The ACE2 expression in human heart indicates new potential mechanism of heart injury among patients infected with SARS-CoV-2.
Identifieur interne : 000392 ( Main/Corpus ); précédent : 000391; suivant : 000393The ACE2 expression in human heart indicates new potential mechanism of heart injury among patients infected with SARS-CoV-2.
Auteurs : Liang Chen ; Xiangjie Li ; Mingquan Chen ; Yi Feng ; Chenglong XiongSource :
- Cardiovascular research [ 1755-3245 ] ; 2020.
English descriptors
- KwdEn :
- Betacoronavirus (metabolism), Betacoronavirus (physiology), Coronavirus Infections (complications), Coronavirus Infections (virology), Gene Expression (MeSH), Gene Expression Profiling (MeSH), Heart (virology), Heart Diseases (etiology), Humans (MeSH), Myocardium (enzymology), Pandemics (MeSH), Peptidyl-Dipeptidase A (genetics), Peptidyl-Dipeptidase A (metabolism), Pericytes (enzymology), Pericytes (virology), Pneumonia, Viral (complications), Pneumonia, Viral (virology), Receptors, Virus (genetics), Receptors, Virus (metabolism), Spike Glycoprotein, Coronavirus (metabolism).
- MESH :
- chemical , genetics : Peptidyl-Dipeptidase A, Receptors, Virus.
- complications : Coronavirus Infections, Pneumonia, Viral.
- enzymology : Myocardium, Pericytes.
- etiology : Heart Diseases.
- metabolism : Betacoronavirus, Peptidyl-Dipeptidase A, Receptors, Virus, Spike Glycoprotein, Coronavirus.
- physiology : Betacoronavirus.
- virology : Coronavirus Infections, Heart, Pericytes, Pneumonia, Viral.
- Gene Expression, Gene Expression Profiling, Humans, Pandemics.
Abstract
A new type of pneumonia caused by a novel coronavirus SARS-CoV-2 outbreaks recently in China and spreads into many other countries. This disease, named as COVID-19, is similar to patients infected by SARS-CoV and MERS-CoV, and nearly 20% of patients developed severe condition. Cardiac injury is a prevalent complication of severe patients, exacerbating the disease severity in coronavirus disease 2019 (COVID-19) patients. Angiotensin-converting enzyme 2 (ACE2), the key host cellular receptor of SARS-CoV-2, has been identified in multiple organs, but its cellular distribution in human heart is not illuminated clearly. This study performed the first state-of-art single cell atlas of adult human heart, and revealed that pericytes with high expression of ACE2 might act as the target cardiac cell of SARS-CoV-2. The pericytes injury due to virus infection may result in capillary endothelial cells dysfunction, inducing microvascular dysfunction. And patients with basic heart failure disease showed increased ACE2 expression at both mRNA and protein levels, meaning that if infected by the virus these patients may have higher risk of heart attack and critically ill condition. The finding of this study explains the high rate of severe cases among COVID-19 patients with basic cardiovascular disease; and these results also perhaps provide important reference to clinical treatment of cardiac injury among severe patients infected by SARS-CoV-2.
DOI: 10.1093/cvr/cvaa078
PubMed: 32227090
PubMed Central: PMC7184507
Links to Exploration step
pubmed:32227090Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The ACE2 expression in human heart indicates new potential mechanism of heart injury among patients infected with SARS-CoV-2.</title><author><name sortKey="Chen, Liang" sort="Chen, Liang" uniqKey="Chen L" first="Liang" last="Chen">Liang Chen</name><affiliation><nlm:affiliation>Department of Epidemiology, School of Public Health, Fudan University, NO. 130 Dong'an Road, Xuhui district, Shanghai 200032, China.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Xiangjie" sort="Li, Xiangjie" uniqKey="Li X" first="Xiangjie" last="Li">Xiangjie Li</name><affiliation><nlm:affiliation>Department of Medical Biostatistics, Center for Applied Statistics, School of Statistics, Renmin University of China, Beijing 100872, China.</nlm:affiliation></affiliation></author><author><name sortKey="Chen, Mingquan" sort="Chen, Mingquan" uniqKey="Chen M" first="Mingquan" last="Chen">Mingquan Chen</name><affiliation><nlm:affiliation>Department of Emergency, Huashan Hospital, Fudan University, Shanghai 200040, China.</nlm:affiliation></affiliation></author><author><name sortKey="Feng, Yi" sort="Feng, Yi" uniqKey="Feng Y" first="Yi" last="Feng">Yi Feng</name><affiliation><nlm:affiliation>Department of Integrative Medicine and Neurobiology, School of Basic Medical Sciences; Institutes of Brain Science, State Key Laboratory of Medical Neurobiology, Fudan Institutes of Integrative Medicine, Fudan University, Shanghai 200032, China.</nlm:affiliation></affiliation></author><author><name sortKey="Xiong, Chenglong" sort="Xiong, Chenglong" uniqKey="Xiong C" first="Chenglong" last="Xiong">Chenglong Xiong</name><affiliation><nlm:affiliation>Department of Epidemiology, School of Public Health, Fudan University, NO. 130 Dong'an Road, Xuhui district, Shanghai 200032, China.