Characteristics and outcomes of patients hospitalized for COVID-19 and cardiac disease in Northern Italy.
Identifieur interne : 000301 ( Main/Corpus ); précédent : 000300; suivant : 000302Characteristics and outcomes of patients hospitalized for COVID-19 and cardiac disease in Northern Italy.
Auteurs : Riccardo M. Inciardi ; Marianna Adamo ; Laura Lupi ; Dario S. Cani ; Mattia Di Pasquale ; Daniela Tomasoni ; Leonardo Italia ; Gregorio Zaccone ; Chiara Tedino ; Davide Fabbricatore ; Antonio Curnis ; Pompilio Faggiano ; Elio Gorga ; Carlo M. Lombardi ; Giuseppe Milesi ; Enrico Vizzardi ; Marco Volpini ; Savina Nodari ; Claudia Specchia ; Roberto Maroldi ; Michela Bezzi ; Marco MetraSource :
- European heart journal [ 1522-9645 ] ; 2020.
English descriptors
- KwdEn :
- Aged (MeSH), Aged, 80 and over (MeSH), Atrial Fibrillation (MeSH), Betacoronavirus (MeSH), Coronavirus Infections (complications), Coronavirus Infections (mortality), Creatinine (blood), Female (MeSH), Heart Diseases (complications), Heart Diseases (mortality), Heart Failure (MeSH), Hospitalization (MeSH), Humans (MeSH), Italy (epidemiology), Male (MeSH), Middle Aged (MeSH), Natriuretic Peptide, Brain (blood), Pandemics (MeSH), Peptide Fragments (blood), Pneumonia, Viral (complications), Pneumonia, Viral (mortality), Prognosis (MeSH), Respiratory Distress Syndrome, Adult (MeSH), Risk Factors (MeSH), Shock, Septic (MeSH), Thromboembolism (MeSH), Troponin T (blood).
- MESH :
- chemical , blood : Creatinine, Natriuretic Peptide, Brain, Peptide Fragments, Troponin T.
- geographic , epidemiology : Italy.
- complications : Coronavirus Infections, Heart Diseases, Pneumonia, Viral.
- mortality : Coronavirus Infections, Heart Diseases, Pneumonia, Viral.
- Aged, Aged, 80 and over, Atrial Fibrillation, Betacoronavirus, Female, Heart Failure, Hospitalization, Humans, Male, Middle Aged, Pandemics, Prognosis, Respiratory Distress Syndrome, Adult, Risk Factors, Shock, Septic, Thromboembolism.
Abstract
AIMS
To compare demographic characteristics, clinical presentation, and outcomes of patients with and without concomitant cardiac disease, hospitalized for COVID-19 in Brescia, Lombardy, Italy.
METHODS AND RESULTS
The study population includes 99 consecutive patients with COVID-19 pneumonia admitted to our hospital between 4 March and 25 March 2020. Fifty-three patients with a history of cardiac disease were compared with 46 without cardiac disease. Among cardiac patients, 40% had a history of heart failure, 36% had atrial fibrillation, and 30% had coronary artery disease. Mean age was 67 ± 12 years, and 80 (81%) patients were males. No differences were found between cardiac and non-cardiac patients except for higher values of serum creatinine, N-terminal probrain natriuretic peptide, and high sensitivity troponin T in cardiac patients. During hospitalization, 26% patients died, 15% developed thrombo-embolic events, 19% had acute respiratory distress syndrome, and 6% had septic shock. Mortality was higher in patients with cardiac disease compared with the others (36% vs. 15%, log-rank P = 0.019; relative risk 2.35; 95% confidence interval 1.08-5.09). The rate of thrombo-embolic events and septic shock during the hospitalization was also higher in cardiac patients (23% vs. 6% and 11% vs. 0%, respectively).
CONCLUSIONS
Hospitalized patients with concomitant cardiac disease and COVID-19 have an extremely poor prognosis compared with subjects without a history of cardiac disease, with higher mortality, thrombo-embolic events, and septic shock rates.
