COVID-19 and Cardiovascular Disease.
Identifieur interne : 000402 ( Main/Corpus ); précédent : 000401; suivant : 000403COVID-19 and Cardiovascular Disease.
Auteurs : Kevin J. Clerkin ; Justin A. Fried ; Jayant Raikhelkar ; Gabriel Sayer ; Jan M. Griffin ; Amirali Masoumi ; Sneha S. Jain ; Daniel Burkhoff ; Deepa Kumaraiah ; Leroy Rabbani ; Allan Schwartz ; Nir UrielSource :
- Circulation [ 1524-4539 ] ; 2020.
English descriptors
- KwdEn :
- Angiotensin Receptor Antagonists (therapeutic use), Angiotensin-Converting Enzyme Inhibitors (therapeutic use), Betacoronavirus (MeSH), Cardiovascular Diseases (complications), Cardiovascular Diseases (enzymology), Coronavirus Infections (complications), Coronavirus Infections (drug therapy), Coronavirus Infections (enzymology), Coronavirus Infections (therapy), Coronavirus Infections (virology), Humans (MeSH), Pandemics (MeSH), Peptidyl-Dipeptidase A (metabolism), Pneumonia, Viral (complications), Pneumonia, Viral (enzymology), Pneumonia, Viral (therapy), Pneumonia, Viral (virology), Receptors, Virus (antagonists & inhibitors), Receptors, Virus (metabolism).
- MESH :
- chemical , antagonists & inhibitors : Receptors, Virus.
- chemical , metabolism : Peptidyl-Dipeptidase A, Receptors, Virus.
- chemical , therapeutic use : Angiotensin Receptor Antagonists, Angiotensin-Converting Enzyme Inhibitors.
- complications : Cardiovascular Diseases, Coronavirus Infections, Pneumonia, Viral.
- drug therapy : Coronavirus Infections.
- enzymology : Cardiovascular Diseases, Coronavirus Infections, Pneumonia, Viral.
- therapy : Coronavirus Infections, Pneumonia, Viral.
- virology : Coronavirus Infections, Pneumonia, Viral.
- Betacoronavirus, Humans, Pandemics.
Abstract
Coronavirus disease 2019 (COVID-19) is a global pandemic affecting 185 countries and >3 000 000 patients worldwide as of April 28, 2020. COVID-19 is caused by severe acute respiratory syndrome coronavirus 2, which invades cells through the angiotensin-converting enzyme 2 receptor. Among patients with COVID-19, there is a high prevalence of cardiovascular disease, and >7% of patients experience myocardial injury from the infection (22% of critically ill patients). Although angiotensin-converting enzyme 2 serves as the portal for infection, the role of angiotensin-converting enzyme inhibitors or angiotensin receptor blockers requires further investigation. COVID-19 poses a challenge for heart transplantation, affecting donor selection, immunosuppression, and posttransplant management. There are a number of promising therapies under active investigation to treat and prevent COVID-19.
DOI: 10.1161/CIRCULATIONAHA.120.046941
PubMed: 32200663
Links to Exploration step
pubmed:32200663Le document en format XML
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Fried</name><affiliation><nlm:affiliation>Department of Medicine, Division of Cardiology, Columbia University Vagelos College of Physicians and Surgeons, New York.</nlm:affiliation></affiliation></author><author><name sortKey="Raikhelkar, Jayant" sort="Raikhelkar, Jayant" uniqKey="Raikhelkar J" first="Jayant" last="Raikhelkar">Jayant Raikhelkar</name><affiliation><nlm:affiliation>Department of Medicine, Division of Cardiology, Columbia University Vagelos College of Physicians and Surgeons, New York.</nlm:affiliation></affiliation></author><author><name sortKey="Sayer, Gabriel" sort="Sayer, Gabriel" uniqKey="Sayer G" first="Gabriel" last="Sayer">Gabriel Sayer</name><affiliation><nlm:affiliation>Department of Medicine, Division of Cardiology, Columbia University Vagelos College of Physicians and Surgeons, New York.</nlm:affiliation></affiliation></author><author><name sortKey="Griffin, Jan M" sort="Griffin, Jan M" uniqKey="Griffin J" first="Jan M" last="Griffin">Jan M. Griffin</name><affiliation><nlm:affiliation>Department of Medicine, Division of Cardiology, Columbia University Vagelos College of Physicians and Surgeons, New York.</nlm:affiliation></affiliation></author><author><name sortKey="Masoumi, Amirali" sort="Masoumi, Amirali" uniqKey="Masoumi A" first="Amirali" last="Masoumi">Amirali Masoumi</name><affiliation><nlm:affiliation>Department of Medicine, Division of Cardiology, Columbia University Vagelos College of Physicians and Surgeons, New York.</nlm:affiliation></affiliation></author><author><name sortKey="Jain, Sneha S" sort="Jain, Sneha S" uniqKey="Jain S" first="Sneha S" last="Jain">Sneha S. Jain</name><affiliation><nlm:affiliation>Department of Medicine, Division of Cardiology, Columbia University Vagelos College of Physicians and Surgeons, New York.</nlm:affiliation></affiliation></author><author><name sortKey="Burkhoff, Daniel" sort="Burkhoff, Daniel" uniqKey="Burkhoff D" first="Daniel" last="Burkhoff">Daniel Burkhoff</name><affiliation><nlm:affiliation>Department of Medicine, Division of Cardiology, Columbia University Vagelos College of Physicians and Surgeons, New York.</nlm:affiliation></affiliation></author><author><name sortKey="Kumaraiah, Deepa" sort="Kumaraiah, Deepa" uniqKey="Kumaraiah D" first="Deepa" last="Kumaraiah">Deepa Kumaraiah</name><affiliation><nlm:affiliation>Department of Medicine, Division of Cardiology, Columbia University Vagelos College of Physicians and Surgeons, New York.</nlm:affiliation></affiliation></author><author><name sortKey="Rabbani, Leroy" sort="Rabbani, Leroy" uniqKey="Rabbani L" first="Leroy" last="Rabbani">Leroy Rabbani</name><affiliation><nlm:affiliation>Department of Medicine, Division of Cardiology, Columbia University Vagelos College of Physicians and Surgeons, New York.</nlm:affiliation></affiliation></author><author><name sortKey="Schwartz, Allan" sort="Schwartz, Allan" uniqKey="Schwartz A" first="Allan" last="Schwartz">Allan Schwartz</name><affiliation><nlm:affiliation>Department of Medicine, Division of Cardiology, Columbia University Vagelos College of Physicians and Surgeons, New York.</nlm:affiliation></affiliation></author><author><name sortKey="Uriel, Nir" sort="Uriel, Nir" uniqKey="Uriel N" first="Nir" last="Uriel">Nir Uriel</name><affiliation><nlm:affiliation>Department of Medicine, Division of Cardiology, Columbia University Vagelos College of Physicians and Surgeons, New York.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32200663</idno><idno type="pmid">32200663</idno><idno type="doi">10.1161/CIRCULATIONAHA.120.046941</idno><idno type="wicri:Area/Main/Corpus">000402</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000402</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">COVID-19 and Cardiovascular Disease.</title><author><name sortKey="Clerkin, Kevin J" sort="Clerkin, Kevin J" uniqKey="Clerkin K" first="Kevin J" last="Clerkin">Kevin J. Clerkin</name><affiliation><nlm:affiliation>Department of Medicine, Division of Cardiology, Columbia University Vagelos College of Physicians and Surgeons, New York.</nlm:affiliation></affiliation></author><author><name sortKey="Fried, Justin A" sort="Fried, Justin A" uniqKey="Fried J" first="Justin A" last="Fried">Justin A. Fried</name><affiliation><nlm:affiliation>Department of Medicine, Division of Cardiology, Columbia University Vagelos College of Physicians and Surgeons, New York.