ExploreASL: An image processing pipeline for multi-center ASL perfusion MRI studies.
Identifieur interne : 000146 ( Main/Corpus ); précédent : 000145; suivant : 000147ExploreASL: An image processing pipeline for multi-center ASL perfusion MRI studies.
Auteurs : Henk J M M. Mutsaerts ; Jan Petr ; Paul Groot ; Pieter Vandemaele ; Silvia Ingala ; Andrew D. Robertson ; Lena Václavů ; Inge Groote ; Hugo Kuijf ; Fernando Zelaya ; Owen O'Daly ; Saima Hilal ; Alle Meije Wink ; Ilse Kant ; Matthan W A. Caan ; Catherine Morgan ; Jeroen De Bresser ; Elisabeth Lysvik ; Anouk Schrantee ; Astrid Bj Rnebekk ; Patricia Clement ; Zahra Shirzadi ; Joost P A. Kuijer ; Viktor Wottschel ; Udunna C. Anazodo ; Dasja Pajkrt ; Edo Richard ; Reinoud P H. Bokkers ; Liesbeth Reneman ; Mario Masellis ; Matthias Günther ; Bradley J. Macintosh ; Eric Achten ; Michael A. Chappell ; Matthias J P. Van Osch ; Xavier Golay ; David L. Thomas ; Enrico De Vita ; Atle Bj Rnerud ; Aart Nederveen ; Jeroen Hendrikse ; Iris Asllani ; Frederik BarkhofSource :
- NeuroImage [ 1095-9572 ] ; 2020.
English descriptors
- KwdEn :
- MESH :
- chemical : Spin Labels.
- diagnostic imaging : Brain.
- methods : Image Processing, Computer-Assisted, Magnetic Resonance Angiography.
- physiology : Cerebrovascular Circulation.
- Algorithms, Humans, Reproducibility of Results, Signal-To-Noise Ratio, Software.
Abstract
Arterial spin labeling (ASL) has undergone significant development since its inception, with a focus on improving standardization and reproducibility of its acquisition and quantification. In a community-wide effort towards robust and reproducible clinical ASL image processing, we developed the software package ExploreASL, allowing standardized analyses across centers and scanners. The procedures used in ExploreASL capitalize on published image processing advancements and address the challenges of multi-center datasets with scanner-specific processing and artifact reduction to limit patient exclusion. ExploreASL is self-contained, written in MATLAB and based on Statistical Parameter Mapping (SPM) and runs on multiple operating systems. To facilitate collaboration and data-exchange, the toolbox follows several standards and recommendations for data structure, provenance, and best analysis practice. ExploreASL was iteratively refined and tested in the analysis of >10,000 ASL scans using different pulse-sequences in a variety of clinical populations, resulting in four processing modules: Import, Structural, ASL, and Population that perform tasks, respectively, for data curation, structural and ASL image processing and quality control, and finally preparing the results for statistical analyses on both single-subject and group level. We illustrate ExploreASL processing results from three cohorts: perinatally HIV-infected children, healthy adults, and elderly at risk for neurodegenerative disease. We show the reproducibility for each cohort when processed at different centers with different operating systems and MATLAB versions, and its effects on the quantification of gray matter cerebral blood flow. ExploreASL facilitates the standardization of image processing and quality control, allowing the pooling of cohorts which may increase statistical power and discover between-group perfusion differences. Ultimately, this workflow may advance ASL for wider adoption in clinical studies, trials, and practice.
DOI: 10.1016/j.neuroimage.2020.117031
PubMed: 32526385
Links to Exploration step
pubmed:32526385Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">ExploreASL: An image processing pipeline for multi-center ASL perfusion MRI studies.</title><author><name sortKey="Mutsaerts, Henk J M M" sort="Mutsaerts, Henk J M M" uniqKey="Mutsaerts H" first="Henk J M M" last="Mutsaerts">Henk J M M. Mutsaerts</name><affiliation><nlm:affiliation>Department of Radiology and Nuclear Medicine, Amsterdam Neuroscience, Amsterdam University Medical Center, Location VUmc, Amsterdam, the Netherlands; Radiology and Nuclear Medicine, Amsterdam Neuroscience, Amsterdam University Medical Centers, Location Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands; Radiology, University Medical Center Utrecht, Utrecht, the Netherlands; Kate Gleason College of Engineering, Rochester Institute of Technology, NY, USA; Ghent Institute for Functional and Metabolic Imaging (GIfMI), Ghent University, Ghent, Belgium. Electronic address: h.j.mutsaerts@amsterdamumc.nl.</nlm:affiliation></affiliation></author><author><name sortKey="Petr, Jan" sort="Petr, Jan" uniqKey="Petr J" first="Jan" last="Petr">Jan Petr</name><affiliation><nlm:affiliation>Kate Gleason College of Engineering, Rochester Institute of Technology, NY, USA; Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Dresden, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Groot, Paul" sort="Groot, Paul" uniqKey="Groot P" first="Paul" last="Groot">Paul Groot</name><affiliation><nlm:affiliation>Radiology and Nuclear Medicine, Amsterdam Neuroscience, Amsterdam University Medical Centers, Location Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Vandemaele, Pieter" sort="Vandemaele, Pieter" uniqKey="Vandemaele P" first="Pieter" last="Vandemaele">Pieter Vandemaele</name><affiliation><nlm:affiliation>Ghent Institute for Functional and Metabolic Imaging (GIfMI), Ghent University, Ghent, Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Ingala, Silvia" sort="Ingala, Silvia" uniqKey="Ingala S" first="Silvia" last="Ingala">Silvia Ingala</name><affiliation><nlm:affiliation>Department of Radiology and Nuclear Medicine, Amsterdam Neuroscience, Amsterdam University Medical Center, Location VUmc, Amsterdam, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Robertson, Andrew D" sort="Robertson, Andrew D" uniqKey="Robertson A" first="Andrew D" last="Robertson">Andrew D. Robertson</name><affiliation><nlm:affiliation>Schlegel-UW Research Institute for Aging, University of Waterloo, Waterloo, Ontario, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Vaclavu, Lena" sort="Vaclavu, Lena" uniqKey="Vaclavu L" first="Lena" last="Václavů">Lena Václavů</name><affiliation><nlm:affiliation>C.J. Gorter Center for High Field MRI, Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Groote, Inge" sort="Groote, Inge" uniqKey="Groote I" first="Inge" last="Groote">Inge Groote</name><affiliation><nlm:affiliation>Department of Diagnostic Physics, Oslo University Hospital, Oslo, Norway.