Effectiveness of Sequential Combined Treatment in Comparison with Treatment as Usual in Preventing Relapse in Alcohol Dependence
Identifieur interne : 001667 ( Istex/Corpus ); précédent : 001666; suivant : 001668Effectiveness of Sequential Combined Treatment in Comparison with Treatment as Usual in Preventing Relapse in Alcohol Dependence
Auteurs : Domingos Neto ; Rita Lambaz ; Pedro Aguiar ; Jonathan ChickSource :
- Alcohol & Alcoholism [ 0735-0414 ] ; 2008.
Abstract
Aim: The aim of this study was to compare the effectiveness of the sequential combined treatment (SCT) and treatment as usual (TU) in relapse prevention in a sample of alcohol-dependent patients, during 180 days of outpatient treatment. Method: 209 alcohol-dependent patients who could attend with an informant adult were randomized to either TU or SCT. The primary outcome measure was time to first relapse, defined as the consumption of any amount of alcohol during the 180 days of follow-up. Secondary outcome measures included maximum duration of continuous abstinence (MDCA), cumulative abstinence duration (CAD), quality of life (ARPQ) and blood test markers of alcohol consumption. Results: The SCT approach was more effective than TU. The KaplanMeier abstinent proportion at the end of the 180 days was 78 for the SCT group and 59 for the TU group (P < 0.01). The mean time to first relapse was 150 days for SCT and 123 days for TU (P < 0.01). The relative risk reduction of relapse was 62 for SCT after adjustment in multiple Cox regression (P < 0.01). SCT had more MDCA (P < 0.05) and more CAD (P < 0.05). Therapy sessions lasted slightly longer for SCT than TU (mean 13 min versus 10 min). Conclusions: SCT can result in better outcomes than TU in the outpatient treatment of alcohol dependence.
Url:
DOI: 10.1093/alcalc/agn075
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Method: 209 alcohol-dependent patients who could attend with an informant adult were randomized to either TU or SCT. The primary outcome measure was time to first relapse, defined as the consumption of any amount of alcohol during the 180 days of follow-up. Secondary outcome measures included maximum duration of continuous abstinence (MDCA), cumulative abstinence duration (CAD), quality of life (ARPQ) and blood test markers of alcohol consumption. Results: The SCT approach was more effective than TU. The KaplanMeier abstinent proportion at the end of the 180 days was 78 for the SCT group and 59 for the TU group (P < 0.01). The mean time to first relapse was 150 days for SCT and 123 days for TU (P < 0.01). The relative risk reduction of relapse was 62 for SCT after adjustment in multiple Cox regression (P < 0.01). SCT had more MDCA (P < 0.05) and more CAD (P < 0.05). Therapy sessions lasted slightly longer for SCT than TU (mean 13 min versus 10 min). Conclusions: SCT can result in better outcomes than TU in the outpatient treatment of alcohol dependence.</div></front></TEI><istex><corpusName>oup</corpusName><author><json:item><name>Domingos Neto</name><affiliations><json:string>Princpio-Actividades Mdicas, Rua Sargento Jos Paulo dos Santos No. 25, 1800-330 Lisboa, Portugal</json:string><json:string>E-mail: dnetoster@gmail.com</json:string></affiliations></json:item><json:item><name>Rita Lambaz</name><affiliations><json:string>Unidade de Alcoologia do IDT, Parque de Sade de Lisboa, Av. do Brasil, 53 A. 1749-006 Lisboa, Portugal</json:string></affiliations></json:item><json:item><name>Pedro Aguiar</name><affiliations><json:string>Escola Nacional de Sade Pblica, Universidade Nova de Lisboa, 1600-560 Lisboa, Portugal</json:string></affiliations></json:item><json:item><name>Jonathan Chick</name><affiliations><json:string>University of Edinburgh, Department of Psychiatry, Royal Edinburgh Hospital, Edinburgh, EH10 5HF, UK</json:string></affiliations></json:item></author><articleId><json:string>agn075</json:string></articleId><language><json:string>unknown</json:string></language><originalGenre><json:string>research-article</json:string></originalGenre><abstract>Aim: The aim of this study was to compare the effectiveness of the sequential combined treatment (SCT) and treatment as usual (TU) in relapse prevention in a sample of alcohol-dependent patients, during 180 days of outpatient treatment. Method: 209 alcohol-dependent patients who could attend with an informant adult were randomized to either TU or SCT. The primary outcome measure was time to first relapse, defined as the consumption of any amount of alcohol during the 180 days of follow-up. Secondary outcome measures included maximum duration of continuous abstinence (MDCA), cumulative abstinence duration (CAD), quality of life (ARPQ) and blood test markers of alcohol consumption. Results: The SCT approach was more effective than TU. The KaplanMeier abstinent proportion at the end of the 180 days was 78 for the SCT group and 59 for the TU group (P > 0.01). The mean time to first relapse was 150 days for SCT and 123 days for TU (P > 0.01). The relative risk reduction of relapse was 62 for SCT after adjustment in multiple Cox regression (P > 0.01). SCT had more MDCA (P > 0.05) and more CAD (P > 0.05). Therapy sessions lasted slightly longer for SCT than TU (mean 13 min versus 10 min). Conclusions: SCT can result in better outcomes than TU in the outpatient treatment of alcohol dependence.</abstract><qualityIndicators><score>9.652</score><pdfVersion>1.2</pdfVersion><pdfPageSize>612.284 x 796.5 pts</pdfPageSize><refBibsNative>false</refBibsNative><keywordCount>0</keywordCount><abstractCharCount>1306</abstractCharCount><pdfWordCount>6062</pdfWordCount><pdfCharCount>35696</pdfCharCount><pdfPageCount>8</pdfPageCount><abstractWordCount>221</abstractWordCount></qualityIndicators><title>Effectiveness of Sequential Combined Treatment in Comparison with Treatment as Usual in Preventing Relapse in Alcohol Dependence</title><genre><json:string>research-article</json:string></genre><host><volume>43</volume><publisherId><json:string>alcalc</json:string></publisherId><pages><last>668</last><first>661</first></pages><issn><json:string>0735-0414</json:string></issn><issue>6</issue><genre><json:string>journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1464-3502</json:string></eissn><title>Alcohol & Alcoholism</title></host><categories><wos><json:string>social science</json:string><json:string>substance abuse</json:string></wos><scienceMetrix><json:string>health sciences</json:string><json:string>public health & health services</json:string><json:string>substance abuse</json:string></scienceMetrix></categories><publicationDate>2008</publicationDate><copyrightDate>2008</copyrightDate><doi><json:string>10.1093/alcalc/agn075</json:string></doi><id>BB13B020CC305B39B4625AB8137BC2E393FCC912</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/BB13B020CC305B39B4625AB8137BC2E393FCC912/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/BB13B020CC305B39B4625AB8137BC2E393FCC912/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/BB13B020CC305B39B4625AB8137BC2E393FCC912/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a">Effectiveness of Sequential Combined Treatment in Comparison with Treatment as Usual in Preventing Relapse in Alcohol Dependence</title><respStmt><resp>Références bibliographiques récupérées via GROBID</resp><name resp="ISTEX-API">ISTEX-API (INIST-CNRS)</name></respStmt></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Oxford University Press</publisher><availability><p>The Author 2008. Published by Oxford University Press on behalf of the Medical Council on Alcohol. All rights reserved</p></availability><date>2008-10-13</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a">Effectiveness of Sequential Combined Treatment in Comparison with Treatment as Usual in Preventing Relapse in Alcohol Dependence</title><author xml:id="author-1"><persName><forename