Influence of cue-conditioning on acquisition, maintenance and relapse of cocaine intravenous self-administration.
Identifieur interne : 001E32 ( Main/Corpus ); précédent : 001E31; suivant : 001E33Influence of cue-conditioning on acquisition, maintenance and relapse of cocaine intravenous self-administration.
Auteurs : Véronique Deroche-Gamonet ; Frédéric Piat ; Michel Le Moal ; Pier Vincenzo PiazzaSource :
- The European journal of neuroscience [ 0953-816X ] ; 2002.
English descriptors
- KwdEn :
- Animals (MeSH), Brain (drug effects), Brain (physiopathology), Cocaine (pharmacology), Cocaine-Related Disorders (physiopathology), Cocaine-Related Disorders (psychology), Conditioning, Psychological (drug effects), Conditioning, Psychological (physiology), Cues (MeSH), Dose-Response Relationship, Drug (MeSH), Extinction, Psychological (drug effects), Extinction, Psychological (physiology), Injections, Intravenous (MeSH), Male (MeSH), Photic Stimulation (MeSH), Rats (MeSH), Rats, Sprague-Dawley (MeSH), Recurrence (MeSH), Self Administration (MeSH).
- MESH :
- chemical , pharmacology : Cocaine.
- drug effects : Brain, Conditioning, Psychological, Extinction, Psychological.
- physiology : Conditioning, Psychological, Extinction, Psychological.
- physiopathology : Brain, Cocaine-Related Disorders.
- psychology : Cocaine-Related Disorders.
- Animals, Cues, Dose-Response Relationship, Drug, Injections, Intravenous, Male, Photic Stimulation, Rats, Rats, Sprague-Dawley, Recurrence, Self Administration.
Abstract
Conditioning theories propose that, through a Pavlovian associative process, discrete stimuli acquire the ability to elicit neural states involved in the maintenance and relapse of a drug-taking behaviour. Experimental evidence indicates that drug-related cues play a role in relapse, however, their influence on the development and maintenance of drug self-administration has been poorly investigated. In this report, we analysed the effects of a drug-associated cue light on acquisition, maintenance and reinstatement of intravenous cocaine self-administration. The results show that a cocaine-associated cue light can act as an incentive in absence of the drug, but does not directly modify drug-reinforcing effects. Contingent and non-contingent presentations of a cocaine-associated cue light reinstated an extinguished self-administration behaviour. However, regardless of whether or not a cue light was associated with cocaine infusions, rats acquire cocaine intravenous self-administration reaching the same levels of intake. Furthermore, after self-administration has been acquired in presence of the cue light, the omission of the cue light or its non-contingent presentation did not modify rat behaviour. In conclusion, our work shows that cocaine-associated explicit cues do not directly interfere with the reinforcing effects of the drug.
DOI: 10.1046/j.1460-9568.2002.01974.x
PubMed: 11994130
Links to Exploration step
pubmed:11994130Le document en format XML
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<author><name sortKey="Deroche Gamonet, Veronique" sort="Deroche Gamonet, Veronique" uniqKey="Deroche Gamonet V" first="Véronique" last="Deroche-Gamonet">Véronique Deroche-Gamonet</name>
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<author><name sortKey="Piat, Frederic" sort="Piat, Frederic" uniqKey="Piat F" first="Frédéric" last="Piat">Frédéric Piat</name>
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<author><name sortKey="Le Moal, Michel" sort="Le Moal, Michel" uniqKey="Le Moal M" first="Michel" last="Le Moal">Michel Le Moal</name>
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<author><name sortKey="Piazza, Pier Vincenzo" sort="Piazza, Pier Vincenzo" uniqKey="Piazza P" first="Pier Vincenzo" last="Piazza">Pier Vincenzo Piazza</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Influence of cue-conditioning on acquisition, maintenance and relapse of cocaine intravenous self-administration.</title>
<author><name sortKey="Deroche Gamonet, Veronique" sort="Deroche Gamonet, Veronique" uniqKey="Deroche Gamonet V" first="Véronique" last="Deroche-Gamonet">Véronique Deroche-Gamonet</name>
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<author><name sortKey="Le Moal, Michel" sort="Le Moal, Michel" uniqKey="Le Moal M" first="Michel" last="Le Moal">Michel Le Moal</name>
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<series><title level="j">The European journal of neuroscience</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term>
<term>Brain (drug effects)</term>
<term>Brain (physiopathology)</term>