</nlm:affiliation></affiliation></author><author><name sortKey="Kuijf, Hugo" sort="Kuijf, Hugo" uniqKey="Kuijf H" first="Hugo" last="Kuijf">Hugo Kuijf</name><affiliation><nlm:affiliation>Image Sciences Institute, University Medical Center Utrecht, Utrecht, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Zelaya, Fernando" sort="Zelaya, Fernando" uniqKey="Zelaya F" first="Fernando" last="Zelaya">Fernando Zelaya</name><affiliation><nlm:affiliation>Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="O Daly, Owen" sort="O Daly, Owen" uniqKey="O Daly O" first="Owen" last="O'Daly">Owen O'Daly</name><affiliation><nlm:affiliation>Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Hilal, Saima" sort="Hilal, Saima" uniqKey="Hilal S" first="Saima" last="Hilal">Saima Hilal</name><affiliation><nlm:affiliation>Department of Pharmacology, National University of Singapore, Singapore; Memory Aging and Cognition Center, National University Health System, Singapore; Saw Swee Hock School of Public Health, National University of Singapore, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Wink, Alle Meije" sort="Wink, Alle Meije" uniqKey="Wink A" first="Alle Meije" last="Wink">Alle Meije Wink</name><affiliation><nlm:affiliation>Department of Radiology and Nuclear Medicine, Amsterdam Neuroscience, Amsterdam University Medical Center, Location VUmc, Amsterdam, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Kant, Ilse" sort="Kant, Ilse" uniqKey="Kant I" first="Ilse" last="Kant">Ilse Kant</name><affiliation><nlm:affiliation>Radiology, University Medical Center Utrecht, Utrecht, the Netherlands; Department of Intensive Care, University Medical Centre, Utrecht, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Caan, Matthan W A" sort="Caan, Matthan W A" uniqKey="Caan M" first="Matthan W A" last="Caan">Matthan W A. Caan</name><affiliation><nlm:affiliation>Department of Biomedical Engineering and Physics, Amsterdam University Medical Center, Location Academic Medical Center, Amsterdam, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Morgan, Catherine" sort="Morgan, Catherine" uniqKey="Morgan C" first="Catherine" last="Morgan">Catherine Morgan</name><affiliation><nlm:affiliation>School of Psychology and Centre for Brain Research, University of Auckland, Auckland, New Zealand.</nlm:affiliation></affiliation></author><author><name sortKey="De Bresser, Jeroen" sort="De Bresser, Jeroen" uniqKey="De Bresser J" first="Jeroen" last="De Bresser">Jeroen De Bresser</name><affiliation><nlm:affiliation>Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Lysvik, Elisabeth" sort="Lysvik, Elisabeth" uniqKey="Lysvik E" first="Elisabeth" last="Lysvik">Elisabeth Lysvik</name><affiliation><nlm:affiliation>Department of Diagnostic Physics, Oslo University Hospital, Oslo, Norway.</nlm:affiliation></affiliation></author><author><name sortKey="Schrantee, Anouk" sort="Schrantee, Anouk" uniqKey="Schrantee A" first="Anouk" last="Schrantee">Anouk Schrantee</name><affiliation><nlm:affiliation>Radiology and Nuclear Medicine, Amsterdam Neuroscience, Amsterdam University Medical Centers, Location Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Bj Rnebekk, Astrid" sort="Bj Rnebekk, Astrid" uniqKey="Bj Rnebekk A" first="Astrid" last="Bj Rnebekk">Astrid Bj Rnebekk</name><affiliation><nlm:affiliation>The Anabolic Androgenic Steroid Research Group, National Advisory Unit on Substance Use Disorder Treatment, Oslo University Hospital, Oslo, Norway.</nlm:affiliation></affiliation></author><author><name sortKey="Clement, Patricia" sort="Clement, Patricia" uniqKey="Clement P" first="Patricia" last="Clement">Patricia Clement</name><affiliation><nlm:affiliation>Ghent Institute for Functional and Metabolic Imaging (GIfMI), Ghent University, Ghent, Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Shirzadi, Zahra" sort="Shirzadi, Zahra" uniqKey="Shirzadi Z" first="Zahra" last="Shirzadi">Zahra Shirzadi</name><affiliation><nlm:affiliation>Sunnybrook Research Institute, University of Toronto, Toronto, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Kuijer, Joost P A" sort="Kuijer, Joost P A" uniqKey="Kuijer J" first="Joost P A" last="Kuijer">Joost P A. Kuijer</name><affiliation><nlm:affiliation>Department of Radiology and Nuclear Medicine, Amsterdam Neuroscience, Amsterdam University Medical Center, Location VUmc, Amsterdam, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Wottschel, Viktor" sort="Wottschel, Viktor" uniqKey="Wottschel V" first="Viktor" last="Wottschel">Viktor Wottschel</name><affiliation><nlm:affiliation>Department of Radiology and Nuclear Medicine, Amsterdam Neuroscience, Amsterdam University Medical Center, Location VUmc, Amsterdam, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Anazodo, Udunna C" sort="Anazodo, Udunna C" uniqKey="Anazodo U" first="Udunna C" last="Anazodo">Udunna C. Anazodo</name><affiliation><nlm:affiliation>Department of Medical Biophysics, University of Western Ontario, London, Canada; Imaging Division, Lawson Health Research Institute, London, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Pajkrt, Dasja" sort="Pajkrt, Dasja" uniqKey="Pajkrt D" first="Dasja" last="Pajkrt">Dasja Pajkrt</name><affiliation><nlm:affiliation>Department of Pediatric Infectious Diseases, Emma Children's Hospital, Amsterdam University Medical Centre, Location Academic Medical Center, Amsterdam, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Richard, Edo" sort="Richard, Edo" uniqKey="Richard E" first="Edo" last="Richard">Edo Richard</name><affiliation><nlm:affiliation>Department of Neurology, Donders Institute for Brain, Behavior and Cognition, Radboud University Medical Centre, Nijmegen, the Netherlands; Neurology, Amsterdam University Medical Center, Location Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Bokkers, Reinoud P H" sort="Bokkers, Reinoud P H" uniqKey="Bokkers R" first="Reinoud P H" last="Bokkers">Reinoud P H. Bokkers</name><affiliation><nlm:affiliation>Department of Radiology, Medical Imaging Center, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Reneman, Liesbeth" sort="Reneman, Liesbeth" uniqKey="Reneman L" first="Liesbeth" last="Reneman">Liesbeth Reneman</name><affiliation><nlm:affiliation>Radiology and Nuclear Medicine, Amsterdam Neuroscience, Amsterdam University