type="first">Domingos</forename><surname>Neto</surname></persName><email>dnetoster@gmail.com</email><affiliation>Princpio-Actividades Mdicas, Rua Sargento Jos Paulo dos Santos No. 25, 1800-330 Lisboa, Portugal</affiliation></author><author xml:id="author-2"><persName><forename type="first">Rita</forename><surname>Lambaz</surname></persName><affiliation>Unidade de Alcoologia do IDT, Parque de Sade de Lisboa, Av. do Brasil, 53 A. 1749-006 Lisboa, Portugal</affiliation></author><author xml:id="author-3"><persName><forename type="first">Pedro</forename><surname>Aguiar</surname></persName><affiliation>Escola Nacional de Sade Pblica, Universidade Nova de Lisboa, 1600-560 Lisboa, Portugal</affiliation></author><author xml:id="author-4"><persName><forename type="first">Jonathan</forename><surname>Chick</surname></persName><affiliation>University of Edinburgh, Department of Psychiatry, Royal Edinburgh Hospital, Edinburgh, EH10 5HF, UK</affiliation></author></analytic><monogr><title level="j">Alcohol & Alcoholism</title><title level="j" type="abbrev">Alcalc</title><idno type="pISSN">0735-0414</idno><idno type="eISSN">1464-3502</idno><imprint><publisher>Oxford University Press</publisher><date type="published" when="2008"></date><biblScope unit="volume">43</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="661">661</biblScope><biblScope unit="page" to="668">668</biblScope></imprint></monogr><idno type="istex">BB13B020CC305B39B4625AB8137BC2E393FCC912</idno><idno type="DOI">10.1093/alcalc/agn075</idno><idno type="ArticleID">agn075</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2008-10-13</date></creation><abstract><p>Aim: The aim of this study was to compare the effectiveness of the sequential combined treatment (SCT) and treatment as usual (TU) in relapse prevention in a sample of alcohol-dependent patients, during 180 days of outpatient treatment. Method: 209 alcohol-dependent patients who could attend with an informant adult were randomized to either TU or SCT. The primary outcome measure was time to first relapse, defined as the consumption of any amount of alcohol during the 180 days of follow-up. Secondary outcome measures included maximum duration of continuous abstinence (MDCA), cumulative abstinence duration (CAD), quality of life (ARPQ) and blood test markers of alcohol consumption. Results: The SCT approach was more effective than TU. The KaplanMeier abstinent proportion at the end of the 180 days was 78 for the SCT group and 59 for the TU group (P < 0.01). The mean time to first relapse was 150 days for SCT and 123 days for TU (P < 0.01). The relative risk reduction of relapse was 62 for SCT after adjustment in multiple Cox regression (P < 0.01). SCT had more MDCA (P < 0.05) and more CAD (P < 0.05). Therapy sessions lasted slightly longer for SCT than TU (mean 13 min versus 10 min). Conclusions: SCT can result in better outcomes than TU in the outpatient treatment of alcohol dependence.</p></abstract></profileDesc><revisionDesc><change when="2008-10-13">Created</change><change when="2008">Published</change><change xml:id="refBibs-istex" who="#ISTEX-API" when="2016-12-22">References added</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/BB13B020CC305B39B4625AB8137BC2E393FCC912/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="corpus oup" wicri:toSee="no header"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//NLM//DTD Journal Publishing DTD v2.3 20070202//EN" URI="journalpublishing.dtd" name="istex:docType"></istex:docType><istex:document><article article-type="research-article"><front><journal-meta><journal-id journal-id-type="publisher-id">alcalc</journal-id><journal-id journal-id-type="hwp">alcalc</journal-id><journal-title>Alcohol & Alcoholism</journal-title><abbrev-journal-title abbrev-type="pubmed">Alcalc</abbrev-journal-title><issn pub-type="ppub">0735-0414</issn><issn pub-type="epub">1464-3502</issn><publisher><publisher-name>Oxford University Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.1093/alcalc/agn075</article-id><article-id pub-id-type="publisher-id">agn075</article-id><article-categories><subj-group subj-group-type="heading"><subject>Treatment</subject></subj-group></article-categories><title-group><article-title>Effectiveness of Sequential Combined Treatment in Comparison with Treatment as Usual in Preventing Relapse in Alcohol Dependence</article-title><alt-title alt-title-type="left-running">Neto <italic>et al.