The Lung, the Heart, the Novel Coronavirus, and the Renin-Angiotensin System; The Need for Clinical Trials.
Identifieur interne : 000124 ( Main/Corpus ); précédent : 000123; suivant : 000125The Lung, the Heart, the Novel Coronavirus, and the Renin-Angiotensin System; The Need for Clinical Trials.
Auteurs : Eugenie R. Lumbers ; Sarah J. Delforce ; Kirsty G. Pringle ; Gary R. SmithSource :
- Frontiers in medicine [ 2296-858X ] ; 2020.
Abstract
Angiotensin-converting enzyme 2 (ACE2) is the receptor for COVID-19 (SARs-CoV-2). ACE2 protects the lung and heart from acute respiratory distress syndrome (ARDS) and acute myocarditis and arrhythmias, because it breaks down Angiotensin II, which has inflammatory effects in the lung and heart as well as in the kidney. When SARS-CoV-2 binds to ACE2, it suppresses it, so this protective action of ACE2 is lost. Death from COVID-19 is due to ARDS and also heart failure and acute cardiac injury. Drugs that prevent the inflammatory actions of Angiotensin II (i.e., Angiotensin receptor blockers, ARBs) prevent acute lung injury caused by SARS-CoV. Clinical trials are underway to test the risks and benefits of ARBs and angiotensin-converting enzyme inhibitors (ACEIs) in COVID-19 patients requiring hospitalization. Other potential treatments are also discussed.
DOI: 10.3389/fmed.2020.00248
PubMed: 32574336
PubMed Central: PMC7256451
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Delforce</name><affiliation><nlm:affiliation>School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW, Australia.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Priority Research Centre for Reproductive Science, University of Newcastle, Callaghan, NSW, Australia.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Pregnancy and Reproduction Program, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Pringle, Kirsty G" sort="Pringle, Kirsty G" uniqKey="Pringle K" first="Kirsty G" last="Pringle">Kirsty G. Pringle</name><affiliation><nlm:affiliation>School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW, Australia.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Priority Research Centre for Reproductive Science, University of Newcastle, Callaghan, NSW, Australia.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Pregnancy and Reproduction Program, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Smith, Gary R" sort="Smith, Gary R" uniqKey="Smith G" first="Gary R" last="Smith">Gary R. Smith</name><affiliation><nlm:affiliation>VP System Practice, International Society for the System Sciences, Pontypool, United Kingdom.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32574336</idno><idno type="pmid">32574336</idno><idno type="doi">10.3389/fmed.2020.00248</idno><idno type="pmc">PMC7256451</idno><idno type="wicri:Area/Main/Corpus">000124</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000124</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The Lung, the Heart, the Novel Coronavirus, and the Renin-Angiotensin System; The Need for Clinical Trials.</title><author><name sortKey="Lumbers, Eugenie R" sort="Lumbers, Eugenie R" uniqKey="Lumbers E" first="Eugenie R" last="Lumbers">Eugenie R. Lumbers</name><affiliation><nlm:affiliation>School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW, Australia.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Priority Research Centre for Reproductive Science, University of Newcastle, Callaghan, NSW, Australia.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Pregnancy and Reproduction Program, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Delforce, Sarah J" sort="Delforce, Sarah J" uniqKey="Delforce S" first="Sarah J" last="Delforce">Sarah J. Delforce</name><affiliation><nlm:affiliation>School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW, Australia.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Priority Research Centre for Reproductive Science, University of Newcastle, Callaghan, NSW, Australia.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Pregnancy and Reproduction Program, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Pringle, Kirsty G" sort="Pringle, Kirsty G" uniqKey="Pringle K" first="Kirsty G" last="Pringle">Kirsty G. Pringle</name><affiliation><nlm:affiliation>School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW, Australia.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Priority Research Centre for Reproductive Science, University of Newcastle, Callaghan, NSW, Australia.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Pregnancy and Reproduction Program, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Smith, Gary R" sort="Smith, Gary R" uniqKey="Smith G" first="Gary R" last="Smith">Gary R. Smith</name><affiliation><nlm:affiliation>VP System Practice, International Society for the System Sciences, Pontypool, United Kingdom.