Effect of delay on self-administration of remifentanil under a drug versus drug choice procedure in rhesus monkeys.
Identifieur interne : 001362 ( Main/Corpus ); précédent : 001361; suivant : 001363Effect of delay on self-administration of remifentanil under a drug versus drug choice procedure in rhesus monkeys.
Auteurs : David R. Maguire ; Lisa R. Gerak ; Charles P. FranceSource :
- The Journal of pharmacology and experimental therapeutics [ 1521-0103 ] ; 2013.
English descriptors
- KwdEn :
- Analgesics, Opioid (administration & dosage), Analgesics, Opioid (pharmacology), Animals (MeSH), Choice Behavior (drug effects), Conditioning, Operant (drug effects), Dose-Response Relationship, Drug (MeSH), Female (MeSH), Infusions, Intravenous (MeSH), Macaca mulatta (MeSH), Male (MeSH), Opioid-Related Disorders (psychology), Piperidines (administration & dosage), Piperidines (pharmacology), Remifentanil (MeSH), Self Administration (MeSH).
- MESH :
- chemical , administration & dosage : Analgesics, Opioid, Piperidines.
- chemical , pharmacology : Analgesics, Opioid, Piperidines.
- drug effects : Choice Behavior, Conditioning, Operant.
- psychology : Opioid-Related Disorders.
- Animals, Dose-Response Relationship, Drug, Female, Infusions, Intravenous, Macaca mulatta, Male, Remifentanil, Self Administration.
Abstract
Drug abuse can be conceptualized as excessive choice of drug over other reinforcers, and factors that affect drug taking can be examined experimentally using choice procedures. This study examined the impact of reinforcer delay on self-administration of the μ-opioid receptor agonist remifentanil in rhesus monkeys (n = 4) lever pressing under a concurrent fixed-ratio 30 schedule. Responding on either lever delivered an intravenous infusion of either remifentanil or saline. Dose-effect curves were first determined when responding on one lever delivered remifentanil and responding on a second lever delivered saline. Monkeys then chose between two doses of remifentanil, and delay to delivery of the large dose was varied systematically. Responding for remifentanil (0.01-1.0 µg/kg/infusion) increased dose-dependently when the alternative was saline or a dose of remifentanil. Delaying delivery of the large dose of remifentanil by 30, 60, 120, or 240 seconds increased responding for smaller, immediately available doses (0.01-0.1 µg/kg/infusion) and, in some cases, increased responding for doses of remifentanil that did not maintain responding when the alternative was saline. These data demonstrate that delaying the delivery of an opioid receptor agonist can significantly affect its reinforcing effectiveness. The imposition of a delay reduces the effectiveness of large doses of drug to maintain responding and increases the effectiveness of immediately available commodities, including smaller doses of drug. Increased reinforcing effectiveness of smaller doses of drug in the context of other delayed reinforcers might contribute to the development and maintenance of opioid abuse.
