COVID-19 and cardiac arrhythmias.
Identifieur interne : 000113 ( Main/Corpus ); précédent : 000112; suivant : 000114COVID-19 and cardiac arrhythmias.
Auteurs : Anjali Bhatla ; Michael M. Mayer ; Srinath Adusumalli ; Matthew C. Hyman ; Eric Oh ; Ann Tierney ; Juwann Moss ; Anwar A. Chahal ; George Anesi ; Srinivas Denduluri ; Christopher M. Domenico ; Jeffrey Arkles ; Benjamin S. Abella ; John R. Bullinga ; David J. Callans ; Sanjay Dixit ; Andrew E. Epstein ; David S. Frankel ; Fermin C. Garcia ; Ramanan Kumareswaram ; Saman Nazarian ; Michael P. Riley ; Pasquale Santangeli ; Robert D. Schaller ; Gregory E. Supple ; David Lin ; Francis Marchlinski ; Rajat DeoSource :
- Heart rhythm [ 1556-3871 ] ; 2020.
Abstract
BACKGROUND
Early studies suggest that coronavirus disease 2019 (COVID-19) is associated with a high incidence of cardiac arrhythmias. Severe acute respiratory syndrome coronavirus 2 infection may cause injury to cardiac myocytes and increase arrhythmia risk.
OBJECTIVES
The purpose of this study was to evaluate the risk of cardiac arrest and arrhythmias including incident atrial fibrillation (AF), bradyarrhythmias, and nonsustained ventricular tachycardia (NSVT) in a large urban population hospitalized for COVID-19. We also evaluated correlations between the presence of these arrhythmias and mortality.
METHODS
We reviewed the characteristics of all patients with COVID-19 admitted to our center over a 9-week period. Throughout hospitalization, we evaluated the incidence of cardiac arrests, arrhythmias, and inpatient mortality. We also used logistic regression to evaluate age, sex, race, body mass index, prevalent cardiovascular disease, diabetes, hypertension, kidney disease, and intensive care unit (ICU) status as potential risk factors for each arrhythmia.
RESULTS
Among 700 patients (mean age 50 ± 18 years; 45% men; 71% African American; 11% received ICU care), there were 9 cardiac arrests, 25 incident AF events, 9 clinically significant bradyarrhythmias, and 10 NSVTs. All cardiac arrests occurred in patients admitted to the ICU. In addition, admission to the ICU was associated with incident AF (odds ratio [OR] 4.68; 95% confidence interval [CI] 1.66-13.18) and NSVT (OR 8.92; 95% CI 1.73-46.06) after multivariable adjustment. Also, age and incident AF (OR 1.05; 95% CI 1.02-1.09) and prevalent heart failure and bradyarrhythmias (OR 9.75; 95% CI 1.95-48.65) were independently associated. Only cardiac arrests were associated with acute in-hospital mortality.
CONCLUSION
Cardiac arrests and arrhythmias are likely the consequence of systemic illness and not solely the direct effects of COVID-19 infection.