DOI: 10.1093/eurheartj/ehaa388
PubMed: 32383763
PubMed Central: PMC7239204
Links to Exploration step
pubmed:32383763Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Characteristics and outcomes of patients hospitalized for COVID-19 and cardiac disease in Northern Italy.</title><author><name sortKey="Inciardi, Riccardo M" sort="Inciardi, Riccardo M" uniqKey="Inciardi R" first="Riccardo M" last="Inciardi">Riccardo M. Inciardi</name><affiliation><nlm:affiliation>Institute of Cardiology, ASST Spedali Civili di Brescia and Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Adamo, Marianna" sort="Adamo, Marianna" uniqKey="Adamo M" first="Marianna" last="Adamo">Marianna Adamo</name><affiliation><nlm:affiliation>Institute of Cardiology, ASST Spedali Civili di Brescia and Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Lupi, Laura" sort="Lupi, Laura" uniqKey="Lupi L" first="Laura" last="Lupi">Laura Lupi</name><affiliation><nlm:affiliation>Institute of Cardiology, ASST Spedali Civili di Brescia and Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Cani, Dario S" sort="Cani, Dario S" uniqKey="Cani D" first="Dario S" last="Cani">Dario S. Cani</name><affiliation><nlm:affiliation>Institute of Cardiology, ASST Spedali Civili di Brescia and Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Di Pasquale, Mattia" sort="Di Pasquale, Mattia" uniqKey="Di Pasquale M" first="Mattia" last="Di Pasquale">Mattia Di Pasquale</name><affiliation><nlm:affiliation>Institute of Cardiology, ASST Spedali Civili di Brescia and Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Tomasoni, Daniela" sort="Tomasoni, Daniela" uniqKey="Tomasoni D" first="Daniela" last="Tomasoni">Daniela Tomasoni</name><affiliation><nlm:affiliation>Institute of Cardiology, ASST Spedali Civili di Brescia and Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Italia, Leonardo" sort="Italia, Leonardo" uniqKey="Italia L" first="Leonardo" last="Italia">Leonardo Italia</name><affiliation><nlm:affiliation>Institute of Cardiology, ASST Spedali Civili di Brescia and Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Zaccone, Gregorio" sort="Zaccone, Gregorio" uniqKey="Zaccone G" first="Gregorio" last="Zaccone">Gregorio Zaccone</name><affiliation><nlm:affiliation>Institute of Cardiology, ASST Spedali Civili di Brescia and Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Tedino, Chiara" sort="Tedino, Chiara" uniqKey="Tedino C" first="Chiara" last="Tedino">Chiara Tedino</name><affiliation><nlm:affiliation>Institute of Cardiology, ASST Spedali Civili di Brescia and Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Fabbricatore, Davide" sort="Fabbricatore, Davide" uniqKey="Fabbricatore D" first="Davide" last="Fabbricatore">Davide Fabbricatore</name><affiliation><nlm:affiliation>Institute of Cardiology, ASST Spedali Civili di Brescia and Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Curnis, Antonio" sort="Curnis, Antonio" uniqKey="Curnis A" first="Antonio" last="Curnis">Antonio Curnis</name><affiliation><nlm:affiliation>Institute of Cardiology, ASST Spedali Civili di Brescia and Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Faggiano, Pompilio" sort="Faggiano, Pompilio" uniqKey="Faggiano P" first="Pompilio" last="Faggiano">Pompilio Faggiano</name><affiliation><nlm:affiliation>Institute of Cardiology, ASST Spedali Civili di Brescia and Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Gorga, Elio" sort="Gorga, Elio" uniqKey="Gorga E" first="Elio" last="Gorga">Elio Gorga</name><affiliation><nlm:affiliation>Institute of Cardiology, ASST Spedali Civili di Brescia and Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Lombardi, Carlo M" sort="Lombardi, Carlo M" uniqKey="Lombardi C" first="Carlo M" last="Lombardi">Carlo M. Lombardi</name><affiliation><nlm:affiliation>Institute of Cardiology, ASST Spedali Civili di Brescia and Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Milesi, Giuseppe" sort="Milesi, Giuseppe" uniqKey="Milesi G" first="Giuseppe" last="Milesi">Giuseppe Milesi</name><affiliation><nlm:affiliation>Institute of Cardiology, ASST Spedali Civili di Brescia and Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Vizzardi, Enrico" sort="Vizzardi, Enrico" uniqKey="Vizzardi E" first="Enrico" last="Vizzardi">Enrico Vizzardi</name><affiliation><nlm:affiliation>Institute of Cardiology, ASST Spedali Civili di Brescia and Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Volpini, Marco" sort="Volpini, Marco" uniqKey="Volpini M" first="Marco" last="Volpini">Marco Volpini</name><affiliation><nlm:affiliation>Institute of Cardiology, ASST Spedali Civili di Brescia and Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Nodari, Savina" sort="Nodari, Savina" uniqKey="Nodari S" first="Savina" last="Nodari">Savina Nodari</name><affiliation><nlm:affiliation>Institute of Cardiology, ASST Spedali Civili di Brescia and Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Specchia, Claudia" sort="Specchia, Claudia" uniqKey="Specchia