Preexposure during or following adolescence differently affects nicotine-rewarding properties in adult rats.
Identifieur interne : 001C74 ( Main/Corpus ); précédent : 001C73; suivant : 001C75Preexposure during or following adolescence differently affects nicotine-rewarding properties in adult rats.
Auteurs : Walter Adriani ; Véronique Deroche-Gamonet ; Michel Le Moal ; Giovanni Laviola ; Pier Vincenzo PiazzaSource :
- Psychopharmacology [ 0033-3158 ] ; 2006.
English descriptors
- KwdEn :
- Age Factors (MeSH), Animals (MeSH), Arousal (drug effects), Association Learning (drug effects), Choice Behavior (drug effects), Conditioning, Classical (MeSH), Disease Models, Animal (MeSH), Dose-Response Relationship, Drug (MeSH), Exploratory Behavior (drug effects), Female (MeSH), Injections, Intraperitoneal (MeSH), Male (MeSH), Motor Activity (drug effects), Nicotine (administration & dosage), Premedication (MeSH), Rats (MeSH), Rats, Sprague-Dawley (MeSH), Reward (MeSH), Self Administration (MeSH), Social Environment (MeSH), Tobacco Use Disorder (psychology).
- MESH :
- chemical , administration & dosage : Nicotine.
- drug effects : Arousal, Association Learning, Choice Behavior, Exploratory Behavior, Motor Activity.
- psychology : Tobacco Use Disorder.
- Age Factors, Animals, Conditioning, Classical, Disease Models, Animal, Dose-Response Relationship, Drug, Female, Injections, Intraperitoneal, Male, Premedication, Rats, Rats, Sprague-Dawley, Reward, Self Administration, Social Environment.
Abstract
RATIONALE
Many people come in contact with psychoactive drugs, yet not all of them become addicts. Epidemiology shows that a late approach with cigarette smoking is associated with a lower probability to develop nicotine dependence. Exposure to nicotine during periadolescence, but not similar exposure in the postadolescent period, increases nicotine self-administration in rats, but underlying mechanisms remain poorly understood.
OBJECTIVE
We investigated whether exposure to nicotine during or after adolescence would alter rewarding properties of the same drug at adulthood, as assessed by place conditioning.
MATERIALS AND METHODS
Periadolescent (PND 34-43) or postadolescent (PND 60-69) rats were injected with saline or nicotine (0.4 mg kg(-1)) for 10 days. The rats received three pairings with saline and three pairings with nicotine (0, 0.3, or 0.6 mg kg(-1)) 5 weeks after pretreatment. The rats were then tested for place conditioning in a drug-free state.
RESULTS
Upon first exposure to the apparatus, animals pretreated with nicotine during adolescence showed elevated novelty-induced activation. The 0.3 (but not the 0.6) mg kg(-1) dose failed to produce both ongoing locomotor sensitization and place conditioning in animals pretreated with nicotine following adolescence. This suggests a rightward shift in the dose-response curve, namely, a reduced efficacy of nicotine. Conversely, the same dose was effective in saline-pretreated controls and noteworthy in rats pretreated during adolescence.
CONCLUSION
Exposure following the adolescent period might diminish the risk to develop nicotine dependence. As for human implications, findings are consistent with a reduced vulnerability to nicotine addiction in people who start smoking late in their life.