</nlm:affiliation></affiliation></author><author><name sortKey="Raikhelkar, Jayant" sort="Raikhelkar, Jayant" uniqKey="Raikhelkar J" first="Jayant" last="Raikhelkar">Jayant Raikhelkar</name><affiliation><nlm:affiliation>Department of Medicine, Division of Cardiology, Columbia University Vagelos College of Physicians and Surgeons, New York.</nlm:affiliation></affiliation></author><author><name sortKey="Sayer, Gabriel" sort="Sayer, Gabriel" uniqKey="Sayer G" first="Gabriel" last="Sayer">Gabriel Sayer</name><affiliation><nlm:affiliation>Department of Medicine, Division of Cardiology, Columbia University Vagelos College of Physicians and Surgeons, New York.</nlm:affiliation></affiliation></author><author><name sortKey="Griffin, Jan M" sort="Griffin, Jan M" uniqKey="Griffin J" first="Jan M" last="Griffin">Jan M. Griffin</name><affiliation><nlm:affiliation>Department of Medicine, Division of Cardiology, Columbia University Vagelos College of Physicians and Surgeons, New York.</nlm:affiliation></affiliation></author><author><name sortKey="Masoumi, Amirali" sort="Masoumi, Amirali" uniqKey="Masoumi A" first="Amirali" last="Masoumi">Amirali Masoumi</name><affiliation><nlm:affiliation>Department of Medicine, Division of Cardiology, Columbia University Vagelos College of Physicians and Surgeons, New York.</nlm:affiliation></affiliation></author><author><name sortKey="Jain, Sneha S" sort="Jain, Sneha S" uniqKey="Jain S" first="Sneha S" last="Jain">Sneha S. Jain</name><affiliation><nlm:affiliation>Department of Medicine, Division of Cardiology, Columbia University Vagelos College of Physicians and Surgeons, New York.</nlm:affiliation></affiliation></author><author><name sortKey="Burkhoff, Daniel" sort="Burkhoff, Daniel" uniqKey="Burkhoff D" first="Daniel" last="Burkhoff">Daniel Burkhoff</name><affiliation><nlm:affiliation>Department of Medicine, Division of Cardiology, Columbia University Vagelos College of Physicians and Surgeons, New York.</nlm:affiliation></affiliation></author><author><name sortKey="Kumaraiah, Deepa" sort="Kumaraiah, Deepa" uniqKey="Kumaraiah D" first="Deepa" last="Kumaraiah">Deepa Kumaraiah</name><affiliation><nlm:affiliation>Department of Medicine, Division of Cardiology, Columbia University Vagelos College of Physicians and Surgeons, New York.</nlm:affiliation></affiliation></author><author><name sortKey="Rabbani, Leroy" sort="Rabbani, Leroy" uniqKey="Rabbani L" first="Leroy" last="Rabbani">Leroy Rabbani</name><affiliation><nlm:affiliation>Department of Medicine, Division of Cardiology, Columbia University Vagelos College of Physicians and Surgeons, New York.</nlm:affiliation></affiliation></author><author><name sortKey="Schwartz, Allan" sort="Schwartz, Allan" uniqKey="Schwartz A" first="Allan" last="Schwartz">Allan Schwartz</name><affiliation><nlm:affiliation>Department of Medicine, Division of Cardiology, Columbia University Vagelos College of Physicians and Surgeons, New York.</nlm:affiliation></affiliation></author><author><name sortKey="Uriel, Nir" sort="Uriel, Nir" uniqKey="Uriel N" first="Nir" last="Uriel">Nir Uriel</name><affiliation><nlm:affiliation>Department of Medicine, Division of Cardiology, Columbia University Vagelos College of Physicians and Surgeons, New York.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Circulation</title><idno type="eISSN">1524-4539</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Angiotensin Receptor Antagonists (therapeutic use)</term><term>Angiotensin-Converting Enzyme Inhibitors (therapeutic use)</term><term>Betacoronavirus (MeSH)</term><term>Cardiovascular Diseases (complications)</term><term>Cardiovascular Diseases (enzymology)</term><term>Coronavirus Infections (complications)</term><term>Coronavirus Infections (drug therapy)</term><term>Coronavirus Infections (enzymology)</term><term>Coronavirus Infections (therapy)</term><term>Coronavirus Infections (virology)</term><term>Humans (MeSH)</term><term>Pandemics (MeSH)</term><term>Peptidyl-Dipeptidase A (metabolism)</term><term>Pneumonia, Viral (complications)</term><term>Pneumonia, Viral (enzymology)</term><term>Pneumonia, Viral (therapy)</term><term>Pneumonia, Viral (virology)</term><term>Receptors, Virus (antagonists & inhibitors)</term><term>Receptors, Virus (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Receptors, Virus</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Peptidyl-Dipeptidase