AutomedicationFrancoV1, Main, Corpus, bibRecord, 001E22

Study of the addictive potential of modafinil in naive and cocaine-experienced rats.

Identifieur interne : 001E22 ( Main/Corpus ); précédent : 001E21; suivant : 001E23

Study of the addictive potential of modafinil in naive and cocaine-experienced rats.

Auteurs : V. Deroche-Gamonet ; M. Darnaudéry ; L. Bruins-Slot ; F. Piat ; M. Le Moal ; P V Piazza

Source :

Psychopharmacology [ 0033-3158 ] ; 2002.

RBID : pubmed:12073166

English descriptors

KwdEn :
- Animals (MeSH), Behavior, Addictive (psychology), Benzhydryl Compounds (pharmacology), Cocaine (pharmacology), Cocaine-Related Disorders (psychology), Conditioning, Psychological (drug effects), Conditioning, Psychological (physiology), Dose-Response Relationship, Drug (MeSH), Male (MeSH), Modafinil (MeSH), Rats (MeSH), Rats, Sprague-Dawley (MeSH), Reinforcement, Psychology (MeSH), Self Administration (psychology).
MESH :
- chemical , pharmacology : Benzhydryl Compounds, Cocaine.
- drug effects : Conditioning, Psychological.
- physiology : Conditioning, Psychological.
- psychology : Behavior, Addictive, Cocaine-Related Disorders, Self Administration.
- Animals, Dose-Response Relationship, Drug, Male, Modafinil, Rats, Rats, Sprague-Dawley, Reinforcement, Psychology.

Abstract

RATIONALE

Modafinil is a drug that promotes wakefulness and, as such, is used to treat hypersomnia and narcolepsy. Preclinical and clinical studies suggest that modafinil could possess weak reinforcing effects in drug-experienced subjects. However, its abuse potential in drug-naive healthy individuals is still totally uninvestigated, despite the fact that availability of modafinil has recently increased.

OBJECTIVES

The purpose of our study was to investigate the potential addictive properties of modafinil by testing its reinforcing effects in naive rats. The interactions of modafinil with the reinforcing effects of cocaine were also tested.

METHODS

First, using i.v. self-administration and place conditioning tests, we studied the reinforcing and rewarding effects of a large range of doses of modafinil in naive rats. Second, we tested the influence of modafinil on reinforcing and incentive effects of cocaine in rats trained for cocaine self-administration. The effects of modafinil were compared with those of amphetamine and haloperidol.

RESULTS

Modafinil did not produce reinforcing or rewarding effects and did not modify the effects of cocaine.

CONCLUSIONS

Our results suggest that modafinil does not possess an addictive potential in naive individuals. Furthermore, it would be behaviorally distinct from classical central nervous system stimulants which are known to alter cocaine-induced effects. However, as shown previously in nonhuman primates and in humans, modafinil could possibly have reinforcing effects in cocaine-experienced individuals.