C" first="Claudia" last="Specchia">Claudia Specchia</name><affiliation><nlm:affiliation>Department of Molecular and Translational Medicine, University of Brescia, Brescia Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Maroldi, Roberto" sort="Maroldi, Roberto" uniqKey="Maroldi R" first="Roberto" last="Maroldi">Roberto Maroldi</name><affiliation><nlm:affiliation>Institute of Radiology, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Bezzi, Michela" sort="Bezzi, Michela" uniqKey="Bezzi M" first="Michela" last="Bezzi">Michela Bezzi</name><affiliation><nlm:affiliation>Respiratory Unit, ASST Spedali Civili di Brescia, Brescia, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Metra, Marco" sort="Metra, Marco" uniqKey="Metra M" first="Marco" last="Metra">Marco Metra</name><affiliation><nlm:affiliation>Institute of Cardiology, ASST Spedali Civili di Brescia and Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32383763</idno><idno type="pmid">32383763</idno><idno type="doi">10.1093/eurheartj/ehaa388</idno><idno type="pmc">PMC7239204</idno><idno type="wicri:Area/Main/Corpus">000301</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000301</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Characteristics and outcomes of patients hospitalized for COVID-19 and cardiac disease in Northern Italy.</title><author><name sortKey="Inciardi, Riccardo M" sort="Inciardi, Riccardo M" uniqKey="Inciardi R" first="Riccardo M" last="Inciardi">Riccardo M. Inciardi</name><affiliation><nlm:affiliation>Institute of Cardiology, ASST Spedali Civili di Brescia and Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Adamo, Marianna" sort="Adamo, Marianna" uniqKey="Adamo M" first="Marianna" last="Adamo">Marianna Adamo</name><affiliation><nlm:affiliation>Institute of Cardiology, ASST Spedali Civili di Brescia and Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Lupi, Laura" sort="Lupi, Laura" uniqKey="Lupi L" first="Laura" last="Lupi">Laura Lupi</name><affiliation><nlm:affiliation>Institute of Cardiology, ASST Spedali Civili di Brescia and Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Cani, Dario S" sort="Cani, Dario S" uniqKey="Cani D" first="Dario S" last="Cani">Dario S. Cani</name><affiliation><nlm:affiliation>Institute of Cardiology, ASST Spedali Civili di Brescia and Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Di Pasquale, Mattia" sort="Di Pasquale, Mattia" uniqKey="Di Pasquale M" first="Mattia" last="Di Pasquale">Mattia Di Pasquale</name><affiliation><nlm:affiliation>Institute of Cardiology, ASST Spedali Civili di Brescia and Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Tomasoni, Daniela" sort="Tomasoni, Daniela" uniqKey="Tomasoni D" first="Daniela" last="Tomasoni">Daniela Tomasoni</name><affiliation><nlm:affiliation>Institute of Cardiology, ASST Spedali Civili di Brescia and Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Italia, Leonardo" sort="Italia, Leonardo" uniqKey="Italia L" first="Leonardo" last="Italia">Leonardo Italia</name><affiliation><nlm:affiliation>Institute of Cardiology, ASST Spedali Civili di Brescia and Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Zaccone, Gregorio" sort="Zaccone, Gregorio" uniqKey="Zaccone G" first="Gregorio" last="Zaccone">Gregorio Zaccone</name><affiliation><nlm:affiliation>Institute of Cardiology, ASST Spedali Civili di Brescia and Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Tedino, Chiara" sort="Tedino, Chiara" uniqKey="Tedino C" first="Chiara" last="Tedino">Chiara Tedino</name><affiliation><nlm:affiliation>Institute of Cardiology, ASST Spedali Civili di Brescia and Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Fabbricatore, Davide" sort="Fabbricatore, Davide" uniqKey="Fabbricatore D" first="Davide" last="Fabbricatore">Davide Fabbricatore</name><affiliation><nlm:affiliation>Institute of Cardiology, ASST Spedali Civili di Brescia and Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Curnis, Antonio" sort="Curnis, Antonio" uniqKey="Curnis A" first="Antonio" last="Curnis">Antonio Curnis</name><affiliation><nlm:affiliation>Institute of Cardiology, ASST Spedali Civili di Brescia and Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Faggiano, Pompilio" sort="Faggiano, Pompilio" uniqKey="Faggiano P" first="Pompilio" last="Faggiano">Pompilio Faggiano</name><affiliation><nlm:affiliation>Institute of Cardiology, ASST Spedali Civili di Brescia and Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Gorga, Elio" sort="Gorga, Elio" uniqKey="Gorga E" first="Elio" last="Gorga">Elio Gorga</name><affiliation><nlm:affiliation>Institute of Cardiology, ASST Spedali Civili di Brescia and Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Lombardi, Carlo M" sort="Lombardi, Carlo M" uniqKey="Lombardi C" first="Carlo M" last="Lombardi">Carlo M. Lombardi</name><affiliation><nlm:affiliation>Institute of Cardiology, ASST Spedali Civili di Brescia and Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Milesi, Giuseppe" sort="Milesi, Giuseppe" uniqKey="Milesi