The effect of increasing the dose of hydroxychloroquine (HCQ) in patients with refractory cutaneous lupus erythematosus (CLE): An open-label prospective pilot study
Identifieur interne : 000119 ( France/Extraction ); précédent : 000118; suivant : 000120The effect of increasing the dose of hydroxychloroquine (HCQ) in patients with refractory cutaneous lupus erythematosus (CLE): An open-label prospective pilot study
Auteurs : François Chasset [France] ; Laurent Arnaud [France] ; Nathalie Costedoat-Chalumeau [France] ; Noël Zahr [France] ; Didier Bessis [France] ; Camille Francès [France]Source :
- Journal of The American Academy of Dermatology [ 0190-9622 ] ; 2016-04.
English descriptors
- mix :
Abstract
BACKGROUND:Up to 30% of patients with cutaneous lupus erythematosus (CLE) fail to respond to hydroxychloroquine (HCQ).OBJECTIVES:We sought to evaluate the efficacy of increased daily doses of HCQ on cutaneous response in refractory CLE.METHODS:We conducted an open-label prospective study between 2010 and 2014. Patients with CLE and HCQ blood level less than or equal to 750 ng/mL were included. The daily dose of HCQ was increased to reach blood concentrations greater than 750 ng/mL. The primary end point was the number of responders defined by an improvement of CLE Disease Area and Severity Index score (4 points or 20% decrease) in patients with HCQ blood concentration greater than 750 ng/mL.RESULTS:We included 34 patients (26 women; median age 45 [range 28-72] years). Two nonadherent patients were excluded. The median CLE Disease Area and Severity Index score before treatment was significantly improved after treatment (8 [range 2-30] vs 1.5 [range 0-30]), P < .001). The primary response criterion was reached in 26 (81%) of the 32 patients analyzed. A decrease in HCQ doses without further CLE flare (median follow-up 15.8 [range 3.06-77.4] months) was achieved in 15 of the 26 responders.LIMITATIONS:The main limitations of the study are its open-label design and the limited number of patients included.CONCLUSIONS:Increasing HCQ doses to reach blood concentrations greater than 750 ng/mL should be considered before addition of other treatments in refractory CLE.
Url:
DOI: 10.1016/j.jaad.2015.09.064
Links toward previous steps (curation, corpus...)
- to stream Hal, to step Corpus: 000239
- to stream Hal, to step Curation: 000239
- to stream Hal, to step Checkpoint: 000078
- to stream Main, to step Merge: 000D42
- to stream Main, to step Curation: 000D42
- to stream Main, to step Exploration: 000D42
Links to Exploration step
Hal:hal-01988149Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The effect of increasing the dose of hydroxychloroquine (HCQ) in patients with refractory cutaneous lupus erythematosus (CLE): An open-label prospective pilot study</title>
<author><name sortKey="Chasset, Francois" sort="Chasset, Francois" uniqKey="Chasset F" first="François" last="Chasset">François Chasset</name>
<affiliation wicri:level="1"><hal:affiliation type="department" xml:id="struct-223222" status="VALID"> <orgName>Service de Dermatologie [CHU Tenon]</orgName>
<desc> <address> <addrLine>4 Rue de la Chine 75020 Paris</addrLine>
<country key="FR"></country>
</address>
</desc>
<listRelation> <relation active="#struct-300068" type="direct"></relation>
<relation active="#struct-328304" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName>
<orgName type="acronym">APHP</orgName>
<desc> <address> <country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle active="#struct-328304" type="direct"><org type="institution" xml:id="struct-328304" status="VALID"> <orgName>CHU Tenon [APHP]</orgName>
<desc> <address> <addrLine>4 Rue de la Chine, 75020 Paris</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.aphp.fr/contenu/hopital-tenon-1</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Arnaud, Laurent" sort="Arnaud, Laurent" uniqKey="Arnaud L" first="Laurent" last="Arnaud">Laurent Arnaud</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-267618" status="OLD"> <idno type="RNSR">201420917E</idno>
<orgName>Institut Pierre Louis d'Epidémiologie et de Santé Publique</orgName>
<orgName type="acronym">iPLESP</orgName>
<desc> <address> <addrLine>56, boulevard Vincent Auriol - CS 81393 - 75646 Paris Cedex 13</addrLine>
<country key="FR"></country>
</address>
<ref type="url">https://www.iplesp.upmc.fr/</ref>
</desc>
<listRelation> <relation active="#struct-93591" type="direct"></relation>
<relation name="U1136" active="#struct-303623" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-93591" type="direct"><org type="institution" xml:id="struct-93591" status="OLD"> <orgName>Université Pierre et Marie Curie - Paris 6</orgName>
<orgName type="acronym">UPMC</orgName>
<date type="end">2017-12-31</date>
<desc> <address> <addrLine>4 place Jussieu - 75005 Paris</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.upmc.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="U1136" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno>
<orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
<orgName type="acronym">INSERM</orgName>
<desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.inserm.fr</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Costedoat Chalumeau, Nathalie" sort="Costedoat Chalumeau, Nathalie" uniqKey="Costedoat Chalumeau N" first="Nathalie" last="Costedoat-Chalumeau">Nathalie Costedoat-Chalumeau</name>
<affiliation wicri:level="1"><hal:affiliation type="department" xml:id="struct-189806" status="VALID"> <orgName>Service de médecine interne et centre de référence des maladies rares [CHU Cochin]</orgName>
<desc> <address> <addrLine>27, rue du Faubourg Saint-Jacques 75014 Paris</addrLine>
<country key="FR"></country>
</address>
</desc>
<listRelation> <relation active="#struct-300123" type="direct"></relation>
<relation active="#struct-300068" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-300123" type="direct"><org type="institution" xml:id="struct-300123" status="VALID"> <orgName>CHU Cochin [AP-HP]</orgName>
<desc> <address> <addrLine>27 Rue du Faubourg Saint-Jacques 75014 Paris</addrLine>
<country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName>
<orgName type="acronym">APHP</orgName>
<desc> <address> <country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Zahr, Noel" sort="Zahr, Noel" uniqKey="Zahr N" first="Noël" last="Zahr">Noël Zahr</name>
<affiliation wicri:level="1"><hal:affiliation type="department" xml:id="struct-41012" status="VALID"> <orgName>Service de pharmacologie biologique [CHU Pitié-Salpâtrière]</orgName>
<desc> <address> <addrLine>47-83, boulevard de l'Hôpital 75651 PARIS Cedex 13</addrLine>
<country key="FR"></country>
</address>
</desc>
<listRelation> <relation active="#struct-300068" type="direct"></relation>
<relation active="#struct-353778" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName>
<orgName type="acronym">APHP</orgName>
<desc> <address> <country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle active="#struct-353778" type="direct"><org type="institution" xml:id="struct-353778" status="VALID"> <orgName>CHU Pitié-Salpêtrière [APHP]</orgName>
<desc> <address> <addrLine>47-83 Boulevard de l'Hôpital, 75013 Paris</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.aphp.fr/contenu/hopital-universitaire-pitie-salpetriere-0</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Bessis, Didier" sort="Bessis, Didier" uniqKey="Bessis D" first="Didier" last="Bessis">Didier Bessis</name>
<affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-258773" status="VALID"> <orgName>Centre Hospitalier Régional Universitaire [Montpellier]</orgName>
<orgName type="acronym">CHRU Montpellier</orgName>
<desc> <address> <addrLine>191 avenue du doyen Gaston Giraud 34295 Montpellier cedex 5</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.chu-montpellier.fr</ref>
</desc>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Frances, Camille" sort="Frances, Camille" uniqKey="Frances C" first="Camille" last="Francès">Camille Francès</name>
<affiliation wicri:level="1"><hal:affiliation type="department" xml:id="struct-223222" status="VALID"> <orgName>Service de Dermatologie [CHU Tenon]</orgName>
<desc> <address> <addrLine>4 Rue de la Chine 75020 Paris</addrLine>
<country key="FR"></country>
</address>
</desc>
<listRelation> <relation active="#struct-300068" type="direct"></relation>
<relation active="#struct-328304" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName>
<orgName type="acronym">APHP</orgName>
<desc> <address> <country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle active="#struct-328304" type="direct"><org type="institution" xml:id="struct-328304" status="VALID"> <orgName>CHU Tenon [APHP]</orgName>
<desc> <address> <addrLine>4 Rue de la Chine, 75020 Paris</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.aphp.fr/contenu/hopital-tenon-1</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">HAL</idno>
<idno type="RBID">Hal:hal-01988149</idno>
<idno type="halId">hal-01988149</idno>
<idno type="halUri">https://hal.umontpellier.fr/hal-01988149</idno>
<idno type="url">https://hal.umontpellier.fr/hal-01988149</idno>
<idno type="doi">10.1016/j.jaad.2015.09.064</idno>
<date when="2016-04">2016-04</date>
<idno type="wicri:Area/Hal/Corpus">000239</idno>
<idno type="wicri:Area/Hal/Curation">000239</idno>
<idno type="wicri:Area/Hal/Checkpoint">000078</idno>
<idno type="wicri:explorRef" wicri:stream="Hal" wicri:step="Checkpoint">000078</idno>
<idno type="wicri:doubleKey">0190-9622:2016:Chasset F:the:effect:of</idno>
<idno type="wicri:Area/Main/Merge">000D42</idno>
<idno type="wicri:Area/Main/Curation">000D42</idno>
<idno type="wicri:Area/Main/Exploration">000D42</idno>