Medical Centers, Location Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Masellis, Mario" sort="Masellis, Mario" uniqKey="Masellis M" first="Mario" last="Masellis">Mario Masellis</name><affiliation><nlm:affiliation>Sunnybrook Research Institute, University of Toronto, Toronto, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Gunther, Matthias" sort="Gunther, Matthias" uniqKey="Gunther M" first="Matthias" last="Günther">Matthias Günther</name><affiliation><nlm:affiliation>Fraunhofer MEVIS, Bremen, Germany; University of Bremen, Bremen, Germany; Mediri GmbH, Heidelberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Macintosh, Bradley J" sort="Macintosh, Bradley J" uniqKey="Macintosh B" first="Bradley J" last="Macintosh">Bradley J. Macintosh</name><affiliation><nlm:affiliation>Sunnybrook Research Institute, University of Toronto, Toronto, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Achten, Eric" sort="Achten, Eric" uniqKey="Achten E" first="Eric" last="Achten">Eric Achten</name><affiliation><nlm:affiliation>Ghent Institute for Functional and Metabolic Imaging (GIfMI), Ghent University, Ghent, Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Chappell, Michael A" sort="Chappell, Michael A" uniqKey="Chappell M" first="Michael A" last="Chappell">Michael A. Chappell</name><affiliation><nlm:affiliation>Institute of Biomedical Engineering, Department of Engineering Science & Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neuroscience, University of Oxford, Oxford, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Van Osch, Matthias J P" sort="Van Osch, Matthias J P" uniqKey="Van Osch M" first="Matthias J P" last="Van Osch">Matthias J P. Van Osch</name><affiliation><nlm:affiliation>C.J. Gorter Center for High Field MRI, Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Golay, Xavier" sort="Golay, Xavier" uniqKey="Golay X" first="Xavier" last="Golay">Xavier Golay</name><affiliation><nlm:affiliation>UCL Queen Square Institute of Neurology, University College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Thomas, David L" sort="Thomas, David L" uniqKey="Thomas D" first="David L" last="Thomas">David L. Thomas</name><affiliation><nlm:affiliation>UCL Queen Square Institute of Neurology, University College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="De Vita, Enrico" sort="De Vita, Enrico" uniqKey="De Vita E" first="Enrico" last="De Vita">Enrico De Vita</name><affiliation><nlm:affiliation>Department of Biomedical Engineering, School of Biomedical Engineering & Imaging Sciences, King's College London, King's Health Partners, St Thomas' Hospital, London, SE1 7EH, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Bj Rnerud, Atle" sort="Bj Rnerud, Atle" uniqKey="Bj Rnerud A" first="Atle" last="Bj Rnerud">Atle Bj Rnerud</name><affiliation><nlm:affiliation>Department of Diagnostic Physics, Oslo University Hospital, Oslo, Norway; Department of Psychology, University of Oslo, Norway.</nlm:affiliation></affiliation></author><author><name sortKey="Nederveen, Aart" sort="Nederveen, Aart" uniqKey="Nederveen A" first="Aart" last="Nederveen">Aart Nederveen</name><affiliation><nlm:affiliation>Radiology and Nuclear Medicine, Amsterdam Neuroscience, Amsterdam University Medical Centers, Location Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Hendrikse, Jeroen" sort="Hendrikse, Jeroen" uniqKey="Hendrikse J" first="Jeroen" last="Hendrikse">Jeroen Hendrikse</name><affiliation><nlm:affiliation>Radiology, University Medical Center Utrecht, Utrecht, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Asllani, Iris" sort="Asllani, Iris" uniqKey="Asllani I" first="Iris" last="Asllani">Iris Asllani</name><affiliation><nlm:affiliation>Kate Gleason College of Engineering, Rochester Institute of Technology, NY, USA; Clinical Imaging Sciences Centre, Department of Neuroscience, Brighton and Sussex Medical School, Brighton, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Barkhof, Frederik" sort="Barkhof, Frederik" uniqKey="Barkhof F" first="Frederik" last="Barkhof">Frederik Barkhof</name><affiliation><nlm:affiliation>Department of Radiology and Nuclear Medicine, Amsterdam Neuroscience, Amsterdam University Medical Center, Location VUmc, Amsterdam, the Netherlands; UCL Queen Square Institute of Neurology, University College London, London, UK; Centre for Medical Image Computing (CMIC), Faculty of Engineering Science, University College London, London, UK.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32526385</idno><idno type="pmid">32526385</idno><idno type="doi">10.1016/j.neuroimage.2020.117031</idno><idno type="wicri:Area/Main/Corpus">000146</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000146</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">ExploreASL: An image processing pipeline for multi-center ASL perfusion MRI studies.</title><author><name sortKey="Mutsaerts, Henk J M M" sort="Mutsaerts, Henk J M M" uniqKey="Mutsaerts H" first="Henk J M M" last="Mutsaerts">Henk J M M. Mutsaerts</name><affiliation><nlm:affiliation>Department of Radiology and Nuclear Medicine, Amsterdam Neuroscience, Amsterdam University Medical Center, Location VUmc, Amsterdam, the Netherlands; Radiology and Nuclear Medicine, Amsterdam Neuroscience, Amsterdam University Medical Centers, Location Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands; Radiology, University Medical Center Utrecht, Utrecht, the Netherlands; Kate Gleason College of Engineering, Rochester Institute of Technology, NY, USA; Ghent Institute for Functional and Metabolic Imaging (GIfMI), Ghent University, Ghent, Belgium. Electronic address: h.j.mutsaerts@amsterdamumc.nl.