DOI: 10.1016/j.hrthm.2020.06.016
PubMed: 32585191
PubMed Central: PMC7307518
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Mayer</name><affiliation><nlm:affiliation>Division of Cardiovascular Medicine, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.</nlm:affiliation></affiliation></author><author><name sortKey="Adusumalli, Srinath" sort="Adusumalli, Srinath" uniqKey="Adusumalli S" first="Srinath" last="Adusumalli">Srinath Adusumalli</name><affiliation><nlm:affiliation>Division of Cardiovascular Medicine, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.</nlm:affiliation></affiliation></author><author><name sortKey="Hyman, Matthew C" sort="Hyman, Matthew C" uniqKey="Hyman M" first="Matthew C" last="Hyman">Matthew C. Hyman</name><affiliation><nlm:affiliation>Division of Cardiovascular Medicine, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.</nlm:affiliation></affiliation></author><author><name sortKey="Oh, Eric" sort="Oh, Eric" uniqKey="Oh E" first="Eric" last="Oh">Eric Oh</name><affiliation><nlm:affiliation>Department of Biostatistics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.</nlm:affiliation></affiliation></author><author><name sortKey="Tierney, Ann" sort="Tierney, Ann" uniqKey="Tierney A" first="Ann" last="Tierney">Ann Tierney</name><affiliation><nlm:affiliation>Department of Biostatistics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.</nlm:affiliation></affiliation></author><author><name sortKey="Moss, Juwann" sort="Moss, Juwann" uniqKey="Moss J" first="Juwann" last="Moss">Juwann Moss</name><affiliation><nlm:affiliation>Division of Cardiovascular Medicine, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.</nlm:affiliation></affiliation></author><author><name sortKey="Chahal, Anwar A" sort="Chahal, Anwar A" uniqKey="Chahal A" first="Anwar A" last="Chahal">Anwar A. Chahal</name><affiliation><nlm:affiliation>Division of Cardiovascular Medicine, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.</nlm:affiliation></affiliation></author><author><name sortKey="Anesi, George" sort="Anesi, George" uniqKey="Anesi G" first="George" last="Anesi">George Anesi</name><affiliation><nlm:affiliation>Division of Pulmonary and Critical Care, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.</nlm:affiliation></affiliation></author><author><name sortKey="Denduluri, Srinivas" sort="Denduluri, Srinivas" uniqKey="Denduluri S" first="Srinivas" last="Denduluri">Srinivas Denduluri</name><affiliation><nlm:affiliation>Division of Cardiovascular Medicine, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.</nlm:affiliation></affiliation></author><author><name sortKey="Domenico, Christopher M" sort="Domenico, Christopher M" uniqKey="Domenico C" first="Christopher M" last="Domenico">Christopher M. Domenico</name><affiliation><nlm:affiliation>Division of Cardiovascular Medicine, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.</nlm:affiliation></affiliation></author><author><name sortKey="Arkles, Jeffrey" sort="Arkles, Jeffrey" uniqKey="Arkles J" first="Jeffrey" last="Arkles">Jeffrey Arkles</name><affiliation><nlm:affiliation>Division of Cardiovascular Medicine, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.</nlm:affiliation></affiliation></author><author><name sortKey="Abella, Benjamin S" sort="Abella, Benjamin S" uniqKey="Abella B" first="Benjamin S" last="Abella">Benjamin S. Abella</name><affiliation><nlm:affiliation>Department of Emergency Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.</nlm:affiliation></affiliation></author><author><name sortKey="Bullinga, John R" sort="Bullinga, John R" uniqKey="Bullinga J" first="John R" last="Bullinga">John R. Bullinga</name><affiliation><nlm:affiliation>Division of Cardiovascular Medicine, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.</nlm:affiliation></affiliation></author><author><name sortKey="Callans, David J" sort="Callans, David J" uniqKey="Callans D" first="David J" last="Callans">David J. Callans</name><affiliation><nlm:affiliation>Division of Cardiovascular Medicine, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.</nlm:affiliation></affiliation></author><author><name sortKey="Dixit, Sanjay" sort="Dixit, Sanjay" uniqKey="Dixit S" first="Sanjay" last="Dixit">Sanjay Dixit</name><affiliation><nlm:affiliation>Division of Cardiovascular Medicine, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.</nlm:affiliation></affiliation></author><author><name sortKey="Epstein, Andrew E" sort="Epstein, Andrew E" uniqKey="Epstein A" first="Andrew E" last="Epstein">Andrew E. Epstein</name><affiliation><nlm:affiliation>Division of Cardiovascular Medicine, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.</nlm:affiliation></affiliation></author><author><name sortKey="Frankel, David S" sort="Frankel, David S" uniqKey="Frankel D" first="David S" last="Frankel">David S. Frankel</name><affiliation><nlm:affiliation>Division of Cardiovascular Medicine, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.</nlm:affiliation></affiliation></author><author><name sortKey="Garcia, Fermin C" sort="Garcia, Fermin C" uniqKey="Garcia F" first="Fermin C" last="Garcia">Fermin C. Garcia</name><affiliation><nlm:affiliation>Division of Cardiovascular Medicine, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.</nlm:affiliation></affiliation></author><author><name sortKey="Kumareswaram, Ramanan" sort="Kumareswaram, Ramanan" uniqKey="Kumareswaram R" first="Ramanan" last="Kumareswaram">Ramanan Kumareswaram</name><affiliation><nlm:affiliation>Division of Cardiovascular Medicine, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.</nlm:affiliation></affiliation></author><author><name sortKey="Nazarian, Saman" sort="Nazarian, Saman" uniqKey="Nazarian S" first="Saman" last="Nazarian">Saman Nazarian</name><affiliation><nlm:affiliation>Division of Cardiovascular Medicine, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.</nlm:affiliation></affiliation></author><author><name sortKey="Riley, Michael P" sort="Riley, Michael P" uniqKey="Riley M" first="Michael P" last="Riley">Michael P. Riley</name><affiliation><nlm:affiliation>Division of Cardiovascular Medicine, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.</nlm:affiliation></affiliation></author><author><name sortKey="Santangeli, Pasquale" sort="Santangeli, Pasquale" uniqKey="Santangeli P" first="Pasquale" last="Santangeli">Pasquale Santangeli</name><affiliation><nlm:affiliation>Division of Cardiovascular Medicine, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.</nlm:affiliation></affiliation></author><author><name sortKey="Schaller, Robert D" sort="Schaller, Robert D" uniqKey="Schaller R" first="Robert D" last="Schaller">Robert D. Schaller</name><affiliation><nlm:affiliation>Division of Cardiovascular Medicine, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.</nlm:affiliation></affiliation></author><author><name sortKey="Supple, Gregory E" sort="Supple, Gregory E" uniqKey="Supple G" first="Gregory E" last="Supple">Gregory E. Supple</name><affiliation><nlm:affiliation>Division of Cardiovascular Medicine, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.</nlm:affiliation></affiliation></author><author><name sortKey="Lin, David" sort="Lin, David" uniqKey="Lin D" first="David" last="Lin">David Lin</name><affiliation><nlm:affiliation>Division of Cardiovascular Medicine, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.</nlm:affiliation></affiliation></author><author><name sortKey="Marchlinski, Francis" sort="Marchlinski, Francis" uniqKey="Marchlinski F" first="Francis" last="Marchlinski">Francis Marchlinski</name><affiliation><nlm:affiliation>Division of Cardiovascular Medicine, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.</nlm:affiliation></affiliation></author><author><name sortKey="Deo, Rajat" sort="Deo, Rajat" uniqKey="Deo R" first="Rajat" last="Deo">Rajat Deo</name><affiliation><nlm:affiliation>Division of Cardiovascular Medicine, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address: Rajat.Deo@pennmedicine.upenn.edu.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32585191</idno><idno type="pmid">32585191</idno><idno type="doi">10.1016/j.hrthm.2020.06.016</idno><idno type="pmc">PMC7307518</idno><idno type="wicri:Area/Main/Corpus">000113</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000113</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">COVID-19 and cardiac arrhythmias.</title><author><name sortKey="Bhatla, Anjali" sort="Bhatla, Anjali" uniqKey="Bhatla A" first="Anjali" last="Bhatla">Anjali Bhatla</name><affiliation><nlm:affiliation>Division of Cardiovascular Medicine, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.</nlm:affiliation></affiliation></author><author><name sortKey="Mayer, Michael M" sort="Mayer, Michael M" uniqKey="Mayer M" first="Michael M" last="Mayer">Michael M. Mayer</name><affiliation><nlm:affiliation>Division of Cardiovascular Medicine, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.</nlm:affiliation></affiliation></author><author><name sortKey="Adusumalli, Srinath" sort="Adusumalli, Srinath" uniqKey="Adusumalli S" first="Srinath" last="Adusumalli">Srinath Adusumalli</name><affiliation><nlm:affiliation>Division of Cardiovascular Medicine, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.