate to this international trial.This trial consists in two parts: a retrospective and a prospective study.The French part of the trial in thrombosis has been granted by the French Minister of Health in December 2015 (the academic trial independent of the pharmaceutical industry PHRC N PAPIRUS) and is coordinated by one of the members of the leading consortium of HIBISCUS.</p> </abstract> <particDesc> <org type="consortium">The investigators are very grateful to Professor Y Shoenfeld for the scientific revision of the design and very valuable remarks. The investigators are also grateful to the patients, patients' association, collaborators and networks involved in the trial and to the research staff at all participating hospitals.</org> </particDesc> </profileDesc> </hal></record>Pour manipuler ce document sous Unix (Dilib)
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