Life events-induced decrease of corticosteroid type I receptors is associated with reduced corticosterone feedback and enhanced vulnerability to amphetamine self-administration.
Identifieur interne : 002062 ( Main/Corpus ); précédent : 002061; suivant : 002063Life events-induced decrease of corticosteroid type I receptors is associated with reduced corticosterone feedback and enhanced vulnerability to amphetamine self-administration.
Auteurs : S. Maccari ; P V Piazza ; J M Deminière ; V. Lemaire ; P. Mormède ; H. Simon ; L. Angelucci ; M. Le MoalSource :
- Brain research [ 0006-8993 ] ; 1991.
English descriptors
- KwdEn :
- Adrenalectomy (MeSH), Amphetamine (pharmacology), Animals (MeSH), Corticosterone (physiology), Environment (MeSH), Feedback (MeSH), Female (MeSH), Hippocampus (drug effects), Hippocampus (metabolism), Hypothalamo-Hypophyseal System (physiopathology), Male (MeSH), Pituitary-Adrenal System (physiopathology), Rats (MeSH), Rats, Inbred Strains (MeSH), Receptors, Glucocorticoid (metabolism), Self Administration (MeSH), Stress, Psychological (metabolism), Stress, Psychological (psychology).
- MESH :
- chemical , metabolism : Receptors, Glucocorticoid.
- chemical , pharmacology : Amphetamine.
- chemical , physiology : Corticosterone.
- drug effects : Hippocampus.
- metabolism : Hippocampus, Stress, Psychological.
- physiopathology : Hypothalamo-Hypophyseal System, Pituitary-Adrenal System.
- psychology : Stress, Psychological.
- Adrenalectomy, Animals, Environment, Feedback, Female, Male, Rats, Rats, Inbred Strains, Self Administration.
Abstract
In this study, we attempted to find out whether a social stress-induced increase in the vulnerability to acquire amphetamine self-administration was associated with a change in number of hippocampal corticosteroid receptors. This was examined in two types of sex-mixed colonies of rats. Animals were maintained for 4 weeks in: (1) 'stable social condition', membership did not change after constitution of the colony; (2) 'unstable social condition', the males were changed daily in a random design. The animals living in the 'stable social' conditions had: (1) a lower number of hippocampal type I corticosteroid receptors; (2) a longer duration of the increase in plasma corticosterone after exposure to novelty; (3) a higher vulnerability to acquire amphetamine self-administration. These findings suggest that a decrease in hippocampal type I corticosteroid receptors may be one of the biological mechanisms responsible for the impaired corticosterone feedback control observed in vulnerable animals. These findings throw more light on the role of hypothalamo-pituitary-adrenal axis in the modulation of adaptive behavior. The availability of drugs which are specific for corticosteroid receptors could represent a new approach to the therapy of certain behavioral disturbances.
DOI: 10.1016/0006-8993(91)90568-g
PubMed: 1860073
Links to Exploration step
pubmed:1860073Le document en format XML
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<author><name sortKey="Maccari, S" sort="Maccari, S" uniqKey="Maccari S" first="S" last="Maccari">S. Maccari</name>
<affiliation><nlm:affiliation>Laboratoire de Psychobiologie des Comportements Adaptatifs, INSERM U259, Bordeaux, France.</nlm:affiliation>
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<author><name sortKey="Piazza, P V" sort="Piazza, P V" uniqKey="Piazza P" first="P V" last="Piazza">P V Piazza</name>
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<author><name sortKey="Deminiere, J M" sort="Deminiere, J M" uniqKey="Deminiere J" first="J M" last="Deminière">J M Deminière</name>
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<author><name sortKey="Lemaire, V" sort="Lemaire, V" uniqKey="Lemaire V" first="V" last="Lemaire">V. Lemaire</name>
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<author><name sortKey="Mormede, P" sort="Mormede, P" uniqKey="Mormede P" first="P" last="Mormède">P. Mormède</name>
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<author><name sortKey="Simon, H" sort="Simon, H" uniqKey="Simon H" first="H" last="Simon">H. Simon</name>
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<author><name sortKey="Angelucci, L" sort="Angelucci, L" uniqKey="Angelucci L" first="L" last="Angelucci">L. Angelucci</name>
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<author><name sortKey="Le Moal, M" sort="Le Moal, M" uniqKey="Le Moal M" first="M" last="Le Moal">M. Le Moal</name>
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<term>Corticosterone (physiology)</term>
<term>Environment (MeSH)</term>
<term>Feedback (MeSH)</term>
<term>Female (MeSH)</term>
<term>Hippocampus (drug effects)</term>
<term>Hippocampus (metabolism)</term>
<term>Hypothalamo-Hypophyseal System (physiopathology)</term>
<term>Male (MeSH)</term>
<term>Pituitary-Adrenal System (physiopathology)</term>
<term>Rats (MeSH)</term>
<term>Rats, Inbred Strains (MeSH)</term>
<term>Receptors, Glucocorticoid (metabolism)</term>
<term>Self Administration (MeSH)</term>
<term>Stress, Psychological (metabolism)</term>
<term>Stress, Psychological (psychology)</term>
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<front><div type="abstract" xml:lang="en">In this study, we attempted to find out whether a social stress-induced increase in the vulnerability to acquire amphetamine self-administration was associated with a change in number of hippocampal corticosteroid receptors. This was examined in two types of sex-mixed colonies of rats. Animals were maintained for 4 weeks in: (1) 'stable social condition', membership did not change after constitution of the colony; (2) 'unstable social condition', the males were changed daily in a random design. The animals living in the 'stable social' conditions had: (1) a lower number of hippocampal type I corticosteroid receptors; (2) a longer duration of the increase in plasma corticosterone after exposure to novelty; (3) a higher vulnerability to acquire amphetamine self-administration. These findings suggest that a decrease in hippocampal type I corticosteroid receptors may be one of the biological mechanisms responsible for the impaired corticosterone feedback control observed in vulnerable animals. These findings throw more light on the role of hypothalamo-pituitary-adrenal axis in the modulation of adaptive behavior. The availability of drugs which are specific for corticosteroid receptors could represent a new approach to the therapy of certain behavioral disturbances.</div>
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<Month>09</Month>
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<Abstract><AbstractText>In this study, we attempted to find out whether a social stress-induced increase in the vulnerability to acquire amphetamine self-administration was associated with a change in number of hippocampal corticosteroid receptors. This was examined in two types of sex-mixed colonies of rats. Animals were maintained for 4 weeks in: (1) 'stable social condition', membership did not change after constitution of the colony; (2) 'unstable social condition', the males were changed daily in a random design. The animals living in the 'stable social' conditions had: (1) a lower number of hippocampal type I corticosteroid receptors; (2) a longer duration of the increase in plasma corticosterone after exposure to novelty; (3) a higher vulnerability to acquire amphetamine self-administration. These findings suggest that a decrease in hippocampal type I corticosteroid receptors may be one of the biological mechanisms responsible for the impaired corticosterone feedback control observed in vulnerable animals. These findings throw more light on the role of hypothalamo-pituitary-adrenal axis in the modulation of adaptive behavior. The availability of drugs which are specific for corticosteroid receptors could represent a new approach to the therapy of certain behavioral disturbances.</AbstractText>
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