DOI: 10.1007/s00213-002-1080-8
PubMed: 12073166

Links to Exploration step

pubmed:12073166

Le document en format XML

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<author><name sortKey="Deroche Gamonet, V" sort="Deroche Gamonet, V" uniqKey="Deroche Gamonet V" first="V" last="Deroche-Gamonet">V. Deroche-Gamonet</name>
<affiliation><nlm:affiliation>Laboratoire de Psychobiologie des Comportements Adaptatifs, Domaine de Carreire, Rue Camille Saint-Saëns, 33077 Bordeaux, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Darnaudery, M" sort="Darnaudery, M" uniqKey="Darnaudery M" first="M" last="Darnaudéry">M. Darnaudéry</name>
</author>
<author><name sortKey="Bruins Slot, L" sort="Bruins Slot, L" uniqKey="Bruins Slot L" first="L" last="Bruins-Slot">L. Bruins-Slot</name>
</author>
<author><name sortKey="Piat, F" sort="Piat, F" uniqKey="Piat F" first="F" last="Piat">F. Piat</name>
</author>
<author><name sortKey="Le Moal, M" sort="Le Moal, M" uniqKey="Le Moal M" first="M" last="Le Moal">M. Le Moal</name>
</author>
<author><name sortKey="Piazza, P V" sort="Piazza, P V" uniqKey="Piazza P" first="P V" last="Piazza">P V Piazza</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Study of the addictive potential of modafinil in naive and cocaine-experienced rats.</title>
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<author><name sortKey="Darnaudery, M" sort="Darnaudery, M" uniqKey="Darnaudery M" first="M" last="Darnaudéry">M. Darnaudéry</name>
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<author><name sortKey="Bruins Slot, L" sort="Bruins Slot, L" uniqKey="Bruins Slot L" first="L" last="Bruins-Slot">L. Bruins-Slot</name>
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<author><name sortKey="Piat, F" sort="Piat, F" uniqKey="Piat F" first="F" last="Piat">F. Piat</name>
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<author><name sortKey="Le Moal, M" sort="Le Moal, M" uniqKey="Le Moal M" first="M" last="Le Moal">M. Le Moal</name>
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<series><title level="j">Psychopharmacology</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term>
<term>Behavior, Addictive (psychology)</term>
<term>Benzhydryl Compounds (pharmacology)</term>
<term>Cocaine (pharmacology)</term>
<term>Cocaine-Related Disorders (psychology)</term>
<term>Conditioning, Psychological (drug effects)</term>
<term>Conditioning, Psychological (physiology)</term>
<term>Dose-Response Relationship, Drug (MeSH)</term>
<term>Male (MeSH)</term>
<term>Modafinil (MeSH)</term>
<term>Rats (MeSH)</term>
<term>Rats, Sprague-Dawley (MeSH)</term>
<term>Reinforcement, Psychology (MeSH)</term>
<term>Self Administration (psychology)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Benzhydryl Compounds</term>
<term>Cocaine</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Conditioning, Psychological</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Conditioning, Psychological</term>
</keywords>
<keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Behavior, Addictive</term>
<term>Cocaine-Related Disorders</term>
<term>Self Administration</term>
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<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Dose-Response Relationship, Drug</term>
<term>Male</term>
<term>Modafinil</term>
<term>Rats</term>
<term>Rats, Sprague-Dawley</term>
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<front><div type="abstract" xml:lang="en"><p><b>RATIONALE</b>
</p>
<p>Modafinil is a drug that promotes wakefulness and, as such, is used to treat hypersomnia and narcolepsy. Preclinical and clinical studies suggest that modafinil could possess weak reinforcing effects in drug-experienced subjects. However, its abuse potential in drug-naive healthy individuals is still totally uninvestigated, despite the fact that availability of modafinil has recently increased.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>OBJECTIVES</b>
</p>
<p>The purpose of our study was to investigate the potential addictive properties of modafinil by testing its reinforcing effects in naive rats. The interactions of modafinil with the reinforcing effects of cocaine were also tested.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>METHODS</b>
</p>
<p>First, using i.v. self-administration and place conditioning tests, we studied the reinforcing and rewarding effects of a large range of doses of modafinil in naive rats. Second, we tested the influence of modafinil on reinforcing and incentive effects of cocaine in rats trained for cocaine self-administration. The effects of modafinil were compared with those of amphetamine and haloperidol.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>RESULTS</b>
</p>
<p>Modafinil did not produce reinforcing or rewarding effects and did not modify the effects of cocaine.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b>
</p>
<p>Our results suggest that modafinil does not possess an addictive potential in naive individuals. Furthermore, it would be behaviorally distinct from classical central nervous system stimulants which are known to alter cocaine-induced effects. However, as shown previously in nonhuman primates and in humans, modafinil could possibly have reinforcing effects in cocaine-experienced individuals.</p>
</div>
</front>
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Study of the addictive potential of modafinil in naive and cocaine-experienced rats.

Study of the addictive potential of modafinil in naive and cocaine-experienced rats.

Source :

English descriptors

Abstract

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki