Factors associated with quality of life in patients with Alzheimer's disease.
Identifieur interne : 000788 ( Main/Corpus ); précédent : 000787; suivant : 000789Factors associated with quality of life in patients with Alzheimer's disease.
Auteurs : Coralie Barbe ; Damien Jolly ; Isabella Morrone ; Aurore Wolak-Thierry ; Moustapha Dramé ; Jean-Luc Novella ; Rachid MahmoudiSource :
- BMC geriatrics [ 1471-2318 ] ; 2018.
English descriptors
- KwdEn :
- Activities of Daily Living (MeSH), Adaptation, Psychological (MeSH), Aged (MeSH), Aged, 80 and over (MeSH), Alzheimer Disease (complications), Alzheimer Disease (psychology), Alzheimer Disease (therapy), Anxiety (MeSH), Caregivers (psychology), Cross-Sectional Studies (MeSH), Depression (psychology), Female (MeSH), Geriatric Assessment (MeSH), Health Status (MeSH), Humans (MeSH), Male (MeSH), Polypharmacy (MeSH), Quality of Life (MeSH), Self Report (MeSH).
- MESH :
- complications : Alzheimer Disease.
- psychology : Alzheimer Disease, Caregivers, Depression.
- therapy : Alzheimer Disease.
- Activities of Daily Living, Adaptation, Psychological, Aged, Aged, 80 and over, Anxiety, Cross-Sectional Studies, Female, Geriatric Assessment, Health Status, Humans, Male, Polypharmacy, Quality of Life, Self Report.
Abstract
BACKGROUND
Evaluation of health-related quality of life (HRQoL) in patients with Alzheimer's disease (AD) is necessary to ensure optimal management. Several scales for assessing HRQoL of patients with AD exist, in particular the Quality of Life in Alzheimer's Disease (QoL-AD), which includes an evaluation by the caregiver of the patient's HRQoL. The aim of this study was to identify factors associated with patient, caregiver and overall HRQoL as assessed by the QoL-AD.
METHODS
Cross-sectional multicenter study in subjects aged 65 years and older, with mild to moderate AD. HRQoL scores from the QoL-AD were recorded (3 scores, corresponding to patient, caregiver and overall), as well as sociodemographic variables for the patient and the caregiver, and data from the geriatric cognitive assessment (cognitive, psycho-behavioral, functional evaluations). Caregiver burden was evaluated using the Zarit caregiver burden scale. Factors associated with each QoL-AD score were identified by multivariate linear regression using t-tests and β estimations. Study was registered in Clinical Trial.gov (NCT02814773).
RESULTS
In total, 123 patients with AD were included. For the patient QoL-AD evaluation, depression was significantly associated with lower HRQoL (β = - 2.56 ± 1.28, p = 0.04), while polypharmacy (β = - 1.80 ± 0.99, p = 0.07) and anxiety (β = - 1.70 ± 1.01, p = 0.09) tended to be associated with lower HRQoL scores. In terms of caregiver evaluations, depression (β = - 3.46 ± 1.09, p = 0.002), polypharmacy (β = - 1.91 ± 0.92, p = 0.04) and the presence of caregiver burden (β = - 3.50 ± 0.91, p = 0.0002) were associated with lower HRQoL. For the overall evaluation, depression (β = - 3.26 ± 1.02, p = 0.002) and polypharmacy (β = - 1.85 ± 0.81, p = 0.03) were significantly related to lower HRQoL.
CONCLUSIONS
Depression and polypharmacy were two factors influencing HRQoL in patients with AD, both by patient self-report and on the caregiver report. Thus, despite the discrepancies between HRQoL as assessed by patients with AD and HRQoL as assessed by their caregiver, the caregiver's assessment may be used to guide patient management when the patient can no longer complete QoL evaluations. Moreover, the association between caregiver burden and the caregiver's QoL-AD score underlines the need to take caregivers into consideration in the overall management of the AD patient.
