Immobilization stress-induced oral opioid self-administration and withdrawal in rats: role of conditioning factors and the effect of stress on "relapse" to opioid drugs.
Identifieur interne : 002043 ( Main/Corpus ); précédent : 002042; suivant : 002044Immobilization stress-induced oral opioid self-administration and withdrawal in rats: role of conditioning factors and the effect of stress on "relapse" to opioid drugs.
Auteurs : Y. ShahamSource :
- Psychopharmacology [ 0033-3158 ] ; 1993.
English descriptors
- KwdEn :
- Animals (MeSH), Conditioning, Psychological (physiology), Corticosterone (blood), Fentanyl (pharmacology), Immobilization (MeSH), Male (MeSH), Morphine (blood), Morphine (pharmacology), Morphine Dependence (psychology), Naloxone (pharmacology), Narcotics (administration & dosage), Narcotics (pharmacology), Rats (MeSH), Rats, Wistar (MeSH), Recurrence (MeSH), Self Administration (MeSH), Stress, Psychological (psychology), Substance Withdrawal Syndrome (psychology).
- MESH :
- chemical , administration & dosage : Narcotics.
- chemical , blood : Corticosterone, Morphine.
- chemical , pharmacology : Fentanyl, Morphine, Naloxone, Narcotics.
- physiology : Conditioning, Psychological.
- psychology : Morphine Dependence, Stress, Psychological, Substance Withdrawal Syndrome.
- Animals, Immobilization, Male, Rats, Rats, Wistar, Recurrence, Self Administration.
Abstract
The effect of 15 min/day of immobilization (IM) stress on oral self-administration (SA) of morphine (0.5 mg/ml) or fentanyl (25 micrograms/ml) and withdrawal was examined in rats. In addition, the role of conditioning factors in these effects was assessed. For each drug, four groups of subjects were exposed for 50 days to IM stress prior to the drug SA period [Paired-Stress (P-S) groups], to IM stress prior to the drug SA period on half of the days and after the drug SA period on the rest of the days [Partial Paired-Stress (PP-S) groups], to IM stress several hours after the drug SA period [Unpaired-Stress (UP-S) groups], or to no IM stress [Control (C) groups]. The P-S and PP-S groups increased their drug SA during choice days in which both the opioid solution and water were available, and tended to manifest a more severe withdrawal syndrome after a naloxone challenge compared with the UP-S and C groups. Reinstatement of the opioid SA under conditions of paired-stress or no stress was further examined after 3 weeks without exposure to either stress or drugs. The paired stress animals had higher levels of drug SA and manifested a more severe withdrawal syndrome than those tested without stress. These results indicate that the learned association between exposure to stress and the drug availability may mediate, in part, the stress-induced enhancement of opioid SA and withdrawal effects.
DOI: 10.1007/BF02253539
PubMed: 7870990
Links to Exploration step
pubmed:7870990Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Immobilization stress-induced oral opioid self-administration and withdrawal in rats: role of conditioning factors and the effect of stress on "relapse" to opioid drugs.</title><author><name sortKey="Shaham, Y" sort="Shaham, Y" uniqKey="Shaham Y" first="Y" last="Shaham">Y. Shaham</name><affiliation><nlm:affiliation>Department of Psychology, Concordia University, Montreal, Quebec, Canada.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1993">1993</date><idno type="RBID">pubmed:7870990</idno><idno type="pmid">7870990</idno><idno type="doi">10.1007/BF02253539</idno><idno type="wicri:Area/Main/Corpus">002043</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">002043</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Immobilization stress-induced oral opioid self-administration and withdrawal in rats: role of conditioning factors and the effect of stress on "relapse" to opioid drugs.</title><author><name sortKey="Shaham, Y" sort="Shaham, Y" uniqKey="Shaham Y" first="Y" last="Shaham">Y. Shaham</name><affiliation><nlm:affiliation>Department of Psychology, Concordia University, Montreal, Quebec, Canada.