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32227090</idno><idno type="pmid">32227090</idno><idno type="doi">10.1093/cvr/cvaa078</idno><idno type="pmc">PMC7184507</idno><idno type="wicri:Area/Main/Corpus">000392</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000392</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The ACE2 expression in human heart indicates new potential mechanism of heart injury among patients infected with SARS-CoV-2.</title><author><name sortKey="Chen, Liang" sort="Chen, Liang" uniqKey="Chen L" first="Liang" last="Chen">Liang Chen</name><affiliation><nlm:affiliation>Department of Epidemiology, School of Public Health, Fudan University, NO. 130 Dong'an Road, Xuhui district, Shanghai 200032, China.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Xiangjie" sort="Li, Xiangjie" uniqKey="Li X" first="Xiangjie" last="Li">Xiangjie Li</name><affiliation><nlm:affiliation>Department of Medical Biostatistics, Center for Applied Statistics, School of Statistics, Renmin University of China, Beijing 100872, China.</nlm:affiliation></affiliation></author><author><name sortKey="Chen, Mingquan" sort="Chen, Mingquan" uniqKey="Chen M" first="Mingquan" last="Chen">Mingquan Chen</name><affiliation><nlm:affiliation>Department of Emergency, Huashan Hospital, Fudan University, Shanghai 200040, China.</nlm:affiliation></affiliation></author><author><name sortKey="Feng, Yi" sort="Feng, Yi" uniqKey="Feng Y" first="Yi" last="Feng">Yi Feng</name><affiliation><nlm:affiliation>Department of Integrative Medicine and Neurobiology, School of Basic Medical Sciences; Institutes of Brain Science, State Key Laboratory of Medical Neurobiology, Fudan Institutes of Integrative Medicine, Fudan University, Shanghai 200032, China.</nlm:affiliation></affiliation></author><author><name sortKey="Xiong, Chenglong" sort="Xiong, Chenglong" uniqKey="Xiong C" first="Chenglong" last="Xiong">Chenglong Xiong</name><affiliation><nlm:affiliation>Department of Epidemiology, School of Public Health, Fudan University, NO. 130 Dong'an Road, Xuhui district, Shanghai 200032, China.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Cardiovascular research</title><idno type="eISSN">1755-3245</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Betacoronavirus (metabolism)</term><term>Betacoronavirus (physiology)</term><term>Coronavirus Infections (complications)</term><term>Coronavirus Infections (virology)</term><term>Gene Expression (MeSH)</term><term>Gene Expression Profiling (MeSH)</term><term>Heart (virology)</term><term>Heart Diseases (etiology)</term><term>Humans (MeSH)</term><term>Myocardium (enzymology)</term><term>Pandemics (MeSH)</term><term>Peptidyl-Dipeptidase A (genetics)</term><term>Peptidyl-Dipeptidase A (metabolism)</term><term>Pericytes (enzymology)</term><term>Pericytes (virology)</term><term>Pneumonia, Viral (complications)</term><term>Pneumonia, Viral (virology)</term><term>Receptors, Virus (genetics)</term><term>Receptors, Virus (metabolism)</term><term>Spike Glycoprotein, Coronavirus (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Peptidyl-Dipeptidase A</term><term>Receptors, Virus</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Myocardium</term><term>Pericytes</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Heart Diseases</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Betacoronavirus</term><term>Peptidyl-Dipeptidase A</term><term>Receptors, Virus</term><term>Spike Glycoprotein, Coronavirus</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Betacoronavirus</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term><term>Heart</term><term>Pericytes</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Gene Expression</term><term>Gene Expression Profiling</term><term>Humans</term><term>Pandemics</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A new type of pneumonia caused by a novel coronavirus SARS-CoV-2 outbreaks recently in China and spreads into many other countries. This disease, named as COVID-19, is similar to patients infected by SARS-CoV and MERS-CoV, and nearly 20% of patients developed severe condition. Cardiac injury is a prevalent complication of severe patients, exacerbating the disease severity in coronavirus disease 2019 (COVID-19) patients. Angiotensin-converting enzyme 2 (ACE2), the key host cellular receptor of SARS-CoV-2, has been identified in multiple organs, but its cellular distribution in human heart is not illuminated clearly. This study performed the first state-of-art single cell atlas of adult human heart, and revealed that pericytes with high expression of ACE2 might act as the target cardiac cell of SARS-CoV-2. The pericytes injury due to virus infection may result in capillary endothelial cells dysfunction, inducing microvascular dysfunction. And patients with basic heart failure disease showed increased ACE2 expression at both mRNA and protein levels, meaning that if infected by the virus these patients may have higher risk of heart attack and critically ill condition. The finding of this study explains the high rate of severe cases among COVID-19 patients with basic cardiovascular disease; and these results also perhaps provide important reference to clinical treatment of cardiac injury among severe patients infected by SARS-CoV-2.