</nlm:affiliation></affiliation></author><author><name sortKey="Hyman, Matthew C" sort="Hyman, Matthew C" uniqKey="Hyman M" first="Matthew C" last="Hyman">Matthew C. Hyman</name><affiliation><nlm:affiliation>Division of Cardiovascular Medicine, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.</nlm:affiliation></affiliation></author><author><name sortKey="Oh, Eric" sort="Oh, Eric" uniqKey="Oh E" first="Eric" last="Oh">Eric Oh</name><affiliation><nlm:affiliation>Department of Biostatistics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.</nlm:affiliation></affiliation></author><author><name sortKey="Tierney, Ann" sort="Tierney, Ann" uniqKey="Tierney A" first="Ann" last="Tierney">Ann Tierney</name><affiliation><nlm:affiliation>Department of Biostatistics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.</nlm:affiliation></affiliation></author><author><name sortKey="Moss, Juwann" sort="Moss, Juwann" uniqKey="Moss J" first="Juwann" last="Moss">Juwann Moss</name><affiliation><nlm:affiliation>Division of Cardiovascular Medicine, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.</nlm:affiliation></affiliation></author><author><name sortKey="Chahal, Anwar A" sort="Chahal, Anwar A" uniqKey="Chahal A" first="Anwar A" last="Chahal">Anwar A. Chahal</name><affiliation><nlm:affiliation>Division of Cardiovascular Medicine, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.</nlm:affiliation></affiliation></author><author><name sortKey="Anesi, George" sort="Anesi, George" uniqKey="Anesi G" first="George" last="Anesi">George Anesi</name><affiliation><nlm:affiliation>Division of Pulmonary and Critical Care, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.</nlm:affiliation></affiliation></author><author><name sortKey="Denduluri, Srinivas" sort="Denduluri, Srinivas" uniqKey="Denduluri S" first="Srinivas" last="Denduluri">Srinivas Denduluri</name><affiliation><nlm:affiliation>Division of Cardiovascular Medicine, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.</nlm:affiliation></affiliation></author><author><name sortKey="Domenico, Christopher M" sort="Domenico, Christopher M" uniqKey="Domenico C" first="Christopher M" last="Domenico">Christopher M. Domenico</name><affiliation><nlm:affiliation>Division of Cardiovascular Medicine, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.</nlm:affiliation></affiliation></author><author><name sortKey="Arkles, Jeffrey" sort="Arkles, Jeffrey" uniqKey="Arkles J" first="Jeffrey" last="Arkles">Jeffrey Arkles</name><affiliation><nlm:affiliation>Division of Cardiovascular Medicine, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.</nlm:affiliation></affiliation></author><author><name sortKey="Abella, Benjamin S" sort="Abella, Benjamin S" uniqKey="Abella B" first="Benjamin S" last="Abella">Benjamin S. Abella</name><affiliation><nlm:affiliation>Department of Emergency Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.</nlm:affiliation></affiliation></author><author><name sortKey="Bullinga, John R" sort="Bullinga, John R" uniqKey="Bullinga J" first="John R" last="Bullinga">John R. Bullinga</name><affiliation><nlm:affiliation>Division of Cardiovascular Medicine, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.</nlm:affiliation></affiliation></author><author><name sortKey="Callans, David J" sort="Callans, David J" uniqKey="Callans D" first="David J" last="Callans">David J. Callans</name><affiliation><nlm:affiliation>Division of Cardiovascular Medicine, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.</nlm:affiliation></affiliation></author><author><name sortKey="Dixit, Sanjay" sort="Dixit, Sanjay" uniqKey="Dixit S" first="Sanjay" last="Dixit">Sanjay Dixit</name><affiliation><nlm:affiliation>Division of Cardiovascular Medicine, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.</nlm:affiliation></affiliation></author><author><name sortKey="Epstein, Andrew E" sort="Epstein, Andrew E" uniqKey="Epstein A" first="Andrew E" last="Epstein">Andrew E. Epstein</name><affiliation><nlm:affiliation>Division of Cardiovascular Medicine, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.</nlm:affiliation></affiliation></author><author><name sortKey="Frankel, David S" sort="Frankel, David S" uniqKey="Frankel D" first="David S" last="Frankel">David S. Frankel</name><affiliation><nlm:affiliation>Division of Cardiovascular Medicine, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.</nlm:affiliation></affiliation></author><author><name sortKey="Garcia, Fermin C" sort="Garcia, Fermin C" uniqKey="Garcia F" first="Fermin C" last="Garcia">Fermin C. Garcia</name><affiliation><nlm:affiliation>Division of Cardiovascular Medicine, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.</nlm:affiliation></affiliation></author><author><name sortKey="Kumareswaram, Ramanan" sort="Kumareswaram, Ramanan" uniqKey="Kumareswaram R" first="Ramanan" last="Kumareswaram">Ramanan Kumareswaram</name><affiliation><nlm:affiliation>Division of Cardiovascular Medicine, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.</nlm:affiliation></affiliation></author><author><name sortKey="Nazarian, Saman" sort="Nazarian, Saman" uniqKey="Nazarian S" first="Saman" last="Nazarian">Saman Nazarian</name><affiliation><nlm:affiliation>Division of Cardiovascular Medicine, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.</nlm:affiliation></affiliation></author><author><name sortKey="Riley, Michael P" sort="Riley, Michael P" uniqKey="Riley M" first="Michael P" last="Riley">Michael P. Riley</name><affiliation><nlm:affiliation>Division of Cardiovascular Medicine, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.</nlm:affiliation></affiliation></author><author><name sortKey="Santangeli, Pasquale" sort="Santangeli, Pasquale" uniqKey="Santangeli P" first="Pasquale" last="Santangeli">Pasquale Santangeli</name><affiliation><nlm:affiliation>Division of Cardiovascular Medicine, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.</nlm:affiliation></affiliation></author><author><name sortKey="Schaller, Robert D" sort="Schaller, Robert D" uniqKey="Schaller R" first="Robert D" last="Schaller">Robert D. Schaller</name><affiliation><nlm:affiliation>Division of Cardiovascular Medicine, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.</nlm:affiliation></affiliation></author><author><name sortKey="Supple, Gregory E" sort="Supple, Gregory E" uniqKey="Supple G" first="Gregory E" last="Supple">Gregory E. Supple</name><affiliation><nlm:affiliation>Division of Cardiovascular Medicine, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.</nlm:affiliation></affiliation></author><author><name sortKey="Lin, David" sort="Lin, David" uniqKey="Lin D" first="David" last="Lin">David Lin</name><affiliation><nlm:affiliation>Division of Cardiovascular Medicine, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.</nlm:affiliation></affiliation></author><author><name sortKey="Marchlinski, Francis" sort="Marchlinski, Francis" uniqKey="Marchlinski F" first="Francis" last="Marchlinski">Francis Marchlinski</name><affiliation><nlm:affiliation>Division of Cardiovascular Medicine, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.</nlm:affiliation></affiliation></author><author><name sortKey="Deo, Rajat" sort="Deo, Rajat" uniqKey="Deo R" first="Rajat" last="Deo">Rajat Deo</name><affiliation><nlm:affiliation>Division of Cardiovascular Medicine, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address: Rajat.Deo@pennmedicine.upenn.edu.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Heart rhythm</title><idno type="eISSN">1556-3871</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>Early studies suggest that coronavirus disease 2019 (COVID-19) is associated with a high incidence of cardiac arrhythmias. Severe acute respiratory syndrome coronavirus 2 infection may cause injury to cardiac myocytes and increase arrhythmia risk.</p></div><div type="abstract" xml:lang="en"><p><b>OBJECTIVES</b></p><p>The purpose of this study was to evaluate the risk of cardiac arrest and arrhythmias including incident atrial fibrillation (AF), bradyarrhythmias, and nonsustained ventricular tachycardia (NSVT) in a large urban population hospitalized for COVID-19. We also evaluated correlations between the presence of these arrhythmias and mortality.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>We reviewed the characteristics of all patients with COVID-19 admitted to our center over a 9-week period. Throughout hospitalization, we evaluated the incidence of cardiac arrests, arrhythmias, and inpatient mortality. We also used logistic regression to evaluate age, sex, race, body mass index, prevalent cardiovascular disease, diabetes, hypertension, kidney disease, and intensive care unit (ICU) status as potential risk factors for each arrhythmia.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>Among 700 patients (mean age 50 ± 18 years; 45% men; 71% African American; 11% received ICU care), there were 9 cardiac arrests, 25 incident AF events, 9 clinically significant bradyarrhythmias, and 10 NSVTs. All cardiac arrests occurred in patients admitted to the ICU. In addition, admission to the ICU was associated with incident AF (odds ratio [OR] 4.68; 95% confidence interval [CI] 1.66-13.18) and NSVT (OR 8.92; 95% CI 1.73-46.06) after multivariable adjustment. Also, age and incident AF (OR 1.05; 95% CI 1.02-1.09) and prevalent heart failure and bradyarrhythmias (OR 9.75; 95% CI 1.95-48.65) were independently associated. Only cardiac arrests were associated with acute in-hospital mortality.