DOI: 10.1124/jpet.113.208355
PubMed: 24042159
PubMed Central: PMC3836318
Links to Exploration step
pubmed:24042159Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Effect of delay on self-administration of remifentanil under a drug versus drug choice procedure in rhesus monkeys.</title><author><name sortKey="Maguire, David R" sort="Maguire, David R" uniqKey="Maguire D" first="David R" last="Maguire">David R. Maguire</name><affiliation><nlm:affiliation>Departments of Pharmacology (D.R.M., L.R.G., C.P.F.) and Psychiatry (C.P.F.), the University of Texas Health Science Center at San Antonio, San Antonio, Texas.</nlm:affiliation></affiliation></author><author><name sortKey="Gerak, Lisa R" sort="Gerak, Lisa R" uniqKey="Gerak L" first="Lisa R" last="Gerak">Lisa R. Gerak</name></author><author><name sortKey="France, Charles P" sort="France, Charles P" uniqKey="France C" first="Charles P" last="France">Charles P. France</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2013">2013</date><idno type="RBID">pubmed:24042159</idno><idno type="pmid">24042159</idno><idno type="doi">10.1124/jpet.113.208355</idno><idno type="pmc">PMC3836318</idno><idno type="wicri:Area/Main/Corpus">001362</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">001362</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Effect of delay on self-administration of remifentanil under a drug versus drug choice procedure in rhesus monkeys.</title><author><name sortKey="Maguire, David R" sort="Maguire, David R" uniqKey="Maguire D" first="David R" last="Maguire">David R. Maguire</name><affiliation><nlm:affiliation>Departments of Pharmacology (D.R.M., L.R.G., C.P.F.) and Psychiatry (C.P.F.), the University of Texas Health Science Center at San Antonio, San Antonio, Texas.</nlm:affiliation></affiliation></author><author><name sortKey="Gerak, Lisa R" sort="Gerak, Lisa R" uniqKey="Gerak L" first="Lisa R" last="Gerak">Lisa R. Gerak</name></author><author><name sortKey="France, Charles P" sort="France, Charles P" uniqKey="France C" first="Charles P" last="France">Charles P. France</name></author></analytic><series><title level="j">The Journal of pharmacology and experimental therapeutics</title><idno type="eISSN">1521-0103</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Analgesics, Opioid (administration & dosage)</term><term>Analgesics, Opioid (pharmacology)</term><term>Animals (MeSH)</term><term>Choice Behavior (drug effects)</term><term>Conditioning, Operant (drug effects)</term><term>Dose-Response Relationship, Drug (MeSH)</term><term>Female (MeSH)</term><term>Infusions, Intravenous (MeSH)</term><term>Macaca mulatta (MeSH)</term><term>Male (MeSH)</term><term>Opioid-Related Disorders (psychology)</term><term>Piperidines (administration & dosage)</term><term>Piperidines (pharmacology)</term><term>Remifentanil (MeSH)</term><term>Self Administration (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Analgesics, Opioid</term><term>Piperidines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Analgesics, Opioid</term><term>Piperidines</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Choice Behavior</term><term>Conditioning, Operant</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Opioid-Related Disorders</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Dose-Response Relationship, Drug</term><term>Female</term><term>Infusions, Intravenous</term><term>Macaca mulatta</term><term>Male</term><term>Remifentanil</term><term>Self Administration</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Drug abuse can be conceptualized as excessive choice of drug over other reinforcers, and factors that affect drug taking can be examined experimentally using choice procedures. This study examined the impact of reinforcer delay on self-administration of the μ-opioid receptor agonist remifentanil in rhesus monkeys (n = 4) lever pressing under a concurrent fixed-ratio 30 schedule. Responding on either lever delivered an intravenous infusion of either remifentanil or saline. Dose-effect curves were first determined when responding on one lever delivered remifentanil and responding on a second lever delivered saline. Monkeys then chose between two doses of remifentanil, and delay to delivery of the large dose was varied systematically. Responding for remifentanil (0.01-1.0 µg/kg/infusion) increased dose-dependently when the alternative was saline or a dose of remifentanil. Delaying delivery of the large dose of remifentanil by 30, 60, 120, or 240 seconds increased responding for smaller, immediately available doses (0.01-0.1 µg/kg/infusion) and, in some cases, increased responding for doses of remifentanil that did not maintain responding when the alternative was saline. These data demonstrate that delaying the delivery of an opioid receptor agonist can significantly affect its reinforcing effectiveness. The imposition of a delay reduces the effectiveness of large doses of drug to maintain responding and increases the effectiveness of immediately available commodities, including smaller doses of drug. Increased reinforcing effectiveness of smaller doses of drug in the context of other delayed reinforcers might contribute to the development and maintenance of opioid abuse. </div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24042159</PMID><DateCompleted><Year>2014</Year><Month>01</Month><Day>23</Day></DateCompleted><DateRevised><Year>2018</Year><Month>12</Month><Day>02</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1521-0103</ISSN><JournalIssue CitedMedium="Internet"><Volume>347</Volume><Issue>3</Issue><PubDate><Year>2013</Year><Month>Dec</Month></PubDate></JournalIssue><Title>The Journal of pharmacology and experimental therapeutics</Title><ISOAbbreviation>J Pharmacol Exp Ther</ISOAbbreviation></Journal><ArticleTitle>Effect of delay on self-administration of remifentanil under a drug versus drug choice procedure in rhesus monkeys.