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32227090</PMID><DateCompleted><Year>2020</Year><Month>04</Month><Day>28</Day></DateCompleted><DateRevised><Year>2020</Year><Month>04</Month><Day>30</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1755-3245</ISSN><JournalIssue CitedMedium="Internet"><Volume>116</Volume><Issue>6</Issue><PubDate><Year>2020</Year><Month>05</Month><Day>01</Day></PubDate></JournalIssue><Title>Cardiovascular research</Title><ISOAbbreviation>Cardiovasc. Res.</ISOAbbreviation></Journal><ArticleTitle>The ACE2 expression in human heart indicates new potential mechanism of heart injury among patients infected with SARS-CoV-2.</ArticleTitle><Pagination><MedlinePgn>1097-1100</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1093/cvr/cvaa078</ELocationID><Abstract><AbstractText>A new type of pneumonia caused by a novel coronavirus SARS-CoV-2 outbreaks recently in China and spreads into many other countries. This disease, named as COVID-19, is similar to patients infected by SARS-CoV and MERS-CoV, and nearly 20% of patients developed severe condition. Cardiac injury is a prevalent complication of severe patients, exacerbating the disease severity in coronavirus disease 2019 (COVID-19) patients. Angiotensin-converting enzyme 2 (ACE2), the key host cellular receptor of SARS-CoV-2, has been identified in multiple organs, but its cellular distribution in human heart is not illuminated clearly. This study performed the first state-of-art single cell atlas of adult human heart, and revealed that pericytes with high expression of ACE2 might act as the target cardiac cell of SARS-CoV-2. The pericytes injury due to virus infection may result in capillary endothelial cells dysfunction, inducing microvascular dysfunction. And patients with basic heart failure disease showed increased ACE2 expression at both mRNA and protein levels, meaning that if infected by the virus these patients may have higher risk of heart attack and critically ill condition. The finding of this study explains the high rate of severe cases among COVID-19 patients with basic cardiovascular disease; and these results also perhaps provide important reference to clinical treatment of cardiac injury among severe patients infected by SARS-CoV-2.</AbstractText><CopyrightInformation>Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2020. For permissions, please email: journals.permissions@oup.com.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Liang</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, School of Public Health, Fudan University, NO. 130 Dong'an Road, Xuhui district, Shanghai 200032, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Xiangjie</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Department of Medical Biostatistics, Center for Applied Statistics, School of Statistics, Renmin University of China, Beijing 100872, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Mingquan</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Emergency, Huashan Hospital, Fudan University, Shanghai 200040, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Feng</LastName><ForeName>Yi</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Integrative Medicine and Neurobiology, School of Basic Medical Sciences; Institutes of Brain Science, State Key Laboratory of Medical Neurobiology, Fudan Institutes of Integrative Medicine, Fudan University, Shanghai 200032, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Xiong</LastName><ForeName>Chenglong</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, School of Public Health, Fudan University, NO. 130 Dong'an Road, Xuhui district, Shanghai 200032, China.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Cardiovasc 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IdType="pmc">PMC7184507</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>N Engl J Med. 2020 Apr 30;382(18):1708-1720</Citation><ArticleIdList><ArticleId IdType="pubmed">32109013</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2004 Nov 2;101(44):15748-53</Citation><ArticleIdList><ArticleId IdType="pubmed">15496474</ArticleId></ArticleIdList></Reference><Reference><Citation>J Proteome Res. 2017 Aug 4;16(8):2863-2876</Citation><ArticleIdList><ArticleId IdType="pubmed">28665611</ArticleId></ArticleIdList></Reference><Reference><Citation>JAMA. 2020 Mar 11;:</Citation><ArticleIdList><ArticleId IdType="pubmed">32159775</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet Respir Med. 2020 Feb 24;:</Citation><ArticleIdList><ArticleId IdType="pubmed">32105632</ArticleId></ArticleIdList></Reference><Reference><Citation>Nature. 2020 Mar;579(7798):270-273</Citation><ArticleIdList><ArticleId IdType="pubmed">32015507</ArticleId></ArticleIdList></Reference><Reference><Citation>J Recept Signal Transduct Res. 2019 Jun;39(3):187-193</Citation><ArticleIdList><ArticleId IdType="pubmed">31429357</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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