ChloroquineV1, France, Analysis, bibRecord, 000151

Antiplasmodial activity of iron(II) and ruthenium(II) organometallic complexes against Plasmodium falciparum blood parasites

Identifieur interne : 000151 ( France/Analysis ); précédent : 000150; suivant : 000152

Antiplasmodial activity of iron(II) and ruthenium(II) organometallic complexes against Plasmodium falciparum blood parasites

Auteurs : Nicolli Bellotti De Souza [Brésil] ; Anna Caroline Campos Aguiar [Brésil] ; Alane Cabral De Oliveira [Brésil] ; Siden Top [France] ; Pascal Pigeon [France] ; Gérard Jaouen [France] ; Marilia Oliveira Fonseca Goulart [Brésil] ; Antoniana Ursine Krettli [Brésil]

Source :

Memórias do Instituto Oswaldo Cruz. [ 0074-0276 ] ; 2015.

RBID : Hal:hal-01261304

English descriptors

mix :
- Plasmodium falciparum, ferrocifens, metallodrug activity, ruthenocifens.

Abstract

This work reports the in vitro activity against Plasmodium falciparumblood forms (W2 clone, chloroquine-resistant) of tamoxifen-based compounds and their ferrocenyl (ferrocifens) and ruthenocenyl (ruthenocifens) derivatives, as well as their cytotoxicity against HepG2 human hepatoma cells. Surprisingly with these series, results indicate that the biological activity of ruthenocifens is better than that of ferrocifens and other tamoxifen-like compounds. The synthesis of a new metal-based compound is also described. It was shown, for the first time, that ruthenocifens are good antiplasmodial prototypes. Further studies will be conducted aiming at a better understanding of their mechanism of action and at obtaining new compounds with better therapeutic profile.

Url:

https://hal.sorbonne-universite.fr/hal-01261304

DOI: 10.1590/0074-02760150163

Affiliations:

Brésil, France

Links toward previous steps (curation, corpus...)

to stream Hal, to step Corpus: 000024
to stream Hal, to step Curation: 000024
to stream Hal, to step Checkpoint: 000110
to stream Main, to step Merge: 000E64
to stream Main, to step Curation: 000E63
to stream Main, to step Exploration: 000E63
to stream France, to step Extraction: 000151