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Frontiers in medicine</title><idno type="ISSN">2296-858X</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Angiotensin-converting enzyme 2 (ACE2) is the receptor for COVID-19 (SARs-CoV-2). ACE2 protects the lung and heart from acute respiratory distress syndrome (ARDS) and acute myocarditis and arrhythmias, because it breaks down Angiotensin II, which has inflammatory effects in the lung and heart as well as in the kidney. When SARS-CoV-2 binds to ACE2, it suppresses it, so this protective action of ACE2 is lost. Death from COVID-19 is due to ARDS and also heart failure and acute cardiac injury. Drugs that prevent the inflammatory actions of Angiotensin II (i.e., Angiotensin receptor blockers, ARBs) prevent acute lung injury caused by SARS-CoV. Clinical trials are underway to test the risks and benefits of ARBs and angiotensin-converting enzyme inhibitors (ACEIs) in COVID-19 patients requiring hospitalization. Other potential treatments are also discussed.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">32574336</PMID><DateRevised><Year>2020</Year><Month>06</Month><Day>23</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Print">2296-858X</ISSN><JournalIssue CitedMedium="Print"><Volume>7</Volume><PubDate><Year>2020</Year></PubDate></JournalIssue><Title>Frontiers in medicine</Title><ISOAbbreviation>Front Med (Lausanne)</ISOAbbreviation></Journal><ArticleTitle>The Lung, the Heart, the Novel Coronavirus, and the Renin-Angiotensin System; The Need for Clinical Trials.</ArticleTitle><Pagination><MedlinePgn>248</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.3389/fmed.2020.00248</ELocationID><Abstract><AbstractText>Angiotensin-converting enzyme 2 (ACE2) is the receptor for COVID-19 (SARs-CoV-2). ACE2 protects the lung and heart from acute respiratory distress syndrome (ARDS) and acute myocarditis and arrhythmias, because it breaks down Angiotensin II, which has inflammatory effects in the lung and heart as well as in the kidney. When SARS-CoV-2 binds to ACE2, it suppresses it, so this protective action of ACE2 is lost. Death from COVID-19 is due to ARDS and also heart failure and acute cardiac injury. Drugs that prevent the inflammatory actions of Angiotensin II (i.e., Angiotensin receptor blockers, ARBs) prevent acute lung injury caused by SARS-CoV. Clinical trials are underway to test the risks and benefits of ARBs and angiotensin-converting enzyme inhibitors (ACEIs) in COVID-19 patients requiring hospitalization. Other potential treatments are also discussed.</AbstractText><CopyrightInformation>Copyright © 2020 Lumbers, Delforce, Pringle and Smith.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lumbers</LastName><ForeName>Eugenie R</ForeName><Initials>ER</Initials><AffiliationInfo><Affiliation>School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Priority Research Centre for Reproductive Science, University of Newcastle, Callaghan, NSW, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Pregnancy and Reproduction Program, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Delforce</LastName><ForeName>Sarah J</ForeName><Initials>SJ</Initials><AffiliationInfo><Affiliation>School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Priority Research Centre for Reproductive Science, University of Newcastle, Callaghan, NSW, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Pregnancy and Reproduction Program, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pringle</LastName><ForeName>Kirsty G</ForeName><Initials>KG</Initials><AffiliationInfo><Affiliation>School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Priority Research Centre for Reproductive Science, University of Newcastle, Callaghan, NSW, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Pregnancy and Reproduction Program, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Smith</LastName><ForeName>Gary R</ForeName><Initials>GR</Initials><AffiliationInfo><Affiliation>VP System Practice, International Society for the System Sciences, Pontypool, United Kingdom.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>05</Month><Day>22</Day></ArticleDate></Article><MedlineJournalInfo><Country>Switzerland</Country><MedlineTA>Front Med (Lausanne)</MedlineTA><NlmUniqueID>101648047</NlmUniqueID><ISSNLinking>2296-858X</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">ACE2</Keyword><Keyword MajorTopicYN="N">COVID-19</Keyword><Keyword MajorTopicYN="N">SARS- CoV-2</Keyword><Keyword MajorTopicYN="N">cardiovascular 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