Emotional feeling in patients suffering from amyotrophic lateral sclerosis.
Identifieur interne : 000677 ( Main/Corpus ); précédent : 000676; suivant : 000678Emotional feeling in patients suffering from amyotrophic lateral sclerosis.
Auteurs : Johanna Unglik ; Catherine Bungener ; Daniel Delgadillo ; François Salachas ; Pierre François Pradat ; Gaëlle Bruneteau ; Timothée Lenglet ; Nadine Le Forestier ; Philippe Couratier ; Yannick Vacher ; Lucette LacomblezSource :
- Geriatrie et psychologie neuropsychiatrie du vieillissement [ 2115-7863 ] ; 2018.
English descriptors
- KwdEn :
- MESH :
- complications : Anxiety.
- psychology : Amyotrophic Lateral Sclerosis, Anxiety.
- Aged, Apathy, Cognition, Emotions, Female, Humans, Male, Middle Aged, Neuropsychological Tests.
Abstract
OBJECTIVE
Amyotrophic lateral sclerosis (ALS) is a fatal and progressive neurodegenerative disorder involving motor neurons of the cerebral cortex, brain stem and spinal cord. Besides the motor signs, cognitive disorders and apathy may be present and may impact the survival time. These elements are therefore to be taken into consideration for medical care because they can influence the disease evolution. The literature shows low psychopathological disorders in this population despite its poor prognosis. The main objective of this study is to explore the emotional feeling in apathetic and non-apathetic patients in relation to their anxiety and depressive symptoms.
METHODS
We included 152 patients at the day hospital for the follow-up of their illness, with an average age of 61±12.2 years. All filled the following self-administered questionnaires: EPN-31 (emotional feeling), HADS (for anxiety and depressive symptoms) and the Marin's apathy evaluation scale. Most of the patients (n=110) had also a cognitive assessment with the ALS-CBS scale.
RESULTS
42% of patients could be considered as apathetic and they felt both positive and negative emotions whose frequency was related to the presence and intensity of anxiety and depressive symptoms. The only significant differences were that apathetic and anxious patients experienced more negative emotions including sadness, shame and anger than non-apathetic and anxious patients. Apathy was negatively correlated with cognitive functioning and survival time.
CONCLUSIONS
These results highlighted the negative impact that apathy seemed to have on the evolution of this disease. However, apathetic patients didn't show emotional blunting and were able to name and feel positive and negative emotions; and even feel more negative emotions than non-apathetic patients when they were anxious. A better understanding of apathetic and no apathetic patients' emotional feelings should lead to a more personalized care for the ALS patients.
DOI: 10.1684/pnv.2018.0762
PubMed: 30355543
Links to Exploration step
pubmed:30355543Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Emotional feeling in patients suffering from amyotrophic lateral sclerosis.</title><author><name sortKey="Unglik, Johanna" sort="Unglik, Johanna" uniqKey="Unglik J" first="Johanna" last="Unglik">Johanna Unglik</name><affiliation><nlm:affiliation>Laboratoire de psychopathologie et processus de santé - EA 4057, Sorbonne-Paris-Cité, Université Paris-Descartes, Paris, France, Département de neurologie, Centre référent SLA, AP-HP, Hôpital Pitié-Salpêtrière, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Bungener, Catherine" sort="Bungener, Catherine" uniqKey="Bungener C" first="Catherine" last="Bungener">Catherine Bungener</name><affiliation><nlm:affiliation>Laboratoire de psychopathologie et processus de santé - EA 4057, Sorbonne-Paris-Cité, Université Paris-Descartes, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Delgadillo, Daniel" sort="Delgadillo, Daniel" uniqKey="Delgadillo D" first="Daniel" last="Delgadillo">Daniel Delgadillo</name><affiliation><nlm:affiliation>Département de neurologie, Centre référent SLA, AP-HP, Hôpital Pitié-Salpêtrière, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Salachas, Francois" sort="Salachas, Francois" uniqKey="Salachas F" first="François" last="Salachas">François Salachas</name><affiliation><nlm:affiliation>Département de neurologie, Centre référent SLA, AP-HP, Hôpital Pitié-Salpêtrière, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Pradat, Pierre Francois" sort="Pradat, Pierre Francois" uniqKey="Pradat P" first="Pierre François" last="Pradat">Pierre François Pradat</name><affiliation><nlm:affiliation>Département de