Impact of order of fixed-ratio presentation on demand for self-administered remifentanil in male rats.
Identifieur interne : 000180 ( Main/Exploration ); précédent : 000179; suivant : 000181Impact of order of fixed-ratio presentation on demand for self-administered remifentanil in male rats.
Auteurs : David R. Maguire ; Vanessa Minervini ; Vikas Dodda ; Charles P. France [États-Unis]Source :
- Behavioural pharmacology [ 1473-5849 ] ; 2020.
Descripteurs français
- KwdFr :
- Analgésiques morphiniques (pharmacologie), Animaux (MeSH), Autoadministration (méthodes), Conditionnement opérant (effets des médicaments et des substances chimiques), Mâle (MeSH), Programme de renforcement (MeSH), Rat Sprague-Dawley (MeSH), Rats (MeSH), Relation dose-effet des médicaments (MeSH), Rémifentanil (métabolisme), Rémifentanil (pharmacologie).
- MESH :
- effets des médicaments et des substances chimiques : Conditionnement opérant.
- métabolisme : Rémifentanil.
- méthodes : Autoadministration.
- pharmacologie : Analgésiques morphiniques, Rémifentanil.
- Animaux, Mâle, Programme de renforcement, Rat Sprague-Dawley, Rats, Relation dose-effet des médicaments.
English descriptors
- KwdEn :
- Analgesics, Opioid (pharmacology), Animals (MeSH), Conditioning, Operant (drug effects), Dose-Response Relationship, Drug (MeSH), Male (MeSH), Rats (MeSH), Rats, Sprague-Dawley (MeSH), Reinforcement Schedule (MeSH), Reinforcement, Psychology (MeSH), Remifentanil (metabolism), Remifentanil (pharmacology), Self Administration (methods).
- MESH :
- chemical , metabolism : Remifentanil.
- chemical , pharmacology : Analgesics, Opioid, Remifentanil.
- drug effects : Conditioning, Operant.
- methods : Self Administration.
- Animals, Dose-Response Relationship, Drug, Male, Rats, Rats, Sprague-Dawley, Reinforcement Schedule, Reinforcement, Psychology.
Abstract
The behavioral economics framework has been used extensively to study factors that control operant behavior, including quantification of reinforcing effectiveness of drugs of abuse. Generally, consumption of a commodity decreases with increasing price, and the rate of decrease reflects demand elasticity, which is inversely related to reinforcing effectiveness. Drugs with low elasticity have greater effectiveness than those with greater elasticity. Price is often manipulated by varying the number of responses required to obtain an infusion (e.g. fixed ratio schedule); however, many studies present the fixed ratio in only one order (usually ascending), which could introduce sequence effects that influence estimates of demand. This study examined the impact of the order of fixed ratio presentation on demand for the mu opioid receptor agonist remifentanil (0.0032 mg/kg/infusion) using an ascending and a mixed order of fixed ratio presentation. Seven male rats lever pressed for intravenous infusions. The fixed ratio varied across 3-session blocks, yielding a demand curve. During the first and third phases, the fixed ratio increased, and, during the second phase, fixed ratio values were presented in a mixed order. On average, rats obtained more than 60 infusions per session under baseline (fixed ratio 1) during the each of the three phases, with the number of infusions received decreasing progressively with increasing fixed ratio values. Estimates of elasticity across the three phases were not statistically different indicating that the order of fixed ratio presentation did not markedly alter estimates of demand and further demonstrating the robustness of price as a source of control over operant behavior, including behavior maintained by drug reinforcers.