DOI: 10.1186/s12877-018-0855-7
PubMed: 29986669
PubMed Central: PMC6038200
Links to Exploration step
pubmed:29986669Le document en format XML
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Public health, Reims University Hospitals, Robert Debré Hospital, F-51092, Reims, France.</nlm:affiliation></affiliation></author><author><name sortKey="Morrone, Isabella" sort="Morrone, Isabella" uniqKey="Morrone I" first="Isabella" last="Morrone">Isabella Morrone</name><affiliation><nlm:affiliation>Faculty of Medicine, EA 3797, University of Reims Champagne-Ardenne, F-51092, Reims, France.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Department of Geriatrics and Internal Medicine, Reims University Hospitals, Maison Blanche Hospital, F-51092, Reims, France.</nlm:affiliation></affiliation></author><author><name sortKey="Wolak Thierry, Aurore" sort="Wolak Thierry, Aurore" uniqKey="Wolak Thierry A" first="Aurore" last="Wolak-Thierry">Aurore Wolak-Thierry</name><affiliation><nlm:affiliation>Faculty of Medicine, EA 3797, University of Reims Champagne-Ardenne, F-51092, Reims, France.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Department of Research and Public health, Reims University Hospitals, Robert Debré Hospital, F-51092, Reims, France.</nlm:affiliation></affiliation></author><author><name sortKey="Drame, Moustapha" sort="Drame, Moustapha" uniqKey="Drame M" first="Moustapha" last="Dramé">Moustapha Dramé</name><affiliation><nlm:affiliation>Faculty of Medicine, EA 3797, University of Reims Champagne-Ardenne, F-51092, Reims, France.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Department of Research and Public health, Reims University Hospitals, Robert Debré Hospital, F-51092, Reims, France.</nlm:affiliation></affiliation></author><author><name sortKey="Novella, Jean Luc" sort="Novella, Jean Luc" uniqKey="Novella J" first="Jean-Luc" last="Novella">Jean-Luc Novella</name><affiliation><nlm:affiliation>Faculty of Medicine, EA 3797, University of Reims Champagne-Ardenne, F-51092, Reims, France.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Department of Geriatrics and Internal Medicine, Reims University Hospitals, Maison Blanche Hospital, F-51092, Reims, France.</nlm:affiliation></affiliation></author><author><name sortKey="Mahmoudi, Rachid" sort="Mahmoudi, Rachid" uniqKey="Mahmoudi R" first="Rachid" last="Mahmoudi">Rachid Mahmoudi</name><affiliation><nlm:affiliation>Faculty of Medicine, EA 3797, University of Reims Champagne-Ardenne, F-51092, Reims, France.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Department of Geriatrics and Internal Medicine, Reims University Hospitals, Maison Blanche Hospital, F-51092, Reims, France.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2018">2018</date><idno type="RBID">pubmed:29986669</idno><idno type="pmid">29986669</idno><idno type="doi">10.1186/s12877-018-0855-7</idno><idno type="pmc">PMC6038200</idno><idno type="wicri:Area/Main/Corpus">000788</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" 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France.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Department of Research and Public health, Reims University Hospitals, Robert Debré Hospital, F-51092, Reims, France.</nlm:affiliation></affiliation></author><author><name sortKey="Morrone, Isabella" sort="Morrone, Isabella" uniqKey="Morrone I" first="Isabella" last="Morrone">Isabella Morrone</name><affiliation><nlm:affiliation>Faculty of Medicine, EA 3797, University of Reims Champagne-Ardenne, F-51092, Reims, France.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Department of Geriatrics and Internal Medicine, Reims University Hospitals, Maison Blanche Hospital, F-51092, Reims, France.</nlm:affiliation></affiliation></author><author><name sortKey="Wolak Thierry, Aurore" sort="Wolak Thierry, Aurore" uniqKey="Wolak Thierry A" first="Aurore" last="Wolak-Thierry">Aurore Wolak-Thierry</name><affiliation><nlm:affiliation>Faculty of Medicine, EA 3797, University of Reims Champagne-Ardenne, F-51092, Reims, France.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Department of Research and Public health, Reims University Hospitals, Robert Debré Hospital, F-51092, Reims, France.</nlm:affiliation></affiliation></author><author><name sortKey="Drame, Moustapha" sort="Drame, Moustapha" uniqKey="Drame M" first="Moustapha" last="Dramé">Moustapha Dramé</name><affiliation><nlm:affiliation>Faculty of Medicine, EA 3797, University of Reims Champagne-Ardenne, F-51092, Reims, France.