neurologie, Centre référent SLA, AP-HP, Hôpital Pitié-Salpêtrière, Paris, France, CNRS, Inserm, Laboratoire d'imagerie biomédicale (LIB), Sorbonne Universités, UPMC Université Paris 06, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Bruneteau, Gaelle" sort="Bruneteau, Gaelle" uniqKey="Bruneteau G" first="Gaëlle" last="Bruneteau">Gaëlle Bruneteau</name><affiliation><nlm:affiliation>Département de neurologie, Centre référent SLA, AP-HP, Hôpital Pitié-Salpêtrière, Paris, France, Inserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Université Paris 06, UMR S 1127, Institut du cerveau et de la moelle épinière, ICM, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Lenglet, Timothee" sort="Lenglet, Timothee" uniqKey="Lenglet T" first="Timothée" last="Lenglet">Timothée Lenglet</name><affiliation><nlm:affiliation>Département de neurophysiologie clinique, AP-HP, Hôpital Pitié-Salpêtrière, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Le Forestier, Nadine" sort="Le Forestier, Nadine" uniqKey="Le Forestier N" first="Nadine" last="Le Forestier">Nadine Le Forestier</name><affiliation><nlm:affiliation>Département de neurologie, Centre référent SLA, AP-HP, Hôpital Pitié-Salpêtrière, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Couratier, Philippe" sort="Couratier, Philippe" uniqKey="Couratier P" first="Philippe" last="Couratier">Philippe Couratier</name><affiliation><nlm:affiliation>Département de neurologie, CHU, Hôpital Dupuytren, Limoges, France.</nlm:affiliation></affiliation></author><author><name sortKey="Vacher, Yannick" sort="Vacher, Yannick" uniqKey="Vacher Y" first="Yannick" last="Vacher">Yannick Vacher</name><affiliation><nlm:affiliation>Département de la recherche clinique et du développement, AP-HP, Hôpital Saint-Louis, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Lacomblez, Lucette" sort="Lacomblez, Lucette" uniqKey="Lacomblez L" first="Lucette" last="Lacomblez">Lucette Lacomblez</name><affiliation><nlm:affiliation>Département de neurologie, Centre référent SLA, AP-HP, Hôpital Pitié-Salpêtrière, Paris, France, CNRS, Inserm, Laboratoire d'imagerie biomédicale (LIB), CIC-1422, Sorbonne Universités, UPMC Université Paris 06, Paris, France.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2018">2018</date><idno type="RBID">pubmed:30355543</idno><idno type="pmid">30355543</idno><idno type="doi">10.1684/pnv.2018.0762</idno><idno type="wicri:Area/Main/Corpus">000677</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000677</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Emotional feeling in patients suffering from amyotrophic lateral sclerosis.</title><author><name sortKey="Unglik, Johanna" sort="Unglik, Johanna" uniqKey="Unglik J" first="Johanna" last="Unglik">Johanna Unglik</name><affiliation><nlm:affiliation>Laboratoire de psychopathologie et processus de santé - EA 4057, Sorbonne-Paris-Cité, Université Paris-Descartes, Paris, France, Département de neurologie, Centre référent SLA, AP-HP, Hôpital Pitié-Salpêtrière, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Bungener, Catherine" sort="Bungener, Catherine" uniqKey="Bungener C" first="Catherine" last="Bungener">Catherine Bungener</name><affiliation><nlm:affiliation>Laboratoire de psychopathologie et processus de santé - EA 4057, Sorbonne-Paris-Cité, Université Paris-Descartes, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Delgadillo, Daniel" sort="Delgadillo, Daniel" uniqKey="Delgadillo D" first="Daniel" last="Delgadillo">Daniel Delgadillo</name><affiliation><nlm:affiliation>Département de neurologie, Centre référent SLA, AP-HP, Hôpital Pitié-Salpêtrière, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Salachas, Francois" sort="Salachas, Francois" uniqKey="Salachas F" first="François" last="Salachas">François Salachas</name><affiliation><nlm:affiliation>Département de neurologie, Centre référent SLA, AP-HP, Hôpital Pitié-Salpêtrière, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Pradat, Pierre Francois" sort="Pradat, Pierre Francois" uniqKey="Pradat P" first="Pierre François" last="Pradat">Pierre François Pradat</name><affiliation><nlm:affiliation>Département de neurologie, Centre référent SLA, AP-HP, Hôpital Pitié-Salpêtrière, Paris, France, CNRS, Inserm, Laboratoire d'imagerie biomédicale (LIB), Sorbonne Universités, UPMC Université Paris 06, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Bruneteau, Gaelle" sort="Bruneteau, Gaelle" uniqKey="Bruneteau G" first="Gaëlle" last="Bruneteau">Gaëlle