Modifications involved in brain glycoconjugate metabolism induced by neonatal capsaicin treatment
Identifieur interne : 000465 ( France/Analysis ); précédent : 000464; suivant : 000466Modifications involved in brain glycoconjugate metabolism induced by neonatal capsaicin treatment
Auteurs : M. Serres-Guillaumond [France] ; B. Dib [France]Source :
- Neuroscience Letters [ 0304-3940 ] ; 1985.
English descriptors
- Teeft :
- Acceptor, Acetylcholinesterase activity, Ache activity, Additional capsaicin dose, Additional injection, Assay, Biosynthesis, Brain gangliosides, Capsaicin, Capsaicin treatment, Cerebral hemispheres, Copper acetate reagent, Direct densitometric scanning, Direct lipid interaction, Enzymatic activities, Ganglioside, Ganglioside content, Ganglioside patterns, Gangliosides, Glycoconjugate biosynthesis, Glycoprotein, Glycoprotein biosynthesis, Glycosyltransferase activity, Lipid, Lipidic acceptors, Membrane properties, Microsomal fraction, Molar percentage, Neonatal capsaicin treatment, Nervous system, Nervous tissue, Pharmacol, Phospholipid, Phospholipid brain content, Phospholipid metabolism, Resorcinol hydrochloric acid reagent, Sialyl residues, Sialyltransferase activity, Significant change, Slight decrease, Statistical significance.
Abstract
Abstract: Neonatal capsaicin treatment induces significant changes in rat brain glycoconjugate metabolism. All glycosyltransferase activity involved either in glycoprotein or glycolipid biosynthesis was strongly enhanced. Higher enzymatic activities were obtained when capsaicin-treated rats (T1) had received an additional capsaicin dose (T2). In this case, the fucosyl and galactosyltransferase activities were markedly increased. However, the enhancement of sialyltransferase activity only affects the biosynthesis of glycoproteins and is not correlated with a significant change in ganglioside content. The present results suggest that the modulation of the microsomal glycosyltransferase activity, after capsaicin treatment, could not be stated up through a direct lipid interaction or a change in membrane properties because the phospholipid brain content is not significantly modified.
Url:
DOI: 10.1016/0304-3940(85)90348-9
Affiliations:
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ISTEX:A8AAF792FE90098297523176387B1FD26D659DA8Le document en format XML
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Serres-Guillaumond</name><affiliation wicri:level="0"><country wicri:rule="zip">France</country></affiliation></author><author><name sortKey="Dib, B" sort="Dib, B" uniqKey="Dib B" first="B." last="Dib">B. Dib</name><affiliation></affiliation><affiliation wicri:level="0"><country wicri:rule="zip">France</country></affiliation></author></analytic><monogr></monogr><series><title level="j">Neuroscience Letters</title><title level="j" type="abbrev">NSL</title><idno type="ISSN">0304-3940</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1985">1985</date><biblScope unit="volume">62</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="157">157</biblScope><biblScope unit="page" to="162">162</biblScope></imprint><idno type="ISSN">0304-3940</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0304-3940</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Acceptor</term><term>Acetylcholinesterase activity</term><term>Ache activity</term><term>Additional capsaicin dose</term><term>Additional injection</term><term>Assay</term><term>Biosynthesis</term><term>Brain gangliosides</term><term>Capsaicin</term><term>Capsaicin treatment</term><term>Cerebral hemispheres</term><term>Copper acetate reagent</term><term>Direct densitometric scanning</term><term>Direct lipid interaction</term><term>Enzymatic activities</term><term>Ganglioside</term><term>Ganglioside content</term><term>Ganglioside patterns</term><term>Gangliosides</term><term>Glycoconjugate biosynthesis</term><term>Glycoprotein</term><term>Glycoprotein biosynthesis</term><term>Glycosyltransferase activity</term><term>Lipid</term><term>Lipidic acceptors</term><term>Membrane properties</term><term>Microsomal fraction</term><term>Molar percentage</term><term>Neonatal capsaicin treatment</term><term>Nervous system</term><term>Nervous tissue</term><term>Pharmacol</term><term>Phospholipid</term><term>Phospholipid brain content</term><term>Phospholipid metabolism</term><term>Resorcinol hydrochloric acid reagent</term><term>Sialyl residues</term><term>Sialyltransferase activity</term><term>Significant change</term><term>Slight decrease</term><term>Statistical significance</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Neonatal capsaicin treatment induces significant changes in rat brain glycoconjugate metabolism. All glycosyltransferase activity involved either in glycoprotein or glycolipid biosynthesis was strongly enhanced. Higher enzymatic activities were obtained when capsaicin-treated rats (T1) had received an additional capsaicin dose (T2). In this case, the fucosyl and galactosyltransferase activities were markedly increased. However, the enhancement of sialyltransferase activity only affects the biosynthesis of glycoproteins and is not correlated with a significant change in ganglioside content. The present results suggest that the modulation of the microsomal glycosyltransferase activity, after capsaicin treatment, could not be stated up through a direct lipid interaction or a change in membrane properties because the phospholipid brain content is not significantly modified.</div></front></TEI><affiliations><list><country><li>France</li></country></list><tree><country name="France"><noRegion><name sortKey="Serres Guillaumond, M" sort="Serres Guillaumond, M" uniqKey="Serres Guillaumond M" first="M." last="Serres-Guillaumond">M. Serres-Guillaumond</name></noRegion><name sortKey="Dib, B" sort="Dib, B" uniqKey="Dib B" first="B." last="Dib">B. Dib</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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