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Department of Research and Public health, Reims University Hospitals, Robert Debré Hospital, F-51092, Reims, France.</nlm:affiliation></affiliation></author><author><name sortKey="Novella, Jean Luc" sort="Novella, Jean Luc" uniqKey="Novella J" first="Jean-Luc" last="Novella">Jean-Luc Novella</name><affiliation><nlm:affiliation>Faculty of Medicine, EA 3797, University of Reims Champagne-Ardenne, F-51092, Reims, France.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Department of Geriatrics and Internal Medicine, Reims University Hospitals, Maison Blanche Hospital, F-51092, Reims, France.</nlm:affiliation></affiliation></author><author><name sortKey="Mahmoudi, Rachid" sort="Mahmoudi, Rachid" uniqKey="Mahmoudi R" first="Rachid" last="Mahmoudi">Rachid Mahmoudi</name><affiliation><nlm:affiliation>Faculty of Medicine, EA 3797, University of Reims Champagne-Ardenne, F-51092, Reims, France.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Department of Geriatrics and Internal Medicine, Reims University Hospitals, Maison Blanche Hospital, F-51092, Reims, France.</nlm:affiliation></affiliation></author></analytic><series><title level="j">BMC geriatrics</title><idno type="eISSN">1471-2318</idno><imprint><date when="2018" type="published">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Activities of Daily Living (MeSH)</term><term>Adaptation, Psychological (MeSH)</term><term>Aged (MeSH)</term><term>Aged, 80 and over (MeSH)</term><term>Alzheimer Disease (complications)</term><term>Alzheimer Disease (psychology)</term><term>Alzheimer Disease (therapy)</term><term>Anxiety (MeSH)</term><term>Caregivers (psychology)</term><term>Cross-Sectional Studies (MeSH)</term><term>Depression (psychology)</term><term>Female (MeSH)</term><term>Geriatric Assessment (MeSH)</term><term>Health Status (MeSH)</term><term>Humans (MeSH)</term><term>Male (MeSH)</term><term>Polypharmacy (MeSH)</term><term>Quality of Life (MeSH)</term><term>Self Report (MeSH)</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Alzheimer Disease</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Alzheimer Disease</term><term>Caregivers</term><term>Depression</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Alzheimer Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Activities of Daily Living</term><term>Adaptation, Psychological</term><term>Aged</term><term>Aged, 80 and over</term><term>Anxiety</term><term>Cross-Sectional Studies</term><term>Female</term><term>Geriatric Assessment</term><term>Health Status</term><term>Humans</term><term>Male</term><term>Polypharmacy</term><term>Quality of Life</term><term>Self Report</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>Evaluation of health-related quality of life (HRQoL) in patients with Alzheimer's disease (AD) is necessary to ensure optimal management. Several scales for assessing HRQoL of patients with AD exist, in particular the Quality of Life in Alzheimer's Disease (QoL-AD), which includes an evaluation by the caregiver of the patient's HRQoL. The aim of this study was to identify factors associated with patient, caregiver and overall HRQoL as assessed by the QoL-AD.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>Cross-sectional multicenter study in subjects aged 65 years and older, with mild to moderate AD. HRQoL scores from the QoL-AD were recorded (3 scores, corresponding to patient, caregiver and overall), as well as sociodemographic variables for the patient and the caregiver, and data from the geriatric cognitive assessment (cognitive, psycho-behavioral, functional evaluations). Caregiver burden was evaluated using the Zarit caregiver burden scale. Factors associated with each QoL-AD score were identified by multivariate linear regression using t-tests and β estimations. Study was registered in Clinical Trial.gov (NCT02814773).</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>In total, 123 patients with AD were included. For the patient QoL-AD evaluation, depression was significantly associated with lower HRQoL (β = - 2.56 ± 1.28, p = 0.04), while polypharmacy (β = - 1.80 ± 0.99, p = 0.07) and anxiety (β = - 1.70 ± 1.01, p = 0.09) tended to be associated with lower HRQoL scores. In terms of caregiver evaluations, depression (β = - 3.46 ± 1.09, p = 0.002), polypharmacy (β = - 1.91 ± 0.92, p = 0.04) and the presence of caregiver burden (β = - 3.50 ± 0.91, p = 0.0002) were associated with lower HRQoL. For the overall evaluation, depression (β = - 3.26 ± 1.02, p = 0.002) and polypharmacy (β = - 1.85 ± 0.81, p = 0.03) were significantly related to lower HRQoL.