A</term><term>Receptors, Virus</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Angiotensin Receptor Antagonists</term><term>Angiotensin-Converting Enzyme Inhibitors</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Cardiovascular Diseases</term><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Cardiovascular Diseases</term><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Betacoronavirus</term><term>Humans</term><term>Pandemics</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Coronavirus disease 2019 (COVID-19) is a global pandemic affecting 185 countries and >3 000 000 patients worldwide as of April 28, 2020. COVID-19 is caused by severe acute respiratory syndrome coronavirus 2, which invades cells through the angiotensin-converting enzyme 2 receptor. Among patients with COVID-19, there is a high prevalence of cardiovascular disease, and >7% of patients experience myocardial injury from the infection (22% of critically ill patients). Although angiotensin-converting enzyme 2 serves as the portal for infection, the role of angiotensin-converting enzyme inhibitors or angiotensin receptor blockers requires further investigation. COVID-19 poses a challenge for heart transplantation, affecting donor selection, immunosuppression, and posttransplant management. There are a number of promising therapies under active investigation to treat and prevent COVID-19.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32200663</PMID><DateCompleted><Year>2020</Year><Month>05</Month><Day>22</Day></DateCompleted><DateRevised><Year>2020</Year><Month>05</Month><Day>22</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1524-4539</ISSN><JournalIssue CitedMedium="Internet"><Volume>141</Volume><Issue>20</Issue><PubDate><Year>2020</Year><Month>May</Month><Day>19</Day></PubDate></JournalIssue><Title>Circulation</Title><ISOAbbreviation>Circulation</ISOAbbreviation></Journal><ArticleTitle>COVID-19 and Cardiovascular Disease.</ArticleTitle><Pagination><MedlinePgn>1648-1655</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1161/CIRCULATIONAHA.120.046941</ELocationID><Abstract><AbstractText>Coronavirus disease 2019 (COVID-19) is a global pandemic affecting 185 countries and >3 000 000 patients worldwide as of April 28, 2020. COVID-19 is caused by severe acute respiratory syndrome coronavirus 2, which invades cells through the angiotensin-converting enzyme 2 receptor. Among patients with COVID-19, there is a high prevalence of cardiovascular disease, and >7% of patients experience myocardial injury from the infection (22% of critically ill patients). Although angiotensin-converting enzyme 2 serves as the portal for infection, the role of angiotensin-converting enzyme inhibitors or angiotensin receptor blockers requires further investigation. COVID-19 poses a challenge for heart transplantation, affecting donor selection, immunosuppression, and posttransplant management. There are a number of promising therapies under active investigation to treat and prevent COVID-19.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Clerkin</LastName><ForeName>Kevin J</ForeName><Initials>KJ</Initials><AffiliationInfo><Affiliation>Department of Medicine, Division of Cardiology, Columbia University Vagelos College of Physicians and Surgeons, New York.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fried</LastName><ForeName>Justin A</ForeName><Initials>JA</Initials><AffiliationInfo><Affiliation>Department of Medicine, Division of Cardiology, Columbia University Vagelos College of Physicians and Surgeons, New York.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Raikhelkar</LastName><ForeName>Jayant</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Medicine, Division of Cardiology, Columbia University Vagelos College of Physicians and Surgeons, New York.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sayer</LastName><ForeName>Gabriel</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Medicine, Division of Cardiology, Columbia University Vagelos College of Physicians and Surgeons, New York.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Griffin</LastName><ForeName>Jan M</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>Department of Medicine, Division of Cardiology, Columbia University Vagelos College of Physicians and Surgeons, New York.