</nlm:affiliation></affiliation></author><author><name sortKey="Petr, Jan" sort="Petr, Jan" uniqKey="Petr J" first="Jan" last="Petr">Jan Petr</name><affiliation><nlm:affiliation>Kate Gleason College of Engineering, Rochester Institute of Technology, NY, USA; Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Dresden, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Groot, Paul" sort="Groot, Paul" uniqKey="Groot P" first="Paul" last="Groot">Paul Groot</name><affiliation><nlm:affiliation>Radiology and Nuclear Medicine, Amsterdam Neuroscience, Amsterdam University Medical Centers, Location Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Vandemaele, Pieter" sort="Vandemaele, Pieter" uniqKey="Vandemaele P" first="Pieter" last="Vandemaele">Pieter Vandemaele</name><affiliation><nlm:affiliation>Ghent Institute for Functional and Metabolic Imaging (GIfMI), Ghent University, Ghent, Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Ingala, Silvia" sort="Ingala, Silvia" uniqKey="Ingala S" first="Silvia" last="Ingala">Silvia Ingala</name><affiliation><nlm:affiliation>Department of Radiology and Nuclear Medicine, Amsterdam Neuroscience, Amsterdam University Medical Center, Location VUmc, Amsterdam, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Robertson, Andrew D" sort="Robertson, Andrew D" uniqKey="Robertson A" first="Andrew D" last="Robertson">Andrew D. Robertson</name><affiliation><nlm:affiliation>Schlegel-UW Research Institute for Aging, University of Waterloo, Waterloo, Ontario, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Vaclavu, Lena" sort="Vaclavu, Lena" uniqKey="Vaclavu L" first="Lena" last="Václavů">Lena Václavů</name><affiliation><nlm:affiliation>C.J. Gorter Center for High Field MRI, Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Groote, Inge" sort="Groote, Inge" uniqKey="Groote I" first="Inge" last="Groote">Inge Groote</name><affiliation><nlm:affiliation>Department of Diagnostic Physics, Oslo University Hospital, Oslo, Norway.</nlm:affiliation></affiliation></author><author><name sortKey="Kuijf, Hugo" sort="Kuijf, Hugo" uniqKey="Kuijf H" first="Hugo" last="Kuijf">Hugo Kuijf</name><affiliation><nlm:affiliation>Image Sciences Institute, University Medical Center Utrecht, Utrecht, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Zelaya, Fernando" sort="Zelaya, Fernando" uniqKey="Zelaya F" first="Fernando" last="Zelaya">Fernando Zelaya</name><affiliation><nlm:affiliation>Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="O Daly, Owen" sort="O Daly, Owen" uniqKey="O Daly O" first="Owen" last="O'Daly">Owen O'Daly</name><affiliation><nlm:affiliation>Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Hilal, Saima" sort="Hilal, Saima" uniqKey="Hilal S" first="Saima" last="Hilal">Saima Hilal</name><affiliation><nlm:affiliation>Department of Pharmacology, National University of Singapore, Singapore; Memory Aging and Cognition Center, National University Health System, Singapore; Saw Swee Hock School of Public Health, National University of Singapore, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Wink, Alle Meije" sort="Wink, Alle Meije" uniqKey="Wink A" first="Alle Meije" last="Wink">Alle Meije Wink</name><affiliation><nlm:affiliation>Department of Radiology and Nuclear Medicine, Amsterdam Neuroscience, Amsterdam University Medical Center, Location VUmc, Amsterdam, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Kant, Ilse" sort="Kant, Ilse" uniqKey="Kant I" first="Ilse" last="Kant">Ilse Kant</name><affiliation><nlm:affiliation>Radiology, University Medical Center Utrecht, Utrecht, the Netherlands; Department of Intensive Care, University Medical Centre, Utrecht, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Caan, Matthan W A" sort="Caan, Matthan W A" uniqKey="Caan M" first="Matthan W A" last="Caan">Matthan W A. Caan</name><affiliation><nlm:affiliation>Department of Biomedical Engineering and Physics, Amsterdam University Medical Center, Location Academic Medical Center, Amsterdam, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Morgan, Catherine" sort="Morgan, Catherine" uniqKey="Morgan C" first="Catherine" last="Morgan">Catherine Morgan</name><affiliation><nlm:affiliation>School of Psychology and Centre for Brain Research, University of Auckland, Auckland, New Zealand.</nlm:affiliation></affiliation></author><author><name sortKey="De Bresser, Jeroen" sort="De Bresser, Jeroen" uniqKey="De Bresser J" first="Jeroen" last="De Bresser">Jeroen De Bresser</name><affiliation><nlm:affiliation>Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Lysvik, Elisabeth" sort="Lysvik, Elisabeth" uniqKey="Lysvik E" first="Elisabeth" last="Lysvik">Elisabeth Lysvik</name><affiliation><nlm:affiliation>Department of Diagnostic Physics, Oslo University Hospital, Oslo, Norway.</nlm:affiliation></affiliation></author><author><name sortKey="Schrantee, Anouk" sort="Schrantee, Anouk" uniqKey="Schrantee A" first="Anouk" last="Schrantee">Anouk Schrantee</name><affiliation><nlm:affiliation>Radiology and Nuclear Medicine, Amsterdam Neuroscience, Amsterdam University Medical Centers, Location Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Bj Rnebekk, Astrid" sort="Bj Rnebekk, Astrid" uniqKey="Bj Rnebekk A" first="Astrid" last="Bj Rnebekk">Astrid Bj Rnebekk</name><affiliation><nlm:affiliation>The Anabolic Androgenic Steroid Research Group, National Advisory Unit on Substance Use Disorder Treatment, Oslo University Hospital, Oslo, Norway.</nlm:affiliation></affiliation></author><author><name sortKey="Clement, Patricia" sort="Clement, Patricia" uniqKey="Clement P" first="Patricia" last="Clement">Patricia Clement</name><affiliation><nlm:affiliation>Ghent Institute for Functional and Metabolic Imaging (GIfMI), Ghent University, Ghent, Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Shirzadi, Zahra" sort="Shirzadi, Zahra" uniqKey="Shirzadi Z" first="Zahra" last="Shirzadi">Zahra Shirzadi</name><affiliation><nlm:affiliation>Sunnybrook Research Institute, University of Toronto, Toronto, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Kuijer, Joost P A" sort="Kuijer, Joost P A" uniqKey="Kuijer J" first="Joost P A" last="Kuijer">Joost P A. Kuijer</name><affiliation><nlm:affiliation>Department of Radiology and Nuclear Medicine, Amsterdam Neuroscience, Amsterdam University Medical Center, Location VUmc, Amsterdam, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Wottschel, Viktor" sort="Wottschel, Viktor" uniqKey="Wottschel V" first="Viktor" last="Wottschel">Viktor Wottschel</name><affiliation><nlm:affiliation>Department of Radiology and Nuclear Medicine, Amsterdam Neuroscience, Amsterdam University Medical Center, Location VUmc, Amsterdam, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Anazodo, Udunna C" sort="Anazodo, Udunna C" uniqKey="Anazodo U" first="Udunna C" last="Anazodo">Udunna C. Anazodo</name><affiliation><nlm:affiliation>Department of Medical Biophysics, University of Western Ontario, London, Canada; Imaging Division, Lawson Health Research Institute, London, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Pajkrt, Dasja" sort="Pajkrt, Dasja" uniqKey="Pajkrt