Factors that predict individual vulnerability to amphetamine self-administration.
Identifieur interne : 002078 ( Main/Corpus ); précédent : 002077; suivant : 002079Factors that predict individual vulnerability to amphetamine self-administration.
Auteurs : P V Piazza ; J M Deminière ; M. Le Moal ; H. SimonSource :
- Science (New York, N.Y.) [ 0036-8075 ] ; 1989.
English descriptors
- KwdEn :
- MESH :
- chemical , pharmacology : Dextroamphetamine.
- drug effects : Motor Activity.
- etiology : Substance-Related Disorders.
- psychology : Substance-Related Disorders.
- Animals, Male, Rats, Rats, Inbred Strains, Risk Factors, Self Administration.
Abstract
Clinical observations show that there is considerable individual variability in the response to the addictive properties of drugs. This individual variability needs to be taken into account in animal models of addiction. Like humans, only some rats readily self-administer low doses of psychostimulants. The individual animals at risk can be identified on the basis of their response to environmental or pharmacological challenges. This predisposition to develop self-administration can be induced by repeated treatment with amphetamine. These results may help elucidate the neurobiological basis of addiction liability observed in both rats and humans.
DOI: 10.1126/science.2781295
PubMed: 2781295
Links to Exploration step
pubmed:2781295Le document en format XML
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Simon</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1989">1989</date><idno type="RBID">pubmed:2781295</idno><idno type="pmid">2781295</idno><idno type="doi">10.1126/science.2781295</idno><idno type="wicri:Area/Main/Corpus">002078</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">002078</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Factors that predict individual vulnerability to amphetamine self-administration.</title><author><name sortKey="Piazza, P V" sort="Piazza, P V" uniqKey="Piazza P" first="P V" last="Piazza">P V Piazza</name><affiliation><nlm:affiliation>INSERM U.259, Université de Bordeaux II, France.</nlm:affiliation></affiliation></author><author><name sortKey="Deminiere, J M" sort="Deminiere, J M" uniqKey="Deminiere J" first="J M" last="Deminière">J M Deminière</name></author><author><name sortKey="Le Moal, M" sort="Le Moal, M" uniqKey="Le Moal M" first="M" last="Le Moal">M. Le Moal</name></author><author><name sortKey="Simon, H" sort="Simon, H" uniqKey="Simon H" first="H" last="Simon">H. Simon</name></author></analytic><series><title level="j">Science (New York, N.Y.)</title><idno type="ISSN">0036-8075</idno><imprint><date when="1989" type="published">1989</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term><term>Dextroamphetamine (pharmacology)</term><term>Male (MeSH)</term><term>Motor Activity (drug effects)</term><term>Rats (MeSH)</term><term>Rats, Inbred Strains (MeSH)</term><term>Risk Factors (MeSH)</term><term>Self Administration (MeSH)</term><term>Substance-Related Disorders (etiology)</term><term>Substance-Related Disorders (psychology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Dextroamphetamine</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Motor Activity</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Substance-Related Disorders</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Substance-Related Disorders</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Male</term><term>Rats</term><term>Rats, Inbred Strains</term><term>Risk Factors</term><term>Self Administration</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Clinical observations show that there is considerable individual variability in the response to the addictive properties of drugs. This individual variability needs to be taken into account in animal models of addiction. Like humans, only some rats readily self-administer low doses of psychostimulants. The individual animals at risk can be identified on the basis of their response to environmental or pharmacological challenges. This predisposition to develop self-administration can be induced by repeated treatment with amphetamine. These results may help elucidate the neurobiological basis of addiction liability observed in both rats and humans.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">2781295</PMID><DateCompleted><Year>1989</Year><Month>10</Month><Day>26</Day></DateCompleted><DateRevised><Year>2019</Year><Month>06</Month><Day>18</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0036-8075</ISSN><JournalIssue CitedMedium="Print"><Volume>245</Volume><Issue>4925</Issue><PubDate><Year>1989</Year><Month>Sep</Month><Day>29</Day></PubDate></JournalIssue><Title>Science (New York, N.Y.)</Title><ISOAbbreviation>Science</ISOAbbreviation></Journal><ArticleTitle>Factors that predict individual vulnerability to amphetamine self-administration.</ArticleTitle><Pagination><MedlinePgn>1511-3</MedlinePgn></Pagination><Abstract><AbstractText>Clinical observations show that there is considerable individual variability in the response to the addictive properties of drugs. This individual variability needs to be taken into account in animal models of addiction. Like humans, only some rats readily self-administer low doses of psychostimulants. The individual animals at risk can be identified on the basis of their response to environmental or pharmacological challenges. This predisposition to develop self-administration can be induced by repeated treatment with amphetamine. These results may help elucidate the neurobiological basis of addiction liability observed in both rats and humans.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Piazza</LastName><ForeName>P V</ForeName><Initials>PV</Initials><AffiliationInfo><Affiliation>INSERM U.259, Université de Bordeaux II, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Deminière</LastName><ForeName>J M</ForeName><Initials>JM</Initials></Author><Author ValidYN="Y"><LastName>Le Moal</LastName><ForeName>M</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Simon</LastName><ForeName>H</ForeName><Initials>H</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Science</MedlineTA><NlmUniqueID>0404511</NlmUniqueID><ISSNLinking>0036-8075</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>TZ47U051FI</RegistryNumber><NameOfSubstance UI="D003913">Dextroamphetamine</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003913" MajorTopicYN="Y">Dextroamphetamine</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009043" MajorTopicYN="N">Motor Activity</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051381" MajorTopicYN="N">Rats</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011919" MajorTopicYN="N">Rats, Inbred Strains</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012646" MajorTopicYN="N">Self Administration</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019966" MajorTopicYN="N">Substance-Related Disorders</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName><QualifierName UI="Q000523" MajorTopicYN="N">psychology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1989</Year><Month>9</Month><Day>29</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1989</Year><Month>9</Month><Day>29</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1989</Year><Month>9</Month><Day>29</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">2781295</ArticleId><ArticleId IdType="doi">10.1126/science.2781295</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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