Clinical utility of cardiac troponin measurement in COVID-19 infection.
Identifieur interne : 000380 ( Main/Corpus ); précédent : 000379; suivant : 000381Clinical utility of cardiac troponin measurement in COVID-19 infection.
Auteurs : David C. GazeSource :
- Annals of clinical biochemistry [ 1758-1001 ] ; 2020.
English descriptors
- KwdEn :
- MESH :
- chemical , blood : Biomarkers, Troponin.
- diagnosis : Coronavirus Infections, Pneumonia, Viral.
- Betacoronavirus, Humans, Pandemics.
Abstract
The novel coronavirus SARS-CoV-2 causes the disease COVID-19, a severe acute respiratory syndrome. COVID-19 is now a global pandemic and public health emergency due to rapid human-to-human transmission. The impact is far-reaching, with enforced social distancing and isolation, detrimental effects on individual physical activity and mental wellbeing, education in the young and economic impact to business. Whilst most COVID-19 patients demonstrate mild-to-moderate symptoms, those with severe disease progression are at a higher risk of mortality. As more is learnt about this novel disease, it is becoming evident that comorbid cardiovascular disease is associated with a greater severity and increased mortality. Many patients positive for COVID-19 demonstrate increased concentrations of cardiac troponin, creating confusion in clinical interpretation. While myocardial infarction is associated with acute infectious respiratory disease, the majority of COVID-19 patients demonstrate stable cTn rather than the dynamically changing values indicative of an acute coronary syndrome. Although full understanding of the mechanism of cTn release in COVID-19 is currently lacking, this mini-review assesses the limited published literature with a view to offering insight to pathophysiological mechanisms and reported treatment regimens.
DOI: 10.1177/0004563220921888
PubMed: 32255359
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Gaze</name><affiliation><nlm:affiliation>Clinical Biochemistry, University of Westminster, London, UK.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Clinical Blood Sciences, South West London Pathology, St George's Healthcare NHS Foundation Trust, London, UK.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32255359</idno><idno type="pmid">32255359</idno><idno type="doi">10.1177/0004563220921888</idno><idno type="wicri:Area/Main/Corpus">000380</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000380</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Clinical utility of cardiac troponin measurement in COVID-19 infection.</title><author><name sortKey="Gaze, David C" sort="Gaze, David C" uniqKey="Gaze D" first="David C" last="Gaze">David C. Gaze</name><affiliation><nlm:affiliation>Clinical Biochemistry, University of Westminster, London, UK.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Clinical Blood Sciences, South West London Pathology, St George's Healthcare NHS Foundation Trust, London, UK.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Annals of clinical biochemistry</title><idno type="eISSN">1758-1001</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Betacoronavirus (MeSH)</term><term>Biomarkers (blood)</term><term>Coronavirus Infections (diagnosis)</term><term>Humans (MeSH)</term><term>Pandemics (MeSH)</term><term>Pneumonia, Viral (diagnosis)</term><term>Troponin (blood)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Biomarkers</term><term>Troponin</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Betacoronavirus</term><term>Humans</term><term>Pandemics</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The novel coronavirus SARS-CoV-2 causes the disease COVID-19, a severe acute respiratory syndrome. COVID-19 is now a global pandemic and public health emergency due to rapid human-to-human transmission. The impact is far-reaching, with enforced social distancing and isolation, detrimental effects on individual physical activity and mental wellbeing, education in the young and economic impact to business. Whilst most COVID-19 patients demonstrate mild-to-moderate symptoms, those with severe disease progression are at a higher risk of mortality. As more is learnt about this novel disease, it is becoming evident that comorbid cardiovascular disease is associated with a greater severity and increased mortality. Many patients positive for COVID-19 demonstrate increased concentrations of cardiac troponin, creating confusion in clinical interpretation. While myocardial infarction is associated with acute infectious respiratory disease, the majority of COVID-19 patients demonstrate stable cTn rather than the dynamically changing values indicative of an acute coronary syndrome. Although full understanding of the mechanism of cTn release in COVID-19 is currently lacking, this mini-review assesses the limited published literature with a view to offering insight to pathophysiological mechanisms and reported treatment regimens.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32255359</PMID><DateCompleted><Year>2020</Year><Month>05</Month><Day>18</Day></DateCompleted><DateRevised><Year>2020</Year><Month>05</Month><Day>18</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1758-1001</ISSN><JournalIssue CitedMedium="Internet"><Volume>57</Volume><Issue>3</Issue><PubDate><Year>2020</Year><Month>05</Month></PubDate></JournalIssue><Title>Annals of clinical biochemistry</Title><ISOAbbreviation>Ann. Clin. Biochem.</ISOAbbreviation></Journal><ArticleTitle>Clinical utility of cardiac troponin measurement in COVID-19 infection.</ArticleTitle><Pagination><MedlinePgn>202-205</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1177/0004563220921888</ELocationID><Abstract><AbstractText>The novel coronavirus SARS-CoV-2 causes the disease COVID-19, a severe acute respiratory syndrome. COVID-19 is now a global pandemic and public health emergency due to rapid human-to-human transmission. The impact is far-reaching, with enforced social distancing and isolation, detrimental effects on individual physical activity and mental wellbeing, education in the young and economic impact to business. Whilst most COVID-19 patients demonstrate mild-to-moderate symptoms, those with severe disease progression are at a higher risk of mortality. As more is learnt about this novel disease, it is becoming evident that comorbid cardiovascular disease is associated with a greater severity and increased mortality. Many patients positive for COVID-19 demonstrate increased concentrations of cardiac troponin, creating confusion in clinical interpretation. While myocardial infarction is associated with acute infectious respiratory disease, the majority of COVID-19 patients demonstrate stable cTn rather than the dynamically changing values indicative of an acute coronary syndrome. Although full understanding of the mechanism of cTn release in COVID-19 is currently lacking, this mini-review assesses the limited published literature with a view to offering insight to pathophysiological mechanisms and reported treatment regimens.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Gaze</LastName><ForeName>David C</ForeName><Initials>DC</Initials><Identifier Source="ORCID">0000-0002-0544-2356</Identifier><AffiliationInfo><Affiliation>Clinical Biochemistry, University of Westminster, London, UK.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Clinical Blood Sciences, South West London Pathology, St George's Healthcare NHS Foundation Trust, London, UK.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>04</Month><Day>27</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Ann Clin Biochem</MedlineTA><NlmUniqueID>0324055</NlmUniqueID><ISSNLinking>0004-5632</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015415">Biomarkers</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014336">Troponin</NameOfSubstance></Chemical></ChemicalList><SupplMeshList><SupplMeshName Type="Disease" UI="C000657245">COVID-19</SupplMeshName><SupplMeshName Type="Organism" UI="C000656484">severe acute respiratory syndrome coronavirus 2</SupplMeshName></SupplMeshList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000073640" MajorTopicYN="N">Betacoronavirus</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015415" MajorTopicYN="N">Biomarkers</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014336" MajorTopicYN="N">Troponin</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Covid-19</Keyword><Keyword MajorTopicYN="Y">SARS-Cov-2</Keyword><Keyword MajorTopicYN="Y">Troponin</Keyword><Keyword MajorTopicYN="Y">analytes</Keyword><Keyword MajorTopicYN="Y">cardiac troponin I</Keyword><Keyword MajorTopicYN="Y">cardiac troponin T</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>4</Month><Day>8</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>5</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>4</Month><Day>8</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32255359</ArticleId><ArticleId IdType="doi">10.1177/0004563220921888</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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