<term>Cocaine (pharmacology)</term>
<term>Cocaine-Related Disorders (physiopathology)</term>
<term>Cocaine-Related Disorders (psychology)</term>
<term>Conditioning, Psychological (drug effects)</term>
<term>Conditioning, Psychological (physiology)</term>
<term>Cues (MeSH)</term>
<term>Dose-Response Relationship, Drug (MeSH)</term>
<term>Extinction, Psychological (drug effects)</term>
<term>Extinction, Psychological (physiology)</term>
<term>Injections, Intravenous (MeSH)</term>
<term>Male (MeSH)</term>
<term>Photic Stimulation (MeSH)</term>
<term>Rats (MeSH)</term>
<term>Rats, Sprague-Dawley (MeSH)</term>
<term>Recurrence (MeSH)</term>
<term>Self Administration (MeSH)</term>
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<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Cocaine</term>
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<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Brain</term>
<term>Conditioning, Psychological</term>
<term>Extinction, Psychological</term>
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<term>Extinction, Psychological</term>
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<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Brain</term>
<term>Cocaine-Related Disorders</term>
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<keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Cocaine-Related Disorders</term>
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<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Cues</term>
<term>Dose-Response Relationship, Drug</term>
<term>Injections, Intravenous</term>
<term>Male</term>
<term>Photic Stimulation</term>
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<front><div type="abstract" xml:lang="en">Conditioning theories propose that, through a Pavlovian associative process, discrete stimuli acquire the ability to elicit neural states involved in the maintenance and relapse of a drug-taking behaviour. Experimental evidence indicates that drug-related cues play a role in relapse, however, their influence on the development and maintenance of drug self-administration has been poorly investigated. In this report, we analysed the effects of a drug-associated cue light on acquisition, maintenance and reinstatement of intravenous cocaine self-administration. The results show that a cocaine-associated cue light can act as an incentive in absence of the drug, but does not directly modify drug-reinforcing effects. Contingent and non-contingent presentations of a cocaine-associated cue light reinstated an extinguished self-administration behaviour. However, regardless of whether or not a cue light was associated with cocaine infusions, rats acquire cocaine intravenous self-administration reaching the same levels of intake. Furthermore, after self-administration has been acquired in presence of the cue light, the omission of the cue light or its non-contingent presentation did not modify rat behaviour. In conclusion, our work shows that cocaine-associated explicit cues do not directly interfere with the reinforcing effects of the drug.</div>
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<Abstract><AbstractText>Conditioning theories propose that, through a Pavlovian associative process, discrete stimuli acquire the ability to elicit neural states involved in the maintenance and relapse of a drug-taking behaviour. Experimental evidence indicates that drug-related cues play a role in relapse, however, their influence on the development and maintenance of drug self-administration has been poorly investigated. In this report, we analysed the effects of a drug-associated cue light on acquisition, maintenance and reinstatement of intravenous cocaine self-administration. The results show that a cocaine-associated cue light can act as an incentive in absence of the drug, but does not directly modify drug-reinforcing effects. Contingent and non-contingent presentations of a cocaine-associated cue light reinstated an extinguished self-administration behaviour. However, regardless of whether or not a cue light was associated with cocaine infusions, rats acquire cocaine intravenous self-administration reaching the same levels of intake. Furthermore, after self-administration has been acquired in presence of the cue light, the omission of the cue light or its non-contingent presentation did not modify rat behaviour. In conclusion, our work shows that cocaine-associated explicit cues do not directly interfere with the reinforcing effects of the drug.</AbstractText>
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