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A reduced factor structure for the PROQOL-HIV questionnaire provided reliable indicators of health-related quality of life.

Identifieur interne : 000F62 ( Main/Corpus ); précédent : 000F61; suivant : 000F63

A reduced factor structure for the PROQOL-HIV questionnaire provided reliable indicators of health-related quality of life.

Auteurs : Christophe Lalanne ; Olivier Chassany ; Patrizia Carrieri ; Fabienne Marcellin ; Andrew R. Armstrong ; France Lert ; Bruno Spire ; Rosemary Dray-Spira ; Martin Duracinsky

Source :

RBID : pubmed:26548542

English descriptors

Abstract

OBJECTIVES

To identify a simplified factor structure for the PROQOL-human immunodeficiency virus (HIV) questionnaire to improve the measurement of the health-related quality of life (HRQL) of HIV-positive patients in clinical care and research settings.

STUDY DESIGN AND SETTING

HRQL data were collected using the eight-dimension PROQOL-HIV questionnaire from 2,537 patients (VESPA2 study). Exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) validated a simpler four-factor structure and assessed measurement invariance (MI). Multigroup analysis assessed the effect of sex, age, and antiretroviral therapy (ART) on the resulting factor scores. Correlations with symptom and Short Form (SF)-12 self-reports assessed convergent validity.

RESULTS

Item analysis, EFA, and CFAs confirmed the validity [comparative fit index (CFI), 0.948; root mean square error of approximation, 0.064] and reliability (α's ≥ 0.8) of four dimensions: physical health and symptoms, health concerns and mental distress, social and intimate relationships, and treatment-related impact. Strong MI was demonstrated across sex and age (decrease in CFI <0.01). A multiple-cause multiple-indicator model indicated that HRQL correlated as expected with sex, age, and the ART status. Correlations of HRQL, symptom reports, and SF-12 scores evidenced convergent validity criterion.

CONCLUSION

The simplified factor structure and scoring scheme for PROQOL-HIV will allow clinicians to monitor with greater reliability the HRQL of patients in clinical care and research settings.


DOI: 10.1016/j.jclinepi.2015.10.009
PubMed: 26548542

Links to Exploration step

pubmed:26548542

Le document en format XML

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<term>Adult (MeSH)</term>
<term>Age Factors (MeSH)</term>
<term>Anti-HIV Agents (therapeutic use)</term>
<term>Cross-Sectional Studies (MeSH)</term>
<term>Factor Analysis, Statistical (MeSH)</term>
<term>Female (MeSH)</term>
<term>HIV Infections (drug therapy)</term>
<term>HIV Infections (physiopathology)</term>
<term>HIV Infections (psychology)</term>
<term>Humans (MeSH)</term>
<term>Male (MeSH)</term>
<term>Middle Aged (MeSH)</term>
<term>Psychometrics (MeSH)</term>
<term>Quality of Life (MeSH)</term>
<term>Reproducibility of Results (MeSH)</term>
<term>Severity of Illness Index (MeSH)</term>
<term>Sex Factors (MeSH)</term>
<term>Socioeconomic Factors (MeSH)</term>
<term>Surveys and Questionnaires (MeSH)</term>
<term>Young Adult (MeSH)</term>
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<term>Anti-HIV Agents</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en">
<term>HIV Infections</term>
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<term>HIV Infections</term>
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<term>HIV Infections</term>
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<term>Age Factors</term>
<term>Cross-Sectional Studies</term>
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<front>
<div type="abstract" xml:lang="en">
<p>
<b>OBJECTIVES</b>
</p>
<p>To identify a simplified factor structure for the PROQOL-human immunodeficiency virus (HIV) questionnaire to improve the measurement of the health-related quality of life (HRQL) of HIV-positive patients in clinical care and research settings.</p>
</div>
<div type="abstract" xml:lang="en">
<p>
<b>STUDY DESIGN AND SETTING</b>
</p>
<p>HRQL data were collected using the eight-dimension PROQOL-HIV questionnaire from 2,537 patients (VESPA2 study). Exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) validated a simpler four-factor structure and assessed measurement invariance (MI). Multigroup analysis assessed the effect of sex, age, and antiretroviral therapy (ART) on the resulting factor scores. Correlations with symptom and Short Form (SF)-12 self-reports assessed convergent validity.</p>
</div>
<div type="abstract" xml:lang="en">
<p>
<b>RESULTS</b>
</p>
<p>Item analysis, EFA, and CFAs confirmed the validity [comparative fit index (CFI), 0.948; root mean square error of approximation, 0.064] and reliability (α's ≥ 0.8) of four dimensions: physical health and symptoms, health concerns and mental distress, social and intimate relationships, and treatment-related impact. Strong MI was demonstrated across sex and age (decrease in CFI <0.01). A multiple-cause multiple-indicator model indicated that HRQL correlated as expected with sex, age, and the ART status. Correlations of HRQL, symptom reports, and SF-12 scores evidenced convergent validity criterion.</p>
</div>
<div type="abstract" xml:lang="en">
<p>
<b>CONCLUSION</b>
</p>
<p>The simplified factor structure and scoring scheme for PROQOL-HIV will allow clinicians to monitor with greater reliability the HRQL of patients in clinical care and research settings.</p>
</div>
</front>
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<AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">To identify a simplified factor structure for the PROQOL-human immunodeficiency virus (HIV) questionnaire to improve the measurement of the health-related quality of life (HRQL) of HIV-positive patients in clinical care and research settings.</AbstractText>
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<Month>10</Month>
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