COVID-19 in the heart and the lungs: could we "Notch" the inflammatory storm?
Identifieur interne : 000370 ( Main/Corpus ); précédent : 000369; suivant : 000371COVID-19 in the heart and the lungs: could we "Notch" the inflammatory storm?
Auteurs : Paola Rizzo ; Francesco Vieceli Dalla Sega ; Francesca Fortini ; Luisa Marracino ; Claudio Rapezzi ; Roberto FerrariSource :
- Basic research in cardiology [ 1435-1803 ] ; 2020.
English descriptors
- KwdEn :
- ADAM17 Protein (antagonists & inhibitors), Betacoronavirus (drug effects), Betacoronavirus (pathogenicity), China (MeSH), Coronavirus Infections (drug therapy), Coronavirus Infections (pathology), Coronavirus Infections (physiopathology), Coronavirus Infections (virology), Disease Progression (MeSH), Furin (metabolism), Heart Arrest (etiology), Heart Arrest (pathology), Heart Diseases (drug therapy), Heart Diseases (etiology), Heart Diseases (pathology), Heart Diseases (physiopathology), Heart Failure (etiology), Heart Failure (pathology), Humans (MeSH), Interleukin-6 (immunology), Lung Diseases (drug therapy), Lung Diseases (etiology), Lung Diseases (pathology), Lung Diseases (physiopathology), Myocarditis (etiology), Myocarditis (pathology), Pandemics (MeSH), Peptidyl-Dipeptidase A (deficiency), Peptidyl-Dipeptidase A (metabolism), Pneumonia, Viral (drug therapy), Pneumonia, Viral (pathology), Pneumonia, Viral (physiopathology), Pneumonia, Viral (virology), Receptors, Notch (antagonists & inhibitors), Receptors, Notch (metabolism), Signal Transduction (drug effects).
- MESH :
- chemical , antagonists & inhibitors : ADAM17 Protein, Receptors, Notch.
- chemical , deficiency : Peptidyl-Dipeptidase A.
- chemical , immunology : Interleukin-6.
- chemical , metabolism : Furin, Peptidyl-Dipeptidase A, Receptors, Notch.
- geographic : China.
- drug effects : Betacoronavirus, Signal Transduction.
- drug therapy : Coronavirus Infections, Heart Diseases, Lung Diseases, Pneumonia, Viral.
- etiology : Heart Arrest, Heart Diseases, Heart Failure, Lung Diseases, Myocarditis.
- pathogenicity : Betacoronavirus.
- pathology : Coronavirus Infections, Heart Arrest, Heart Diseases, Heart Failure, Lung Diseases, Myocarditis, Pneumonia, Viral.
- physiopathology : Coronavirus Infections, Heart Diseases, Lung Diseases, Pneumonia, Viral.
- virology : Coronavirus Infections, Pneumonia, Viral.
- Disease Progression, Humans, Pandemics.
Abstract
From January 2020, coronavirus disease (COVID-19) originated in China has spread around the world. The disease is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The presence of myocarditis, cardiac arrest, and acute heart failure in COVID-19 patients suggests the existence of a relationship between SARS-CoV-2 infection and cardiac disease. The Notch signalling is a major regulator of cardiovascular function and it is also implicated in several biological processes mediating viral infections. In this report we discuss the possibility to target Notch signalling to prevent SARS-CoV-2 infection and interfere with the progression of COVID-19- associated heart and lungs disease.
