Clinical characteristics and outcomes of patients with severe covid-19 with diabetes.
Identifieur interne : 000275 ( Main/Exploration ); précédent : 000274; suivant : 000276Clinical characteristics and outcomes of patients with severe covid-19 with diabetes.
Auteurs : Yongli Yan [République populaire de Chine] ; Yan Yang [République populaire de Chine] ; Fen Wang [République populaire de Chine] ; Huihui Ren [République populaire de Chine] ; Shujun Zhang [République populaire de Chine] ; Xiaoli Shi [République populaire de Chine] ; Xuefeng Yu [République populaire de Chine] ; Kun Dong [Oman]Source :
- BMJ open diabetes research & care [ 2052-4897 ] ; 2020.
Descripteurs français
- KwdFr :
- Adulte (MeSH), Adulte d'âge moyen (MeSH), Betacoronavirus (MeSH), Chine (MeSH), Diabète (virologie), Estimation de Kaplan-Meier (MeSH), Facteurs de risque (MeSH), Femelle (MeSH), Humains (MeSH), Infections à coronavirus (complications), Infections à coronavirus (mortalité), Inflammation (MeSH), Mâle (MeSH), Pandémies (MeSH), Pneumopathie virale (complications), Pneumopathie virale (mortalité), Sujet âgé (MeSH), Ventilation artificielle (MeSH), Études rétrospectives (MeSH).
- MESH :
- mortalité : Infections à coronavirus, Pneumopathie virale.
- virologie : Diabète.
- Adulte, Adulte d'âge moyen, Betacoronavirus, Chine, Estimation de Kaplan-Meier, Facteurs de risque, Femelle, Humains, Infections à coronavirus, Inflammation, Mâle, Pandémies, Pneumopathie virale, Sujet âgé, Ventilation artificielle, Études rétrospectives.
- Wicri :
- geographic : République populaire de Chine.
English descriptors
- KwdEn :
- Adult (MeSH), Aged (MeSH), Betacoronavirus (MeSH), China (MeSH), Coronavirus Infections (complications), Coronavirus Infections (mortality), Diabetes Mellitus (virology), Female (MeSH), Humans (MeSH), Inflammation (MeSH), Kaplan-Meier Estimate (MeSH), Male (MeSH), Middle Aged (MeSH), Pandemics (MeSH), Pneumonia, Viral (complications), Pneumonia, Viral (mortality), Respiration, Artificial (MeSH), Retrospective Studies (MeSH), Risk Factors (MeSH).
- MESH :
- geographic : China.
- complications : Coronavirus Infections, Pneumonia, Viral.
- mortality : Coronavirus Infections, Pneumonia, Viral.
- virology : Diabetes Mellitus.
- Adult, Aged, Betacoronavirus, Female, Humans, Inflammation, Kaplan-Meier Estimate, Male, Middle Aged, Pandemics, Respiration, Artificial, Retrospective Studies, Risk Factors.
Abstract
OBJECTIVE
This study explores the clinical characteristics of patients with diabetes with severe covid-19, and the association of diabetes with survival duration in patients with severe covid-19.
RESEARCH DESIGN AND METHODS
In this single-center, retrospective, observational study, the clinical and laboratory characteristics of 193 patients with severe covid-19 were collected. 48 patients with severe covid-19 had diabetes, and 145 patients (ie, the controls) did not have diabetes. A severe case was defined as including at least one of the following criteria: (1) Respiratory rate >30/min. (2) Oxygen saturation ≤93%. (3) PaO
RESULTS
Of 193 patients with severe covid-19, 48 (24.9%) had diabetes. Compared with patients with severe covid-19 without diabetes, patients with diabetes were older, susceptible to receiving mechanical ventilation and admission to ICU, and had higher mortality. In addition, patients with severe covid-19 with diabetes had higher levels of leukocyte count, neutrophil count, high-sensitivity C reaction protein, procalcitonin, ferritin, interleukin (IL) 2 receptor, IL-6, IL-8, tumor necrosis factor α, D-dimer, fibrinogen, lactic dehydrogenase and N-terminal pro-brain natriuretic peptide. Among patients with severe covid-19 with diabetes, more non-survivors were men (30 (76.9%)
CONCLUSION
The mortality rate in patients with severe covid-19 with diabetes is considerable. Diabetes may lead to an increase in the risk of death.