<idno type="wicri:Area/France/Extraction">000119</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">The effect of increasing the dose of hydroxychloroquine (HCQ) in patients with refractory cutaneous lupus erythematosus (CLE): An open-label prospective pilot study</title>
<author><name sortKey="Chasset, Francois" sort="Chasset, Francois" uniqKey="Chasset F" first="François" last="Chasset">François Chasset</name>
<affiliation wicri:level="1"><hal:affiliation type="department" xml:id="struct-223222" status="VALID"> <orgName>Service de Dermatologie [CHU Tenon]</orgName>
<desc> <address> <addrLine>4 Rue de la Chine 75020 Paris</addrLine>
<country key="FR"></country>
</address>
</desc>
<listRelation> <relation active="#struct-300068" type="direct"></relation>
<relation active="#struct-328304" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName>
<orgName type="acronym">APHP</orgName>
<desc> <address> <country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle active="#struct-328304" type="direct"><org type="institution" xml:id="struct-328304" status="VALID"> <orgName>CHU Tenon [APHP]</orgName>
<desc> <address> <addrLine>4 Rue de la Chine, 75020 Paris</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.aphp.fr/contenu/hopital-tenon-1</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Arnaud, Laurent" sort="Arnaud, Laurent" uniqKey="Arnaud L" first="Laurent" last="Arnaud">Laurent Arnaud</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-267618" status="OLD"> <idno type="RNSR">201420917E</idno>
<orgName>Institut Pierre Louis d'Epidémiologie et de Santé Publique</orgName>
<orgName type="acronym">iPLESP</orgName>
<desc> <address> <addrLine>56, boulevard Vincent Auriol - CS 81393 - 75646 Paris Cedex 13</addrLine>
<country key="FR"></country>
</address>
<ref type="url">https://www.iplesp.upmc.fr/</ref>
</desc>
<listRelation> <relation active="#struct-93591" type="direct"></relation>
<relation name="U1136" active="#struct-303623" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-93591" type="direct"><org type="institution" xml:id="struct-93591" status="OLD"> <orgName>Université Pierre et Marie Curie - Paris 6</orgName>
<orgName type="acronym">UPMC</orgName>
<date type="end">2017-12-31</date>
<desc> <address> <addrLine>4 place Jussieu - 75005 Paris</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.upmc.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="U1136" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno>
<orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
<orgName type="acronym">INSERM</orgName>
<desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.inserm.fr</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Costedoat Chalumeau, Nathalie" sort="Costedoat Chalumeau, Nathalie" uniqKey="Costedoat Chalumeau N" first="Nathalie" last="Costedoat-Chalumeau">Nathalie Costedoat-Chalumeau</name>
<affiliation wicri:level="1"><hal:affiliation type="department" xml:id="struct-189806" status="VALID"> <orgName>Service de médecine interne et centre de référence des maladies rares [CHU Cochin]</orgName>
<desc> <address> <addrLine>27, rue du Faubourg Saint-Jacques 75014 Paris</addrLine>
<country key="FR"></country>
</address>
</desc>
<listRelation> <relation active="#struct-300123" type="direct"></relation>
<relation active="#struct-300068" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-300123" type="direct"><org type="institution" xml:id="struct-300123" status="VALID"> <orgName>CHU Cochin [AP-HP]</orgName>
<desc> <address> <addrLine>27 Rue du Faubourg Saint-Jacques 75014 Paris</addrLine>
<country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName>
<orgName type="acronym">APHP</orgName>
<desc> <address> <country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Zahr, Noel" sort="Zahr, Noel" uniqKey="Zahr N" first="Noël" last="Zahr">Noël Zahr</name>
<affiliation wicri:level="1"><hal:affiliation type="department" xml:id="struct-41012" status="VALID"> <orgName>Service de pharmacologie biologique [CHU Pitié-Salpâtrière]</orgName>
<desc> <address> <addrLine>47-83, boulevard de l'Hôpital 75651 PARIS Cedex 13</addrLine>
<country key="FR"></country>
</address>
</desc>
<listRelation> <relation active="#struct-300068" type="direct"></relation>
<relation active="#struct-353778" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName>
<orgName type="acronym">APHP</orgName>
<desc> <address> <country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle active="#struct-353778" type="direct"><org type="institution" xml:id="struct-353778" status="VALID"> <orgName>CHU Pitié-Salpêtrière [APHP]</orgName>
<desc> <address> <addrLine>47-83 Boulevard de l'Hôpital, 75013 Paris</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.aphp.fr/contenu/hopital-universitaire-pitie-salpetriere-0</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Bessis, Didier" sort="Bessis, Didier" uniqKey="Bessis D" first="Didier" last="Bessis">Didier Bessis</name>
<affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-258773" status="VALID"> <orgName>Centre Hospitalier Régional Universitaire [Montpellier]</orgName>