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Psychopharmacology</title><idno type="ISSN">0033-3158</idno><imprint><date when="1993" type="published">1993</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term><term>Conditioning, Psychological (physiology)</term><term>Corticosterone (blood)</term><term>Fentanyl (pharmacology)</term><term>Immobilization (MeSH)</term><term>Male (MeSH)</term><term>Morphine (blood)</term><term>Morphine (pharmacology)</term><term>Morphine Dependence (psychology)</term><term>Naloxone (pharmacology)</term><term>Narcotics (administration & dosage)</term><term>Narcotics (pharmacology)</term><term>Rats (MeSH)</term><term>Rats, Wistar (MeSH)</term><term>Recurrence (MeSH)</term><term>Self Administration (MeSH)</term><term>Stress, Psychological (psychology)</term><term>Substance Withdrawal Syndrome (psychology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Narcotics</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Corticosterone</term><term>Morphine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Fentanyl</term><term>Morphine</term><term>Naloxone</term><term>Narcotics</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Conditioning, Psychological</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Morphine Dependence</term><term>Stress, Psychological</term><term>Substance Withdrawal Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Immobilization</term><term>Male</term><term>Rats</term><term>Rats, Wistar</term><term>Recurrence</term><term>Self Administration</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The effect of 15 min/day of immobilization (IM) stress on oral self-administration (SA) of morphine (0.5 mg/ml) or fentanyl (25 micrograms/ml) and withdrawal was examined in rats. In addition, the role of conditioning factors in these effects was assessed. For each drug, four groups of subjects were exposed for 50 days to IM stress prior to the drug SA period [Paired-Stress (P-S) groups], to IM stress prior to the drug SA period on half of the days and after the drug SA period on the rest of the days [Partial Paired-Stress (PP-S) groups], to IM stress several hours after the drug SA period [Unpaired-Stress (UP-S) groups], or to no IM stress [Control (C) groups]. The P-S and PP-S groups increased their drug SA during choice days in which both the opioid solution and water were available, and tended to manifest a more severe withdrawal syndrome after a naloxone challenge compared with the UP-S and C groups. Reinstatement of the opioid SA under conditions of paired-stress or no stress was further examined after 3 weeks without exposure to either stress or drugs. The paired stress animals had higher levels of drug SA and manifested a more severe withdrawal syndrome than those tested without stress. These results indicate that the learned association between exposure to stress and the drug availability may mediate, in part, the stress-induced enhancement of opioid SA and withdrawal effects.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">7870990</PMID><DateCompleted><Year>1995</Year><Month>03</Month><Day>28</Day></DateCompleted><DateRevised><Year>2019</Year><Month>12</Month><Day>10</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0033-3158</ISSN><JournalIssue CitedMedium="Print"><Volume>111</Volume><Issue>4</Issue><PubDate><Year>1993</Year></PubDate></JournalIssue><Title>Psychopharmacology</Title><ISOAbbreviation>Psychopharmacology (Berl)</ISOAbbreviation></Journal><ArticleTitle>Immobilization stress-induced oral opioid self-administration and withdrawal in rats: role of conditioning factors and the effect of stress on "relapse" to opioid drugs.</ArticleTitle><Pagination><MedlinePgn>477-85</MedlinePgn></Pagination><Abstract><AbstractText>The effect of 15 min/day of immobilization (IM) stress on oral self-administration (SA) of morphine (0.5 mg/ml) or fentanyl (25 micrograms/ml) and withdrawal was examined in rats. In addition, the role of conditioning factors in these effects was assessed. For each drug, four groups of subjects were exposed for 50 days to IM stress prior to the drug SA period [Paired-Stress (P-S) groups], to IM stress prior to the drug SA period on half of the days and after the drug SA period on the rest of the days [Partial Paired-Stress (PP-S) groups], to IM stress