D" first="Dasja" last="Pajkrt">Dasja Pajkrt</name><affiliation><nlm:affiliation>Department of Pediatric Infectious Diseases, Emma Children's Hospital, Amsterdam University Medical Centre, Location Academic Medical Center, Amsterdam, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Richard, Edo" sort="Richard, Edo" uniqKey="Richard E" first="Edo" last="Richard">Edo Richard</name><affiliation><nlm:affiliation>Department of Neurology, Donders Institute for Brain, Behavior and Cognition, Radboud University Medical Centre, Nijmegen, the Netherlands; Neurology, Amsterdam University Medical Center, Location Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Bokkers, Reinoud P H" sort="Bokkers, Reinoud P H" uniqKey="Bokkers R" first="Reinoud P H" last="Bokkers">Reinoud P H. Bokkers</name><affiliation><nlm:affiliation>Department of Radiology, Medical Imaging Center, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Reneman, Liesbeth" sort="Reneman, Liesbeth" uniqKey="Reneman L" first="Liesbeth" last="Reneman">Liesbeth Reneman</name><affiliation><nlm:affiliation>Radiology and Nuclear Medicine, Amsterdam Neuroscience, Amsterdam University Medical Centers, Location Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Masellis, Mario" sort="Masellis, Mario" uniqKey="Masellis M" first="Mario" last="Masellis">Mario Masellis</name><affiliation><nlm:affiliation>Sunnybrook Research Institute, University of Toronto, Toronto, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Gunther, Matthias" sort="Gunther, Matthias" uniqKey="Gunther M" first="Matthias" last="Günther">Matthias Günther</name><affiliation><nlm:affiliation>Fraunhofer MEVIS, Bremen, Germany; University of Bremen, Bremen, Germany; Mediri GmbH, Heidelberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Macintosh, Bradley J" sort="Macintosh, Bradley J" uniqKey="Macintosh B" first="Bradley J" last="Macintosh">Bradley J. Macintosh</name><affiliation><nlm:affiliation>Sunnybrook Research Institute, University of Toronto, Toronto, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Achten, Eric" sort="Achten, Eric" uniqKey="Achten E" first="Eric" last="Achten">Eric Achten</name><affiliation><nlm:affiliation>Ghent Institute for Functional and Metabolic Imaging (GIfMI), Ghent University, Ghent, Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Chappell, Michael A" sort="Chappell, Michael A" uniqKey="Chappell M" first="Michael A" last="Chappell">Michael A. Chappell</name><affiliation><nlm:affiliation>Institute of Biomedical Engineering, Department of Engineering Science & Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neuroscience, University of Oxford, Oxford, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Van Osch, Matthias J P" sort="Van Osch, Matthias J P" uniqKey="Van Osch M" first="Matthias J P" last="Van Osch">Matthias J P. Van Osch</name><affiliation><nlm:affiliation>C.J. Gorter Center for High Field MRI, Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Golay, Xavier" sort="Golay, Xavier" uniqKey="Golay X" first="Xavier" last="Golay">Xavier Golay</name><affiliation><nlm:affiliation>UCL Queen Square Institute of Neurology, University College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Thomas, David L" sort="Thomas, David L" uniqKey="Thomas D" first="David L" last="Thomas">David L. Thomas</name><affiliation><nlm:affiliation>UCL Queen Square Institute of Neurology, University College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="De Vita, Enrico" sort="De Vita, Enrico" uniqKey="De Vita E" first="Enrico" last="De Vita">Enrico De Vita</name><affiliation><nlm:affiliation>Department of Biomedical Engineering, School of Biomedical Engineering & Imaging Sciences, King's College London, King's Health Partners, St Thomas' Hospital, London, SE1 7EH, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Bj Rnerud, Atle" sort="Bj Rnerud, Atle" uniqKey="Bj Rnerud A" first="Atle" last="Bj Rnerud">Atle Bj Rnerud</name><affiliation><nlm:affiliation>Department of Diagnostic Physics, Oslo University Hospital, Oslo, Norway; Department of Psychology, University of Oslo, Norway.</nlm:affiliation></affiliation></author><author><name sortKey="Nederveen, Aart" sort="Nederveen, Aart" uniqKey="Nederveen A" first="Aart" last="Nederveen">Aart Nederveen</name><affiliation><nlm:affiliation>Radiology and Nuclear Medicine, Amsterdam Neuroscience, Amsterdam University Medical Centers, Location Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Hendrikse, Jeroen" sort="Hendrikse, Jeroen" uniqKey="Hendrikse J" first="Jeroen" last="Hendrikse">Jeroen Hendrikse</name><affiliation><nlm:affiliation>Radiology, University Medical Center Utrecht, Utrecht, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Asllani, Iris" sort="Asllani, Iris" uniqKey="Asllani I" first="Iris" last="Asllani">Iris Asllani</name><affiliation><nlm:affiliation>Kate Gleason College of Engineering, Rochester Institute of Technology, NY, USA; Clinical Imaging Sciences Centre, Department of Neuroscience, Brighton and Sussex Medical School, Brighton, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Barkhof, Frederik" sort="Barkhof, Frederik" uniqKey="Barkhof F" first="Frederik" last="Barkhof">Frederik Barkhof</name><affiliation><nlm:affiliation>Department of Radiology and Nuclear Medicine, Amsterdam Neuroscience, Amsterdam University Medical Center, Location VUmc, Amsterdam, the Netherlands; UCL Queen Square Institute of Neurology, University College London, London, UK; Centre for Medical Image Computing (CMIC), Faculty of Engineering Science, University College London, London, UK.