A Randomized Clinical Trial of Behavioral Activation (BA) Therapy for Improving Psychological and Physical Health in Dementia Caregivers: Results of the Pleasant Events Program (PEP)
Identifieur interne : 000265 ( Pmc/Corpus ); précédent : 000264; suivant : 000266A Randomized Clinical Trial of Behavioral Activation (BA) Therapy for Improving Psychological and Physical Health in Dementia Caregivers: Results of the Pleasant Events Program (PEP)
Auteurs : Raeanne C. Moore ; Elizabeth A. Chattillion ; Jennifer Ceglowski ; Jennifer Ho ; Roland Von K Nel ; Paul J. Mills ; Michael G. Ziegler ; Thomas L. Patterson ; Igor Grant ; Brent T. MausbachSource :
- Behaviour research and therapy [ 0005-7967 ] ; 2013.
Abstract
Dementia caregiving is associated with elevations in depressive symptoms and increased risk for cardiovascular diseases (CVD). This study evaluated the efficacy of the Pleasant Events Program (PEP), a 6-week Behavioral Activation intervention designed to reduce CVD risk and depressive symptoms in caregivers. One hundred dementia family caregivers were randomized to either the 6-week PEP intervention (N=49) or a time-equivalent Information-Support (IS) control condition (N=51). Assessments were completed pre- and post-intervention and at 1-year follow-up. Biological assessments included CVD risk markers Interleukin-6 (IL-6) and D-dimer. Psychosocial outcomes included depressive symptoms, positive affect, and negative affect. Participants receiving the PEP intervention had significantly greater reductions in IL-6 (p=.040), depressive symptoms (p=.039), and negative affect (p=.021) from pre- to post-treatment. For IL-6, clinically significant improvement was observed in 20.0% of PEP participants and 6.5% of IS participants. For depressive symptoms, clinically significant improvement was found for 32.7% of PEP vs 11.8% of IS participants. Group differences in change from baseline to 1-year follow-up were non-significant for all outcomes. The PEP program decreased depression and improved a measure of physiological health in older dementia caregivers. Future research should examine the efficacy of PEP for improving other CVD biomarkers and seek to sustain the intervention’s effects.
Url:
DOI: 10.1016/j.brat.2013.07.005
PubMed: 23916631
PubMed Central: 3774137
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Chattillion</name><affiliation><nlm:aff id="A3">San Diego State University/University of California, San Diego, Joint Doctoral Program in Clinical Psychology</nlm:aff></affiliation></author><author><name sortKey="Ceglowski, Jennifer" sort="Ceglowski, Jennifer" uniqKey="Ceglowski J" first="Jennifer" last="Ceglowski">Jennifer Ceglowski</name><affiliation><nlm:aff id="A1">Department of Psychiatry, University of California San Diego</nlm:aff></affiliation></author><author><name sortKey="Ho, Jennifer" sort="Ho, Jennifer" uniqKey="Ho J" first="Jennifer" last="Ho">Jennifer Ho</name><affiliation><nlm:aff id="A3">San Diego State University/University of California, San Diego, Joint Doctoral Program in Clinical Psychology</nlm:aff></affiliation></author><author><name sortKey="Von K Nel, Roland" sort="Von K Nel, Roland" uniqKey="Von K Nel R" first="Roland" last="Von K Nel">Roland Von K Nel</name><affiliation><nlm:aff id="A1">Department of Psychiatry, University of California San Diego</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Division of Psychosomatic Medicine, Department of General Internal Medicine, Inselspital, Bern University Hospital and University of Bern, Switzerland</nlm:aff></affiliation><affiliation><nlm:aff id="A5">Department of Clinical Research, University of Bern, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Mills, Paul J" sort="Mills, Paul J" uniqKey="Mills P" first="Paul J" last="Mills">Paul J. 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Moore</name><affiliation><nlm:aff id="A1">Department of Psychiatry, University of California San Diego</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Sam and Rose Stein Institute for Research on Aging, University of California San Diego</nlm:aff></affiliation></author><author><name sortKey="Chattillion, Elizabeth A" sort="Chattillion, Elizabeth A" uniqKey="Chattillion E" first="Elizabeth A" last="Chattillion">Elizabeth A. Chattillion</name><affiliation><nlm:aff id="A3">San Diego State University/University of California, San Diego, Joint Doctoral Program in Clinical Psychology</nlm:aff></affiliation></author><author><name sortKey="Ceglowski, Jennifer" sort="Ceglowski, Jennifer" uniqKey="Ceglowski J" first="Jennifer" last="Ceglowski">Jennifer Ceglowski</name><affiliation><nlm:aff id="A1">Department of Psychiatry, University of California San Diego</nlm:aff></affiliation></author><author><name sortKey="Ho, Jennifer" sort="Ho, Jennifer" uniqKey="Ho