Effect of delay on self-administration of remifentanil under a drug versus drug choice procedure in rhesus monkeys.
Identifieur interne : 001362 ( Main/Corpus ); précédent : 001361; suivant : 001363Effect of delay on self-administration of remifentanil under a drug versus drug choice procedure in rhesus monkeys.
Auteurs : David R. Maguire ; Lisa R. Gerak ; Charles P. FranceSource :
- The Journal of pharmacology and experimental therapeutics [ 1521-0103 ] ; 2013.
English descriptors
- KwdEn :
- Analgesics, Opioid (administration & dosage), Analgesics, Opioid (pharmacology), Animals (MeSH), Choice Behavior (drug effects), Conditioning, Operant (drug effects), Dose-Response Relationship, Drug (MeSH), Female (MeSH), Infusions, Intravenous (MeSH), Macaca mulatta (MeSH), Male (MeSH), Opioid-Related Disorders (psychology), Piperidines (administration & dosage), Piperidines (pharmacology), Remifentanil (MeSH), Self Administration (MeSH).
- MESH :
- chemical , administration & dosage : Analgesics, Opioid, Piperidines.
- chemical , pharmacology : Analgesics, Opioid, Piperidines.
- drug effects : Choice Behavior, Conditioning, Operant.
- psychology : Opioid-Related Disorders.
- Animals, Dose-Response Relationship, Drug, Female, Infusions, Intravenous, Macaca mulatta, Male, Remifentanil, Self Administration.
Abstract
Drug abuse can be conceptualized as excessive choice of drug over other reinforcers, and factors that affect drug taking can be examined experimentally using choice procedures. This study examined the impact of reinforcer delay on self-administration of the μ-opioid receptor agonist remifentanil in rhesus monkeys (n = 4) lever pressing under a concurrent fixed-ratio 30 schedule. Responding on either lever delivered an intravenous infusion of either remifentanil or saline. Dose-effect curves were first determined when responding on one lever delivered remifentanil and responding on a second lever delivered saline. Monkeys then chose between two doses of remifentanil, and delay to delivery of the large dose was varied systematically. Responding for remifentanil (0.01-1.0 µg/kg/infusion) increased dose-dependently when the alternative was saline or a dose of remifentanil. Delaying delivery of the large dose of remifentanil by 30, 60, 120, or 240 seconds increased responding for smaller, immediately available doses (0.01-0.1 µg/kg/infusion) and, in some cases, increased responding for doses of remifentanil that did not maintain responding when the alternative was saline. These data demonstrate that delaying the delivery of an opioid receptor agonist can significantly affect its reinforcing effectiveness. The imposition of a delay reduces the effectiveness of large doses of drug to maintain responding and increases the effectiveness of immediately available commodities, including smaller doses of drug. Increased reinforcing effectiveness of smaller doses of drug in the context of other delayed reinforcers might contribute to the development and maintenance of opioid abuse.
DOI: 10.1124/jpet.113.208355
PubMed: 24042159
PubMed Central: PMC3836318
Links to Exploration step
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<term>Animals (MeSH)</term>
<term>Choice Behavior (drug effects)</term>
<term>Conditioning, Operant (drug effects)</term>
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<term>Opioid-Related Disorders (psychology)</term>
<term>Piperidines (administration & dosage)</term>
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<front><div type="abstract" xml:lang="en">Drug abuse can be conceptualized as excessive choice of drug over other reinforcers, and factors that affect drug taking can be examined experimentally using choice procedures. This study examined the impact of reinforcer delay on self-administration of the μ-opioid receptor agonist remifentanil in rhesus monkeys (n = 4) lever pressing under a concurrent fixed-ratio 30 schedule. Responding on either lever delivered an intravenous infusion of either remifentanil or saline. Dose-effect curves were first determined when responding on one lever delivered remifentanil and responding on a second lever delivered saline. Monkeys then chose between two doses of remifentanil, and delay to delivery of the large dose was varied systematically. Responding for remifentanil (0.01-1.0 µg/kg/infusion) increased dose-dependently when the alternative was saline or a dose of remifentanil. Delaying delivery of the large dose of remifentanil by 30, 60, 120, or 240 seconds increased responding for smaller, immediately available doses (0.01-0.1 µg/kg/infusion) and, in some cases, increased responding for doses of remifentanil that did not maintain responding when the alternative was saline. These data demonstrate that delaying the delivery of an opioid receptor agonist can significantly affect its reinforcing effectiveness. The imposition of a delay reduces the effectiveness of large doses of drug to maintain responding and increases the effectiveness of immediately available commodities, including smaller doses of drug. Increased reinforcing effectiveness of smaller doses of drug in the context of other delayed reinforcers might contribute to the development and maintenance of opioid abuse. </div>
