CardioCovidV1, Main, Exploration, bibRecord, 000223

Diabetes increases the mortality of patients with COVID-19: a meta-analysis.

Identifieur interne : 000223 ( Main/Exploration ); précédent : 000222; suivant : 000224

Diabetes increases the mortality of patients with COVID-19: a meta-analysis.

Auteurs : Zeng-Hong Wu [République populaire de Chine] ; Yun Tang [République populaire de Chine] ; Qing Cheng [République populaire de Chine]

Source :

Acta diabetologica [ 1432-5233 ] ; 2020.

RBID : pubmed:32583078

Abstract

AIMS

Nowadays, the ongoing pandemic of COVID-19 caused by the novel coronavirus Syndrome-Coronavirus-2 (SARS-CoV-2) is an emerging, rapidly evolving situation. Complications such as hypertension, diabetes, COPD, cardiovascular disease, and cerebrovascular disease are major risk factors for patients with COVID-19.

METHODS

No meta-analysis has explored if or not diabetes related to mortality of patients with COVID-19. Therefore, this meta-analysis first aims to explore the possible clinical mortality between diabetes and COVID-19, analyze if diabetes patients infected with SARS-CoV-2 are exposed to the worst clinical prognostic risk, and to evaluate the reliability of the evidence.

RESULTS

Our results showed a close relationship between diabetes and mortality of COVID-19, with a pooled OR of 1.75 (95% CI 1.31-2.36; P = 0.0002). The pooled data were calculated with the fixed effects model (FEM) as no heterogeneity appeared in the studies. Sensitivity analysis showed that after omitting any single study or converting a random effect model to FEM, the main results still held.

CONCLUSIONS

Our meta-analysis showed that diabetes increases the mortality of patients with COVID-19. These results indicated the disturbance of blood glucose in the COVID-19 patients. More importantly, this meta-analysis grades the reliability of evidence for further basic and clinical research into the diabetes dysfunction in COVID-19 patients.

DOI: 10.1007/s00592-020-01546-0
PubMed: 32583078
PubMed Central: PMC7311595

Affiliations:

République populaire de Chine

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<author><name sortKey="Wu, Zeng Hong" sort="Wu, Zeng Hong" uniqKey="Wu Z" first="Zeng-Hong" last="Wu">Zeng-Hong Wu</name>
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<author><name sortKey="Tang, Yun" sort="Tang, Yun" uniqKey="Tang Y" first="Yun" last="Tang">Yun Tang</name>
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<p>Nowadays, the ongoing pandemic of COVID-19 caused by the novel coronavirus Syndrome-Coronavirus-2 (SARS-CoV-2) is an emerging, rapidly evolving situation. Complications such as hypertension, diabetes, COPD, cardiovascular disease, and cerebrovascular disease are major risk factors for patients with COVID-19.</p>
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<div type="abstract" xml:lang="en"><p><b>METHODS</b>
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<p>No meta-analysis has explored if or not diabetes related to mortality of patients with COVID-19. Therefore, this meta-analysis first aims to explore the possible clinical mortality between diabetes and COVID-19, analyze if diabetes patients infected with SARS-CoV-2 are exposed to the worst clinical prognostic risk, and to evaluate the reliability of the evidence.</p>
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<p>Our results showed a close relationship between diabetes and mortality of COVID-19, with a pooled OR of 1.75 (95% CI 1.31-2.36; P = 0.0002). The pooled data were calculated with the fixed effects model (FEM) as no heterogeneity appeared in the studies. Sensitivity analysis showed that after omitting any single study or converting a random effect model to FEM, the main results still held.</p>
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<div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b>
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<p>Our meta-analysis showed that diabetes increases the mortality of patients with COVID-19. These results indicated the disturbance of blood glucose in the COVID-19 patients. More importantly, this meta-analysis grades the reliability of evidence for further basic and clinical research into the diabetes dysfunction in COVID-19 patients.</p>
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Diabetes increases the mortality of patients with COVID-19: a meta-analysis.

Diabetes increases the mortality of patients with COVID-19: a meta-analysis.

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Abstract

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