G" first="Giuseppe" last="Milesi">Giuseppe Milesi</name><affiliation><nlm:affiliation>Institute of Cardiology, ASST Spedali Civili di Brescia and Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Vizzardi, Enrico" sort="Vizzardi, Enrico" uniqKey="Vizzardi E" first="Enrico" last="Vizzardi">Enrico Vizzardi</name><affiliation><nlm:affiliation>Institute of Cardiology, ASST Spedali Civili di Brescia and Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Volpini, Marco" sort="Volpini, Marco" uniqKey="Volpini M" first="Marco" last="Volpini">Marco Volpini</name><affiliation><nlm:affiliation>Institute of Cardiology, ASST Spedali Civili di Brescia and Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Nodari, Savina" sort="Nodari, Savina" uniqKey="Nodari S" first="Savina" last="Nodari">Savina Nodari</name><affiliation><nlm:affiliation>Institute of Cardiology, ASST Spedali Civili di Brescia and Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Specchia, Claudia" sort="Specchia, Claudia" uniqKey="Specchia C" first="Claudia" last="Specchia">Claudia Specchia</name><affiliation><nlm:affiliation>Department of Molecular and Translational Medicine, University of Brescia, Brescia Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Maroldi, Roberto" sort="Maroldi, Roberto" uniqKey="Maroldi R" first="Roberto" last="Maroldi">Roberto Maroldi</name><affiliation><nlm:affiliation>Institute of Radiology, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Bezzi, Michela" sort="Bezzi, Michela" uniqKey="Bezzi M" first="Michela" last="Bezzi">Michela Bezzi</name><affiliation><nlm:affiliation>Respiratory Unit, ASST Spedali Civili di Brescia, Brescia, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Metra, Marco" sort="Metra, Marco" uniqKey="Metra M" first="Marco" last="Metra">Marco Metra</name><affiliation><nlm:affiliation>Institute of Cardiology, ASST Spedali Civili di Brescia and Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.</nlm:affiliation></affiliation></author></analytic><series><title level="j">European heart journal</title><idno type="eISSN">1522-9645</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged (MeSH)</term><term>Aged, 80 and over (MeSH)</term><term>Atrial Fibrillation (MeSH)</term><term>Betacoronavirus (MeSH)</term><term>Coronavirus Infections (complications)</term><term>Coronavirus Infections (mortality)</term><term>Creatinine (blood)</term><term>Female (MeSH)</term><term>Heart Diseases (complications)</term><term>Heart Diseases (mortality)</term><term>Heart Failure (MeSH)</term><term>Hospitalization (MeSH)</term><term>Humans (MeSH)</term><term>Italy (epidemiology)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>Natriuretic Peptide, Brain (blood)</term><term>Pandemics (MeSH)</term><term>Peptide Fragments (blood)</term><term>Pneumonia, Viral (complications)</term><term>Pneumonia, Viral (mortality)</term><term>Prognosis (MeSH)</term><term>Respiratory Distress Syndrome, Adult (MeSH)</term><term>Risk Factors (MeSH)</term><term>Shock, Septic (MeSH)</term><term>Thromboembolism (MeSH)</term><term>Troponin T (blood)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Creatinine</term><term>Natriuretic Peptide, Brain</term><term>Peptide Fragments</term><term>Troponin T</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Italy</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Coronavirus Infections</term><term>Heart Diseases</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Coronavirus Infections</term><term>Heart Diseases</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Atrial Fibrillation</term><term>Betacoronavirus</term><term>Female</term><term>Heart Failure</term><term>Hospitalization</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Pandemics</term><term>Prognosis</term><term>Respiratory Distress Syndrome, Adult</term><term>Risk Factors</term><term>Shock, Septic</term><term>Thromboembolism</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>AIMS</b></p><p>To compare demographic characteristics, clinical presentation, and outcomes of patients with and without concomitant cardiac disease, hospitalized for COVID-19 in Brescia, Lombardy, Italy.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS AND RESULTS</b></p><p>The study population includes 99 consecutive patients with COVID-19 pneumonia admitted to our hospital between 4 March and 25 March 2020. Fifty-three patients with a history of cardiac disease were compared with 46 without cardiac disease. Among cardiac patients, 40% had a history of heart failure, 36% had atrial fibrillation, and 30% had coronary artery disease. Mean age was 67 ± 12 years, and 80 (81%) patients were males. No differences were found between cardiac and non-cardiac patients except for higher values of serum creatinine, N-terminal probrain natriuretic peptide, and high sensitivity troponin T in cardiac patients. During hospitalization, 26% patients died, 15% developed thrombo-embolic events, 19% had acute respiratory distress syndrome, and 6% had septic shock. Mortality was higher in patients with cardiac disease compared with the others (36% vs. 15%, log-rank P = 0.019; relative risk 2.35; 95% confidence interval 1.08-5.09). The rate of thrombo-embolic events and septic shock during the hospitalization was also higher in cardiac patients (23% vs. 6% and 11% vs. 0%, respectively).