Corticosterone in the range of stress-induced levels possesses reinforcing properties: implications for sensation-seeking behaviors.
Identifieur interne : 002021 ( Main/Corpus ); précédent : 002020; suivant : 002022Corticosterone in the range of stress-induced levels possesses reinforcing properties: implications for sensation-seeking behaviors.
Auteurs : P V Piazza ; V. Deroche ; J M Deminière ; S. Maccari ; M. Le Moal ; H. SimonSource :
- Proceedings of the National Academy of Sciences of the United States of America [ 0027-8424 ] ; 1993.
English descriptors
- KwdEn :
- Analysis of Variance (MeSH), Animals (MeSH), Corticosterone (administration & dosage), Corticosterone (blood), Humans (MeSH), Hypothalamo-Hypophyseal System (physiology), Hypothalamo-Hypophyseal System (physiopathology), Male (MeSH), Pituitary-Adrenal System (physiology), Pituitary-Adrenal System (physiopathology), Rats (MeSH), Rats, Sprague-Dawley (MeSH), Reinforcement, Psychology (MeSH), Self Administration (MeSH), Stress, Psychological (blood), Stress, Psychological (physiopathology).
- MESH :
- chemical , administration & dosage : Corticosterone.
- chemical , blood : Corticosterone.
- blood : Stress, Psychological.
- physiology : Hypothalamo-Hypophyseal System, Pituitary-Adrenal System.
- physiopathology : Hypothalamo-Hypophyseal System, Pituitary-Adrenal System, Stress, Psychological.
- Analysis of Variance, Animals, Humans, Male, Rats, Rats, Sprague-Dawley, Reinforcement, Psychology, Self Administration.
Abstract
In both humans and animals certain individuals seek stimuli or situations that are considered stressful and consequently avoided by others. A common feature of such situations is an activation of the hypothalamo-pituitary-adrenal axis leading to secretion of glucocorticoids. Since glucocorticoids have euphoric effects in some individuals and have been shown to potentiate the reinforcing properties of drugs of abuse in animals, we hypothesized that corticosterone secretion during stress-like situations may have reinforcing effects and that a higher sensitivity to the reinforcing effects of glucocorticoids might be a biological basis of sensation seeking. In this report we show that (i) corticosterone has reinforcing properties, as evidenced by the development of intravenous self-administration, (ii) self-administration of corticosterone is observed at plasma levels that are comparable to those induced by stress, and (iii) there are individual differences in corticosterone self-administration, which are related to individual reactivity to novelty and sensitivity to drugs of abuse, behavioral features akin to certain traits of high-sensation seekers. These findings provide insight into the physiological role of glucocorticoids and the biology of sensation seeking and may have clinical implications.
DOI: 10.1073/pnas.90.24.11738
PubMed: 8265619
PubMed Central: PMC48059
Links to Exploration step
pubmed:8265619Le document en format XML
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Le Moal</name></author><author><name sortKey="Simon, H" sort="Simon, H" uniqKey="Simon H" first="H" last="Simon">H. Simon</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1993">1993</date><idno type="RBID">pubmed:8265619</idno><idno type="pmid">8265619</idno><idno type="pmc">PMC48059</idno><idno type="doi">10.1073/pnas.90.24.11738</idno><idno type="wicri:Area/Main/Corpus">002021</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">002021</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Corticosterone in the range of stress-induced levels possesses reinforcing properties: implications for sensation-seeking behaviors.</title><author><name sortKey="Piazza, P V" sort="Piazza, P V" uniqKey="Piazza P" first="P V" last="Piazza">P V Piazza</name><affiliation><nlm:affiliation>Institute National de la Santé et de la Recherche Médicale (INSERM) Unité 259, Université de Bordeaux II, France.</nlm:affiliation></affiliation></author><author><name sortKey="Deroche, V" sort="Deroche, V" uniqKey="Deroche V" first="V" last="Deroche">V. Deroche</name></author><author><name sortKey="Deminiere, J M" sort="Deminiere, J M" uniqKey="Deminiere J" first="J M" last="Deminière">J M Deminière</name></author><author><name sortKey="Maccari, S" sort="Maccari, S" uniqKey="Maccari S" first="S" last="Maccari">S. Maccari</name></author><author><name sortKey="Le Moal, M" sort="Le Moal, M" uniqKey="Le Moal M" first="M" last="Le Moal">M. Le Moal</name></author><author><name sortKey="Simon, H" sort="Simon, H" uniqKey="Simon H" first="H" last="Simon">H. Simon</name></author></analytic><series><title level="j">Proceedings of the National Academy of Sciences of the United States of America</title><idno type="ISSN">0027-8424</idno><imprint><date when="1993" type="published">1993</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Analysis of Variance (MeSH)</term><term>Animals (MeSH)</term><term>Corticosterone (administration & dosage)</term><term>Corticosterone (blood)</term><term>Humans (MeSH)</term><term>Hypothalamo-Hypophyseal System (physiology)</term><term>Hypothalamo-Hypophyseal System (physiopathology)</term><term>Male (MeSH)</term><term>Pituitary-Adrenal System (physiology)</term><term>Pituitary-Adrenal System (physiopathology)</term><term>Rats (MeSH)</term><term>Rats, Sprague-Dawley (MeSH)</term><term>Reinforcement, Psychology (MeSH)</term><term>Self Administration (MeSH)</term><term>Stress, Psychological (blood)</term><term>Stress, Psychological (physiopathology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Corticosterone</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Corticosterone</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Stress, Psychological</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Hypothalamo-Hypophyseal System</term><term>Pituitary-Adrenal System</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Hypothalamo-Hypophyseal System</term><term>Pituitary-Adrenal System</term><term>Stress, Psychological</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Analysis of Variance</term><term>Animals</term><term>Humans</term><term>Male</term><term>Rats</term><term>Rats, Sprague-Dawley</term><term>Reinforcement, Psychology</term><term>Self Administration</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In both humans and animals certain individuals seek stimuli or situations that are considered stressful and consequently avoided by others. A common feature of such situations is an activation of the hypothalamo-pituitary-adrenal axis leading to secretion of glucocorticoids. Since glucocorticoids have euphoric effects in some individuals and have been shown to potentiate the reinforcing properties of drugs of abuse in animals, we hypothesized that corticosterone secretion during stress-like situations may have reinforcing effects and that a higher sensitivity to the reinforcing effects of glucocorticoids might be a biological basis of sensation seeking. In this report we show that (i) corticosterone has reinforcing properties, as evidenced by the development of intravenous self-administration, (ii) self-administration of corticosterone is observed at plasma levels that are comparable to those induced by stress, and (iii) there are individual differences in corticosterone self-administration, which are related to individual reactivity to novelty and sensitivity to drugs of abuse, behavioral features akin to certain traits of high-sensation seekers. These findings provide insight into the physiological role of glucocorticoids and the biology of sensation seeking and may have clinical implications.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">8265619</PMID><DateCompleted><Year>1994</Year><Month>01</Month><Day>21</Day></DateCompleted><DateRevised><Year>2019</Year><Month>12</Month><Day>10</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0027-8424</ISSN><JournalIssue CitedMedium="Print"><Volume>90</Volume><Issue>24</Issue><PubDate><Year>1993</Year><Month>Dec</Month><Day>15</Day></PubDate></JournalIssue><Title>Proceedings of the National Academy of Sciences of the United States of America</Title><ISOAbbreviation>Proc Natl Acad Sci U S A</ISOAbbreviation></Journal><ArticleTitle>Corticosterone in the range of stress-induced levels possesses reinforcing properties: implications for sensation-seeking behaviors.</ArticleTitle><Pagination><MedlinePgn>11738-42</MedlinePgn></Pagination><Abstract><AbstractText>In both humans and animals certain individuals seek stimuli or situations that are considered stressful and consequently avoided by others. A common feature of such situations is an activation of the hypothalamo-pituitary-adrenal axis leading to secretion of glucocorticoids. Since glucocorticoids have euphoric effects in some individuals and have been shown to potentiate the reinforcing properties of drugs of abuse in animals, we hypothesized that corticosterone secretion during stress-like situations may have reinforcing effects and that a higher sensitivity to the reinforcing effects of glucocorticoids might be a biological basis of sensation seeking. In this report we show that (i) corticosterone has reinforcing properties, as evidenced by the development of intravenous self-administration, (ii) self-administration of corticosterone is observed at plasma levels that are comparable to those induced by stress, and (iii) there are individual differences in corticosterone self-administration, which are related to individual reactivity to novelty and sensitivity to drugs of abuse, behavioral features akin to certain traits of high-sensation seekers. These findings provide insight into the physiological role of glucocorticoids and the biology of sensation seeking and may have clinical implications.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Piazza</LastName><ForeName>P V</ForeName><Initials>PV</Initials><AffiliationInfo><Affiliation>Institute National de la Santé et de la Recherche Médicale (INSERM) Unité 259, Université de Bordeaux II, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Deroche</LastName><ForeName>V</ForeName><Initials>V</Initials></Author><Author ValidYN="Y"><LastName>Deminière</LastName><ForeName>J M</ForeName><Initials>JM</Initials></Author><Author ValidYN="Y"><LastName>Maccari</LastName><ForeName>S</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Le Moal</LastName><ForeName>M</ForeName><Initials>M</Initials></Author><Author 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