DOI: 10.1007/s00395-020-0791-5
PubMed: 32274570
PubMed Central: PMC7144545
Links to Exploration step
pubmed:32274570Le document en format XML
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Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Fortini, Francesca" sort="Fortini, Francesca" uniqKey="Fortini F" first="Francesca" last="Fortini">Francesca Fortini</name><affiliation><nlm:affiliation>Maria Cecilia Hospital, GVM Care & Research, Cotignola, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Marracino, Luisa" sort="Marracino, Luisa" uniqKey="Marracino L" first="Luisa" last="Marracino">Luisa Marracino</name><affiliation><nlm:affiliation>Department of Morphology, Surgery and Experimental Medicine and Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, Ferrara, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Rapezzi, Claudio" sort="Rapezzi, Claudio" uniqKey="Rapezzi C" first="Claudio" last="Rapezzi">Claudio Rapezzi</name><affiliation><nlm:affiliation>Maria Cecilia Hospital, GVM Care & Research, Cotignola, 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Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Fortini, Francesca" sort="Fortini, Francesca" uniqKey="Fortini F" first="Francesca" last="Fortini">Francesca Fortini</name><affiliation><nlm:affiliation>Maria Cecilia Hospital, GVM Care & Research, Cotignola, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Marracino, Luisa" sort="Marracino, Luisa" uniqKey="Marracino L" first="Luisa" last="Marracino">Luisa Marracino</name><affiliation><nlm:affiliation>Department of Morphology, Surgery and Experimental Medicine and Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, Ferrara, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Rapezzi, Claudio" sort="Rapezzi, Claudio" uniqKey="Rapezzi C" first="Claudio" last="Rapezzi">Claudio Rapezzi</name><affiliation><nlm:affiliation>Maria Cecilia Hospital, GVM Care & Research, Cotignola, Italy.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Cardiovascular Center, University Hospital of Cona, Ferrara, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Ferrari, Roberto" sort="Ferrari, Roberto" uniqKey="Ferrari R" first="Roberto" last="Ferrari">Roberto Ferrari</name><affiliation><nlm:affiliation>Maria Cecilia Hospital, GVM Care & Research, Cotignola, Italy.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Cardiovascular Center, University Hospital of Cona, Ferrara, Italy.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Basic research in cardiology</title><idno type="eISSN">1435-1803</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>ADAM17 Protein (antagonists & inhibitors)</term><term>Betacoronavirus (drug effects)</term><term>Betacoronavirus 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(deficiency)</term><term>Peptidyl-Dipeptidase A (metabolism)</term><term>Pneumonia, Viral (drug therapy)</term><term>Pneumonia, Viral (pathology)</term><term>Pneumonia, Viral (physiopathology)</term><term>Pneumonia, Viral (virology)</term><term>Receptors, Notch (antagonists & inhibitors)</term><term>Receptors, Notch (metabolism)</term><term>Signal Transduction (drug effects)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>ADAM17 Protein</term><term>Receptors, Notch</term></keywords><keywords scheme="MESH" type="chemical" qualifier="deficiency" xml:lang="en"><term>Peptidyl-Dipeptidase A</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Interleukin-6</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Furin</term><term>Peptidyl-Dipeptidase A</term><term>Receptors, Notch</term></keywords><keywords scheme="MESH" 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qualifier="physiopathology" xml:lang="en"><term>Coronavirus Infections</term><term>Heart Diseases</term><term>Lung Diseases</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Disease Progression</term><term>Humans</term><term>Pandemics</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">From January 2020, coronavirus disease (COVID-19) originated in China has spread around the world. The disease is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The presence of myocarditis, cardiac arrest, and acute heart failure in COVID-19 patients suggests the existence of a relationship between SARS-CoV-2 infection and cardiac disease. The Notch signalling is a major regulator of cardiovascular function and it is also implicated in several biological processes mediating viral infections. In this report we discuss the possibility to target Notch signalling to prevent SARS-CoV-2 infection and interfere with the progression of COVID-19- associated heart and lungs disease.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32274570</PMID><DateCompleted><Year>2020</Year><Month>04</Month><Day>15</Day></DateCompleted><DateRevised><Year>2020</Year><Month>05</Month><Day>12</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1435-1803</ISSN><JournalIssue CitedMedium="Internet"><Volume>115</Volume><Issue>3</Issue><PubDate><Year>2020</Year><Month>04</Month><Day>09</Day></PubDate></JournalIssue><Title>Basic research in cardiology</Title><ISOAbbreviation>Basic Res. Cardiol.</ISOAbbreviation></Journal><ArticleTitle>COVID-19 in the heart and the lungs: could we "Notch" the inflammatory storm?</ArticleTitle><Pagination><MedlinePgn>31</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1007/s00395-020-0791-5</ELocationID><Abstract><AbstractText>From January 2020, coronavirus disease (COVID-19) originated in China has spread around the world. The disease is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The presence of myocarditis, cardiac arrest, and acute heart failure in COVID-19 patients suggests the existence of a relationship between SARS-CoV-2 infection and cardiac disease. The Notch signalling is a major regulator of cardiovascular function and it is also implicated in several biological processes mediating viral infections. In this report we discuss the possibility to target Notch signalling to prevent SARS-CoV-2 infection and interfere with the progression of COVID-19- associated heart and lungs disease.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Rizzo</LastName><ForeName>Paola</ForeName><Initials>P</Initials><Identifier Source="ORCID">http://orcid.org/0000-0001-7174-9674</Identifier><AffiliationInfo><Affiliation>Department of Morphology, Surgery and Experimental Medicine and Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, Ferrara, Italy. rzzpla@unife.it.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Maria Cecilia Hospital, GVM Care & Research, Cotignola, Italy. rzzpla@unife.it.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vieceli Dalla Sega</LastName><ForeName>Francesco</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Maria Cecilia Hospital, GVM Care & Research, Cotignola, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fortini</LastName><ForeName>Francesca</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Maria Cecilia Hospital, GVM Care & Research, Cotignola, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Marracino</LastName><ForeName>Luisa</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Morphology, Surgery and Experimental Medicine and Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, Ferrara, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rapezzi</LastName><ForeName>Claudio</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Maria Cecilia Hospital, GVM Care & Research, Cotignola, Italy.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Cardiovascular Center, University Hospital of Cona, Ferrara, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ferrari</LastName><ForeName>Roberto</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Maria Cecilia Hospital, GVM Care & Research, Cotignola, Italy.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Cardiovascular Center, University Hospital of Cona, Ferrara, Italy.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016421">Editorial</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>04</Month><Day>09</Day></ArticleDate></Article><MedlineJournalInfo><Country>Germany</Country><MedlineTA>Basic Res Cardiol</MedlineTA><NlmUniqueID>0360342</NlmUniqueID><ISSNLinking>0300-8428</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015850">Interleukin-6</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D051880">Receptors, Notch</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.4.15.1</RegistryNumber><NameOfSubstance UI="D007703">Peptidyl-Dipeptidase A</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.4.17.-</RegistryNumber><NameOfSubstance UI="C413524">angiotensin converting enzyme 2</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.4.21.75</RegistryNumber><NameOfSubstance UI="D045683">Furin</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.4.24.86</RegistryNumber><NameOfSubstance UI="D000072198">ADAM17 Protein</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.4.24.86</RegistryNumber><NameOfSubstance UI="C000606462">ADAM17 protein, human</NameOfSubstance></Chemical></ChemicalList><SupplMeshList><SupplMeshName Type="Disease" UI="C000657245">COVID-19</SupplMeshName><SupplMeshName Type="Organism" UI="C000656484">severe acute respiratory syndrome coronavirus 2</SupplMeshName></SupplMeshList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000072198" MajorTopicYN="N">ADAM17 Protein</DescriptorName><QualifierName UI="Q000037" MajorTopicYN="N">antagonists & inhibitors</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000073640" MajorTopicYN="N">Betacoronavirus</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000472" MajorTopicYN="Y">pathogenicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002681" MajorTopicYN="N" Type="Geographic">China</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018450" MajorTopicYN="N">Disease Progression</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D045683" MajorTopicYN="N">Furin</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006323" MajorTopicYN="N">Heart Arrest</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006331" MajorTopicYN="N">Heart Diseases</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName><QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006333" MajorTopicYN="N">Heart Failure</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015850" MajorTopicYN="N">Interleukin-6</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008171" MajorTopicYN="N">Lung Diseases</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName><QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009205" MajorTopicYN="N">Myocarditis</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007703" MajorTopicYN="N">Peptidyl-Dipeptidase A</DescriptorName><QualifierName UI="Q000172" MajorTopicYN="N">deficiency</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051880" MajorTopicYN="N">Receptors, Notch</DescriptorName><QualifierName UI="Q000037" MajorTopicYN="Y">antagonists & inhibitors</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015398" MajorTopicYN="N">Signal Transduction</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">ADAM17</Keyword><Keyword MajorTopicYN="Y">Angiotensin-converting enzyme 2</Keyword><Keyword MajorTopicYN="Y">COVID-19</Keyword><Keyword MajorTopicYN="Y">Cardiovascular disease</Keyword><Keyword MajorTopicYN="Y">Coronavirus disease</Keyword><Keyword MajorTopicYN="Y">Furin</Keyword><Keyword MajorTopicYN="Y">Notch</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>03</Month><Day>21</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>03</Month><Day>30</Day></PubMedPubDate><PubMedPubDate 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