Bruneteau</name><affiliation><nlm:affiliation>Département de neurologie, Centre référent SLA, AP-HP, Hôpital Pitié-Salpêtrière, Paris, France, Inserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Université Paris 06, UMR S 1127, Institut du cerveau et de la moelle épinière, ICM, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Lenglet, Timothee" sort="Lenglet, Timothee" uniqKey="Lenglet T" first="Timothée" last="Lenglet">Timothée Lenglet</name><affiliation><nlm:affiliation>Département de neurophysiologie clinique, AP-HP, Hôpital Pitié-Salpêtrière, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Le Forestier, Nadine" sort="Le Forestier, Nadine" uniqKey="Le Forestier N" first="Nadine" last="Le Forestier">Nadine Le Forestier</name><affiliation><nlm:affiliation>Département de neurologie, Centre référent SLA, AP-HP, Hôpital Pitié-Salpêtrière, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Couratier, Philippe" sort="Couratier, Philippe" uniqKey="Couratier P" first="Philippe" last="Couratier">Philippe Couratier</name><affiliation><nlm:affiliation>Département de neurologie, CHU, Hôpital Dupuytren, Limoges, France.</nlm:affiliation></affiliation></author><author><name sortKey="Vacher, Yannick" sort="Vacher, Yannick" uniqKey="Vacher Y" first="Yannick" last="Vacher">Yannick Vacher</name><affiliation><nlm:affiliation>Département de la recherche clinique et du développement, AP-HP, Hôpital Saint-Louis, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Lacomblez, Lucette" sort="Lacomblez, Lucette" uniqKey="Lacomblez L" first="Lucette" last="Lacomblez">Lucette Lacomblez</name><affiliation><nlm:affiliation>Département de neurologie, Centre référent SLA, AP-HP, Hôpital Pitié-Salpêtrière, Paris, France, CNRS, Inserm, Laboratoire d'imagerie biomédicale (LIB), CIC-1422, Sorbonne Universités, UPMC Université Paris 06, Paris, France.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Geriatrie et psychologie neuropsychiatrie du vieillissement</title><idno type="eISSN">2115-7863</idno><imprint><date when="2018" type="published">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged (MeSH)</term><term>Amyotrophic Lateral Sclerosis (psychology)</term><term>Anxiety (complications)</term><term>Anxiety (psychology)</term><term>Apathy (MeSH)</term><term>Cognition (MeSH)</term><term>Emotions (MeSH)</term><term>Female (MeSH)</term><term>Humans (MeSH)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>Neuropsychological Tests (MeSH)</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Anxiety</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Amyotrophic Lateral Sclerosis</term><term>Anxiety</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Apathy</term><term>Cognition</term><term>Emotions</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>OBJECTIVE</b></p><p>Amyotrophic lateral sclerosis (ALS) is a fatal and progressive neurodegenerative disorder involving motor neurons of the cerebral cortex, brain stem and spinal cord. Besides the motor signs, cognitive disorders and apathy may be present and may impact the survival time. These elements are therefore to be taken into consideration for medical care because they can influence the disease evolution. The literature shows low psychopathological disorders in this population despite its poor prognosis. The main objective of this study is to explore the emotional feeling in apathetic and non-apathetic patients in relation to their anxiety and depressive symptoms.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>We included 152 patients at the day hospital for the follow-up of their illness, with an average age of 61±12.2 years. All filled the following self-administered questionnaires: EPN-31 (emotional feeling), HADS (for anxiety and depressive symptoms) and the Marin's apathy evaluation scale. Most of the patients (n=110) had also a cognitive assessment with the ALS-CBS scale.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>42% of patients could be considered as apathetic and they felt both positive and negative emotions whose frequency was related to the presence and intensity of anxiety and depressive symptoms. The only significant differences were that apathetic and anxious patients experienced more negative emotions including sadness, shame and anger than non-apathetic and anxious patients. Apathy was negatively correlated with cognitive functioning and survival time.