DOI: 10.1007/s00213-005-0125-1
PubMed: 16163527
Links to Exploration step
pubmed:16163527Le document en format XML
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Saint-Saëns, Bordeaux Cedex, 33077, France. adriani@iss.it</nlm:affiliation></affiliation></author><author><name sortKey="Deroche Gamonet, Veronique" sort="Deroche Gamonet, Veronique" uniqKey="Deroche Gamonet V" first="Véronique" last="Deroche-Gamonet">Véronique Deroche-Gamonet</name></author><author><name sortKey="Le Moal, Michel" sort="Le Moal, Michel" uniqKey="Le Moal M" first="Michel" last="Le Moal">Michel Le Moal</name></author><author><name sortKey="Laviola, Giovanni" sort="Laviola, Giovanni" uniqKey="Laviola G" first="Giovanni" last="Laviola">Giovanni Laviola</name></author><author><name sortKey="Piazza, Pier Vincenzo" sort="Piazza, Pier Vincenzo" uniqKey="Piazza P" first="Pier Vincenzo" last="Piazza">Pier Vincenzo Piazza</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2006">2006</date><idno type="RBID">pubmed:16163527</idno><idno type="pmid">16163527</idno><idno type="doi">10.1007/s00213-005-0125-1</idno><idno type="wicri:Area/Main/Corpus">001C74</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">001C74</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Preexposure during or following adolescence differently affects nicotine-rewarding properties in adult rats.</title><author><name sortKey="Adriani, Walter" sort="Adriani, Walter" uniqKey="Adriani W" first="Walter" last="Adriani">Walter Adriani</name><affiliation><nlm:affiliation>INSERM U. 588, Institut François Magendie, Domaine de Carreire, Rue C. Saint-Saëns, Bordeaux Cedex, 33077, France. adriani@iss.it</nlm:affiliation></affiliation></author><author><name sortKey="Deroche Gamonet, Veronique" sort="Deroche Gamonet, Veronique" uniqKey="Deroche Gamonet V" first="Véronique" last="Deroche-Gamonet">Véronique Deroche-Gamonet</name></author><author><name sortKey="Le Moal, Michel" sort="Le Moal, Michel" uniqKey="Le Moal M" first="Michel" last="Le Moal">Michel Le Moal</name></author><author><name sortKey="Laviola, Giovanni" sort="Laviola, Giovanni" uniqKey="Laviola G" first="Giovanni" last="Laviola">Giovanni Laviola</name></author><author><name sortKey="Piazza, Pier Vincenzo" sort="Piazza, Pier Vincenzo" uniqKey="Piazza P" first="Pier Vincenzo" last="Piazza">Pier Vincenzo Piazza</name></author></analytic><series><title level="j">Psychopharmacology</title><idno type="ISSN">0033-3158</idno><imprint><date when="2006" type="published">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Age Factors (MeSH)</term><term>Animals (MeSH)</term><term>Arousal (drug effects)</term><term>Association Learning (drug effects)</term><term>Choice Behavior (drug effects)</term><term>Conditioning, Classical (MeSH)</term><term>Disease Models, Animal (MeSH)</term><term>Dose-Response Relationship, Drug (MeSH)</term><term>Exploratory Behavior (drug effects)</term><term>Female (MeSH)</term><term>Injections, Intraperitoneal (MeSH)</term><term>Male (MeSH)</term><term>Motor Activity (drug effects)</term><term>Nicotine (administration & dosage)</term><term>Premedication (MeSH)</term><term>Rats (MeSH)</term><term>Rats, Sprague-Dawley (MeSH)</term><term>Reward (MeSH)</term><term>Self Administration (MeSH)</term><term>Social Environment (MeSH)</term><term>Tobacco Use Disorder (psychology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Nicotine</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Arousal</term><term>Association Learning</term><term>Choice Behavior</term><term>Exploratory Behavior</term><term>Motor Activity</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Tobacco Use Disorder</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Age Factors</term><term>Animals</term><term>Conditioning, Classical</term><term>Disease Models, Animal</term><term>Dose-Response Relationship, Drug</term><term>Female</term><term>Injections, Intraperitoneal</term><term>Male</term><term>Premedication</term><term>Rats</term><term>Rats, Sprague-Dawley</term><term>Reward</term><term>Self Administration</term><term>Social Environment</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>RATIONALE</b></p><p>Many people come in contact with psychoactive drugs, yet not all of them become addicts. Epidemiology shows that a late approach with cigarette smoking is associated with a lower probability to develop nicotine dependence. Exposure to nicotine during periadolescence, but not similar exposure in the postadolescent period, increases nicotine self-administration in rats, but underlying mechanisms remain poorly understood.