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSION</b></p><p>Cardiac arrests and arrhythmias are likely the consequence of systemic illness and not solely the direct effects of COVID-19 infection.</p></div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">32585191</PMID><DateRevised><Year>2020</Year><Month>07</Month><Day>13</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1556-3871</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2020</Year><Month>Jun</Month><Day>22</Day></PubDate></JournalIssue><Title>Heart rhythm</Title><ISOAbbreviation>Heart Rhythm</ISOAbbreviation></Journal><ArticleTitle>COVID-19 and cardiac arrhythmias.</ArticleTitle><ELocationID EIdType="pii" ValidYN="Y">S1547-5271(20)30594-4</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.hrthm.2020.06.016</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Early studies suggest that coronavirus disease 2019 (COVID-19) is associated with a high incidence of cardiac arrhythmias. Severe acute respiratory syndrome coronavirus 2 infection may cause injury to cardiac myocytes and increase arrhythmia risk.</AbstractText><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">The purpose of this study was to evaluate the risk of cardiac arrest and arrhythmias including incident atrial fibrillation (AF), bradyarrhythmias, and nonsustained ventricular tachycardia (NSVT) in a large urban population hospitalized for COVID-19. We also evaluated correlations between the presence of these arrhythmias and mortality.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">We reviewed the characteristics of all patients with COVID-19 admitted to our center over a 9-week period. Throughout hospitalization, we evaluated the incidence of cardiac arrests, arrhythmias, and inpatient mortality. We also used logistic regression to evaluate age, sex, race, body mass index, prevalent cardiovascular disease, diabetes, hypertension, kidney disease, and intensive care unit (ICU) status as potential risk factors for each arrhythmia.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Among 700 patients (mean age 50 ± 18 years; 45% men; 71% African American; 11% received ICU care), there were 9 cardiac arrests, 25 incident AF events, 9 clinically significant bradyarrhythmias, and 10 NSVTs. All cardiac arrests occurred in patients admitted to the ICU. In addition, admission to the ICU was associated with incident AF (odds ratio [OR] 4.68; 95% confidence interval [CI] 1.66-13.18) and NSVT (OR 8.92; 95% CI 1.73-46.06) after multivariable adjustment. Also, age and incident AF (OR 1.05; 95% CI 1.02-1.09) and prevalent heart failure and bradyarrhythmias (OR 9.75; 95% CI 1.95-48.65) were independently associated. Only cardiac arrests were associated with acute in-hospital mortality.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Cardiac arrests and arrhythmias are likely the consequence of systemic illness and not solely the direct effects of COVID-19 infection.</AbstractText><CopyrightInformation>Copyright © 2020. Published by Elsevier Inc.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Bhatla</LastName><ForeName>Anjali</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Division of Cardiovascular Medicine, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mayer</LastName><ForeName>Michael M</ForeName><Initials>MM</Initials><AffiliationInfo><Affiliation>Division of Cardiovascular Medicine, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Adusumalli</LastName><ForeName>Srinath</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Division of Cardiovascular Medicine, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hyman</LastName><ForeName>Matthew C</ForeName><Initials>MC</Initials><AffiliationInfo><Affiliation>Division of Cardiovascular Medicine, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Oh</LastName><ForeName>Eric</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Biostatistics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tierney</LastName><ForeName>Ann</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Biostatistics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Moss</LastName><ForeName>Juwann</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Division of Cardiovascular Medicine, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chahal</LastName><ForeName>Anwar A</ForeName><Initials>AA</Initials><AffiliationInfo><Affiliation>Division of Cardiovascular Medicine, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Anesi</LastName><ForeName>George</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Division of Pulmonary and Critical Care, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Denduluri</LastName><ForeName>Srinivas</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Division