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>These results highlighted the negative impact that apathy seemed to have on the evolution of this disease. However, apathetic patients didn't show emotional blunting and were able to name and feel positive and negative emotions; and even feel more negative emotions than non-apathetic patients when they were anxious. A better understanding of apathetic and no apathetic patients' emotional feelings should lead to a more personalized care for the ALS patients.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">30355543</PMID><DateCompleted><Year>2019</Year><Month>04</Month><Day>01</Day></DateCompleted><DateRevised><Year>2019</Year><Month>04</Month><Day>01</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">2115-7863</ISSN><JournalIssue CitedMedium="Internet"><Volume>16</Volume><Issue>4</Issue><PubDate><Year>2018</Year><Month>Dec</Month><Day>01</Day></PubDate></JournalIssue><Title>Geriatrie et psychologie neuropsychiatrie du vieillissement</Title><ISOAbbreviation>Geriatr Psychol Neuropsychiatr Vieil</ISOAbbreviation></Journal><ArticleTitle>Emotional feeling in patients suffering from amyotrophic lateral sclerosis.</ArticleTitle><Pagination><MedlinePgn>414-422</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1684/pnv.2018.0762</ELocationID><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">Amyotrophic lateral sclerosis (ALS) is a fatal and progressive neurodegenerative disorder involving motor neurons of the cerebral cortex, brain stem and spinal cord. Besides the motor signs, cognitive disorders and apathy may be present and may impact the survival time. These elements are therefore to be taken into consideration for medical care because they can influence the disease evolution. The literature shows low psychopathological disorders in this population despite its poor prognosis. The main objective of this study is to explore the emotional feeling in apathetic and non-apathetic patients in relation to their anxiety and depressive symptoms.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">We included 152 patients at the day hospital for the follow-up of their illness, with an average age of 61±12.2 years. All filled the following self-administered questionnaires: EPN-31 (emotional feeling), HADS (for anxiety and depressive symptoms) and the Marin's apathy evaluation scale. Most of the patients (n=110) had also a cognitive assessment with the ALS-CBS scale.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">42% of patients could be considered as apathetic and they felt both positive and negative emotions whose frequency was related to the presence and intensity of anxiety and depressive symptoms. The only significant differences were that apathetic and anxious patients experienced more negative emotions including sadness, shame and anger than non-apathetic and anxious patients. Apathy was negatively correlated with cognitive functioning and survival time.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">These results highlighted the negative impact that apathy seemed to have on the evolution of this disease. However, apathetic patients didn't show emotional blunting and were able to name and feel positive and negative emotions; and even feel more negative emotions than non-apathetic patients when they were anxious. A better understanding of apathetic and no apathetic patients' emotional feelings should lead to a more personalized care for the ALS patients.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Unglik</LastName><ForeName>Johanna</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Laboratoire de psychopathologie et processus de santé - EA 4057, Sorbonne-Paris-Cité, Université Paris-Descartes, Paris, France, Département de neurologie, Centre référent SLA, AP-HP, Hôpital Pitié-Salpêtrière, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bungener</LastName><ForeName>Catherine</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Laboratoire de psychopathologie et processus de santé - EA 4057, Sorbonne-Paris-Cité, Université Paris-Descartes, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Delgadillo</LastName><ForeName>Daniel</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Département de neurologie, Centre référent SLA, AP-HP, Hôpital Pitié-Salpêtrière, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Salachas</LastName><ForeName>François</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Département de neurologie, Centre référent SLA, AP-HP, Hôpital Pitié-Salpêtrière, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pradat</LastName><ForeName>Pierre