DOI: 10.1136/bmjdrc-2020-001343
PubMed: 32345579
PubMed Central: PMC7222577
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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<term>Betacoronavirus (MeSH)</term>
<term>China (MeSH)</term>
<term>Coronavirus Infections (complications)</term>
<term>Coronavirus Infections (mortality)</term>
<term>Diabetes Mellitus (virology)</term>
<term>Female (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Inflammation (MeSH)</term>
<term>Kaplan-Meier Estimate (MeSH)</term>
<term>Male (MeSH)</term>
<term>Middle Aged (MeSH)</term>
<term>Pandemics (MeSH)</term>
<term>Pneumonia, Viral (complications)</term>
<term>Pneumonia, Viral (mortality)</term>
<term>Respiration, Artificial (MeSH)</term>
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<term>Adulte d'âge moyen (MeSH)</term>
<term>Betacoronavirus (MeSH)</term>
<term>Chine (MeSH)</term>
<term>Diabète (virologie)</term>
<term>Estimation de Kaplan-Meier (MeSH)</term>
<term>Facteurs de risque (MeSH)</term>
<term>Femelle (MeSH)</term>
<term>Humains (MeSH)</term>
<term>Infections à coronavirus (complications)</term>
<term>Infections à coronavirus (mortalité)</term>
<term>Inflammation (MeSH)</term>
<term>Mâle (MeSH)</term>
<term>Pandémies (MeSH)</term>
<term>Pneumopathie virale (complications)</term>
<term>Pneumopathie virale (mortalité)</term>
<term>Sujet âgé (MeSH)</term>
<term>Ventilation artificielle (MeSH)</term>
<term>Études rétrospectives (MeSH)</term>
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</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
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<keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Infections à coronavirus</term>
<term>Pneumopathie virale</term>
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<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Diabète</term>
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<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Diabetes Mellitus</term>
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<term>Aged</term>
<term>Betacoronavirus</term>
<term>Female</term>
<term>Humans</term>
<term>Inflammation</term>
<term>Kaplan-Meier Estimate</term>
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<term>Estimation de Kaplan-Meier</term>
<term>Facteurs de risque</term>
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<term>Mâle</term>
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<front><div type="abstract" xml:lang="en"><p><b>OBJECTIVE</b>
</p>
<p>This study explores the clinical characteristics of patients with diabetes with severe covid-19, and the association of diabetes with survival duration in patients with severe covid-19.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>RESEARCH DESIGN AND METHODS</b>
</p>
<p>In this single-center, retrospective, observational study, the clinical and laboratory characteristics of 193 patients with severe covid-19 were collected. 48 patients with severe covid-19 had diabetes, and 145 patients (ie, the controls) did not have diabetes. A severe case was defined as including at least one of the following criteria: (1) Respiratory rate >30/min. (2) Oxygen saturation ≤93%. (3) PaO</p>
</div>
<div type="abstract" xml:lang="en"><p><b>RESULTS</b>
</p>
<p>Of 193 patients with severe covid-19, 48 (24.9%) had diabetes. Compared with patients with severe covid-19 without diabetes, patients with diabetes were older, susceptible to receiving mechanical ventilation and admission to ICU, and had higher mortality. In addition, patients with severe covid-19 with diabetes had higher levels of leukocyte count, neutrophil count, high-sensitivity C reaction protein, procalcitonin, ferritin, interleukin (IL) 2 receptor, IL-6, IL-8, tumor necrosis factor α, D-dimer, fibrinogen, lactic dehydrogenase and N-terminal pro-brain natriuretic peptide. Among patients with severe covid-19 with diabetes, more non-survivors were men (30 (76.9%) </p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSION</b>
</p>
<p>The mortality rate in patients with severe covid-19 with diabetes is considerable. Diabetes may lead to an increase in the risk of death.</p>
</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32345579</PMID>
<DateCompleted><Year>2020</Year>
<Month>04</Month>
<Day>30</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>05</Month>
<Day>16</Day>
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<Article PubModel="Print"><Journal><ISSN IssnType="Electronic">2052-4897</ISSN>
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<Issue>1</Issue>
<PubDate><Year>2020</Year>
<Month>04</Month>
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<Title>BMJ open diabetes research & care</Title>
<ISOAbbreviation>BMJ Open Diabetes Res Care</ISOAbbreviation>
</Journal>
<ArticleTitle>Clinical characteristics and outcomes of patients with severe covid-19 with diabetes.</ArticleTitle>
<ELocationID EIdType="pii" ValidYN="Y">e001343</ELocationID>
<ELocationID EIdType="doi" ValidYN="Y">10.1136/bmjdrc-2020-001343</ELocationID>
<Abstract><AbstractText Label="OBJECTIVE">This study explores the clinical characteristics of patients with diabetes with severe covid-19, and the association of diabetes with survival duration in patients with severe covid-19.</AbstractText>
