Relapse to heroin-seeking in rats under opioid maintenance: the effects of stress, heroin priming, and withdrawal.
Identifieur interne : 001F88 ( Main/Corpus ); précédent : 001F87; suivant : 001F89Relapse to heroin-seeking in rats under opioid maintenance: the effects of stress, heroin priming, and withdrawal.
Auteurs : Y. Shaham ; H. Rajabi ; J. StewartSource :
- The Journal of neuroscience : the official journal of the Society for Neuroscience [ 0270-6474 ] ; 1996.
English descriptors
- KwdEn :
- Animals (MeSH), Electroshock (MeSH), Heroin (administration & dosage), Heroin (pharmacology), Heroin Dependence (etiology), Infusion Pumps (MeSH), Male (MeSH), Microdialysis (MeSH), Naloxone (pharmacology), Rats (MeSH), Rats, Inbred Strains (MeSH), Recurrence (MeSH), Self Administration (MeSH), Stress, Physiological (complications), Substance Withdrawal Syndrome (etiology).
- MESH :
- chemical , administration & dosage : Heroin.
- chemical , pharmacology : Heroin, Naloxone.
- complications : Stress, Physiological.
- etiology : Heroin Dependence, Substance Withdrawal Syndrome.
- Animals, Electroshock, Infusion Pumps, Male, Microdialysis, Rats, Rats, Inbred Strains, Recurrence, Self Administration.
Abstract
It is widely believed that opioid withdrawal symptoms contribute to relapse to opioid use, but relapse is highly probable in experienced users even after prolonged abstinence and during opioid maintenance therapy. We have found using an animal model of relapse, the reinstatement procedure, that the two events that reliably reinstate heroin-seeking behavior are reexposure to heroin, and brief exposure to footshock stress. Contrary to expectation, opioid antagonist-induced withdrawal does not reinstate heroin-seeking. We now report on reinstatement of heroin-seeking in rats trained to self-administer heroin and subsequently exposed to a maintenance dose of heroin via minipump and allowed to self-administer saline. With the minipump in, naloxone-induced withdrawal did not reinstate drug-seeking, a priming injection on heroin was only mildly effective, and footshock was highly effective. Twenty-four hours after removal of the minipump (spontaneous withdrawal), animals reinitiated heroin-seeking and, subsequently, both heroin and footshock reinstated heroin-seeking. In summary, brief exposure to stress reinstated heroin-seeking in both heroin-maintained and withdrawn animals. The heroin prime reliably reinstated drug-seeking only in the absence of the minipump; opioid "withdrawal," as such, did not reinstate drug-seeking behavior. Naloxone given to heroin-maintained animals induced withdrawal symptoms, caused a mild depression in the levels of dopamine and its metabolites in the nucleus accumbens septi (NAS), but did not reinstate drug-seeking. Reinstatement of heroin-seeking during spontaneous withdrawal was not accompanied by reductions in basal dopamine and its metabolites in NAS.
PubMed: 8774462
PubMed Central: PMC6578687
Links to Exploration step
pubmed:8774462Le document en format XML
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<author><name sortKey="Shaham, Y" sort="Shaham, Y" uniqKey="Shaham Y" first="Y" last="Shaham">Y. Shaham</name>
<affiliation><nlm:affiliation>Department of Psychology, Concordia University, Montreal, Quebec, Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Rajabi, H" sort="Rajabi, H" uniqKey="Rajabi H" first="H" last="Rajabi">H. Rajabi</name>
</author>
<author><name sortKey="Stewart, J" sort="Stewart, J" uniqKey="Stewart J" first="J" last="Stewart">J. Stewart</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Relapse to heroin-seeking in rats under opioid maintenance: the effects of stress, heroin priming, and withdrawal.</title>
<author><name sortKey="Shaham, Y" sort="Shaham, Y" uniqKey="Shaham Y" first="Y" last="Shaham">Y. Shaham</name>
<affiliation><nlm:affiliation>Department of Psychology, Concordia University, Montreal, Quebec, Canada.</nlm:affiliation>
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<author><name sortKey="Rajabi, H" sort="Rajabi, H" uniqKey="Rajabi H" first="H" last="Rajabi">H. Rajabi</name>
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<author><name sortKey="Stewart, J" sort="Stewart, J" uniqKey="Stewart J" first="J" last="Stewart">J. Stewart</name>
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<series><title level="j">The Journal of neuroscience : the official journal of the Society for Neuroscience</title>
<idno type="ISSN">0270-6474</idno>
<imprint><date when="1996" type="published">1996</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term>
<term>Electroshock (MeSH)</term>
<term>Heroin (administration & dosage)</term>
<term>Heroin (pharmacology)</term>
<term>Heroin Dependence (etiology)</term>
<term>Infusion Pumps (MeSH)</term>
<term>Male (MeSH)</term>
<term>Microdialysis (MeSH)</term>
<term>Naloxone (pharmacology)</term>
<term>Rats (MeSH)</term>
<term>Rats, Inbred Strains (MeSH)</term>
<term>Recurrence (MeSH)</term>
<term>Self Administration (MeSH)</term>
<term>Stress, Physiological (complications)</term>
<term>Substance Withdrawal Syndrome (etiology)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Heroin</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Heroin</term>
<term>Naloxone</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Stress, Physiological</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Heroin Dependence</term>
<term>Substance Withdrawal Syndrome</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Electroshock</term>
<term>Infusion Pumps</term>
<term>Male</term>
<term>Microdialysis</term>
<term>Rats</term>
<term>Rats, Inbred Strains</term>
<term>Recurrence</term>
<term>Self Administration</term>