several hours after the drug SA period [Unpaired-Stress (UP-S) groups], or to no IM stress [Control (C) groups]. The P-S and PP-S groups increased their drug SA during choice days in which both the opioid solution and water were available, and tended to manifest a more severe withdrawal syndrome after a naloxone challenge compared with the UP-S and C groups. Reinstatement of the opioid SA under conditions of paired-stress or no stress was further examined after 3 weeks without exposure to either stress or drugs. The paired stress animals had higher levels of drug SA and manifested a more severe withdrawal syndrome than those tested without stress. These results indicate that the learned association between exposure to stress and the drug availability may mediate, in part, the stress-induced enhancement of opioid SA and withdrawal effects.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Shaham</LastName><ForeName>Y</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Psychology, Concordia University, Montreal, Quebec, Canada.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013486">Research Support, U.S. Gov't, Non-P.H.S.</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Germany</Country><MedlineTA>Psychopharmacology (Berl)</MedlineTA><NlmUniqueID>7608025</NlmUniqueID><ISSNLinking>0033-3158</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D009294">Narcotics</NameOfSubstance></Chemical><Chemical><RegistryNumber>36B82AMQ7N</RegistryNumber><NameOfSubstance UI="D009270">Naloxone</NameOfSubstance></Chemical><Chemical><RegistryNumber>76I7G6D29C</RegistryNumber><NameOfSubstance UI="D009020">Morphine</NameOfSubstance></Chemical><Chemical><RegistryNumber>UF599785JZ</RegistryNumber><NameOfSubstance UI="D005283">Fentanyl</NameOfSubstance></Chemical><Chemical><RegistryNumber>W980KJ009P</RegistryNumber><NameOfSubstance UI="D003345">Corticosterone</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CitationSubset>S</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003213" MajorTopicYN="N">Conditioning, Psychological</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003345" MajorTopicYN="N">Corticosterone</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005283" MajorTopicYN="N">Fentanyl</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007103" MajorTopicYN="N">Immobilization</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009020" MajorTopicYN="N">Morphine</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009021" MajorTopicYN="N">Morphine Dependence</DescriptorName><QualifierName UI="Q000523" MajorTopicYN="Y">psychology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009270" MajorTopicYN="N">Naloxone</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009294" MajorTopicYN="N">Narcotics</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051381" MajorTopicYN="N">Rats</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017208" MajorTopicYN="N">Rats, Wistar</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012008" MajorTopicYN="N">Recurrence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012646" MajorTopicYN="N">Self Administration</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013315" MajorTopicYN="N">Stress, Psychological</DescriptorName><QualifierName UI="Q000523" MajorTopicYN="Y">psychology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013375" MajorTopicYN="N">Substance Withdrawal Syndrome</DescriptorName><QualifierName UI="Q000523" MajorTopicYN="Y">psychology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1993</Year><Month>1</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1993</Year><Month>1</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1993</Year><Month>1</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">7870990</ArticleId><ArticleId IdType="doi">10.1007/BF02253539</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>J Pharmacol Exp Ther. 1984 Dec;231(3):555-65</Citation><ArticleIdList><ArticleId IdType="pubmed">6502514</ArticleId></ArticleIdList></Reference><Reference><Citation>Pharmacol Biochem Behav. 1990 Oct;37(2):303-10</Citation><ArticleIdList><ArticleId IdType="pubmed">2080193</ArticleId></ArticleIdList></Reference><Reference><Citation>Neuroendocrinology. 