ChloroquineV1, France, Analysis, bibRecord, 000463

Preparation and characterisation of liposomes containing mannosylated phospholipids capable of targetting drugs to macrophages

Identifieur interne : 000463 ( France/Analysis ); précédent : 000462; suivant : 000464

Preparation and characterisation of liposomes containing mannosylated phospholipids capable of targetting drugs to macrophages

Auteurs : Gillian Barratt [France] ; Jean-Pierre Tenu [France] ; Alexandre Yapo [France] ; Jean-François Petit [France]

Source :

BBA - Biomembranes [ 0005-2736 ] ; 1986.

RBID : ISTEX:DFC9C620FB2702D57ECEFD4E4215366499F47105

English descriptors

KwdEn :
- Drug delivery, Drug targeting, Endocytosis, Liposome, Mannose receptor, Mannosylated phospholipids.
Teeft :
- Acta, Alveolar macrophages, Aqueous phase, Biochim, Biol, Biophys, Bovine serum albumin, Cholesterol liposomes, Encapsulation, Encapsulation ratio, Endocytosis, Fidler, Filtration, Fluorescent mannosylated, Foetal calf serum, High liposome concentrations, Latex beads, Latex particles, Leakage, Lipid, Liposome, Liposome uptake, Macrophage, Mannose, Mannosylated, Mannosylated liposomes, Mannosylated phospholipid, Mannosylated phospholipids, Millipore, Nuclepore, Phospholipid, Receptor, Same time, Schroit, Serum albumin, Tenu, Triton, Unlabelled, Unlabelled liposomes, Uptake, Vesicle.

Abstract

Abstract: We have prepared liposomes from mannosylated phosphatidyl myo-inositol, derived from mycobacteria, and cholesterol. The size of the particles so formed could be controlled by membrane filtration. The vesicles encapsulated a significant amount of aqueous phase (about 8 μl per mg phospholipid). Markers of the liposomal membrane and aqueous phase rapidly associated with mouse peritoneal macrophages and, more slowly, with rat alveolar macrophages. The uptake was saturable at high loposome concentrations, although phagocytosis of latex particles of the same mean diameter was not saturable at these concentrations. An excess of unlabelled liposomes composed of phosphatidylcholine and phosphatidylserine, which were also taken up readily by macrophages, did not inhibit the uptake of mannosylated liposomes. The uptake of fluorescent mannosylated bovine serum albumin was inhibited by these liposomes, suggesting a specific interaction with the macrophage mannose-fucose receptor. We conclude that this type of liposome would be useful for the delivery of immunomodulators to reticuloendothelial cells.

Url:

https://api.istex.fr/ark:/67375/6H6-J2ZF9TZ7-4/fulltext.pdf

DOI: 10.1016/0005-2736(86)90479-7

Affiliations:

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ISTEX:DFC9C620FB2702D57ECEFD4E4215366499F47105

Le document en format XML

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<author><name sortKey="Tenu, Jean Pierre" sort="Tenu, Jean Pierre" uniqKey="Tenu J" first="Jean-Pierre" last="Tenu">Jean-Pierre Tenu</name>
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<author><name sortKey="Yapo, Alexandre" sort="Yapo, Alexandre" uniqKey="Yapo A" first="Alexandre" last="Yapo">Alexandre Yapo</name>
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<author><name sortKey="Petit, Jean Francois" sort="Petit, Jean Francois" uniqKey="Petit J" first="Jean-François" last="Petit">Jean-François Petit</name>
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<term>Bovine serum albumin</term>
<term>Cholesterol liposomes</term>
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<term>Liposome</term>
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<front><div type="abstract" xml:lang="en">Abstract: We have prepared liposomes from mannosylated phosphatidyl myo-inositol, derived from mycobacteria, and cholesterol. The size of the particles so formed could be controlled by membrane filtration. The vesicles encapsulated a significant amount of aqueous phase (about 8 μl per mg phospholipid). Markers of the liposomal membrane and aqueous phase rapidly associated with mouse peritoneal macrophages and, more slowly, with rat alveolar macrophages. The uptake was saturable at high loposome concentrations, although phagocytosis of latex particles of the same mean diameter was not saturable at these concentrations. An excess of unlabelled liposomes composed of phosphatidylcholine and phosphatidylserine, which were also taken up readily by macrophages, did not inhibit the uptake of mannosylated liposomes. The uptake of fluorescent mannosylated bovine serum albumin was inhibited by these liposomes, suggesting a specific interaction with the macrophage mannose-fucose receptor. We conclude that this type of liposome would be useful for the delivery of immunomodulators to reticuloendothelial cells.</div>
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Preparation and characterisation of liposomes containing mannosylated phospholipids capable of targetting drugs to macrophages

Preparation and characterisation of liposomes containing mannosylated phospholipids capable of targetting drugs to macrophages

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

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Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri