Sci Rep (2015) Bi

Highly Pathogenic Avian Influenza A(H5N1) Virus Struck Migratory Birds in China in 2015.

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Authors Yuhai Bi(1), Zhenjie Zhang(2), Wenjun Liu(3), Yanbo Yin(4), Jianmin Hong(5), Xiangdong Li(6), Haiming Wang(7), Gary Wong(8), Jianjun Chen(9), Yunfeng Li(10), Wendong Ru(10), Ruyi Gao(10), Di Liu(3), Yingxia Liu(11), Boping Zhou(11), George F. Gao(12), Weifeng Shi(2), Fumin Lei(13) Affiliations (1) 1] CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China [2] Shenzhen Key Laboratory of Pathogen and Immunity, Shenzhen Third People's Hospital, Shenzhen 518112, China [3] Center for Influenza Research and Early-warning (CASCIRE), Chinese Academy of Sciences, Beijing 100101, China. (10) National Urban Wetland Park of Sanmenxia Swan Lake, Sanmenxia 472000, China. (11) Shenzhen Key Laboratory of Pathogen and Immunity, Shenzhen Third People's Hospital, Shenzhen 518112, China. (12) 1] CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China [2] Shenzhen Key Laboratory of Pathogen and Immunity, Shenzhen Third People's Hospital, Shenzhen 518112, China [3] Center for Influenza Research and Early-warning (CASCIRE), Chinese Academy of Sciences, Beijing 100101, China [4] Collaborative Innovation Center for Diagnosis and Treatment of Infectious disease, Zhejiang University, Hanzhou 310003, China. (13) 1] CAS Key Laboratory of Zoological Systematics and Evolution, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China [2] Center for Influenza Research and Early-warning (CASCIRE), Chinese Academy of Sciences, Beijing 100101, China. (2) Institute of Pathogen Biology, Taishan Medical College, Taian 271016, China. (3) 1] CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China [2] Center for Influenza Research and Early-warning (CASCIRE), Chinese Academy of Sciences, Beijing 100101, China. (4) College of Animal Science and Veterinary Medicine, Qingdao Agricultural University, Qingdao 266109, China. (5) Beijing Key Laboratory of Plant Genetic Resources and Low-carbon Environmental Biotechnology, Capital Normal University, Beijing 100048, China. (6) State Key Laboratory for Agrobiotechnology, China Agricultural University, Beijing 100193, China. (7) College of Animal Science and Veterinary Medicine, Shandong Agricultural University, Taian 271018, China. (8) CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China. (9) 1] Center for Influenza Research and Early-warning (CASCIRE), Chinese Academy of Sciences, Beijing 100101, China [2] CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China. In Scientific reports, (2015) On line

Abstract

Approximately 100 migratory birds, including whooper swans and pochards, were found dead in the Sanmenxia Reservoir Area of China during January 2015. The causative agent behind this outbreak was identified as H5N1 highly pathogenic avian influenza virus (HPAIV). Genetic and phylogenetic analyses revealed that this Sanmenxia H5N1 virus was a novel reassortant, possessing a Clade 2.3.2.1c HA gene and a H9N2-derived PB2 gene. Sanmenxia Clade 2.3.2.1c-like H5N1 viruses possess the closest genetic identity to A/Alberta/01/2014 (H5N1), which recently caused a fatal respiratory infection in Canada with signs of meningoencephalitis, a highly unusual symptom with influenza infections in humans. Furthermore, this virus was shown to be highly pathogenic to both birds and mammals, and demonstrate tropism for the nervous system. Due to the geographical location of Sanmenxia, these novel H5N1 viruses also have the potential to be imported to other regions through the migration of wild birds, similar to the H5N1 outbreak amongst migratory birds in Qinghai Lake during 2005. Therefore, further investigation and monitoring is required to prevent this novel reassortant virus from becoming a new threat to public health.

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External links

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