</nlm:affiliation></affiliation></author></analytic><series><title level="j">NeuroImage</title><idno type="eISSN">1095-9572</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Algorithms (MeSH)</term><term>Brain (diagnostic imaging)</term><term>Cerebrovascular Circulation (physiology)</term><term>Humans (MeSH)</term><term>Image Processing, Computer-Assisted (methods)</term><term>Magnetic Resonance Angiography (methods)</term><term>Reproducibility of Results (MeSH)</term><term>Signal-To-Noise Ratio (MeSH)</term><term>Software (MeSH)</term><term>Spin Labels (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Spin Labels</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Brain</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Image Processing, Computer-Assisted</term><term>Magnetic Resonance Angiography</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Cerebrovascular Circulation</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Algorithms</term><term>Humans</term><term>Reproducibility of Results</term><term>Signal-To-Noise Ratio</term><term>Software</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Arterial spin labeling (ASL) has undergone significant development since its inception, with a focus on improving standardization and reproducibility of its acquisition and quantification. In a community-wide effort towards robust and reproducible clinical ASL image processing, we developed the software package ExploreASL, allowing standardized analyses across centers and scanners. The procedures used in ExploreASL capitalize on published image processing advancements and address the challenges of multi-center datasets with scanner-specific processing and artifact reduction to limit patient exclusion. ExploreASL is self-contained, written in MATLAB and based on Statistical Parameter Mapping (SPM) and runs on multiple operating systems. To facilitate collaboration and data-exchange, the toolbox follows several standards and recommendations for data structure, provenance, and best analysis practice. ExploreASL was iteratively refined and tested in the analysis of >10,000 ASL scans using different pulse-sequences in a variety of clinical populations, resulting in four processing modules: Import, Structural, ASL, and Population that perform tasks, respectively, for data curation, structural and ASL image processing and quality control, and finally preparing the results for statistical analyses on both single-subject and group level. We illustrate ExploreASL processing results from three cohorts: perinatally HIV-infected children, healthy adults, and elderly at risk for neurodegenerative disease. We show the reproducibility for each cohort when processed at different centers with different operating systems and MATLAB versions, and its effects on the quantification of gray matter cerebral blood flow. ExploreASL facilitates the standardization of image processing and quality control, allowing the pooling of cohorts which may increase statistical power and discover between-group perfusion differences. Ultimately, this workflow may advance ASL for wider adoption in clinical studies, trials, and practice.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32526385</PMID><DateCompleted><Year>2021</Year><Month>02</Month><Day>23</Day></DateCompleted><DateRevised><Year>2021</Year><Month>02</Month><Day>23</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1095-9572</ISSN><JournalIssue CitedMedium="Internet"><Volume>219</Volume><PubDate><Year>2020</Year><Month>10</Month><Day>01</Day></PubDate></JournalIssue><Title>NeuroImage</Title><ISOAbbreviation>Neuroimage</ISOAbbreviation></Journal><ArticleTitle>ExploreASL: An image processing pipeline for multi-center ASL perfusion MRI studies.</ArticleTitle><Pagination><MedlinePgn>117031</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S1053-8119(20)30517-6</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.neuroimage.2020.117031</ELocationID><Abstract><AbstractText>Arterial spin labeling (ASL) has undergone significant development since its inception, with a focus on improving standardization and reproducibility of its acquisition and quantification. In a community-wide effort towards robust and reproducible clinical ASL image processing, we developed the software package ExploreASL, allowing standardized analyses across centers and scanners. The procedures used in ExploreASL capitalize on published image processing advancements and address the challenges of multi-center datasets with scanner-specific processing and artifact reduction to limit patient exclusion. ExploreASL is self-contained, written in MATLAB and based on Statistical Parameter Mapping (SPM) and runs on multiple operating systems. To facilitate collaboration and data-exchange, the toolbox follows several standards and recommendations for data structure, provenance, and best analysis practice. ExploreASL was iteratively refined and tested in the analysis of >10,000 ASL scans using different pulse-sequences in a variety of clinical populations, resulting in four processing modules: Import, Structural, ASL, and Population that perform tasks, respectively, for data curation, structural and ASL image processing and quality control, and finally preparing the results for statistical analyses on both single-subject and group level. We illustrate ExploreASL processing results from three cohorts: perinatally HIV-infected children, healthy adults, and elderly at risk for neurodegenerative disease. We show the reproducibility for each cohort when processed at different centers with different operating systems and MATLAB versions, and its effects on the quantification of gray matter cerebral blood flow. ExploreASL facilitates the standardization of image processing and quality control, allowing the pooling of cohorts which may increase statistical power and discover between-group perfusion differences. Ultimately, this workflow may advance ASL for wider adoption in clinical studies, trials, and practice.</AbstractText><CopyrightInformation>Copyright © 2020. Published by Elsevier Inc.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Mutsaerts</LastName><ForeName>Henk J M M</ForeName><Initials>HJMM</Initials><AffiliationInfo><Affiliation>Department of Radiology and Nuclear Medicine, Amsterdam Neuroscience, Amsterdam University Medical Center, Location VUmc, Amsterdam, the Netherlands; Radiology and Nuclear Medicine, Amsterdam Neuroscience, Amsterdam University Medical Centers, Location Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands; Radiology, University Medical Center Utrecht, Utrecht, the Netherlands; Kate Gleason College of Engineering, Rochester Institute of Technology, NY, USA; Ghent Institute for Functional and Metabolic Imaging (GIfMI), Ghent University, Ghent, Belgium. Electronic address: h.j.mutsaerts@amsterdamumc.nl.