DOI: 10.1097/FBP.0000000000000502
PubMed: 31577559
Affiliations:
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Maguire</name><affiliation><nlm:affiliation>Department of Pharmacology.</nlm:affiliation><wicri:noCountry code="no comma">Department of Pharmacology.</wicri:noCountry><wicri:noCountry code="no comma">Department of Pharmacology.</wicri:noCountry></affiliation><affiliation><nlm:affiliation>Addiction Research, Training, and Teaching Center of Excellence.</nlm:affiliation><wicri:noCountry code="subField">and Teaching Center of Excellence</wicri:noCountry></affiliation></author><author><name sortKey="Minervini, Vanessa" sort="Minervini, Vanessa" uniqKey="Minervini V" first="Vanessa" last="Minervini">Vanessa Minervini</name><affiliation><nlm:affiliation>Department of Pharmacology.</nlm:affiliation><wicri:noCountry code="no comma">Department of Pharmacology.</wicri:noCountry><wicri:noCountry code="no comma">Department of Pharmacology.</wicri:noCountry></affiliation><affiliation><nlm:affiliation>Addiction Research, Training, and Teaching Center of Excellence.</nlm:affiliation><wicri:noCountry code="subField">and Teaching Center of Excellence</wicri:noCountry></affiliation></author><author><name sortKey="Dodda, Vikas" sort="Dodda, Vikas" uniqKey="Dodda V" first="Vikas" last="Dodda">Vikas Dodda</name><affiliation><nlm:affiliation>Department of Pharmacology.</nlm:affiliation><wicri:noCountry code="no comma">Department of Pharmacology.</wicri:noCountry><wicri:noCountry code="no comma">Department of Pharmacology.</wicri:noCountry></affiliation><affiliation><nlm:affiliation>Addiction Research, Training, and Teaching Center of Excellence.</nlm:affiliation><wicri:noCountry code="subField">and Teaching Center of Excellence</wicri:noCountry></affiliation></author><author><name sortKey="France, Charles P" sort="France, Charles P" uniqKey="France C" first="Charles P" last="France">Charles P. France</name><affiliation><nlm:affiliation>Department of Pharmacology.</nlm:affiliation><wicri:noCountry code="no comma">Department of Pharmacology.</wicri:noCountry><wicri:noCountry code="no comma">Department of Pharmacology.</wicri:noCountry></affiliation><affiliation><nlm:affiliation>Addiction Research, Training, and Teaching Center of Excellence.</nlm:affiliation><wicri:noCountry code="subField">and Teaching Center of Excellence</wicri:noCountry></affiliation><affiliation wicri:level="2"><nlm:affiliation>Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, Texas</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author></analytic><series><title level="j">Behavioural pharmacology</title><idno type="eISSN">1473-5849</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Analgesics, Opioid (pharmacology)</term><term>Animals (MeSH)</term><term>Conditioning, Operant (drug effects)</term><term>Dose-Response Relationship, Drug (MeSH)</term><term>Male (MeSH)</term><term>Rats (MeSH)</term><term>Rats, Sprague-Dawley (MeSH)</term><term>Reinforcement Schedule (MeSH)</term><term>Reinforcement, Psychology (MeSH)</term><term>Remifentanil (metabolism)</term><term>Remifentanil (pharmacology)</term><term>Self Administration (methods)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Analgésiques morphiniques (pharmacologie)</term><term>Animaux (MeSH)</term><term>Autoadministration (méthodes)</term><term>Conditionnement opérant (effets des médicaments et des substances chimiques)</term><term>Mâle (MeSH)</term><term>Programme de renforcement (MeSH)</term><term>Rat Sprague-Dawley (MeSH)</term><term>Rats (MeSH)</term><term>Relation dose-effet des médicaments (MeSH)</term><term>Rémifentanil (métabolisme)</term><term>Rémifentanil (pharmacologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Remifentanil</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Analgesics, Opioid</term><term>Remifentanil</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Conditioning, Operant</term></keywords><keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Conditionnement opérant</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Self Administration</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Rémifentanil</term></keywords><keywords scheme="MESH" qualifier="méthodes" xml:lang="fr"><term>Autoadministration</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Analgésiques morphiniques</term><term>Rémifentanil</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Dose-Response Relationship, Drug</term><term>Male</term><term>Rats</term><term>Rats, Sprague-Dawley</term><term>Reinforcement Schedule</term><term>Reinforcement, Psychology</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Mâle</term><term>Programme de renforcement</term><term>Rat Sprague-Dawley</term><term>Rats</term><term>Relation dose-effet des médicaments</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The behavioral economics framework has been used extensively to study factors that control operant behavior, including quantification of reinforcing effectiveness of drugs of abuse. Generally, consumption of a commodity decreases with increasing price, and the rate of decrease reflects demand elasticity, which is inversely related to reinforcing effectiveness. Drugs with low elasticity have greater effectiveness than those with greater elasticity. Price is often manipulated by varying the number of responses required to obtain an infusion (e.g. fixed ratio schedule); however, many studies present the fixed ratio in only one order (usually ascending), which could introduce sequence effects that influence estimates of demand. This study examined the impact of the order of fixed ratio presentation on demand for the mu opioid receptor agonist remifentanil (0.0032 mg/kg/infusion) using an ascending and a mixed order of fixed ratio presentation. Seven male rats lever pressed for intravenous infusions. The fixed ratio varied across 3-session blocks, yielding a demand curve. During the first and third phases, the fixed ratio increased, and, during the second phase, fixed ratio values were presented in a mixed order. On average, rats obtained more than 60 infusions per session under baseline (fixed ratio 1) during the each of the three phases, with the number of infusions received decreasing progressively with increasing fixed ratio values. Estimates of elasticity across the three phases were not statistically different indicating that the order of fixed ratio presentation did not markedly alter estimates of demand and further demonstrating the robustness of price as a source of control over operant behavior, including behavior maintained by drug reinforcers.