Unusual Early Recovery of a Critical COVID-19 Patient After Administration of Intravenous Vitamin C.
Identifieur interne : 000037 ( Main/Exploration ); précédent : 000036; suivant : 000038Unusual Early Recovery of a Critical COVID-19 Patient After Administration of Intravenous Vitamin C.
Auteurs : Hafiz Muhammad Waqas Khan [États-Unis] ; Niraj Parikh [États-Unis] ; Shady Maher Megala [États-Unis] ; George Silviu Predeteanu [États-Unis]Source :
- The American journal of case reports [ 1941-5923 ] ; 2020.
Abstract
BACKGROUND Coronavirus disease 2019 (COVID-19) continues to spread, with confirmed cases now in more than 200 countries. Thus far there are no proven therapeutic options to treat COVID-19. We report a case of COVID-19 with acute respiratory distress syndrome who was treated with high-dose vitamin C infusion and was the first case to have early recovery from the disease at our institute. CASE REPORT A 74-year-old woman with no recent sick contacts or travel history presented with fever, cough, and shortness of breath. Her vital signs were normal except for oxygen saturation of 87% and bilateral rhonchi on lung auscultation. Chest radiography revealed air space opacity in the right upper lobe, suspicious for pneumonia. A nasopharyngeal swab for severe acute respiratory syndrome coronavirus-2 came back positive while the patient was in the airborne-isolation unit. Laboratory data showed lymphopenia and elevated lactate dehydrogenase, ferritin, and interleukin-6. The patient was initially started on oral hydroxychloroquine and azithromycin. On day 6, she developed ARDS and septic shock, for which mechanical ventilation and pressor support were started, along with infusion of high-dose intravenous vitamin C. The patient improved clinically and was able to be taken off mechanical ventilation within 5 days. CONCLUSIONS This report highlights the potential benefits of high-dose intravenous vitamin C in critically ill COVID-19 patients in terms of rapid recovery and shortened length of mechanical ventilation and ICU stay. Further studies will elaborate on the efficacy of intravenous vitamin C in critically ill COVID-19.
DOI: 10.12659/AJCR.925521
PubMed: 32709838
Affiliations:
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wicri:level="2"><nlm:affiliation>Department of Pulmonary and Critical Care, McLaren-Flint/Michigan State University, Flint, MI, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pulmonary and Critical Care, McLaren-Flint/Michigan State University, Flint, MI</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Megala, Shady Maher" sort="Megala, Shady Maher" uniqKey="Megala S" first="Shady Maher" last="Megala">Shady Maher Megala</name><affiliation wicri:level="2"><nlm:affiliation>Department of Internal Medicine, McLaren-Flint/Michigan State University, Flint, MI, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Internal Medicine, McLaren-Flint/Michigan State University, Flint, MI</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Predeteanu, George Silviu" sort="Predeteanu, George Silviu" uniqKey="Predeteanu G" first="George Silviu" last="Predeteanu">George Silviu Predeteanu</name><affiliation wicri:level="2"><nlm:affiliation>Department of Cardiovascular Disease, McLaren-Flint/Michigan State University, Flint, MI, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Cardiovascular Disease, McLaren-Flint/Michigan State University, Flint, MI</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author></analytic><series><title level="j">The American journal of case reports</title><idno type="eISSN">1941-5923</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">BACKGROUND Coronavirus disease 2019 (COVID-19) continues to spread, with confirmed cases now in more than 200 countries. Thus far there are no proven therapeutic options to treat COVID-19. We report a case of COVID-19 with acute respiratory distress syndrome who was treated with high-dose vitamin C infusion and was the first case to have early recovery from the disease at our institute. CASE REPORT A 74-year-old woman with no recent sick contacts or travel history presented with fever, cough, and shortness of breath. Her vital signs were normal except for oxygen saturation of 87% and bilateral rhonchi on lung auscultation. Chest radiography revealed air space opacity in the right upper lobe, suspicious for pneumonia. A nasopharyngeal swab for severe acute respiratory syndrome coronavirus-2 came back positive while the patient was in the airborne-isolation unit. Laboratory data showed lymphopenia and elevated lactate dehydrogenase, ferritin, and interleukin-6. The patient was initially started on oral hydroxychloroquine and azithromycin. On day 6, she developed ARDS and septic shock, for which mechanical ventilation and pressor support were started, along with infusion of high-dose intravenous vitamin C. The patient improved clinically and was able to be taken off mechanical ventilation within 5 days. CONCLUSIONS This report highlights the potential benefits of high-dose intravenous vitamin C in critically ill COVID-19 patients in terms of rapid recovery and shortened length of mechanical ventilation and ICU stay. Further studies will elaborate on the efficacy of intravenous vitamin C in critically ill COVID-19.