Links to Exploration step

Hal:hal-01261304

Le document en format XML

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            <relation active="#struct-93591" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle name="UMR8232" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-93591" type="direct"><org type="institution" xml:id="struct-93591" status="OLD">          <orgName>Université Pierre et Marie Curie - Paris 6</orgName>
          <orgName type="acronym">UPMC</orgName>
          <date type="end">2017-12-31</date>
          <desc>            <address>              <addrLine>4 place Jussieu - 75005 Paris</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.upmc.fr/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Goulart, Marilia Oliveira Fonseca" sort="Goulart, Marilia Oliveira Fonseca" uniqKey="Goulart M" first="Marilia Oliveira Fonseca" last="Goulart">Marilia Oliveira Fonseca Goulart</name>
<affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-520416" status="VALID">          <orgName>Universidade Federal de Alagoas = Federal University of Alagoas</orgName>
          <orgName type="acronym">UFAL</orgName>
          <date type="start">1961-01-01</date>
          <desc>            <address>              <addrLine>Maceió/A. C. Simões, Arapiraca and Delmiro Gouveia/Sertão</addrLine>
              <country key="BR"></country>
            </address>
            <ref type="url">https://ufal.br/</ref>
          </desc>
        </hal:affiliation>
<country>Brésil</country>
</affiliation>
</author>
<author><name sortKey="Krettli, Antoniana Ursine" sort="Krettli, Antoniana Ursine" uniqKey="Krettli A" first="Antoniana Ursine" last="Krettli">Antoniana Ursine Krettli</name>
<affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-488707" status="VALID">          <orgName>Fundação Oswaldo Cruz</orgName>
          <orgName type="acronym">FIOCRUZ</orgName>
          <desc>            <address>              <addrLine>Av. Brasil, 4365 - Manguinhos, Rio de Janeiro</addrLine>
              <country key="BR"></country>
            </address>
            <ref type="url">https://portal.fiocruz.br/</ref>
          </desc>
          <listRelation>            <relation active="#struct-301247" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-301247" type="direct"><org type="regroupinstitution" xml:id="struct-301247" status="VALID">          <orgName>Réseau International des Instituts Pasteur</orgName>
          <orgName type="acronym">RIIP</orgName>
          <desc>            <address>              <addrLine>25, rue du Dr Roux 75724 Paris Cedex 15</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">https://research.pasteur.fr/ip-network</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>Brésil</country>
</affiliation>
</author>
</analytic>
<idno type="DOI">10.1590/0074-02760150163</idno>
<series><title level="j">Memórias do Instituto Oswaldo Cruz.</title>
<idno type="ISSN">0074-0276</idno>
<imprint><date type="datePub">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="mix" xml:lang="en"><term>Plasmodium falciparum</term>
<term>ferrocifens</term>
<term>metallodrug activity</term>
<term>ruthenocifens</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">              <p>This work reports the in vitro activity against Plasmodium falciparumblood forms (W2 clone, chloroquine-resistant) of tamoxifen-based compounds and their ferrocenyl (ferrocifens) and ruthenocenyl (ruthenocifens) derivatives, as well as their cytotoxicity against HepG2 human hepatoma cells. Surprisingly with these series, results indicate that the biological activity of ruthenocifens is better than that of ferrocifens and other tamoxifen-like compounds. The synthesis of a new metal-based compound is also described. It was shown, for the first time, that ruthenocifens are good antiplasmodial prototypes. Further studies will be conducted aiming at a better understanding of their mechanism of action and at obtaining new compounds with better therapeutic profile.</p>
            </div>
</front>
</TEI>
<affiliations><list><country><li>Brésil</li>
<li>France</li>
</country>
</list>
<tree><country name="Brésil"><noRegion><name sortKey="Souza, Nicolli Bellotti De" sort="Souza, Nicolli Bellotti De" uniqKey="Souza N" first="Nicolli Bellotti De" last="Souza">Nicolli Bellotti De Souza</name>
</noRegion>
<name sortKey="Aguiar, Anna Caroline Campos" sort="Aguiar, Anna Caroline Campos" uniqKey="Aguiar A" first="Anna Caroline Campos" last="Aguiar">Anna Caroline Campos Aguiar</name>
<name sortKey="Goulart, Marilia Oliveira Fonseca" sort="Goulart, Marilia Oliveira Fonseca" uniqKey="Goulart M" first="Marilia Oliveira Fonseca" last="Goulart">Marilia Oliveira Fonseca Goulart</name>
<name sortKey="Krettli, Antoniana Ursine" sort="Krettli, Antoniana Ursine" uniqKey="Krettli A" first="Antoniana Ursine" last="Krettli">Antoniana Ursine Krettli</name>
<name sortKey="Oliveira, Alane Cabral De" sort="Oliveira, Alane Cabral De" uniqKey="Oliveira A" first="Alane Cabral De" last="Oliveira">Alane Cabral De Oliveira</name>
</country>
<country name="France"><noRegion><name sortKey="Top, Siden" sort="Top, Siden" uniqKey="Top S" first="Siden" last="Top">Siden Top</name>
</noRegion>
<name sortKey="Jaouen, Gerard" sort="Jaouen, Gerard" uniqKey="Jaouen G" first="Gérard" last="Jaouen">Gérard Jaouen</name>
<name sortKey="Pigeon, Pascal" sort="Pigeon, Pascal" uniqKey="Pigeon P" first="Pascal" last="Pigeon">Pascal Pigeon</name>
</country>
</tree>
</affiliations>
</record>

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Antiplasmodial activity of iron(II) and ruthenium(II) organometallic complexes against Plasmodium falciparum blood parasites

Antiplasmodial activity of iron(II) and ruthenium(II) organometallic complexes against Plasmodium falciparum blood parasites

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