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">31577559</PMID><DateCompleted><Year>2020</Year><Month>11</Month><Day>17</Day></DateCompleted><DateRevised><Year>2021</Year><Month>02</Month><Day>02</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1473-5849</ISSN><JournalIssue CitedMedium="Internet"><Volume>31</Volume><Issue>2&3</Issue><PubDate><Year>2020</Year><Month>04</Month></PubDate></JournalIssue><Title>Behavioural pharmacology</Title><ISOAbbreviation>Behav Pharmacol</ISOAbbreviation></Journal><ArticleTitle>Impact of order of fixed-ratio presentation on demand for self-administered remifentanil in male rats.</ArticleTitle><Pagination><MedlinePgn>216-220</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1097/FBP.0000000000000502</ELocationID><Abstract><AbstractText>The behavioral economics framework has been used extensively to study factors that control operant behavior, including quantification of reinforcing effectiveness of drugs of abuse. Generally, consumption of a commodity decreases with increasing price, and the rate of decrease reflects demand elasticity, which is inversely related to reinforcing effectiveness. Drugs with low elasticity have greater effectiveness than those with greater elasticity. Price is often manipulated by varying the number of responses required to obtain an infusion (e.g. fixed ratio schedule); however, many studies present the fixed ratio in only one order (usually ascending), which could introduce sequence effects that influence estimates of demand. This study examined the impact of the order of fixed ratio presentation on demand for the mu opioid receptor agonist remifentanil (0.0032 mg/kg/infusion) using an ascending and a mixed order of fixed ratio presentation. Seven male rats lever pressed for intravenous infusions. The fixed ratio varied across 3-session blocks, yielding a demand curve. During the first and third phases, the fixed ratio increased, and, during the second phase, fixed ratio values were presented in a mixed order. On average, rats obtained more than 60 infusions per session under baseline (fixed ratio 1) during the each of the three phases, with the number of infusions received decreasing progressively with increasing fixed ratio values. Estimates of elasticity across the three phases were not statistically different indicating that the order of fixed ratio presentation did not markedly alter estimates of demand and further demonstrating the robustness of price as a source of control over operant behavior, including behavior maintained by drug reinforcers.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Maguire</LastName><ForeName>David R</ForeName><Initials>DR</Initials><AffiliationInfo><Affiliation>Department of Pharmacology.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Addiction Research, Training, and Teaching Center of Excellence.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Minervini</LastName><ForeName>Vanessa</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Department of Pharmacology.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Addiction Research, Training, and Teaching Center of Excellence.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dodda</LastName><ForeName>Vikas</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Department of Pharmacology.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Addiction Research, Training, and Teaching Center of Excellence.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>France</LastName><ForeName>Charles P</ForeName><Initials>CP</Initials><AffiliationInfo><Affiliation>Department of Pharmacology.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Addiction Research, Training, and Teaching Center of Excellence.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Behav Pharmacol</MedlineTA><NlmUniqueID>9013016</NlmUniqueID><ISSNLinking>0955-8810</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000701">Analgesics, Opioid</NameOfSubstance></Chemical><Chemical><RegistryNumber>P10582JYYK</RegistryNumber><NameOfSubstance UI="D000077208">Remifentanil</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000701" MajorTopicYN="N">Analgesics, Opioid</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003216" MajorTopicYN="N">Conditioning, Operant</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004305" MajorTopicYN="N">Dose-Response Relationship, Drug</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051381" MajorTopicYN="N">Rats</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017207" MajorTopicYN="N">Rats, Sprague-Dawley</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012055" MajorTopicYN="Y">Reinforcement Schedule</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012054" MajorTopicYN="N">Reinforcement, Psychology</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000077208" MajorTopicYN="N">Remifentanil</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012646" MajorTopicYN="N">Self Administration</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2019</Year><Month>10</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>11</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2019</Year><Month>10</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">31577559</ArticleId><ArticleId IdType="doi">10.1097/FBP.0000000000000502</ArticleId><ArticleId IdType="pii">00008877-202004000-00013</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>Amlung M, Mackillop J. 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Psychopharmacology (Berl). 2018; 235:47–58</Citation></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country><region><li>Texas</li></region></list><tree><noCountry><name sortKey="Dodda, Vikas" sort="Dodda, Vikas" uniqKey="Dodda V" first="Vikas" last="Dodda">Vikas Dodda</name><name sortKey="Maguire, David R" sort="Maguire, David R" uniqKey="Maguire D" first="David R" last="Maguire">David R. Maguire</name><name sortKey="Minervini, Vanessa" sort="Minervini, Vanessa" uniqKey="Minervini V" first="Vanessa" last="Minervini">Vanessa Minervini</name></noCountry><country name="États-Unis"><region name="Texas"><name sortKey="France, Charles P" sort="France, Charles P" uniqKey="France C" first="Charles P" last="France">Charles P. France</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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