Comorbid Chronic Diseases and Acute Organ Injuries Are Strongly Correlated with Disease Severity and Mortality among COVID-19 Patients: A Systemic Review and Meta-Analysis.
Identifieur interne : 000303 ( Main/Corpus ); précédent : 000302; suivant : 000304Comorbid Chronic Diseases and Acute Organ Injuries Are Strongly Correlated with Disease Severity and Mortality among COVID-19 Patients: A Systemic Review and Meta-Analysis.
Auteurs : Xinhui Wang ; Xuexian Fang ; Zhaoxian Cai ; Xiaotian Wu ; Xiaotong Gao ; Junxia Min ; Fudi WangSource :
- Research (Washington, D.C.) [ 2639-5274 ] ; 2020.
Abstract
The recent outbreak of COVID-19 has been rapidly spreading on a global scale. To date, there is no specific vaccine against the causative virus, SARS-CoV-2, nor is there an effective medicine for treating COVID-19, thus raising concerns with respect to the effect of risk factors such as clinical course and pathophysiological parameters on disease severity and outcome in patients with COVID-19. By extracting and analyzing all available published clinical data, we identified several major clinical characteristics associated with increased disease severity and mortality among patients with COVID-19. Specifically, preexisting chronic conditions such as hypertension, cardiovascular disease, chronic kidney disease, and diabetes are strongly associated with an increased risk of developing severe COVID-19; surprisingly, however, we found no correlation between chronic liver disease and increased disease severity. In addition, we found that both acute cardiac injury and acute kidney injury are highly correlated with an increased risk of COVID-19-related mortality. Given the high risk of comorbidity and the high mortality rate associated with tissue damage, organ function should be monitored closely in patients diagnosed with COVID-19, and this approach should be included when establishing new guidelines for managing these high-risk patients. Moreover, additional clinical data are needed in order to determine whether a supportive therapy can help mitigate the development of severe, potentially fatal complications, and further studies are needed to identify the pathophysiology and the mechanism underlying this novel coronavirus-associated infectious disease. Taken together, these findings provide new insights regarding clinical strategies for improving the management and outcome of patients with COVID-19.
DOI: 10.34133/2020/2402961
PubMed: 32377638
PubMed Central: PMC7187729
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uniqKey="Cai Z" first="Zhaoxian" last="Cai">Zhaoxian Cai</name><affiliation><nlm:affiliation>The First Affiliated Hospital, School of Public Health, Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China.</nlm:affiliation></affiliation></author><author><name sortKey="Wu, Xiaotian" sort="Wu, Xiaotian" uniqKey="Wu X" first="Xiaotian" last="Wu">Xiaotian Wu</name><affiliation><nlm:affiliation>The First Affiliated Hospital, School of Public Health, Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China.</nlm:affiliation></affiliation></author><author><name sortKey="Gao, Xiaotong" sort="Gao, Xiaotong" uniqKey="Gao X" first="Xiaotong" last="Gao">Xiaotong Gao</name><affiliation><nlm:affiliation>The First Affiliated Hospital, School of Public Health, Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China.</nlm:affiliation></affiliation></author><author><name sortKey="Min, Junxia" sort="Min, Junxia" uniqKey="Min J" first="Junxia" last="Min">Junxia Min</name><affiliation><nlm:affiliation>The First Affiliated Hospital, School of Public Health, Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Fudi" sort="Wang, Fudi" uniqKey="Wang F" first="Fudi" last="Wang">Fudi Wang</name><affiliation><nlm:affiliation>The First Affiliated Hospital, School of Public Health, Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32377638</idno><idno type="pmid">32377638</idno><idno type="doi">10.34133/2020/2402961</idno><idno type="pmc">PMC7187729</idno><idno type="wicri:Area/Main/Corpus">000303</idno><idno type="wicri:explorRef" 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China.</nlm:affiliation></affiliation></author><author><name sortKey="Cai, Zhaoxian" sort="Cai, Zhaoxian" uniqKey="Cai Z" first="Zhaoxian" last="Cai">Zhaoxian Cai</name><affiliation><nlm:affiliation>The First Affiliated Hospital, School of Public Health, Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China.</nlm:affiliation></affiliation></author><author><name sortKey="Wu, Xiaotian" sort="Wu, Xiaotian" uniqKey="Wu X" first="Xiaotian" last="Wu">Xiaotian Wu</name><affiliation><nlm:affiliation>The First Affiliated Hospital, School of Public Health, Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China.</nlm:affiliation></affiliation></author><author><name sortKey="Gao, Xiaotong" sort="Gao, Xiaotong" uniqKey="Gao X" first="Xiaotong" last="Gao">Xiaotong Gao</name><affiliation><nlm:affiliation>The First Affiliated Hospital, School of Public Health, Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China.</nlm:affiliation></affiliation></author><author><name sortKey="Min, Junxia" sort="Min, Junxia" uniqKey="Min J" first="Junxia" last="Min">Junxia Min</name><affiliation><nlm:affiliation>The First Affiliated Hospital, School of Public Health, Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Fudi" sort="Wang, Fudi" uniqKey="Wang F" first="Fudi" last="Wang">Fudi Wang</name><affiliation><nlm:affiliation>The First Affiliated Hospital, School of Public Health, Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Research (Washington, D.C.)