<orgName type="acronym">CHRU Montpellier</orgName>
<desc> <address> <addrLine>191 avenue du doyen Gaston Giraud 34295 Montpellier cedex 5</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.chu-montpellier.fr</ref>
</desc>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Frances, Camille" sort="Frances, Camille" uniqKey="Frances C" first="Camille" last="Francès">Camille Francès</name>
<affiliation wicri:level="1"><hal:affiliation type="department" xml:id="struct-223222" status="VALID"> <orgName>Service de Dermatologie [CHU Tenon]</orgName>
<desc> <address> <addrLine>4 Rue de la Chine 75020 Paris</addrLine>
<country key="FR"></country>
</address>
</desc>
<listRelation> <relation active="#struct-300068" type="direct"></relation>
<relation active="#struct-328304" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName>
<orgName type="acronym">APHP</orgName>
<desc> <address> <country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle active="#struct-328304" type="direct"><org type="institution" xml:id="struct-328304" status="VALID"> <orgName>CHU Tenon [APHP]</orgName>
<desc> <address> <addrLine>4 Rue de la Chine, 75020 Paris</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.aphp.fr/contenu/hopital-tenon-1</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
</analytic>
<idno type="DOI">10.1016/j.jaad.2015.09.064</idno>
<series><title level="j">Journal of The American Academy of Dermatology</title>
<idno type="ISSN">0190-9622</idno>
<imprint><date type="datePub">2016-04</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="mix" xml:lang="en"><term>antimalarials</term>
<term>cutaneous lupus erythematosus</term>
<term>hydroxychloroquine</term>
<term>hydroxychloroquine blood concentration</term>
<term>increasing dose</term>
<term>retinal toxicity</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"> <p>BACKGROUND:Up to 30% of patients with cutaneous lupus erythematosus (CLE) fail to respond to hydroxychloroquine (HCQ).OBJECTIVES:We sought to evaluate the efficacy of increased daily doses of HCQ on cutaneous response in refractory CLE.METHODS:We conducted an open-label prospective study between 2010 and 2014. Patients with CLE and HCQ blood level less than or equal to 750 ng/mL were included. The daily dose of HCQ was increased to reach blood concentrations greater than 750 ng/mL. The primary end point was the number of responders defined by an improvement of CLE Disease Area and Severity Index score (4 points or 20% decrease) in patients with HCQ blood concentration greater than 750 ng/mL.RESULTS:We included 34 patients (26 women; median age 45 [range 28-72] years). Two nonadherent patients were excluded. The median CLE Disease Area and Severity Index score before treatment was significantly improved after treatment (8 [range 2-30] vs 1.5 [range 0-30]), P < .001). The primary response criterion was reached in 26 (81%) of the 32 patients analyzed. A decrease in HCQ doses without further CLE flare (median follow-up 15.8 [range 3.06-77.4] months) was achieved in 15 of the 26 responders.LIMITATIONS:The main limitations of the study are its open-label design and the limited number of patients included.CONCLUSIONS:Increasing HCQ doses to reach blood concentrations greater than 750 ng/mL should be considered before addition of other treatments in refractory CLE.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
</country>
</list>
<tree><country name="France"><noRegion><name sortKey="Chasset, Francois" sort="Chasset, Francois" uniqKey="Chasset F" first="François" last="Chasset">François Chasset</name>
</noRegion>
<name sortKey="Arnaud, Laurent" sort="Arnaud, Laurent" uniqKey="Arnaud L" first="Laurent" last="Arnaud">Laurent Arnaud</name>
<name sortKey="Bessis, Didier" sort="Bessis, Didier" uniqKey="Bessis D" first="Didier" last="Bessis">Didier Bessis</name>
<name sortKey="Costedoat Chalumeau, Nathalie" sort="Costedoat Chalumeau, Nathalie" uniqKey="Costedoat Chalumeau N" first="Nathalie" last="Costedoat-Chalumeau">Nathalie Costedoat-Chalumeau</name>
<name sortKey="Frances, Camille" sort="Frances, Camille" uniqKey="Frances C" first="Camille" last="Francès">Camille Francès</name>
<name sortKey="Zahr, Noel" sort="Zahr, Noel" uniqKey="Zahr N" first="Noël" last="Zahr">Noël Zahr</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/France/Extraction
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000119 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/France/Extraction/biblio.hfd -nk 000119 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= ChloroquineV1 |flux= France |étape= Extraction |type= RBID |clé= Hal:hal-01988149 |texte= The effect of increasing the dose of hydroxychloroquine (HCQ) in patients with refractory cutaneous lupus erythematosus (CLE): An open-label prospective pilot study }}
This area was generated with Dilib version V0.6.33. |