Specific Inhibition of Gluconeogenesis by Biguanides
Identifieur interne : 000476 ( France/Analysis ); précédent : 000475; suivant : 000477Specific Inhibition of Gluconeogenesis by Biguanides
Auteurs : Francois Meyer [France] ; M. Ipaktchi [France] ; H. Clauser [France]Source :
- Nature [ 0028-0836 ] ; 1967-01-14.
Abstract
POSSIBLE schemes for the mechanism of the hypoglycaemic action of biguanides have raised considerable controversy in recent years. The possibility that these drugs may act through inhibition of oxidative phosphorylation, which may increase the glucose uptake of peripheral tissues1, has been frequently emphasized25, but experiments on the kinetics of glucose loads6 as well as the demonstration that no correlation exists between the hypoglycaemic effect of various biguanides and their inhibitory action on oxidative phosphorylations7,8 did not support this hypothesis. Moreover, it is now well established that the biguanide drugs have no effect on the glycaemia of normal animals and men, and that their action is restricted to the diabetic and fasting animal. Thus it appeared reasonable to assume that they may interfere with one or more metabolic pathways which are widely different in the normal and diabetic organism. One of these is the gluconeogenetic pathway, resulting in the synthesis of glucose from metabolites containing three or four carbon atoms, including amino-acids. The possibility that such a mechanism may explain the anti-diabetic action of at least two biguanides (phenylethylbiguanide (PEBG) and dimethylbiguanide (DMBG)) has been investigated.
Url:
DOI: 10.1038/213203a0
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 002833
- to stream Istex, to step Curation: 002833
- to stream Istex, to step Checkpoint: 002A14
- to stream Main, to step Merge: 003D76
- to stream Main, to step Curation: 003C90
- to stream Main, to step Exploration: 003C90
- to stream France, to step Extraction: 000476
Links to Exploration step
ISTEX:25F75569A27CA7BD99F494A2027A16557B0D0633Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Specific Inhibition of Gluconeogenesis by Biguanides</title><author><name sortKey="Meyer, Francois" sort="Meyer, Francois" uniqKey="Meyer F" first="Francois" last="Meyer">Francois Meyer</name></author><author><name sortKey="Ipaktchi, M" sort="Ipaktchi, M" uniqKey="Ipaktchi M" first="M." last="Ipaktchi">M. Ipaktchi</name></author><author><name sortKey="Clauser, H" sort="Clauser, H" uniqKey="Clauser H" first="H." last="Clauser">H. Clauser</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:25F75569A27CA7BD99F494A2027A16557B0D0633</idno><date when="1967" year="1967">1967</date><idno type="doi">10.1038/213203a0</idno><idno type="url">https://api.istex.fr/ark:/67375/GT4-WD1BN3VZ-F/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">002833</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">002833</idno><idno type="wicri:Area/Istex/Curation">002833</idno><idno type="wicri:Area/Istex/Checkpoint">002A14</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">002A14</idno><idno type="wicri:doubleKey">0028-0836:1967:Meyer F:specific:inhibition:of</idno><idno type="wicri:Area/Main/Merge">003D76</idno><idno type="wicri:Area/Main/Curation">003C90</idno><idno type="wicri:Area/Main/Exploration">003C90</idno><idno type="wicri:Area/France/Extraction">000476</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Specific Inhibition of Gluconeogenesis by Biguanides</title><author><name sortKey="Meyer, Francois" sort="Meyer, Francois" uniqKey="Meyer F" first="Francois" last="Meyer">Francois Meyer</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Institut de Biochimie, Facult des Sciences, 91-Orsay</wicri:regionArea><wicri:noRegion>91-Orsay</wicri:noRegion><wicri:noRegion>91-Orsay</wicri:noRegion></affiliation></author><author><name sortKey="Ipaktchi, M" sort="Ipaktchi, M" uniqKey="Ipaktchi M" first="M." last="Ipaktchi">M. Ipaktchi</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Institut de Biochimie, Facult des Sciences, 91-Orsay</wicri:regionArea><wicri:noRegion>91-Orsay</wicri:noRegion><wicri:noRegion>91-Orsay</wicri:noRegion></affiliation></author><author><name sortKey="Clauser, H" sort="Clauser, H" uniqKey="Clauser H" first="H." last="Clauser">H. Clauser</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Institut de Biochimie, Facult des Sciences, 91-Orsay</wicri:regionArea><wicri:noRegion>91-Orsay</wicri:noRegion><wicri:noRegion>91-Orsay</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Nature</title><imprint><publisher>Nature Publishing Group</publisher><date when="1967-01-14">1967-01-14</date><biblScope unit="vol">213</biblScope><biblScope unit="issue">5072</biblScope><biblScope unit="page" from="203">203</biblScope><biblScope unit="page" to="204">204</biblScope><date type="Copyright" when="1967">1967</date></imprint><idno type="ISSN">0028-0836</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0028-0836</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">POSSIBLE schemes for the mechanism of the hypoglycaemic action of biguanides have raised considerable controversy in recent years. The possibility that these drugs may act through inhibition of oxidative phosphorylation, which may increase the glucose uptake of peripheral tissues1, has been frequently emphasized25, but experiments on the kinetics of glucose loads6 as well as the demonstration that no correlation exists between the hypoglycaemic effect of various biguanides and their inhibitory action on oxidative phosphorylations7,8 did not support this hypothesis. Moreover, it is now well established that the biguanide drugs have no effect on the glycaemia of normal animals and men, and that their action is restricted to the diabetic and fasting animal. Thus it appeared reasonable to assume that they may interfere with one or more metabolic pathways which are widely different in the normal and diabetic organism. One of these is the gluconeogenetic pathway, resulting in the synthesis of glucose from metabolites containing three or four carbon atoms, including amino-acids. The possibility that such a mechanism may explain the anti-diabetic action of at least two biguanides (phenylethylbiguanide (PEBG) and dimethylbiguanide (DMBG)) has been investigated.</div></front></TEI><affiliations><list><country><li>France</li></country></list><tree><country name="France"><noRegion><name sortKey="Meyer, Francois" sort="Meyer, Francois" uniqKey="Meyer F" first="Francois" last="Meyer">Francois Meyer</name></noRegion><name sortKey="Clauser, H" sort="Clauser, H" uniqKey="Clauser H" first="H." last="Clauser">H. Clauser</name><name sortKey="Ipaktchi, M" sort="Ipaktchi, M" uniqKey="Ipaktchi M" first="M." last="Ipaktchi">M. Ipaktchi</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/France/Analysis
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000476 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/France/Analysis/biblio.hfd -nk 000476 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= ChloroquineV1
|flux= France
|étape= Analysis
|type= RBID
|clé= ISTEX:25F75569A27CA7BD99F494A2027A16557B0D0633
|texte= Specific Inhibition of Gluconeogenesis by Biguanides
}}
| This area was generated with Dilib version V0.6.33. |  |