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>Depression and polypharmacy were two factors influencing HRQoL in patients with AD, both by patient self-report and on the caregiver report. Thus, despite the discrepancies between HRQoL as assessed by patients with AD and HRQoL as assessed by their caregiver, the caregiver's assessment may be used to guide patient management when the patient can no longer complete QoL evaluations. Moreover, the association between caregiver burden and the caregiver's QoL-AD score underlines the need to take caregivers into consideration in the overall management of the AD patient.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" IndexingMethod="Curated" Owner="NLM"><PMID Version="1">29986669</PMID><DateCompleted><Year>2019</Year><Month>03</Month><Day>07</Day></DateCompleted><DateRevised><Year>2019</Year><Month>03</Month><Day>07</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1471-2318</ISSN><JournalIssue CitedMedium="Internet"><Volume>18</Volume><Issue>1</Issue><PubDate><Year>2018</Year><Month>07</Month><Day>09</Day></PubDate></JournalIssue><Title>BMC geriatrics</Title><ISOAbbreviation>BMC Geriatr</ISOAbbreviation></Journal><ArticleTitle>Factors associated with quality of life in patients with Alzheimer's disease.</ArticleTitle><Pagination><MedlinePgn>159</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1186/s12877-018-0855-7</ELocationID><Abstract><AbstractText Label="BACKGROUND">Evaluation of health-related quality of life (HRQoL) in patients with Alzheimer's disease (AD) is necessary to ensure optimal management. Several scales for assessing HRQoL of patients with AD exist, in particular the Quality of Life in Alzheimer's Disease (QoL-AD), which includes an evaluation by the caregiver of the patient's HRQoL. The aim of this study was to identify factors associated with patient, caregiver and overall HRQoL as assessed by the QoL-AD.</AbstractText><AbstractText Label="METHODS">Cross-sectional multicenter study in subjects aged 65 years and older, with mild to moderate AD. HRQoL scores from the QoL-AD were recorded (3 scores, corresponding to patient, caregiver and overall), as well as sociodemographic variables for the patient and the caregiver, and data from the geriatric cognitive assessment (cognitive, psycho-behavioral, functional evaluations). Caregiver burden was evaluated using the Zarit caregiver burden scale. Factors associated with each QoL-AD score were identified by multivariate linear regression using t-tests and β estimations. Study was registered in Clinical Trial.gov (NCT02814773).</AbstractText><AbstractText Label="RESULTS">In total, 123 patients with AD were included. For the patient QoL-AD evaluation, depression was significantly associated with lower HRQoL (β = - 2.56 ± 1.28, p = 0.04), while polypharmacy (β = - 1.80 ± 0.99, p = 0.07) and anxiety (β = - 1.70 ± 1.01, p = 0.09) tended to be associated with lower HRQoL scores. In terms of caregiver evaluations, depression (β = - 3.46 ± 1.09, p = 0.002), polypharmacy (β = - 1.91 ± 0.92, p = 0.04) and the presence of caregiver burden (β = - 3.50 ± 0.91, p = 0.0002) were associated with lower HRQoL. For the overall evaluation, depression (β = - 3.26 ± 1.02, p = 0.002) and polypharmacy (β = - 1.85 ± 0.81, p = 0.03) were significantly related to lower HRQoL.</AbstractText><AbstractText Label="CONCLUSIONS">Depression and polypharmacy were two factors influencing HRQoL in patients with AD, both by patient self-report and on the caregiver report. Thus, despite the discrepancies between HRQoL as assessed by patients with AD and HRQoL as assessed by their caregiver, the caregiver's assessment may be used to guide patient management when the patient can no longer complete QoL evaluations. Moreover, the association between caregiver burden and the caregiver's QoL-AD score underlines the need to take caregivers into consideration in the overall management of the AD patient.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Barbe</LastName><ForeName>Coralie</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Faculty of Medicine, EA 3797, University of Reims Champagne-Ardenne, F-51092, Reims, France. cbarbe@chu-reims.fr.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Research and Public health, Reims University Hospitals, Robert Debré Hospital, F-51092, Reims, France. cbarbe@chu-reims.fr.