</italic></alt-title><alt-title alt-title-type="right-running">A Randomized Comparative Study of Treatments in Alcohol Relapse Prevention</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Neto</surname><given-names>Domingos</given-names></name><xref ref-type="aff" rid="af1">1</xref><xref ref-type="corresp" rid="COR1">*</xref></contrib><contrib contrib-type="author"><name><surname>Lambaz</surname><given-names>Rita</given-names></name><xref ref-type="aff" rid="af2">2</xref></contrib><contrib contrib-type="author"><name><surname>Aguiar</surname><given-names>Pedro</given-names></name><xref ref-type="aff" rid="af3">3</xref></contrib><contrib contrib-type="author"><name><surname>Chick</surname><given-names>Jonathan</given-names></name><xref ref-type="aff" rid="af4">4</xref></contrib></contrib-group><aff id="af1"><label>1</label><addr-line>Princípio-Actividades Médicas, Rua Sargento José Paulo dos Santos No. 25, 1800-330 Lisboa</addr-line>, <country>Portugal</country></aff><aff id="af2"><label>2</label><addr-line>Unidade de Alcoologia do IDT, Parque de Saúde de Lisboa, Av. do Brasil, 53 A. 1749-006 Lisboa</addr-line>, <country>Portugal</country></aff><aff id="af3"><label>3</label><addr-line>Escola Nacional de Saúde Pública</addr-line>, <institution>Universidade Nova de Lisboa</institution>, <addr-line>1600-560 Lisboa</addr-line>, <country>Portugal</country></aff><aff id="af4"><label>4</label><institution>University of Edinburgh</institution>, <addr-line>Department of Psychiatry, Royal Edinburgh Hospital, Edinburgh, EH10 5HF</addr-line>, <country>UK</country></aff><author-notes><corresp id="COR1"><label>*</label>Corresponding author: Domingos Neto, at Princípio-Actividades Médicas, Rua Sargento José Paulo dos Santos No. 25, 1800-330 Lisboa, Portugal. Tel: <phone>+00-351-919-365-614</phone>; E-mail: <email>dnetoster@gmail.com</email></corresp></author-notes><pub-date pub-type="ppub"><season>November-December</season><year>2008</year></pub-date><pub-date pub-type="epub"><day>13</day><month>10</month><year>2008</year></pub-date><volume>43</volume><issue>6</issue><fpage>661</fpage><lpage>668</lpage><history><date date-type="received"><day>10</day><month>3</month><year>2008</year></date><date date-type="rev-request"><day>6</day><month>5</month><year>2008</year></date><date date-type="rev-recd"><day>19</day><month>6</month><year>2008</year></date><date date-type="rev-recd"><day>25</day><month>7</month><year>2008</year></date><date date-type="accepted"><day>31</day><month>7</month><year>2008</year></date></history><permissions><copyright-statement>© The Author 2008. Published by Oxford University Press on behalf of the Medical Council on Alcohol. All rights reserved</copyright-statement><copyright-year>2008</copyright-year><copyright-holder>Oxford University Press</copyright-holder></permissions><abstract><p><bold>Aim:</bold> The aim of this study was to compare the effectiveness of the sequential combined treatment (SCT) and treatment as usual (TU) in relapse prevention in a sample of alcohol-dependent patients, during 180 days of outpatient treatment. <bold>Method:</bold> 209 alcohol-dependent patients who could attend with an informant adult were randomized to either TU or SCT. The primary outcome measure was time to first relapse, defined as the consumption of any amount of alcohol during the 180 days of follow-up. Secondary outcome measures included maximum duration of continuous abstinence (MDCA), cumulative abstinence duration (CAD), quality of life (ARPQ) and blood test markers of alcohol