of Cardiovascular Medicine, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Domenico</LastName><ForeName>Christopher M</ForeName><Initials>CM</Initials><AffiliationInfo><Affiliation>Division of Cardiovascular Medicine, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Arkles</LastName><ForeName>Jeffrey</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Division of Cardiovascular Medicine, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Abella</LastName><ForeName>Benjamin S</ForeName><Initials>BS</Initials><AffiliationInfo><Affiliation>Department of Emergency Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bullinga</LastName><ForeName>John R</ForeName><Initials>JR</Initials><AffiliationInfo><Affiliation>Division of Cardiovascular Medicine, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Callans</LastName><ForeName>David J</ForeName><Initials>DJ</Initials><AffiliationInfo><Affiliation>Division of Cardiovascular Medicine, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dixit</LastName><ForeName>Sanjay</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Division of Cardiovascular Medicine, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Epstein</LastName><ForeName>Andrew E</ForeName><Initials>AE</Initials><AffiliationInfo><Affiliation>Division of Cardiovascular Medicine, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Frankel</LastName><ForeName>David S</ForeName><Initials>DS</Initials><AffiliationInfo><Affiliation>Division of Cardiovascular Medicine, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Garcia</LastName><ForeName>Fermin C</ForeName><Initials>FC</Initials><AffiliationInfo><Affiliation>Division of Cardiovascular Medicine, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kumareswaram</LastName><ForeName>Ramanan</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Division of Cardiovascular Medicine, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nazarian</LastName><ForeName>Saman</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Division of Cardiovascular Medicine, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Riley</LastName><ForeName>Michael P</ForeName><Initials>MP</Initials><AffiliationInfo><Affiliation>Division of Cardiovascular Medicine, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Santangeli</LastName><ForeName>Pasquale</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Division of Cardiovascular Medicine, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schaller</LastName><ForeName>Robert D</ForeName><Initials>RD</Initials><AffiliationInfo><Affiliation>Division of Cardiovascular Medicine, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Supple</LastName><ForeName>Gregory E</ForeName><Initials>GE</Initials><AffiliationInfo><Affiliation>Division of Cardiovascular Medicine, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lin</LastName><ForeName>David</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Division of Cardiovascular Medicine, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Marchlinski</LastName><ForeName>Francis</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Division of Cardiovascular Medicine, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Deo</LastName><ForeName>Rajat</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Division of Cardiovascular Medicine, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address: Rajat.Deo@pennmedicine.upenn.edu.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>06</Month><Day>22</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Heart Rhythm</MedlineTA><NlmUniqueID>101200317</NlmUniqueID><ISSNLinking>1547-5271</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Arrhythmia</Keyword><Keyword MajorTopicYN="N">COVID-19</Keyword><Keyword MajorTopicYN="N">Cardiac arrest</Keyword><Keyword MajorTopicYN="N">Mortality</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>05</Month><Day>17</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2020</Year><Month>06</Month><Day>14</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>06</Month><Day>15</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>6</Month><Day>26</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>6</Month><Day>26</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>6</Month><Day>26</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32585191</ArticleId><ArticleId IdType="pii">S1547-5271(20)30594-4</ArticleId><ArticleId IdType="doi">10.1016/j.hrthm.2020.06.016</ArticleId><ArticleId IdType="pmc">PMC7307518</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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