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Petr</LastName><ForeName>Jan</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Kate Gleason College of Engineering, Rochester Institute of Technology, NY, USA; Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Dresden, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Groot</LastName><ForeName>Paul</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Radiology and Nuclear Medicine, Amsterdam Neuroscience, Amsterdam University Medical Centers, Location Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vandemaele</LastName><ForeName>Pieter</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Ghent Institute for Functional and Metabolic Imaging (GIfMI), Ghent University, Ghent, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ingala</LastName><ForeName>Silvia</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Radiology and Nuclear Medicine, Amsterdam Neuroscience, Amsterdam University Medical Center, Location VUmc, Amsterdam, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Robertson</LastName><ForeName>Andrew D</ForeName><Initials>AD</Initials><AffiliationInfo><Affiliation>Schlegel-UW Research Institute for Aging, University of Waterloo, Waterloo, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Václavů</LastName><ForeName>Lena</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>C.J. Gorter Center for High Field MRI, Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Groote</LastName><ForeName>Inge</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Department of Diagnostic Physics, Oslo University Hospital, Oslo, Norway.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kuijf</LastName><ForeName>Hugo</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Image Sciences Institute, University Medical Center Utrecht, Utrecht, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zelaya</LastName><ForeName>Fernando</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>O'Daly</LastName><ForeName>Owen</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hilal</LastName><ForeName>Saima</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Pharmacology, National University of Singapore, Singapore; Memory Aging and Cognition Center, National University Health System, Singapore; Saw Swee Hock School of Public Health, National University of Singapore, Singapore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wink</LastName><ForeName>Alle Meije</ForeName><Initials>AM</Initials><AffiliationInfo><Affiliation>Department of Radiology and Nuclear Medicine, Amsterdam Neuroscience, Amsterdam University Medical Center, Location VUmc, Amsterdam, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kant</LastName><ForeName>Ilse</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Radiology, University Medical Center Utrecht, Utrecht, the Netherlands; Department of Intensive Care, University Medical Centre, Utrecht, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Caan</LastName><ForeName>Matthan W A</ForeName><Initials>MWA</Initials><AffiliationInfo><Affiliation>Department of Biomedical Engineering and Physics, Amsterdam University Medical Center, Location Academic Medical Center, Amsterdam, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Morgan</LastName><ForeName>Catherine</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>School of Psychology and Centre for Brain Research, University of Auckland, Auckland, New Zealand.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>de Bresser</LastName><ForeName>Jeroen</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lysvik</LastName><ForeName>Elisabeth</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Diagnostic Physics, Oslo University Hospital, Oslo, Norway.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schrantee</LastName><ForeName>Anouk</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Radiology and Nuclear Medicine, Amsterdam Neuroscience, Amsterdam University Medical Centers, Location Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bjørnebekk</LastName><ForeName>Astrid</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>The Anabolic Androgenic Steroid Research Group, National Advisory Unit on Substance Use Disorder Treatment, Oslo University Hospital, Oslo, Norway.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Clement</LastName><ForeName>Patricia</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Ghent Institute for Functional and Metabolic Imaging (GIfMI), Ghent University, Ghent, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shirzadi</LastName><ForeName>Zahra</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Sunnybrook Research Institute, University of Toronto, Toronto, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kuijer</LastName><ForeName>Joost P A</ForeName><Initials>JPA</Initials><AffiliationInfo><Affiliation>Department of Radiology and Nuclear Medicine, Amsterdam Neuroscience, Amsterdam University Medical Center, Location VUmc, Amsterdam, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wottschel</LastName><ForeName>Viktor</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Department of Radiology and Nuclear Medicine, Amsterdam Neuroscience, Amsterdam University Medical Center, Location VUmc, Amsterdam, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Anazodo</LastName><ForeName>Udunna C</ForeName><Initials>UC</Initials><AffiliationInfo><Affiliation>Department of Medical Biophysics, University of Western Ontario, London, Canada; Imaging Division, Lawson Health Research Institute, London, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pajkrt</LastName><ForeName>Dasja</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Pediatric Infectious Diseases, Emma Children's Hospital, Amsterdam University Medical Centre, Location Academic Medical Center, Amsterdam, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Richard</LastName><ForeName>Edo</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Neurology, Donders Institute for Brain, Behavior and Cognition, Radboud University Medical Centre, Nijmegen, the Netherlands; Neurology, Amsterdam University Medical Center, Location Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bokkers</LastName><ForeName>Reinoud P H</ForeName><Initials>RPH</Initials><AffiliationInfo><Affiliation>Department of Radiology, Medical Imaging Center, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Reneman</LastName><ForeName>Liesbeth</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Radiology and Nuclear Medicine, Amsterdam Neuroscience, Amsterdam