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<front><div type="abstract" xml:lang="en">It is widely believed that opioid withdrawal symptoms contribute to relapse to opioid use, but relapse is highly probable in experienced users even after prolonged abstinence and during opioid maintenance therapy. We have found using an animal model of relapse, the reinstatement procedure, that the two events that reliably reinstate heroin-seeking behavior are reexposure to heroin, and brief exposure to footshock stress. Contrary to expectation, opioid antagonist-induced withdrawal does not reinstate heroin-seeking. We now report on reinstatement of heroin-seeking in rats trained to self-administer heroin and subsequently exposed to a maintenance dose of heroin via minipump and allowed to self-administer saline. With the minipump in, naloxone-induced withdrawal did not reinstate drug-seeking, a priming injection on heroin was only mildly effective, and footshock was highly effective. Twenty-four hours after removal of the minipump (spontaneous withdrawal), animals reinitiated heroin-seeking and, subsequently, both heroin and footshock reinstated heroin-seeking. In summary, brief exposure to stress reinstated heroin-seeking in both heroin-maintained and withdrawn animals. The heroin prime reliably reinstated drug-seeking only in the absence of the minipump; opioid "withdrawal," as such, did not reinstate drug-seeking behavior. Naloxone given to heroin-maintained animals induced withdrawal symptoms, caused a mild depression in the levels of dopamine and its metabolites in the nucleus accumbens septi (NAS), but did not reinstate drug-seeking. Reinstatement of heroin-seeking during spontaneous withdrawal was not accompanied by reductions in basal dopamine and its metabolites in NAS.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">8774462</PMID>
<DateCompleted><Year>1997</Year>
<Month>01</Month>
<Day>03</Day>
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<DateRevised><Year>2019</Year>
<Month>11</Month>
<Day>01</Day>
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<Article PubModel="Print"><Journal><ISSN IssnType="Print">0270-6474</ISSN>
<JournalIssue CitedMedium="Print"><Volume>16</Volume>
<Issue>5</Issue>
<PubDate><Year>1996</Year>
<Month>Mar</Month>
<Day>01</Day>
</PubDate>
</JournalIssue>
<Title>The Journal of neuroscience : the official journal of the Society for Neuroscience</Title>
<ISOAbbreviation>J Neurosci</ISOAbbreviation>
</Journal>
<ArticleTitle>Relapse to heroin-seeking in rats under opioid maintenance: the effects of stress, heroin priming, and withdrawal.</ArticleTitle>
<Pagination><MedlinePgn>1957-63</MedlinePgn>
</Pagination>
<Abstract><AbstractText>It is widely believed that opioid withdrawal symptoms contribute to relapse to opioid use, but relapse is highly probable in experienced users even after prolonged abstinence and during opioid maintenance therapy. We have found using an animal model of relapse, the reinstatement procedure, that the two events that reliably reinstate heroin-seeking behavior are reexposure to heroin, and brief exposure to footshock stress. Contrary to expectation, opioid antagonist-induced withdrawal does not reinstate heroin-seeking. We now report on reinstatement of heroin-seeking in rats trained to self-administer heroin and subsequently exposed to a maintenance dose of heroin via minipump and allowed to self-administer saline. With the minipump in, naloxone-induced withdrawal did not reinstate drug-seeking, a priming injection on heroin was only mildly effective, and footshock was highly effective. Twenty-four hours after removal of the minipump (spontaneous withdrawal), animals reinitiated heroin-seeking and, subsequently, both heroin and footshock reinstated heroin-seeking. In summary, brief exposure to stress reinstated heroin-seeking in both heroin-maintained and withdrawn animals. The heroin prime reliably reinstated drug-seeking only in the absence of the minipump; opioid "withdrawal," as such, did not reinstate drug-seeking behavior. Naloxone given to heroin-maintained animals induced withdrawal symptoms, caused a mild depression in the levels of dopamine and its metabolites in the nucleus accumbens septi (NAS), but did not reinstate drug-seeking. Reinstatement of heroin-seeking during spontaneous withdrawal was not accompanied by reductions in basal dopamine and its metabolites in NAS.</AbstractText>
</Abstract>
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<Author ValidYN="Y"><LastName>Stewart</LastName>
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<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType>
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<ChemicalList><Chemical><RegistryNumber>36B82AMQ7N</RegistryNumber>
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<MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
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<MeshHeading><DescriptorName UI="D004597" MajorTopicYN="N">Electroshock</DescriptorName>
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<MeshHeading><DescriptorName UI="D003932" MajorTopicYN="N">Heroin</DescriptorName>
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<MeshHeading><DescriptorName UI="D006556" MajorTopicYN="N">Heroin Dependence</DescriptorName>
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<MeshHeading><DescriptorName UI="D007260" MajorTopicYN="N">Infusion Pumps</DescriptorName>
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<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
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<MeshHeading><DescriptorName UI="D017551" MajorTopicYN="N">Microdialysis</DescriptorName>
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<MeshHeading><DescriptorName UI="D051381" MajorTopicYN="N">Rats</DescriptorName>
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<MeshHeading><DescriptorName UI="D011919" MajorTopicYN="N">Rats, Inbred Strains</DescriptorName>
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<MeshHeading><DescriptorName UI="D012008" MajorTopicYN="N">Recurrence</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012646" MajorTopicYN="N">Self Administration</DescriptorName>
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<MeshHeading><DescriptorName UI="D013312" MajorTopicYN="N">Stress, Physiological</DescriptorName>
<QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName>
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<MeshHeading><DescriptorName UI="D013375" MajorTopicYN="Y">Substance Withdrawal Syndrome</DescriptorName>
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