<AbstractText Label="RESEARCH DESIGN AND METHODS">In this single-center, retrospective, observational study, the clinical and laboratory characteristics of 193 patients with severe covid-19 were collected. 48 patients with severe covid-19 had diabetes, and 145 patients (ie, the controls) did not have diabetes. A severe case was defined as including at least one of the following criteria: (1) Respiratory rate >30/min. (2) Oxygen saturation ≤93%. (3) PaO<sub>2</sub>
/FiO<sub>2</sub>
≤300 mm Hg. (4) Patients, either with shock or respiratory failure, requiring mechanical ventilation, or combined with other organ failure, requiring admission to intensive care unit (ICU).</AbstractText>
<AbstractText Label="RESULTS">Of 193 patients with severe covid-19, 48 (24.9%) had diabetes. Compared with patients with severe covid-19 without diabetes, patients with diabetes were older, susceptible to receiving mechanical ventilation and admission to ICU, and had higher mortality. In addition, patients with severe covid-19 with diabetes had higher levels of leukocyte count, neutrophil count, high-sensitivity C reaction protein, procalcitonin, ferritin, interleukin (IL) 2 receptor, IL-6, IL-8, tumor necrosis factor α, D-dimer, fibrinogen, lactic dehydrogenase and N-terminal pro-brain natriuretic peptide. Among patients with severe covid-19 with diabetes, more non-survivors were men (30 (76.9%) <i>vs</i>
9 (23.1%)). Non-survivors had severe inflammatory response, and cardiac, hepatic, renal and coagulation impairment. Finally, the Kaplan-Meier survival curve showed a trend towards poorer survival in patients with severe covid-19 with diabetes than patients without diabetes. The HR was 1.53 (95% CI 1.02 to 2.30; p=0.041) after adjustment for age, sex, hypertension, cardiovascular disease and cerebrovascular disease by Cox regression. The median survival durations from hospital admission in patients with severe covid-19 with and without diabetes were 10 days and 18 days, respectively.</AbstractText>
<AbstractText Label="CONCLUSION">The mortality rate in patients with severe covid-19 with diabetes is considerable. Diabetes may lead to an increase in the risk of death.</AbstractText>
<CopyrightInformation>© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Yan</LastName>
<ForeName>Yongli</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Endocrinology, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, China.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Yang</LastName>
<ForeName>Yan</ForeName>
<Initials>Y</Initials>
<Identifier Source="ORCID">0000-0001-8146-8040</Identifier>
<AffiliationInfo><Affiliation>Endocrinology, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, China.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Fen</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Endocrinology, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, China.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Ren</LastName>
<ForeName>Huihui</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Endocrinology, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, China.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Zhang</LastName>
<ForeName>Shujun</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Endocrinology, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, China.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Shi</LastName>
<ForeName>Xiaoli</ForeName>
<Initials>X</Initials>
<AffiliationInfo><Affiliation>Endocrinology, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, China.</Affiliation>
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<Author ValidYN="Y"><LastName>Yu</LastName>
<ForeName>Xuefeng</ForeName>
<Initials>X</Initials>
<Identifier Source="ORCID">0000-0003-3961-9321</Identifier>
<AffiliationInfo><Affiliation>Endocrinology, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, China.</Affiliation>
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<Author ValidYN="Y"><LastName>Dong</LastName>
<ForeName>Kun</ForeName>
<Initials>K</Initials>
<Identifier Source="ORCID">0000-0003-3204-078X</Identifier>
<AffiliationInfo><Affiliation>Endocrinology, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, China kundong2019@hotmail.com.</Affiliation>
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<MedlineTA>BMJ Open Diabetes Res Care</MedlineTA>
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<CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>BMJ Open Diabetes Res Care. 2020 Apr;8(1):</RefSource>
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<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">adult diabetes</Keyword>
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<CoiStatement>Competing interests: None declared.</CoiStatement>
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<Month>04</Month>
<Day>02</Day>
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<affiliations><list><country><li>Oman</li>
<li>République populaire de Chine</li>
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<name sortKey="Ren, Huihui" sort="Ren, Huihui" uniqKey="Ren H" first="Huihui" last="Ren">Huihui Ren</name>
<name sortKey="Shi, Xiaoli" sort="Shi, Xiaoli" uniqKey="Shi X" first="Xiaoli" last="Shi">Xiaoli Shi</name>
<name sortKey="Wang, Fen" sort="Wang, Fen" uniqKey="Wang F" first="Fen" last="Wang">Fen Wang</name>
<name sortKey="Yang, Yan" sort="Yang, Yan" uniqKey="Yang Y" first="Yan" last="Yang">Yan Yang</name>
<name sortKey="Yu, Xuefeng" sort="Yu, Xuefeng" uniqKey="Yu X" first="Xuefeng" last="Yu">Xuefeng Yu</name>
<name sortKey="Zhang, Shujun" sort="Zhang, Shujun" uniqKey="Zhang S" first="Shujun" last="Zhang">Shujun Zhang</name>
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