</p></div><div type="abstract" xml:lang="en"><p><b>OBJECTIVE</b></p><p>We investigated whether exposure to nicotine during or after adolescence would alter rewarding properties of the same drug at adulthood, as assessed by place conditioning.</p></div><div type="abstract" xml:lang="en"><p><b>MATERIALS AND METHODS</b></p><p>Periadolescent (PND 34-43) or postadolescent (PND 60-69) rats were injected with saline or nicotine (0.4 mg kg(-1)) for 10 days. The rats received three pairings with saline and three pairings with nicotine (0, 0.3, or 0.6 mg kg(-1)) 5 weeks after pretreatment. The rats were then tested for place conditioning in a drug-free state.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>Upon first exposure to the apparatus, animals pretreated with nicotine during adolescence showed elevated novelty-induced activation. The 0.3 (but not the 0.6) mg kg(-1) dose failed to produce both ongoing locomotor sensitization and place conditioning in animals pretreated with nicotine following adolescence. This suggests a rightward shift in the dose-response curve, namely, a reduced efficacy of nicotine. Conversely, the same dose was effective in saline-pretreated controls and noteworthy in rats pretreated during adolescence.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSION</b></p><p>Exposure following the adolescent period might diminish the risk to develop nicotine dependence. As for human implications, findings are consistent with a reduced vulnerability to nicotine addiction in people who start smoking late in their life.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">16163527</PMID><DateCompleted><Year>2006</Year><Month>10</Month><Day>06</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">0033-3158</ISSN><JournalIssue CitedMedium="Print"><Volume>184</Volume><Issue>3-4</Issue><PubDate><Year>2006</Year><Month>Mar</Month></PubDate></JournalIssue><Title>Psychopharmacology</Title><ISOAbbreviation>Psychopharmacology (Berl)</ISOAbbreviation></Journal><ArticleTitle>Preexposure during or following adolescence differently affects nicotine-rewarding properties in adult rats.</ArticleTitle><Pagination><MedlinePgn>382-90</MedlinePgn></Pagination><Abstract><AbstractText Label="RATIONALE" NlmCategory="BACKGROUND">Many people come in contact with psychoactive drugs, yet not all of them become addicts. Epidemiology shows that a late approach with cigarette smoking is associated with a lower probability to develop nicotine dependence. Exposure to nicotine during periadolescence, but not similar exposure in the postadolescent period, increases nicotine self-administration in rats, but underlying mechanisms remain poorly understood.</AbstractText><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">We investigated whether exposure to nicotine during or after adolescence would alter rewarding properties of the same drug at adulthood, as assessed by place conditioning.</AbstractText><AbstractText Label="MATERIALS AND METHODS" NlmCategory="METHODS">Periadolescent (PND 34-43) or postadolescent (PND 60-69) rats were injected with saline or nicotine (0.4 mg kg(-1)) for 10 days. The rats received three pairings with saline and three pairings with nicotine (0, 0.3, or 0.6 mg kg(-1)) 5 weeks after pretreatment. The rats were then tested for place conditioning in a drug-free state.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Upon first exposure to the apparatus, animals pretreated with nicotine during adolescence showed elevated novelty-induced activation. The 0.3 (but not the 0.6) mg kg(-1) dose failed to produce both ongoing locomotor sensitization and place conditioning in animals pretreated with nicotine following adolescence. This suggests a rightward shift in the dose-response curve, namely, a reduced efficacy of nicotine. Conversely, the same dose was effective in saline-pretreated controls and noteworthy in rats pretreated during adolescence.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Exposure following the adolescent period might diminish the risk to develop nicotine dependence. 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Saint-Saëns, Bordeaux Cedex, 33077, France. adriani@iss.it</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Deroche-Gamonet</LastName><ForeName>Véronique</ForeName><Initials>V</Initials></Author><Author ValidYN="Y"><LastName>Le Moal</LastName><ForeName>Michel</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Laviola</LastName><ForeName>Giovanni</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Piazza</LastName><ForeName>Pier Vincenzo</ForeName><Initials>PV</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate 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