</title><idno type="eISSN">2639-5274</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The recent outbreak of COVID-19 has been rapidly spreading on a global scale. To date, there is no specific vaccine against the causative virus, SARS-CoV-2, nor is there an effective medicine for treating COVID-19, thus raising concerns with respect to the effect of risk factors such as clinical course and pathophysiological parameters on disease severity and outcome in patients with COVID-19. By extracting and analyzing all available published clinical data, we identified several major clinical characteristics associated with increased disease severity and mortality among patients with COVID-19. Specifically, preexisting chronic conditions such as hypertension, cardiovascular disease, chronic kidney disease, and diabetes are strongly associated with an increased risk of developing severe COVID-19; surprisingly, however, we found no correlation between chronic liver disease and increased disease severity. In addition, we found that both acute cardiac injury and acute kidney injury are highly correlated with an increased risk of COVID-19-related mortality. Given the high risk of comorbidity and the high mortality rate associated with tissue damage, organ function should be monitored closely in patients diagnosed with COVID-19, and this approach should be included when establishing new guidelines for managing these high-risk patients. Moreover, additional clinical data are needed in order to determine whether a supportive therapy can help mitigate the development of severe, potentially fatal complications, and further studies are needed to identify the pathophysiology and the mechanism underlying this novel coronavirus-associated infectious disease. Taken together, these findings provide new insights regarding clinical strategies for improving the management and outcome of patients with COVID-19.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">32377638</PMID><DateRevised><Year>2020</Year><Month>05</Month><Day>09</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Electronic">2639-5274</ISSN><JournalIssue CitedMedium="Internet"><Volume>2020</Volume><PubDate><Year>2020</Year></PubDate></JournalIssue><Title>Research (Washington, D.C.)</Title><ISOAbbreviation>Research (Wash D C)</ISOAbbreviation></Journal><ArticleTitle>Comorbid Chronic Diseases and Acute Organ Injuries Are Strongly Correlated with Disease Severity and Mortality among COVID-19 Patients: A Systemic Review and Meta-Analysis.</ArticleTitle><Pagination><MedlinePgn>2402961</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.34133/2020/2402961</ELocationID><Abstract><AbstractText>The recent outbreak of COVID-19 has been rapidly spreading on a global scale. To date, there is no specific vaccine against the causative virus, SARS-CoV-2, nor is there an effective medicine for treating COVID-19, thus raising concerns with respect to the effect of risk factors such as clinical course and pathophysiological parameters on disease severity and outcome in patients with COVID-19. By extracting and analyzing all available published clinical data, we identified several major clinical characteristics associated with increased disease severity and mortality among patients with COVID-19. Specifically, preexisting chronic conditions such as hypertension, cardiovascular disease, chronic kidney disease, and diabetes are strongly associated with an increased risk of developing severe COVID-19; surprisingly, however, we found no correlation between chronic liver disease and increased disease severity. In addition, we found that both acute cardiac injury and acute kidney injury are highly correlated with an increased risk of COVID-19-related mortality. Given the high risk of comorbidity and the high mortality rate associated with tissue damage, organ function should be monitored closely in patients diagnosed with COVID-19, and this approach should be included when establishing new guidelines for managing these high-risk patients. Moreover, additional clinical data are needed in order to determine whether a supportive therapy can help mitigate the development of severe, potentially fatal complications, and further studies are needed to identify the pathophysiology and the mechanism underlying this novel coronavirus-associated infectious disease. Taken together, these findings provide new insights regarding clinical strategies for improving the management and outcome of patients with COVID-19.</AbstractText><CopyrightInformation>Copyright © 2020 Xinhui Wang et al.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Xinhui</ForeName><Initials>X</Initials><Identifier Source="ORCID">https://orcid.org/0000-0001-7713-6262</Identifier><AffiliationInfo><Affiliation>The First Affiliated Hospital, School of Public Health, Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fang</LastName><ForeName>Xuexian</ForeName><Initials>X</Initials><Identifier Source="ORCID">https://orcid.org/0000-0001-5414-9888</Identifier><AffiliationInfo><Affiliation>The First Affiliated Hospital, School of Public Health, Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cai</LastName><ForeName>Zhaoxian</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>The First Affiliated Hospital, School of Public Health, Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wu</LastName><ForeName>Xiaotian</ForeName><Initials>X</Initials><Identifier Source="ORCID">https://orcid.org/0000-0002-0769-6878</Identifier><AffiliationInfo><Affiliation>The First Affiliated Hospital, School of Public Health, Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gao</LastName><ForeName>Xiaotong</ForeName><Initials>X</Initials><Identifier Source="ORCID">https://orcid.org/0000-0003-2670-9678</Identifier><AffiliationInfo><Affiliation>The First Affiliated Hospital, School of Public Health, Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Min</LastName><ForeName>Junxia</ForeName><Initials>J</Initials><Identifier Source="ORCID">https://orcid.org/0000-0001-8099-6327</Identifier><AffiliationInfo><Affiliation>The First Affiliated Hospital, School of Public Health, Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Fudi</ForeName><Initials>F</Initials><Identifier Source="ORCID">https://orcid.org/0000-0001-8730-0003</Identifier><AffiliationInfo><Affiliation>The First Affiliated Hospital, School of Public Health, Institute of Translational Medicine, Zhejiang University 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