consumption. <bold>Results:</bold> The SCT approach was more effective than TU. The Kaplan–Meier abstinent proportion at the end of the 180 days was 78% for the SCT group and 59% for the TU group (<italic>P</italic> < 0.01). The mean time to first relapse was 150 days for SCT and 123 days for TU (<italic>P</italic> < 0.01). The relative risk reduction of relapse was 62% for SCT after adjustment in multiple Cox regression (<italic>P</italic> < 0.01). SCT had more MDCA (<italic>P</italic> < 0.05) and more CAD (<italic>P</italic> < 0.05). Therapy sessions lasted slightly longer for SCT than TU (mean 13 min versus 10 min). <bold>Conclusions:</bold> SCT can result in better outcomes than TU in the outpatient treatment of alcohol dependence.</p></abstract></article-meta></front></article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Effectiveness of Sequential Combined Treatment in Comparison with Treatment as Usual in Preventing Relapse in Alcohol Dependence</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Effectiveness of Sequential Combined Treatment in Comparison with Treatment as Usual in Preventing Relapse in Alcohol Dependence</title></titleInfo><name type="personal"><namePart type="given">Domingos</namePart><namePart type="family">Neto</namePart><affiliation>Princpio-Actividades Mdicas, Rua Sargento Jos Paulo dos Santos No. 25, 1800-330 Lisboa, Portugal</affiliation><affiliation>E-mail: dnetoster@gmail.com</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Rita</namePart><namePart type="family">Lambaz</namePart><affiliation>Unidade de Alcoologia do IDT, Parque de Sade de Lisboa, Av. do Brasil, 53 A. 1749-006 Lisboa, Portugal</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Pedro</namePart><namePart type="family">Aguiar</namePart><affiliation>Escola Nacional de Sade Pblica, Universidade Nova de Lisboa, 1600-560 Lisboa, Portugal</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jonathan</namePart><namePart type="family">Chick</namePart><affiliation>University of Edinburgh, Department of Psychiatry, Royal Edinburgh Hospital, Edinburgh, EH10 5HF, UK</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="research-article"></genre><originInfo><publisher>Oxford University Press</publisher><dateIssued encoding="w3cdtf">2008</dateIssued><dateCreated encoding="w3cdtf">2008-10-13</dateCreated><copyrightDate encoding="w3cdtf">2008</copyrightDate></originInfo><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract>Aim: The aim of this study was to compare the effectiveness of the sequential combined treatment (SCT) and treatment as usual (TU) in relapse prevention in a sample of alcohol-dependent patients, during 180 days of outpatient treatment. Method: 209 alcohol-dependent patients who could attend with an informant adult were randomized to either TU or SCT. The primary outcome measure was time to first relapse, defined as the consumption of any amount of alcohol during the 180 days of follow-up. Secondary outcome measures included maximum duration of continuous abstinence (MDCA), cumulative abstinence duration (CAD), quality of life (ARPQ) and blood test markers of alcohol consumption. Results: The SCT approach was more effective than TU. The KaplanMeier abstinent proportion at the end of the 180 days was 78 for the SCT group and 59 for the TU group (P < 0.01). The mean time to first relapse was 150 days for SCT and 123 days for TU (P < 0.01). The relative risk reduction of relapse was 62 for SCT after adjustment in multiple Cox regression (P < 0.01). SCT had more MDCA (P < 0.05) and more CAD (P < 0.05). Therapy sessions lasted slightly longer for SCT than TU (mean 13 min versus 10 min). 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|clé= ISTEX:BB13B020CC305B39B4625AB8137BC2E393FCC912
|texte= Effectiveness of Sequential Combined Treatment in Comparison with Treatment as Usual in Preventing Relapse in Alcohol Dependence
}}
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