J" first="Jennifer" last="Ho">Jennifer Ho</name><affiliation><nlm:aff id="A3">San Diego State University/University of California, San Diego, Joint Doctoral Program in Clinical Psychology</nlm:aff></affiliation></author><author><name sortKey="Von K Nel, Roland" sort="Von K Nel, Roland" uniqKey="Von K Nel R" first="Roland" last="Von K Nel">Roland Von K Nel</name><affiliation><nlm:aff id="A1">Department of Psychiatry, University of California San Diego</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Division of Psychosomatic Medicine, Department of General Internal Medicine, Inselspital, Bern University Hospital and University of Bern, Switzerland</nlm:aff></affiliation><affiliation><nlm:aff id="A5">Department of Clinical Research, University of Bern, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Mills, Paul J" sort="Mills, Paul J" uniqKey="Mills P" first="Paul J" last="Mills">Paul J. 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Patterson</name><affiliation><nlm:aff id="A1">Department of Psychiatry, University of California San Diego</nlm:aff></affiliation></author><author><name sortKey="Grant, Igor" sort="Grant, Igor" uniqKey="Grant I" first="Igor" last="Grant">Igor Grant</name><affiliation><nlm:aff id="A1">Department of Psychiatry, University of California San Diego</nlm:aff></affiliation></author><author><name sortKey="Mausbach, Brent T" sort="Mausbach, Brent T" uniqKey="Mausbach B" first="Brent T" last="Mausbach">Brent T. Mausbach</name><affiliation><nlm:aff id="A1">Department of Psychiatry, University of California San Diego</nlm:aff></affiliation></author></analytic><series><title level="j">Behaviour research and therapy</title><idno type="ISSN">0005-7967</idno><idno type="eISSN">1873-622X</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P2">Dementia caregiving is associated with elevations in depressive symptoms and increased risk for cardiovascular diseases (CVD). This study evaluated the efficacy of the Pleasant Events Program (PEP), a 6-week Behavioral Activation intervention designed to reduce CVD risk and depressive symptoms in caregivers. One hundred dementia family caregivers were randomized to either the 6-week PEP intervention (N=49) or a time-equivalent Information-Support (IS) control condition (N=51). Assessments were completed pre- and post-intervention and at 1-year follow-up. Biological assessments included CVD risk markers Interleukin-6 (IL-6) and D-dimer. Psychosocial outcomes included depressive symptoms, positive affect, and negative affect. Participants receiving the PEP intervention had significantly greater reductions in IL-6 (p=.040), depressive symptoms (p=.039), and negative affect (p=.021) from pre- to post-treatment. For IL-6, clinically significant improvement was observed in 20.0% of PEP participants and 6.5% of IS participants. For depressive symptoms, clinically significant improvement was found for 32.7% of PEP vs 11.8% of IS participants. Group differences in change from baseline to 1-year follow-up were non-significant for all outcomes. The PEP program decreased depression and improved a measure of physiological health in older dementia caregivers. Future research should examine the efficacy of PEP for improving other CVD biomarkers and seek to sustain the intervention’s effects.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">0372477</journal-id><journal-id journal-id-type="pubmed-jr-id">965</journal-id><journal-id journal-id-type="nlm-ta">Behav Res Ther</journal-id><journal-id journal-id-type="iso-abbrev">Behav Res Ther</journal-id><journal-title-group><journal-title>Behaviour research and therapy</journal-title></journal-title-group><issn pub-type="ppub">0005-7967</issn><issn pub-type="epub">1873-622X</issn></journal-meta><article-meta><article-id pub-id-type="pmid">23916631</article-id><article-id pub-id-type="pmc">3774137</article-id><article-id pub-id-type="doi">10.1016/j.brat.2013.07.005</article-id><article-id pub-id-type="manuscript">NIHMS507754</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>A Randomized Clinical Trial of Behavioral Activation (BA) Therapy for Improving Psychological and Physical Health in Dementia Caregivers: Results of the Pleasant Events Program (PEP)</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Moore</surname><given-names>Raeanne C</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A1">a</xref><xref ref-type="aff" rid="A2">b</xref></contrib><contrib contrib-type="author"><name><surname>Chattillion</surname><given-names>Elizabeth A</given-names></name><degrees>MS</degrees><xref ref-type="aff" rid="A3">c</xref></contrib><contrib contrib-type="author"><name><surname>Ceglowski</surname><given-names>Jennifer</given-names></name><degrees>MS</degrees><xref ref-type="aff" rid="A1">a</xref></contrib><contrib