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Masoumi</LastName><ForeName>Amirali</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Medicine, Division of Cardiology, Columbia University Vagelos College of Physicians and Surgeons, New York.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jain</LastName><ForeName>Sneha S</ForeName><Initials>SS</Initials><AffiliationInfo><Affiliation>Department of Medicine, Division of Cardiology, Columbia University Vagelos College of Physicians and Surgeons, New York.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Burkhoff</LastName><ForeName>Daniel</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Medicine, Division of Cardiology, Columbia University Vagelos College of Physicians and Surgeons, New York.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kumaraiah</LastName><ForeName>Deepa</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Medicine, Division of Cardiology, Columbia University Vagelos College of Physicians and Surgeons, New York.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rabbani</LastName><ForeName>LeRoy</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Medicine, Division of Cardiology, Columbia University Vagelos College of Physicians and Surgeons, New York.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schwartz</LastName><ForeName>Allan</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Medicine, Division of Cardiology, Columbia University Vagelos College of Physicians and Surgeons, New York.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Uriel</LastName><ForeName>Nir</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Medicine, Division of Cardiology, Columbia University Vagelos College of Physicians and Surgeons, New York.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>03</Month><Day>21</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Circulation</MedlineTA><NlmUniqueID>0147763</NlmUniqueID><ISSNLinking>0009-7322</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D057911">Angiotensin Receptor Antagonists</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000806">Angiotensin-Converting Enzyme Inhibitors</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011991">Receptors, Virus</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.4.15.1</RegistryNumber><NameOfSubstance UI="D007703">Peptidyl-Dipeptidase A</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.4.17.-</RegistryNumber><NameOfSubstance UI="C413524">angiotensin converting enzyme 2</NameOfSubstance></Chemical></ChemicalList><SupplMeshList><SupplMeshName Type="Disease" UI="C000657245">COVID-19</SupplMeshName><SupplMeshName Type="Protocol" UI="C000705127">COVID-19 drug treatment</SupplMeshName><SupplMeshName Type="Organism" UI="C000656484">severe acute respiratory syndrome coronavirus 2</SupplMeshName></SupplMeshList><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D057911" MajorTopicYN="N">Angiotensin Receptor Antagonists</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000806" MajorTopicYN="N">Angiotensin-Converting Enzyme Inhibitors</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000073640" MajorTopicYN="Y">Betacoronavirus</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002318" MajorTopicYN="Y">Cardiovascular Diseases</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000201" MajorTopicYN="N">enzymology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018352" MajorTopicYN="Y">Coronavirus Infections</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName><QualifierName UI="Q000201" MajorTopicYN="N">enzymology</QualifierName><QualifierName UI="Q000628" MajorTopicYN="N">therapy</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D058873" MajorTopicYN="Y">Pandemics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007703" MajorTopicYN="Y">Peptidyl-Dipeptidase A</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011024" MajorTopicYN="Y">Pneumonia, Viral</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000201" MajorTopicYN="N">enzymology</QualifierName><QualifierName UI="Q000628" MajorTopicYN="N">therapy</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011991" MajorTopicYN="N">Receptors, Virus</DescriptorName><QualifierName UI="Q000037" MajorTopicYN="N">antagonists & inhibitors</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">COVID-19</Keyword><Keyword MajorTopicYN="N">cardiovascular diseases</Keyword><Keyword MajorTopicYN="N">pandemics</Keyword><Keyword MajorTopicYN="N">severe acute respiratory syndrome coronavirus 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