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<Abstract><AbstractText>Drug abuse can be conceptualized as excessive choice of drug over other reinforcers, and factors that affect drug taking can be examined experimentally using choice procedures. This study examined the impact of reinforcer delay on self-administration of the μ-opioid receptor agonist remifentanil in rhesus monkeys (n = 4) lever pressing under a concurrent fixed-ratio 30 schedule. Responding on either lever delivered an intravenous infusion of either remifentanil or saline. Dose-effect curves were first determined when responding on one lever delivered remifentanil and responding on a second lever delivered saline. Monkeys then chose between two doses of remifentanil, and delay to delivery of the large dose was varied systematically. Responding for remifentanil (0.01-1.0 µg/kg/infusion) increased dose-dependently when the alternative was saline or a dose of remifentanil. Delaying delivery of the large dose of remifentanil by 30, 60, 120, or 240 seconds increased responding for smaller, immediately available doses (0.01-0.1 µg/kg/infusion) and, in some cases, increased responding for doses of remifentanil that did not maintain responding when the alternative was saline. These data demonstrate that delaying the delivery of an opioid receptor agonist can significantly affect its reinforcing effectiveness. The imposition of a delay reduces the effectiveness of large doses of drug to maintain responding and increases the effectiveness of immediately available commodities, including smaller doses of drug. Increased reinforcing effectiveness of smaller doses of drug in the context of other delayed reinforcers might contribute to the development and maintenance of opioid abuse. </AbstractText>
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<ReferenceList><Reference><Citation>Psychopharmacology (Berl). 2013 Sep;229(2):323-30</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23636304</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Psychopharmacology (Berl). 2002 Sep;163(2):174-82</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12202964</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Neuropharmacology. 2014 Jan;76 Pt B:518-27</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23806805</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Adv Pharmacol Sci. 2012;2012:281768</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23243420</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Drug Alcohol Depend. 2006 Feb 1;81(2):103-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16023304</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Psychopharmacology (Berl). 1992;108(3):295-300</Citation>
<ArticleIdList><ArticleId IdType="pubmed">1523280</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Exp Anal Behav. 2006 Sep;86(2):181-95</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17002226</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Exp Clin Psychopharmacol. 1997 Aug;5(3):256-62</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9260073</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Addiction. 2001 Jan;96(1):73-86</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11177521</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Neuropsychopharmacology. 2003 May;28(5):919-31</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12637948</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Prog Neuropsychopharmacol Biol Psychiatry. 2012 Jan 10;36(1):189-93</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22015480</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Psychopharmacology (Berl). 2008 Sep;200(1):1-26</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18600315</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Exp Anal Behav. 1978 Sep;30(2):169-75</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16812096</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Pharmacol Exp Ther. 2002 May;301(2):698-704</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11961075</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Pain Physician. 2010 Sep-Oct;13(5):401-35</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20859312</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Interv. 2006 Oct;6(5):273-83</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17035668</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Exp Clin Psychopharmacol. 2007 Jun;15(3):238-44</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17563210</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Drug Alcohol Depend. 1993 Dec;34(1):37-43</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8174501</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Pharmacol Ther. 2012 Jun;134(3):287-97</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22387232</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Psychopharmacology (Berl). 2002 Oct;163(3-4):345-51</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12373435</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Exp Anal Behav. 1967 Jan;10(1):67-74</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16811307</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Pharmacol Exp Ther. 1975 May;193(2):676-88</Citation>
<ArticleIdList><ArticleId IdType="pubmed">1142112</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Exp Psychol Gen. 1999 Mar;128(1):78-87</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10100392</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Exp Anal Behav. 1974 Jul;22(1):179-96</Citation>
<ArticleIdList><ArticleId IdType="pubmed">4455758</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Psychopharmacology (Berl). 2003 Jun;167(4):424-30</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12690423</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Psychopharmacology (Berl). 2006 May;186(1):99-106</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16568283</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
</record>
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