Relationship Between ACE2 and Other Components of the Renin-Angiotensin System.
Identifieur interne : 000099 ( Main/Corpus ); précédent : 000098; suivant : 000100Relationship Between ACE2 and Other Components of the Renin-Angiotensin System.
Auteurs : Jordana B. Cohen ; Thomas C. Hanff ; Adam P. Bress ; Andrew M. SouthSource :
- Current hypertension reports [ 1534-3111 ] ; 2020.
English descriptors
- KwdEn :
- MESH :
- chemical , physiology : Peptidyl-Dipeptidase A, Receptors, Virus.
- physiopathology : Coronavirus Infections, Pneumonia, Viral.
- Betacoronavirus, Humans, Pandemics, Renin-Angiotensin System.
Abstract
PURPOSE OF THE REVIEW
Angiotensin-converting enzyme 2 (ACE2) is a key counter-regulatory component of the renin-angiotensin system. Here, we briefly review the mechanistic and target organ effects related to ACE2 activity, and the importance of ACE2 in SARS-CoV-2 infection.
RECENT FINDINGS
ACE2 converts angiotensin (Ang) II to Ang-(1-7), which directly opposes the vasoconstrictive, proinflammatory, and prothrombotic effects of Ang II. ACE2 also facilitates SARS-CoV-2 viral entry into host cells. Drugs that interact with the renin-angiotensin system may impact ACE2 expression and COVID-19 pathogenesis; however, the magnitude and direction of these effects are unknown at this time. High quality research is needed to improve our understanding of how agents that act on the renin-angiotensin system impact ACE2 and COVID-19-related disease outcomes.
DOI: 10.1007/s11906-020-01048-y
PubMed: 32591908
PubMed Central: PMC7317893
Links to Exploration step
pubmed:32591908Le document en format XML
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<term>Humans (MeSH)</term>
<term>Pandemics (MeSH)</term>
<term>Peptidyl-Dipeptidase A (physiology)</term>
<term>Pneumonia, Viral (physiopathology)</term>
<term>Receptors, Virus (physiology)</term>
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<front><div type="abstract" xml:lang="en"><p><b>PURPOSE OF THE REVIEW</b>
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<p>Angiotensin-converting enzyme 2 (ACE2) is a key counter-regulatory component of the renin-angiotensin system. Here, we briefly review the mechanistic and target organ effects related to ACE2 activity, and the importance of ACE2 in SARS-CoV-2 infection.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>RECENT FINDINGS</b>
</p>
<p>ACE2 converts angiotensin (Ang) II to Ang-(1-7), which directly opposes the vasoconstrictive, proinflammatory, and prothrombotic effects of Ang II. ACE2 also facilitates SARS-CoV-2 viral entry into host cells. Drugs that interact with the renin-angiotensin system may impact ACE2 expression and COVID-19 pathogenesis; however, the magnitude and direction of these effects are unknown at this time. High quality research is needed to improve our understanding of how agents that act on the renin-angiotensin system impact ACE2 and COVID-19-related disease outcomes.</p>
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<AbstractText Label="RECENT FINDINGS">ACE2 converts angiotensin (Ang) II to Ang-(1-7), which directly opposes the vasoconstrictive, proinflammatory, and prothrombotic effects of Ang II. ACE2 also facilitates SARS-CoV-2 viral entry into host cells. Drugs that interact with the renin-angiotensin system may impact ACE2 expression and COVID-19 pathogenesis; however, the magnitude and direction of these effects are unknown at this time. High quality research is needed to improve our understanding of how agents that act on the renin-angiotensin system impact ACE2 and COVID-19-related disease outcomes.</AbstractText>
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