1984 May;38(5):411-7</Citation><ArticleIdList><ArticleId IdType="pubmed">6328347</ArticleId></ArticleIdList></Reference><Reference><Citation>Psychol Rev. 1987 Oct;94(4):469-92</Citation><ArticleIdList><ArticleId IdType="pubmed">3317472</ArticleId></ArticleIdList></Reference><Reference><Citation>Psychopharmacologia. 1970;17(2):137-50</Citation><ArticleIdList><ArticleId IdType="pubmed">5462744</ArticleId></ArticleIdList></Reference><Reference><Citation>Pain. 1985 Oct;23(2):177-85</Citation><ArticleIdList><ArticleId IdType="pubmed">3840877</ArticleId></ArticleIdList></Reference><Reference><Citation>Brain Res Brain Res Rev. 1991 Sep-Dec;16(3):223-44</Citation><ArticleIdList><ArticleId IdType="pubmed">1665095</ArticleId></ArticleIdList></Reference><Reference><Citation>Behav Neurosci. 1986 Jun;100(3):368-75</Citation><ArticleIdList><ArticleId IdType="pubmed">3730144</ArticleId></ArticleIdList></Reference><Reference><Citation>Drug Alcohol Depend. 1991 Dec;29(1):97-106</Citation><ArticleIdList><ArticleId IdType="pubmed">1797523</ArticleId></ArticleIdList></Reference><Reference><Citation>Behav Neurosci. 1984 Oct;98(5):836-46</Citation><ArticleIdList><ArticleId IdType="pubmed">6541499</ArticleId></ArticleIdList></Reference><Reference><Citation>Int J Addict. 1976;11(3):525-44</Citation><ArticleIdList><ArticleId IdType="pubmed">965128</ArticleId></ArticleIdList></Reference><Reference><Citation>Psychol Bull. 1982 Sep;92(2):367-81</Citation><ArticleIdList><ArticleId IdType="pubmed">7146233</ArticleId></ArticleIdList></Reference><Reference><Citation>Br J Addict. 1987 Feb;82(2):127-37</Citation><ArticleIdList><ArticleId IdType="pubmed">3552008</ArticleId></ArticleIdList></Reference><Reference><Citation>Pharmacol Biochem Behav. 1993 Oct;46(2):315-22</Citation><ArticleIdList><ArticleId IdType="pubmed">8265686</ArticleId></ArticleIdList></Reference><Reference><Citation>Pharmacol Biochem Behav. 1992 Mar;41(3):615-9</Citation><ArticleIdList><ArticleId IdType="pubmed">1584842</ArticleId></ArticleIdList></Reference><Reference><Citation>Psychosom Med. 1974 May-Jun;36(3):189-98</Citation><ArticleIdList><ArticleId IdType="pubmed">4829614</ArticleId></ArticleIdList></Reference><Reference><Citation>Pain. 1982 Aug;13(4):395-406</Citation><ArticleIdList><ArticleId IdType="pubmed">7133734</ArticleId></ArticleIdList></Reference><Reference><Citation>Psychopharmacology (Berl). 1977 Oct 20;54(2):159-64</Citation><ArticleIdList><ArticleId IdType="pubmed">412210</ArticleId></ArticleIdList></Reference><Reference><Citation>Ann N Y Acad Sci. 1986;467:14-29</Citation><ArticleIdList><ArticleId IdType="pubmed">3524377</ArticleId></ArticleIdList></Reference><Reference><Citation>Physiol Behav. 1987;40(6):775-9</Citation><ArticleIdList><ArticleId IdType="pubmed">2823307</ArticleId></ArticleIdList></Reference><Reference><Citation>Psychopharmacologia. 1967;10(3):255-84</Citation><ArticleIdList><ArticleId IdType="pubmed">5626647</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 1988 Nov 4;242(4879):715-23</Citation><ArticleIdList><ArticleId IdType="pubmed">2903550</ArticleId></ArticleIdList></Reference><Reference><Citation>Psychol Rev. 1982 Sep;89(5):507-28</Citation><ArticleIdList><ArticleId IdType="pubmed">7178331</ArticleId></ArticleIdList></Reference><Reference><Citation>Arch Gen Psychiatry. 1986 Aug;43(8):733-8</Citation><ArticleIdList><ArticleId IdType="pubmed">3729667</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/AutomedicationFrancoV1/Data/Main/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002043 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Corpus/biblio.hfd -nk 002043 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= AutomedicationFrancoV1
|flux= Main
|étape= Corpus
|type= RBID
|clé= pubmed:7870990
|texte= Immobilization stress-induced oral opioid self-administration and withdrawal in rats: role of conditioning factors and the effect of stress on "relapse" to opioid drugs.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Corpus/RBID.i -Sk "pubmed:7870990" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a AutomedicationFrancoV1
| This area was generated with Dilib version V0.6.38. |  |