contrib-type="author"><name><surname>Ho</surname><given-names>Jennifer</given-names></name><xref ref-type="aff" rid="A3">c</xref></contrib><contrib contrib-type="author"><name><surname>von Känel</surname><given-names>Roland</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A1">a</xref><xref ref-type="aff" rid="A4">d</xref><xref ref-type="aff" rid="A5">e</xref></contrib><contrib contrib-type="author"><name><surname>Mills</surname><given-names>Paul J</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A1">a</xref></contrib><contrib contrib-type="author"><name><surname>Ziegler</surname><given-names>Michael G</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A6">f</xref></contrib><contrib contrib-type="author"><name><surname>Patterson</surname><given-names>Thomas L</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A1">a</xref></contrib><contrib contrib-type="author"><name><surname>Grant</surname><given-names>Igor</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A1">a</xref></contrib><contrib contrib-type="author"><name><surname>Mausbach</surname><given-names>Brent T</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A1">a</xref></contrib></contrib-group><aff id="A1"><label>a</label>Department of Psychiatry, University of California San Diego</aff><aff id="A2"><label>b</label>Sam and Rose Stein Institute for Research on Aging, University of California San Diego</aff><aff id="A3"><label>c</label>San Diego State University/University of California, San Diego, Joint Doctoral Program in Clinical Psychology</aff><aff id="A4"><label>d</label>Division of Psychosomatic Medicine, Department of General Internal Medicine, Inselspital, Bern University Hospital and University of Bern, Switzerland</aff><aff id="A5"><label>e</label>Department of Clinical Research, University of Bern, Switzerland</aff><aff id="A6"><label>f</label>Department of Medicine, University of California San Diego</aff><author-notes><corresp id="FN1">Corresponding Author: Brent T Mausbach, PhD; Department of Psychiatry (0993), University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093-0993. Tel: (858) 822-7529; <email>bmausbach@ucsd.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>26</day><month>8</month><year>2013</year></pub-date><pub-date pub-type="epub"><day>19</day><month>7</month><year>2013</year></pub-date><pub-date pub-type="ppub"><month>10</month><year>2013</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>10</month><year>2014</year></pub-date><volume>51</volume><issue>10</issue><fpage>623</fpage><lpage>632</lpage><permissions><copyright-statement>© 2013 Elsevier Ltd. All rights reserved.</copyright-statement><copyright-year>2013</copyright-year></permissions><abstract><p id="P2">Dementia caregiving is associated with elevations in depressive symptoms and increased risk for cardiovascular diseases (CVD). This study evaluated the efficacy of the Pleasant Events Program (PEP), a 6-week Behavioral Activation intervention designed to reduce CVD risk and depressive symptoms in caregivers. One hundred dementia family caregivers were randomized to either the 6-week PEP intervention (N=49) or a time-equivalent Information-Support (IS) control condition (N=51). Assessments were completed pre- and post-intervention and at 1-year follow-up. Biological assessments included CVD risk markers Interleukin-6 (IL-6) and D-dimer. Psychosocial outcomes included depressive symptoms, positive affect, and negative affect. Participants receiving the PEP intervention had significantly greater reductions in IL-6 (p=.040), depressive symptoms (p=.039), and negative affect (p=.021) from pre- to post-treatment. For IL-6, clinically significant improvement was observed in 20.0% of PEP participants and 6.5% of IS participants. For depressive symptoms, clinically significant improvement was found for 32.7% of PEP vs 11.8% of IS participants. Group differences in change from baseline to 1-year follow-up were non-significant for all outcomes. The PEP program decreased depression and improved a measure of physiological health in older dementia caregivers. Future research should examine the efficacy of PEP for improving other CVD biomarkers and seek to sustain the intervention’s effects.</p></abstract><kwd-group><kwd>Depression</kwd><kwd>Cardiovascular Disease</kwd><kwd>Alzheimer’s Disease</kwd><kwd>Intervention</kwd><kwd>Treatment</kwd></kwd-group><funding-group><award-group><funding-source country="United States">National Institute on Aging : NIA</funding-source><award-id>R01 AG031090 || AG</award-id></award-group><award-group><funding-source country="United States">National Institute on Aging : NIA</funding-source><award-id>R01 AG015301 || AG</award-id></award-group></funding-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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