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jolly</LastName><ForeName>Damien</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Faculty of Medicine, EA 3797, University of Reims Champagne-Ardenne, F-51092, Reims, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Research and Public health, Reims University Hospitals, Robert Debré Hospital, F-51092, Reims, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Morrone</LastName><ForeName>Isabella</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Faculty of Medicine, EA 3797, University of Reims Champagne-Ardenne, F-51092, Reims, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Geriatrics and Internal Medicine, Reims University Hospitals, Maison Blanche Hospital, F-51092, Reims, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wolak-Thierry</LastName><ForeName>Aurore</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Faculty of Medicine, EA 3797, University of Reims Champagne-Ardenne, F-51092, Reims, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Research and Public health, Reims University Hospitals, Robert Debré Hospital, F-51092, Reims, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dramé</LastName><ForeName>Moustapha</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Faculty of Medicine, EA 3797, University of Reims Champagne-Ardenne, F-51092, Reims, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Research and Public health, Reims University Hospitals, Robert Debré Hospital, F-51092, Reims, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Novella</LastName><ForeName>Jean-Luc</ForeName><Initials>JL</Initials><AffiliationInfo><Affiliation>Faculty of Medicine, EA 3797, University of Reims Champagne-Ardenne, F-51092, Reims, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Geriatrics and Internal Medicine, Reims University Hospitals, Maison Blanche Hospital, F-51092, Reims, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mahmoudi</LastName><ForeName>Rachid</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Faculty of Medicine, EA 3797, University of Reims Champagne-Ardenne, F-51092, Reims, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Geriatrics and Internal Medicine, Reims University Hospitals, Maison Blanche Hospital, F-51092, Reims, France.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><DataBankList CompleteYN="Y"><DataBank><DataBankName>ClinicalTrials.gov</DataBankName><AccessionNumberList><AccessionNumber>NCT02814773</AccessionNumber></AccessionNumberList></DataBank></DataBankList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016448">Multicenter Study</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2018</Year><Month>07</Month><Day>09</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>BMC Geriatr</MedlineTA><NlmUniqueID>100968548</NlmUniqueID><ISSNLinking>1471-2318</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000203" MajorTopicYN="N">Activities of Daily Living</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000223" MajorTopicYN="N">Adaptation, Psychological</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000544" MajorTopicYN="N">Alzheimer Disease</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName><QualifierName UI="Q000523" MajorTopicYN="Y">psychology</QualifierName><QualifierName UI="Q000628" MajorTopicYN="N">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001007" MajorTopicYN="N">Anxiety</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017028" MajorTopicYN="N">Caregivers</DescriptorName><QualifierName UI="Q000523" MajorTopicYN="N">psychology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003430" MajorTopicYN="N">Cross-Sectional Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003863" MajorTopicYN="N">Depression</DescriptorName><QualifierName UI="Q000523" MajorTopicYN="N">psychology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015577" MajorTopicYN="N">Geriatric Assessment</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006304" MajorTopicYN="N">Health Status</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019338" MajorTopicYN="N">Polypharmacy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011788" MajorTopicYN="Y">Quality of Life</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D057566" MajorTopicYN="N">Self Report</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Alzheimer’s disease</Keyword><Keyword MajorTopicYN="Y">Associated factors</Keyword><Keyword MajorTopicYN="Y">QoL-AD</Keyword><Keyword MajorTopicYN="Y">Quality of life</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2017</Year><Month>04</Month><Day>26</Day></PubMedPubDate><PubMedPubDate 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