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">32709838</PMID><DateRevised><Year>2020</Year><Month>07</Month><Day>27</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1941-5923</ISSN><JournalIssue CitedMedium="Internet"><Volume>21</Volume><PubDate><Year>2020</Year><Month>Jul</Month><Day>25</Day></PubDate></JournalIssue><Title>The American journal of case reports</Title><ISOAbbreviation>Am J Case Rep</ISOAbbreviation></Journal><ArticleTitle>Unusual Early Recovery of a Critical COVID-19 Patient After Administration of Intravenous Vitamin C.</ArticleTitle><Pagination><MedlinePgn>e925521</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.12659/AJCR.925521</ELocationID><Abstract><AbstractText>BACKGROUND Coronavirus disease 2019 (COVID-19) continues to spread, with confirmed cases now in more than 200 countries. Thus far there are no proven therapeutic options to treat COVID-19. We report a case of COVID-19 with acute respiratory distress syndrome who was treated with high-dose vitamin C infusion and was the first case to have early recovery from the disease at our institute. CASE REPORT A 74-year-old woman with no recent sick contacts or travel history presented with fever, cough, and shortness of breath. Her vital signs were normal except for oxygen saturation of 87% and bilateral rhonchi on lung auscultation. Chest radiography revealed air space opacity in the right upper lobe, suspicious for pneumonia. A nasopharyngeal swab for severe acute respiratory syndrome coronavirus-2 came back positive while the patient was in the airborne-isolation unit. Laboratory data showed lymphopenia and elevated lactate dehydrogenase, ferritin, and interleukin-6. The patient was initially started on oral hydroxychloroquine and azithromycin. On day 6, she developed ARDS and septic shock, for which mechanical ventilation and pressor support were started, along with infusion of high-dose intravenous vitamin C. The patient improved clinically and was able to be taken off mechanical ventilation within 5 days. CONCLUSIONS This report highlights the potential benefits of high-dose intravenous vitamin C in critically ill COVID-19 patients in terms of rapid recovery and shortened length of mechanical ventilation and ICU stay. Further studies will elaborate on the efficacy of intravenous vitamin C in critically ill COVID-19.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Waqas Khan</LastName><ForeName>Hafiz Muhammad</ForeName><Initials>HM</Initials><AffiliationInfo><Affiliation>Department of Cardiovascular Disease, McLaren-Flint/Michigan State University, Flint, MI, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Parikh</LastName><ForeName>Niraj</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Pulmonary and Critical Care, McLaren-Flint/Michigan State University, Flint, MI, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Megala</LastName><ForeName>Shady Maher</ForeName><Initials>SM</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, McLaren-Flint/Michigan State University, Flint, MI, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Predeteanu</LastName><ForeName>George Silviu</ForeName><Initials>GS</Initials><AffiliationInfo><Affiliation>Department of Cardiovascular Disease, McLaren-Flint/Michigan State University, Flint, MI, USA.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>07</Month><Day>25</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Am J Case Rep</MedlineTA><NlmUniqueID>101489566</NlmUniqueID><ISSNLinking>1941-5923</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>7</Month><Day>26</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>7</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>7</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32709838</ArticleId><ArticleId IdType="pii">925521</ArticleId><ArticleId IdType="doi">10.12659/AJCR.925521</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country><region><li>Michigan</li></region></list><tree><country name="États-Unis"><region name="Michigan"><name sortKey="Waqas Khan, Hafiz Muhammad" sort="Waqas Khan, Hafiz Muhammad" uniqKey="Waqas Khan H" first="Hafiz Muhammad" last="Waqas Khan">Hafiz Muhammad Waqas Khan</name></region><name sortKey="Megala, Shady Maher" sort="Megala, Shady Maher" uniqKey="Megala S" first="Shady Maher" last="Megala">Shady Maher Megala</name><name sortKey="Parikh, Niraj" sort="Parikh, Niraj" uniqKey="Parikh N" first="Niraj" last="Parikh">Niraj Parikh</name><name sortKey="Predeteanu, George Silviu" sort="Predeteanu, George Silviu" uniqKey="Predeteanu G" first="George Silviu" last="Predeteanu">George Silviu Predeteanu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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