University Medical Centers, Location Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Masellis</LastName><ForeName>Mario</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Sunnybrook Research Institute, University of Toronto, Toronto, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Günther</LastName><ForeName>Matthias</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Fraunhofer MEVIS, Bremen, Germany; University of Bremen, Bremen, Germany; Mediri GmbH, Heidelberg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>MacIntosh</LastName><ForeName>Bradley J</ForeName><Initials>BJ</Initials><AffiliationInfo><Affiliation>Sunnybrook Research Institute, University of Toronto, Toronto, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Achten</LastName><ForeName>Eric</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Ghent Institute for Functional and Metabolic Imaging (GIfMI), Ghent University, Ghent, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chappell</LastName><ForeName>Michael A</ForeName><Initials>MA</Initials><AffiliationInfo><Affiliation>Institute of Biomedical Engineering, Department of Engineering Science & Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neuroscience, University of Oxford, Oxford, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>van Osch</LastName><ForeName>Matthias J P</ForeName><Initials>MJP</Initials><AffiliationInfo><Affiliation>C.J. Gorter Center for High Field MRI, Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Golay</LastName><ForeName>Xavier</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>UCL Queen Square Institute of Neurology, University College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Thomas</LastName><ForeName>David L</ForeName><Initials>DL</Initials><AffiliationInfo><Affiliation>UCL Queen Square Institute of Neurology, University College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>De Vita</LastName><ForeName>Enrico</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Biomedical Engineering, School of Biomedical Engineering & Imaging Sciences, King's College London, King's Health Partners, St Thomas' Hospital, London, SE1 7EH, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bjørnerud</LastName><ForeName>Atle</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Diagnostic Physics, Oslo University Hospital, Oslo, Norway; Department of Psychology, University of Oslo, Norway.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nederveen</LastName><ForeName>Aart</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Radiology and Nuclear Medicine, Amsterdam Neuroscience, Amsterdam University Medical Centers, Location Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hendrikse</LastName><ForeName>Jeroen</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Radiology, University Medical Center Utrecht, Utrecht, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Asllani</LastName><ForeName>Iris</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Kate Gleason College of Engineering, Rochester Institute of Technology, NY, USA; Clinical Imaging Sciences Centre, Department of Neuroscience, Brighton and Sussex Medical School, Brighton, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Barkhof</LastName><ForeName>Frederik</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Department of Radiology and Nuclear Medicine, Amsterdam Neuroscience, Amsterdam University Medical Center, Location VUmc, Amsterdam, the Netherlands; UCL Queen Square Institute of Neurology, University College London, London, UK; Centre for Medical Image Computing (CMIC), Faculty of Engineering Science, University College London, London, UK.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><Acronym>DH_</Acronym><Agency>Department of Health</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>WT 203148/Z/16/Z</GrantID><Acronym>WT_</Acronym><Agency>Wellcome Trust</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>203139/Z/16/Z</GrantID><Acronym>WT_</Acronym><Agency>Wellcome Trust</Agency><Country>United Kingdom</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>06</Month><Day>08</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Neuroimage</MedlineTA><NlmUniqueID>9215515</NlmUniqueID><ISSNLinking>1053-8119</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D013113">Spin Labels</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000465" MajorTopicYN="N">Algorithms</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001921" MajorTopicYN="N">Brain</DescriptorName><QualifierName UI="Q000000981" MajorTopicYN="Y">diagnostic imaging</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002560" MajorTopicYN="N">Cerebrovascular Circulation</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007091" MajorTopicYN="N">Image Processing, Computer-Assisted</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018810" MajorTopicYN="N">Magnetic Resonance Angiography</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015203" MajorTopicYN="N">Reproducibility of Results</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D059629" MajorTopicYN="N">Signal-To-Noise Ratio</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012984" MajorTopicYN="N">Software</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013113" MajorTopicYN="N">Spin Labels</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Arterial spin labeling</Keyword><Keyword MajorTopicYN="Y">Cerebral perfusion</Keyword><Keyword MajorTopicYN="Y">Image processing</Keyword><Keyword MajorTopicYN="Y">Multi-center</Keyword><Keyword MajorTopicYN="Y">Quality control</Keyword></KeywordList><CoiStatement>Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2019</Year><Month>12</Month><Day>20</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2020</Year><Month>05</Month><Day>29</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>06</Month><Day>04</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>6</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2021</Year><Month>2</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>6</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32526385</ArticleId><ArticleId IdType="pii">S1053-8119(20)30517-6</ArticleId><ArticleId IdType="doi">10.1016/j.neuroimage.2020.117031</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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