</ArticleTitle><Pagination><MedlinePgn>557-63</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1124/jpet.113.208355</ELocationID><Abstract><AbstractText>Drug abuse can be conceptualized as excessive choice of drug over other reinforcers, and factors that affect drug taking can be examined experimentally using choice procedures. This study examined the impact of reinforcer delay on self-administration of the μ-opioid receptor agonist remifentanil in rhesus monkeys (n = 4) lever pressing under a concurrent fixed-ratio 30 schedule. Responding on either lever delivered an intravenous infusion of either remifentanil or saline. Dose-effect curves were first determined when responding on one lever delivered remifentanil and responding on a second lever delivered saline. Monkeys then chose between two doses of remifentanil, and delay to delivery of the large dose was varied systematically. Responding for remifentanil (0.01-1.0 µg/kg/infusion) increased dose-dependently when the alternative was saline or a dose of remifentanil. Delaying delivery of the large dose of remifentanil by 30, 60, 120, or 240 seconds increased responding for smaller, immediately available doses (0.01-0.1 µg/kg/infusion) and, in some cases, increased responding for doses of remifentanil that did not maintain responding when the alternative was saline. These data demonstrate that delaying the delivery of an opioid receptor agonist can significantly affect its reinforcing effectiveness. The imposition of a delay reduces the effectiveness of large doses of drug to maintain responding and increases the effectiveness of immediately available commodities, including smaller doses of drug. Increased reinforcing effectiveness of smaller doses of drug in the context of other delayed reinforcers might contribute to the development and maintenance of opioid abuse. </AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Maguire</LastName><ForeName>David R</ForeName><Initials>DR</Initials><AffiliationInfo><Affiliation>Departments of Pharmacology (D.R.M., L.R.G., C.P.F.) and Psychiatry (C.P.F.), the University of Texas Health Science Center at San Antonio, San Antonio, Texas.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gerak</LastName><ForeName>Lisa R</ForeName><Initials>LR</Initials></Author><Author ValidYN="Y"><LastName>France</LastName><ForeName>Charles P</ForeName><Initials>CP</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>T32DA031115</GrantID><Acronym>DA</Acronym><Agency>NIDA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>K05DA017918</GrantID><Acronym>DA</Acronym><Agency>NIDA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>K05 DA017918</GrantID><Acronym>DA</Acronym><Agency>NIDA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01DA029254</GrantID><Acronym>DA</Acronym><Agency>NIDA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>F32 DA035605</GrantID><Acronym>DA</Acronym><Agency>NIDA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 DA029254</GrantID><Acronym>DA</Acronym><Agency>NIDA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>T32 DA031115</GrantID><Acronym>DA</Acronym><Agency>NIDA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>F32DA035605</GrantID><Acronym>DA</Acronym><Agency>NIDA NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2013</Year><Month>09</Month><Day>16</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Pharmacol Exp Ther</MedlineTA><NlmUniqueID>0376362</NlmUniqueID><ISSNLinking>0022-3565</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000701">Analgesics, Opioid</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010880">Piperidines</NameOfSubstance></Chemical><Chemical><RegistryNumber>P10582JYYK</RegistryNumber><NameOfSubstance UI="D000077208">Remifentanil</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000701" MajorTopicYN="N">Analgesics, Opioid</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002755" MajorTopicYN="N">Choice Behavior</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003216" MajorTopicYN="N">Conditioning, Operant</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004305" MajorTopicYN="N">Dose-Response Relationship, Drug</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007262" MajorTopicYN="N">Infusions, Intravenous</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008253" MajorTopicYN="N">Macaca 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