</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>Hospitalized patients with concomitant cardiac disease and COVID-19 have an extremely poor prognosis compared with subjects without a history of cardiac disease, with higher mortality, thrombo-embolic events, and septic shock rates.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32383763</PMID><DateCompleted><Year>2020</Year><Month>05</Month><Day>19</Day></DateCompleted><DateRevised><Year>2020</Year><Month>05</Month><Day>29</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1522-9645</ISSN><JournalIssue CitedMedium="Internet"><Volume>41</Volume><Issue>19</Issue><PubDate><Year>2020</Year><Month>05</Month><Day>14</Day></PubDate></JournalIssue><Title>European heart journal</Title><ISOAbbreviation>Eur. Heart J.</ISOAbbreviation></Journal><ArticleTitle>Characteristics and outcomes of patients hospitalized for COVID-19 and cardiac disease in Northern Italy.</ArticleTitle><Pagination><MedlinePgn>1821-1829</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1093/eurheartj/ehaa388</ELocationID><Abstract><AbstractText Label="AIMS">To compare demographic characteristics, clinical presentation, and outcomes of patients with and without concomitant cardiac disease, hospitalized for COVID-19 in Brescia, Lombardy, Italy.</AbstractText><AbstractText Label="METHODS AND RESULTS">The study population includes 99 consecutive patients with COVID-19 pneumonia admitted to our hospital between 4 March and 25 March 2020. Fifty-three patients with a history of cardiac disease were compared with 46 without cardiac disease. Among cardiac patients, 40% had a history of heart failure, 36% had atrial fibrillation, and 30% had coronary artery disease. Mean age was 67 ± 12 years, and 80 (81%) patients were males. No differences were found between cardiac and non-cardiac patients except for higher values of serum creatinine, N-terminal probrain natriuretic peptide, and high sensitivity troponin T in cardiac patients. During hospitalization, 26% patients died, 15% developed thrombo-embolic events, 19% had acute respiratory distress syndrome, and 6% had septic shock. Mortality was higher in patients with cardiac disease compared with the others (36% vs. 15%, log-rank P = 0.019; relative risk 2.35; 95% confidence interval 1.08-5.09). The rate of thrombo-embolic events and septic shock during the hospitalization was also higher in cardiac patients (23% vs. 6% and 11% vs. 0%, respectively).</AbstractText><AbstractText Label="CONCLUSIONS">Hospitalized patients with concomitant cardiac disease and COVID-19 have an extremely poor prognosis compared with subjects without a history of cardiac disease, with higher mortality, thrombo-embolic events, and septic shock rates.</AbstractText><CopyrightInformation>Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2020. For permissions, please email: journals.permissions@oup.com.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Inciardi</LastName><ForeName>Riccardo M</ForeName><Initials>RM</Initials><AffiliationInfo><Affiliation>Institute of Cardiology, ASST Spedali Civili di Brescia and Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Adamo</LastName><ForeName>Marianna</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Institute of Cardiology, ASST Spedali Civili di Brescia and Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lupi</LastName><ForeName>Laura</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Institute of Cardiology, ASST Spedali Civili di Brescia and Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cani</LastName><ForeName>Dario S</ForeName><Initials>DS</Initials><AffiliationInfo><Affiliation>Institute of Cardiology, ASST Spedali Civili di Brescia and Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Di Pasquale</LastName><ForeName>Mattia</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Institute of Cardiology, ASST Spedali Civili di Brescia and Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tomasoni</LastName><ForeName>Daniela</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Institute of Cardiology, ASST Spedali Civili di Brescia and Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Italia</LastName><ForeName>Leonardo</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Institute of Cardiology, ASST Spedali Civili di Brescia and Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zaccone</LastName><ForeName>Gregorio</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Institute of Cardiology, ASST Spedali Civili di Brescia and Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tedino</LastName><ForeName>Chiara</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Institute of Cardiology, ASST Spedali Civili di Brescia and Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fabbricatore</LastName><ForeName>Davide</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Institute of Cardiology, ASST Spedali Civili di Brescia and Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Curnis</LastName><ForeName>Antonio</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Institute of Cardiology, ASST Spedali Civili di Brescia and Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Faggiano</LastName><ForeName>Pompilio</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Institute of Cardiology, ASST Spedali Civili di Brescia and Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gorga</LastName><ForeName>Elio</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Institute of Cardiology, ASST Spedali Civili di Brescia and Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lombardi</LastName><ForeName>Carlo M</ForeName><Initials>CM</Initials><AffiliationInfo><Affiliation>Institute of Cardiology, ASST Spedali Civili di Brescia and Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Milesi</LastName><ForeName>Giuseppe</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Institute of Cardiology, ASST Spedali Civili di Brescia and Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vizzardi</LastName><ForeName>Enrico</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Institute of Cardiology, ASST Spedali Civili di Brescia and Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Volpini</LastName><ForeName>Marco</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Institute of Cardiology, ASST Spedali Civili di Brescia and Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nodari</LastName><ForeName>Savina</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Institute of Cardiology, ASST Spedali Civili di Brescia and Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Specchia</LastName><ForeName>Claudia</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Molecular and Translational Medicine, University of Brescia, Brescia Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Maroldi</LastName><ForeName>Roberto</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Institute of Radiology, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bezzi</LastName><ForeName>Michela</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Respiratory Unit, ASST Spedali Civili di Brescia, Brescia, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Metra</LastName><ForeName>Marco</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Institute of Cardiology, ASST Spedali Civili di Brescia and Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Eur Heart J</MedlineTA><NlmUniqueID>8006263</NlmUniqueID><ISSNLinking>0195-668X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010446">Peptide Fragments</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D020107">Troponin T</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C109794">pro-brain natriuretic peptide (1-76)</NameOfSubstance></Chemical><Chemical><RegistryNumber>114471-18-0</RegistryNumber><NameOfSubstance UI="D020097">Natriuretic Peptide, Brain</NameOfSubstance></Chemical><Chemical><RegistryNumber>AYI8EX34EU</RegistryNumber><NameOfSubstance UI="D003404">Creatinine</NameOfSubstance></Chemical></ChemicalList><SupplMeshList><SupplMeshName Type="Disease" UI="C000657245">COVID-19</SupplMeshName><SupplMeshName Type="Organism" UI="C000656484">severe acute respiratory syndrome coronavirus 2</SupplMeshName></SupplMeshList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>Eur Heart J. 2020 May 14;41(19):1830-1832</RefSource><PMID Version="1">32405639</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001281" MajorTopicYN="N">Atrial Fibrillation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000073640" MajorTopicYN="N">Betacoronavirus</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000401" MajorTopicYN="Y">mortality</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003404" MajorTopicYN="N">Creatinine</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006331" MajorTopicYN="N">Heart Diseases</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000401" MajorTopicYN="Y">mortality</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006333" MajorTopicYN="N">Heart Failure</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006760" MajorTopicYN="Y">Hospitalization</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007558" MajorTopicYN="N" Type="Geographic">Italy</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020097" MajorTopicYN="N">Natriuretic Peptide, Brain</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010446" MajorTopicYN="N">Peptide Fragments</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000401" 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