François</ForeName><Initials>PF</Initials><AffiliationInfo><Affiliation>Département de neurologie, Centre référent SLA, AP-HP, Hôpital Pitié-Salpêtrière, Paris, France, CNRS, Inserm, Laboratoire d'imagerie biomédicale (LIB), Sorbonne Universités, UPMC Université Paris 06, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bruneteau</LastName><ForeName>Gaëlle</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Département de neurologie, Centre référent SLA, AP-HP, Hôpital Pitié-Salpêtrière, Paris, France, Inserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Université Paris 06, UMR S 1127, Institut du cerveau et de la moelle épinière, ICM, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lenglet</LastName><ForeName>Timothée</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Département de neurophysiologie clinique, AP-HP, Hôpital Pitié-Salpêtrière, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Le Forestier</LastName><ForeName>Nadine</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Département de neurologie, Centre référent SLA, AP-HP, Hôpital Pitié-Salpêtrière, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Couratier</LastName><ForeName>Philippe</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Département de neurologie, CHU, Hôpital Dupuytren, Limoges, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vacher</LastName><ForeName>Yannick</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Département de la recherche clinique et du développement, AP-HP, Hôpital Saint-Louis, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lacomblez</LastName><ForeName>Lucette</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Département de neurologie, Centre référent SLA, AP-HP, Hôpital Pitié-Salpêtrière, Paris, France, CNRS, Inserm, Laboratoire d'imagerie biomédicale (LIB), CIC-1422, Sorbonne Universités, UPMC Université Paris 06, Paris, France.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><VernacularTitle>Émotions ressenties chez des patients atteints de sclérose latérale amyotrophique.</VernacularTitle></Article><MedlineJournalInfo><Country>France</Country><MedlineTA>Geriatr Psychol Neuropsychiatr Vieil</MedlineTA><NlmUniqueID>101553404</NlmUniqueID><ISSNLinking>2115-7863</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>Geriatr Psychol Neuropsychiatr Vieil. 2018 Dec 1;16(4):398</RefSource><PMID Version="1">30563800</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000690" MajorTopicYN="N">Amyotrophic Lateral Sclerosis</DescriptorName><QualifierName UI="Q000523" MajorTopicYN="Y">psychology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001007" MajorTopicYN="N">Anxiety</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000523" MajorTopicYN="N">psychology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D057565" MajorTopicYN="N">Apathy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003071" MajorTopicYN="N">Cognition</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004644" MajorTopicYN="Y">Emotions</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009483" MajorTopicYN="N">Neuropsychological Tests</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">amyotrophic lateral sclerosis</Keyword><Keyword MajorTopicYN="N">anxiety</Keyword><Keyword MajorTopicYN="N">apathy</Keyword><Keyword MajorTopicYN="N">depressive symptoms</Keyword><Keyword MajorTopicYN="N">emotion</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2018</Year><Month>10</Month><Day>26</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2019</Year><Month>4</Month><Day>2</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2018</Year><Month>10</Month><Day>26</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">30355543</ArticleId><ArticleId IdType="pii">pnv.2018.0762</ArticleId><ArticleId IdType="doi">10.1684/pnv.2018.0762</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/AutomedicationFrancoV1/Data/Main/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000677 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Corpus/biblio.hfd -nk 000677 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= AutomedicationFrancoV1
|flux= Main
|étape= Corpus
|type= RBID
|clé= pubmed:30355543
|texte= Emotional feeling in patients suffering from amyotrophic lateral sclerosis.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Corpus/RBID.i -Sk "pubmed:30355543" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a AutomedicationFrancoV1
| This area was generated with Dilib version V0.6.38. |  |